Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 590,000 properties worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Santorini Island Independent Hotels

See all 967 Hotels in Santorini Island
Lilium Villas

Lilium Villas

Fira Town, Santorini
5.0 out of 5.0

$129

$129
Ira Hotel & Spa

Ira Hotel & Spa

Firostefani, Santorini
4.0 out of 5.0
Loizos Apartments

Loizos Apartments

Fira, Santorini
4.0 out of 5.0
Mill Houses Elegant Suites

Mill Houses Elegant Suites

Firostefani, Santorini
4.5 out of 5.0

$104

$104
Azzurro Suites

Azzurro Suites

Fira City, Santorini
4.5 out of 5.0
Hotel Sunny Villas

Hotel Sunny Villas

Imerovigli, Santorini
4.0 out of 5.0
Dana Villas

Dana Villas

Fira, Santorini
4.5 out of 5.0

$93

$93
Santorini Palace

Santorini Palace

Fira town, Santorini
4.5 out of 5.0
Andronis Boutique Hotel

Andronis Boutique Hotel

Oia, Santorini
5.0 out of 5.0
Katikies Hotel

Katikies Hotel

Oia, Santorini
5.0 out of 5.0
Volcano View Hotel & Villas

Volcano View Hotel & Villas

Fira, Santorini
5.0 out of 5.0
Santorini Princess Luxury Spa Hotel

Santorini Princess Luxury Spa Hotel

Imerovigli, Santorini
5.0 out of 5.0
Agnadema Apartments

Agnadema Apartments

Firostefani, Santorini
4.0 out of 5.0
De Sol Spa Hotel

De Sol Spa Hotel

Fira, Santorini
5.0 out of 5.0

$109

$109
Alexander's Boutique Hotel

Alexander's Boutique Hotel

Oia, Santorini
4.5 out of 5.0
Belvedere Suites

Belvedere Suites

Georgiou Nomikou Street, Santorini
4.5 out of 5.0
Oia's Sunset

Oia's Sunset

Oia, Santorini
2.5 out of 5.0
Finikia Memories Hotel

Finikia Memories Hotel

Oia, Santorini
3.5 out of 5.0
Tzekos Villas

Tzekos Villas

Marinatou, Fira, Santorini
4.5 out of 5.0
Residence Suites

Residence Suites

Oia, Santorini
3.5 out of 5.0

$68

$68

Recently booked Santorini Island hotels

De Sol Spa Hotel
5.0 out of 5.0
Last booking: 44 minutes ago
Aigialos Niche Residences & Suites
5.0 out of 5.0
Last booking: 2 hours ago
Golden Sunset
3.5 out of 5.0
Last booking: 2 hours ago
Manos Small World
3.5 out of 5.0
Last booking: 3 hours ago
Santorini Secret Suites & Spa
4.5 out of 5.0
Last booking: 3 hours ago
Athermi Suites
3.5 out of 5.0
Last booking: 3 hours ago
Dream Island Hotel
3.5 out of 5.0
Last booking: 4 hours ago
San Antonio
4.0 out of 5.0
Last booking: 5 hours ago
Agnadema Apartments
4.0 out of 5.0
Last booking: 6 hours ago

Independent Santorini Island Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Santorini Island, Santorini. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Santorini Island hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Santorini Island Independent locations may even offer extra little benefits and discounts for frequent travelers.