South Eastern Region Vacations & Trips from $1,285

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Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

A cityscape with prominent domed buildings and a historic church.

Valletta

Valletta
A nighttime cityscape with illuminated buildings reflecting on the water.

Floriana

Floriana
An aerial view of a city with a prominent cathedral featuring a large red dome, surrounded by urban buildings and streets.

Zabbar

Zabbar
A harbor with numerous boats, a historic cityscape, and a clear sky.

Birgu

Birgu
A coastal cityscape with historic buildings, a fortified harbor, and a calm sea at dusk.

Senglea

Senglea
A marina with various boats docked, a large stone wall, and buildings in the background.

Kalkara

Kalkara

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Ramla Bay Resort

Ramla Bay Resort

$1,285
per person
Oct 31 - Nov 6
found 2 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Luqa (MLA)
8.6/10 Excellent! (805 reviews)
After spending a few days in busy, crowded Valletta, Ramla Bay Resort was the perfect place to relax and enjoy the ocean and island views. Nice room with a big balcony, great restaurants, and a friendly staff. There are multiple swimming pools and a beach area - all with plenty of lounge chairs and umbrellas.

Reviewed on Sep 24, 2026

Iniala Valletta

Iniala Valletta

$2,326
per person
Dec 1 - Dec 5
found 6 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Luqa (MLA)
9.8/10 Exceptional! (124 reviews)
A fantastic boutique hotel. Great location and excellent service- cannot fault it in any way.

Reviewed on Sep 22, 2026

SU29 Boutique Hotel

SU29 Boutique Hotel

$1,481
per person
Nov 21 - Nov 26
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Luqa (MLA)
9.2/10 Wonderful! (211 reviews)
Great location, very friendly and helpful staff

Reviewed on Sep 26, 2026

Lulu Boutique Hotel

Lulu Boutique Hotel

$1,490
per person
Nov 21 - Nov 26
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Luqa (MLA)
10/10 Exceptional! (52 reviews)
U Collection Suites & Apartments

U Collection Suites & Apartments

$2,409
per person
Oct 31 - Nov 7
found 1 day ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Luqa (MLA)
8/10 Very Good! (11 reviews)
Overall, a lovely stay with a few minor areas for improvement We had some initial difficulty finding the hotel, but the staff was very helpful and assisted us upon arrival. We booked the Deluxe Penthouse, and overall, the space was very nice. It featured a great view, a wonderful hot tub, reliable air conditioning, and a good TV. However, the internet connection was not working very well on our final day. There are two main downsides worth noting for future guests: * Amenities clarification: We checked with Expedia beforehand and were told the unit had a washer and dryer, but we later learned from the owner that it does not. The listing on the Expedia app should be updated to make this clearer. * Bathroom layout: The glass shower enclosure does not have a door, which causes water to spill out onto the bathroom floor during showers. Despite these minor issues, we enjoyed our stay and appreciated the helpful staff and great views.

Reviewed on Sep 24, 2026

Where to stay in South Eastern Region

Find the best South Eastern Region areas and neighborhoods for the activities you enjoy most.

San Tumas

When in San Tumas, you can plan a visit to St. Peter's Pool and Pretty Bay, some noteworthy sights in the nearby area.

Bellavista

While Bellavista might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Marsaxlokk Bay and Grand Harbour.

Misraħ Strejnu

While there might not be top attractions in Misraħ Strejnu, you can explore the larger area and discover places like Marsaxlokk Bay and St. Peter's Pool.

Tal-Plier

While Tal-Plier might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Grand Harbour and Vittoriosa Yacht Marina.

Zejtun Center

While there might not be top attractions in Zejtun Center, you can explore the larger area and discover places like Marsaxlokk Bay and Hal Saflieni Hypogeum.

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$300 nightly
$324 total
Oct 27 - Oct 28
Total with taxes and fees
8.8/10 Excellent! (1,008 reviews)
"Beautiful property and incredible location. Property will be shutting down soon for rennovation."

Reviewed on Sep 28, 2026

Grand Hotel Excelsior
The Phoenicia Malta - The Leading Hotels of the World

The Phoenicia Malta - The Leading Hotels of the World

The Mall Floriana Malta
Fully refundableReserve now, pay when you stay
$635 nightly
$683 total
Oct 26 - Oct 27
Total with taxes and fees
The Phoenicia Malta - The Leading Hotels of the World
Tritoni Valletta Boutique Hotel

Tritoni Valletta Boutique Hotel

33 Triq Vincenzo Dimech Floriana
Fully refundableReserve now, pay when you stay
$124 nightly
$136 total
Oct 5 - Oct 6
Total with taxes and fees
8.6/10 Excellent! (260 reviews)
"Hotel is in the Middle of everything, and short distance to the bus terminal,clean and quiet, but the best thing about the hotel is the staff, specially the front desk, thank you all for all the help"

Reviewed on Sep 24, 2026

Tritoni Valletta Boutique Hotel
See all 1,047 properties in South Eastern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Eastern Region attractions

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties
A stone bridge with arches and people sitting on benches.

Upper Barrakka Gardens

9.0/10 (1,783 reviews)
Perched above Valletta's Grand Harbour is an exquisite park of flowers and statues, from where a cannon salute is fired every day.
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An ornate altar with a large chandelier, golden decorations, and a detailed ceiling fresco.
Photo by Robby Delaware

St. Johns Co - Cathedral

9.4/10 (738 reviews)
After visiting St. Johns Co - Cathedral, make a plan to see the other sights and activities in Valletta. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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A historic stone wall with greenery growing on it, a building with green shutters, and a clear blue sky.

Fort St. Elmo

8.8/10 (1,361 reviews)
This battle-scared fortress has stood watch over Malta’s capital city for more than 400 hundred years. Learn about the historic sieges that took place here through dramatic reenactments.
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A waterfront promenade at night with illuminated buildings and a boat docked by the water.
Photo by Rosmarie Danz

The Valletta Waterfront

9.4/10 (144 reviews)
After visiting The Valletta Waterfront, make a plan to see the other sights and activities in Floriana. Stroll along the seaside in this family-friendly area, or check out its lively bars.
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A street with parked cars and people walking. There is a banner hanging from a building that reads "Casa Rocca Piccola 16th Century Palazzo Open".

Casa Rocca Piccola

9.0/10 (69 reviews)
Get a glimpse into the lives of an aristocratic Maltese family when you tour this 16th-century palace.
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Mediterranean Conference Centre

8.2/10 (138 reviews)
Mediterranean Conference Centre is just one of the places to see in Valletta, so why not enjoy the other things to explore during your travels? Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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Grand Masters Palace

8.6/10 (45 reviews)
After visiting Grand Masters Palace, make a plan to see the other sights and activities in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
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What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$37
per adult
88% of travellers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

$34
per adult
90% of travellers recommend
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour
Malta Boat: Comino Blue Lagoon,Crystal Lagoon, Gozo & Caves

Malta Boat: Comino Blue Lagoon, Crystal Lagoon, Gozo & Caves

$40
per adult
98% of travellers recommend
Malta Boat: Comino Blue Lagoon, Crystal Lagoon, Gozo & Caves
See all activities in South Eastern Region
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