Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Sikeston Family Hotels

See all 56 Hotels in Sikeston
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

3265 William St, Cape Girardeau
3.0 out of 5.0
4.5 out of 5 (357 reviews)
Clean hotel I love staying here when I travel for my job. Great breakfast and quiet.
  Jan 17, 2018

$79

$79
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Sikeston
3.5 out of 5.0
4.7 out of 5 (437 reviews)
Sikeston, MO Fast and friendly check in. Nice, clean room in a nice, clean building.
  Jan 5, 2018

$125

$125
Pear Tree Inn - Sikeston

Pear Tree Inn - Sikeston

2602 E Malone Avenue, Sikeston
3.0 out of 5.0
4.4 out of 5 (421 reviews)
My Second stayDown on urgent family business , staff was very nice , it was as nice as my last stay.
  Jan 8, 2018

$80

$80
Best Western Plus Sikeston

Best Western Plus Sikeston

120 S Interstate Drive, Sikeston
3.0 out of 5.0
4.3 out of 5 (406 reviews)
Nice hotel just off I-55, convenient to highway.We enjoyed our stay there, Staff was friendly, room was clean, breakfast was good and overall a very good experience. Would stay there again.
  Jan 16, 2018

$80

$80
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3303 Campster Drive, Cape Girardeau
3.5 out of 5.0
4.7 out of 5 (168 reviews)
Great shopping locationPlenty of room to relax after an all day shopping trip
  Nov 19, 2017

$100

$100
Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau

2904 Old Orchard Rd, Jackson
3.0 out of 5.0
4.3 out of 5 (291 reviews)
This hotel worked perfect for our family of 5 with three small children
  Jan 6, 2018

$90

$90
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

225 Drury Lane, Jackson
3.5 out of 5.0
4.7 out of 5 (283 reviews)
Terrific StayThe staff are so helpful and friendly, and the snacks and drinks they provide are wonderful
  Dec 22, 2017

$95

$95
Holiday Inn Express Hotel & Suites Cape Girardeau I-55

Holiday Inn Express Hotel & Suites Cape Girardeau I-55

3253 William Street, Cape Girardeau
3.0 out of 5.0
4.8 out of 5 (367 reviews)
This is our 3rd trip to this hotel. It’s our favorite hotel to stay in Cape Girardeau.
  Jan 14, 2018

$102

$102
Dexter Inn

Dexter Inn

1807 W Business US Highway 60, Dexter
3.0 out of 5.0
3.3 out of 5 (35 reviews)
Good LocationThis is an excellent place if looking for access to shopping, entertainment and dining for the traveler. Would recommend it to anyone.
  Oct 31, 2017

$65

$65
Quality Inn Charleston

Quality Inn Charleston

102 Drake St, Charleston
3.0 out of 5.0
3.9 out of 5 (74 reviews)
We stayed at the Quality Inn because it was about the half point on our trip back home and we were able to get a discount by booking the room online. For the most part, we were very pleased with the experience. The room was much larger than I had anticipated. We were provided a warm breakfast including ...
  Jan 14, 2018

$57

$57
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau
3.0 out of 5.0
4.1 out of 5 (530 reviews)
Front desk ladies are always so nice and helpful!!
  Jan 17, 2018

$80

$80
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

207 S Mt Auburn Rd, Cape Girardeau
3.0 out of 5.0
4.9 out of 5 (119 reviews)
Nice, as always! We always stay here, consistently nice hotel, consistently nice staff!
  Dec 12, 2017

$101

$101
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau
3.0 out of 5.0
4.2 out of 5 (237 reviews)
Going homeConvenient to highway and shopping. Clean room. Friendly staff.
  Dec 27, 2017

$80

$80
Baymont Inn & Suites Dexter

Baymont Inn & Suites Dexter

1608 Hwy Business 60 W, Dexter
3.0 out of 5.0
3.7 out of 5 (143 reviews)
hotel was close to resturantsThe hotel was very clean and staff was nice. If we needed anything they went out of their way to help us exspecially the cleaning personnal. We were in and out of hotel visiting our relatives. The price was right too.
  Oct 30, 2017

$73

$73
Candlewood Suites Cape Girardeau

Candlewood Suites Cape Girardeau

485 S Mount Auburn Rd, Cape Girardeau
2.5 out of 5.0
4.3 out of 5 (211 reviews)
Best hotel with the best staffWe loved the hotel and the staff. Everything was super clean. The bed was really comfortable. We would definitely stay there again.
  Jan 2, 2018

$85

$85
Holiday Inn Express & Suites Sikeston Southwest

Holiday Inn Express & Suites Sikeston Southwest

115 Hospitality Dr, Sikeston
3.0 out of 5.0
4.3 out of 5 (66 reviews)
Best I’ve stayed in!Everything was awesome from the staff all the way up to the food and cleanliness. Rooms are huge. I would even say it was better than most of the outdated Vegas rooms.
  Dec 30, 2017

$110

$110
Super 8 Cape Girardeau

Super 8 Cape Girardeau

2011 North Kingshighway, Cape Girardeau
2.5 out of 5.0
3.3 out of 5 (266 reviews)
Adequate for the price.The room was large and comfortable. Fridge, but no Micro, had to use the one in the Breakfast Area. Hot Breakfast was a Toaster! and Microwave! Washer & Dryer available for guests to use. No WiFi offered, access in lobby! Was VERY pleased that SBN was available on the cable TV so I didn't miss Church ...
  Sep 2, 2015
Americas Best Value Inn & Suites Sikeston

Americas Best Value Inn & Suites Sikeston

220 S Interstate Dr, Sikeston
2.5 out of 5.0
3.5 out of 5 (279 reviews)
Staff was really nice. I booked two rooms. Stayed one night on the way to our destination and two weeks later, one night on the way back. Night clerk already had my keys ready when I arrived. I was pleased on how big the rooms were. I was disappointed that the rooms were a little on the dirty ...
  Jan 11, 2018

$65

$65
Super 8 - Sikeston/Miner Area

Super 8 - Sikeston/Miner Area

2609 E Malone Ave, Sikeston
2.5 out of 5.0
3.1 out of 5 (222 reviews)
Nice place but not quite up to my cleanliness standards.
  Nov 20, 2017

$51

$51
Econo Lodge Dexter

Econo Lodge Dexter

913 Outer Rd, Dexter
2.5 out of 5.0
3.3 out of 5 (43 reviews)
Perfect location.Accommodations were fine. Fridge, microwave, coffee maker, hair dryer, iron. More than I expected. Not sure about the air conditioner. Would stay there again.
  Aug 23, 2017

$57

$57
Map

Recently booked Family Hotels in Sikeston

Holiday Inn Express Hotel & Suites Cape Girardeau I-55
3.0 out of 5.0
Last booking: 3 hours ago
Econo Lodge Dexter
2.5 out of 5.0
Last booking: 6 hours ago
Auburn Place Hotel And Suites
3.0 out of 5.0
Last booking: 8 hours ago
Drury Inn & Suites Sikeston, MO
3.5 out of 5.0
Last booking: 9 hours ago
Pear Tree Inn Cape Girardeau Near the Medical Center
3.0 out of 5.0
Last booking: 9 hours ago
Dexter Inn
3.0 out of 5.0
Last booking: 10 hours ago
Comfort Suites Jackson-Cape Girardeau
3.0 out of 5.0
Last booking: 10 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
3.5 out of 5.0
Last booking: 12 hours ago
Motel 6 Sikeston MO
2.5 out of 5.0
Last booking: 15 hours ago

All set for a vacation that will go down in the history books? Get your kids together and find out why a great deal of travelers like you have booked a trip to Sikeston this year. Travelers are increasingly showing interest in this city due to all the exciting attractions and activities you'll find in town. Whether you're making friends with other vacationing families or getting travel advice from the locals, you'll leave town happy.

Find the Best Sikeston Family Hotel

It's time to get this family vacation started! Allow us to help. Here at Expedia.com, we invite you to browse through our selection of various hotels. From roomy interiors to places with friendly service, you'll come across exactly what your fam desires. Whether your family wants to get to know the town or simply relax at the hotel, the ideal accommodation is waiting for you to book today.

As Sikeston continues to climb in popularity, everyone is flocking here for a family vacation. In fact, this place saw plenty of visitors last year, and you can read all the useful tips they left in our review section. You'll be blown away at how many people would tell others about their hotel! Once you arrive at your accommodation, you'll see why these places received such good ratings. The rooms are clean and tidy, while the property grounds are especially welcoming. From the amazing rooms to the welcoming staff members, your family will be well on its way to being spoiled.

Your family won't be able to contain their happiness when you schedule a trip to Sikeston. Don't waste another second imagining your getaway. This is the ultimate time to book. Pinpoint your Sikeston family hotel now, and start marking off the days until your vacation officially begins!