Find hotels by Best Western in Seneca, SC from $89
Most hotels are fully refundable. Because flexibility matters.
Save 10% or more on over 100,000 hotels worldwide as a One Key member.
Search over 2.9 million properties and 550 airlines worldwide.
Compare rooms and suites by Best Western in Seneca with rates, reviews, and availability. Most hotels are fully refundable.
Best Western Seneca Hotel Guide
Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Best Western hotels in Seneca, South Carolina. Known for well-appointed rooms and friendly, personalized service, each of the top Best Western Seneca hotels guarantees an unparalleled level of comfort and quality.
You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Seneca Best Western locations may even offer extra little benefits and discounts for frequent travelers.
Recent reviews of Seneca hotelsExpedia verified reviews
Clemson University's James F. Martin Inn
Seneca Hotels by Brand
Hotels in Seneca Neighborhoods
Hotels near popular Seneca Attractions
- Hotels near Clemson University
- Hotels near Tallulah Gorge State Park
- Hotels near Lake Hartwell
- Hotels near Lake Keowee
- Hotels near Lake Jocassee
- Hotels near Chattahoochee National Forest
- Hotels near Table Rock State Park
- Hotels near Toccoa Falls
- Hotels near Devils Fork State Park
- Hotels near Anderson University
More Hotel Options in Seneca
- Beach Hotels (1)
- Business Hotels (4)
- Cheap Hotels (3)
- Family Hotels (9)
- Fishing Resorts & Hotels (2)
- Golf Hotels (1)
- Historic Hotels (1)
- Hotel Wedding Venues (1)
- Hotels & Resorts for Couples (7)
- Hotels on the Lake (9)
- Hotels with Air Conditioning (10)
- Hotels with Balconies (4)
- Hotels with Bars (1)
- Hotels with Connecting Rooms (2)
- Hotels with Fireplaces (5)
- Hotels with Free Breakfast (4)
- Hotels with Free Parking (4)
- Hotels with Free Wifi (4)
- Hotels with Hot Tubs (2)
- Hotels with Laundry Facilities (3)
- Hotels with Restaurants (7)
- Hotels with a Gym (3)
- Hotels with a Pool (5)
- Hotels with a View (4)
- Hotels with an Outdoor Pool (5)
- Hotels with smoking rooms (1)
- Non-Smoking Hotels (7)
- Pet-friendly Hotels (4)
- Quiet Resorts & Hotels (3)
- Resorts & Hotels with Spas (1)
- Romantic Hotels (5)
- Ski Hotels (1)
More Accommodation Types in Seneca
- Condo Rentals (15,362)
- Vacation Homes (12,842)
- Apartments (3,622)
- Villas (3,123)
- Cottages (940)
- Resorts (685)
- Aparthotels (167)
- Cabin Rentals (161)
- Motels (156)
- B&B (73)
- Guest Houses (66)
- Farmstay (31)
- RV Parks (25)
- Condo Resorts (13)
- Lodges (13)
- Chalets (6)
- Houseboats (6)
- Inns (4)
- Castles (2)
- Country Houses (1)
- Hostels (1)
- Residences (1)
Explore more
More Popular Hotels in South Carolina
- Inn @ Clemson
- Best Western Plus Clemson Hotel & Conference Center
- Holiday Inn Express & Suites Clemson, an IHG Hotel
- The Inn at Patrick Square
- Hampton Inn Clemson-University Area
- Highlands Panoramic Mountain Views Designer Cottage
- Comfort Inn & Suites Clemson - University Area
- Clemson University's James F. Martin Inn
- Microtel Inn & Suites by Wyndham Anderson/Clemson
- The Abernathy of Clemson
- Baymont by Wyndham Easley/Greenville
- Courtyard Marriott Clemson
- Comfort Suites Anderson-Clemson
- Holiday Inn Express Hotel & Suites Anderson-I-85, an IHG Hotel
- Quality Inn Clemson near University
- Days Inn by Wyndham Clemson
- Home2 Suites by Hilton Anderson Downtown
- Holiday Inn Anderson, an IHG Hotel
- Hilton Garden Inn Anderson
- Luxury cabins in the foothills of the Blue Ridge Mountains