South Eastern Region Vacations & Trips from $1,135

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Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

A cityscape with prominent domed buildings and a historic church.

Valletta

Valletta
A nighttime cityscape with illuminated buildings reflecting on the water.

Floriana

Floriana
A harbor with numerous boats, a historic cityscape, and a clear sky.

Birgu

Birgu
An aerial view of a city with a prominent cathedral featuring a large red dome, surrounded by urban buildings and streets.

Zabbar

Zabbar
A coastal cityscape with historic buildings, a fortified harbor, and a calm sea at dusk.

Senglea

Senglea

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Lulu Boutique Hotel

Lulu Boutique Hotel

$1,135
per person
Oct 17 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
10/10 Exceptional! (49 reviews)
Wow what a wonderful experience staying at this beautiful hotel. The whole stay was exceptional, the design, decor and detail was second to none. The owners and staff could not do enough for us, they made our holiday an even better one with their hospitality and knowledge of the whole island, nothing was too much!! Our room was spotlessly clean and the bed was so comfortable, we also had a balcony overlooking the small but so peaceful pool area. Breakfast was amazing too, we were offered anything at all from a lite bite to a full cooked breakfast which was fresh and delicious. I have got to say that this is possibly the best hospitality I have ever been given and would return in a heartbeat.

Reviewed on Aug 25, 2026

Iniala Valletta

Iniala Valletta

Save 100% on your flight
$2,775
per person
Nov 14 - Nov 23
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.8/10 Exceptional! (119 reviews)
I've stayed in many luxury hotels and Iniala Valletta is at the top of the list!!! I'm so happy I didn't stay in the St. Julian area. This was a beautiful view of the grand Harbour... quiet and elegant. I cannot compliment the staff and hotel enough.

Reviewed on Aug 25, 2026

Avalon Boutique

Avalon Boutique

$1,304
per person
Nov 14 - Nov 23
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.2/10 Wonderful! (13 reviews)
This was a lovely stay in the heart of Valletta (which is a tiny city). Irregardless, it is super close to excellent food and many of the points of interest. Staff was friendly, room was very nice.

Reviewed on Apr 4, 2026

Hotel Pjazza Merkanti - Boutique Living

Hotel Pjazza Merkanti - Boutique Living

$1,155
per person
Nov 14 - Nov 23
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.4/10 Exceptional! (142 reviews)
Great stay! Centrally located and staff were very friendly and helpful. Would recommend to a friend or family member

Reviewed on Aug 10, 2026

Valletta Lucente

Valletta Lucente

$1,356
per person
Nov 14 - Nov 23
found 23 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.6/10 Exceptional! (211 reviews)
Overall an excellent visit. Spacious room. Very soundproof. It blocked out most of the outside noise. Conveniently located to many restaurants. Walkable to everything. Definitely would recommend.

Reviewed on Aug 25, 2026

Where to stay in South Eastern Region

Find the best South Eastern Region areas and neighborhoods for the activities you enjoy most.

San Tumas

When in San Tumas, you can plan a visit to St. Peter's Pool and Pretty Bay, some noteworthy sights in the nearby area.

Bellavista

While Bellavista might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Marsaxlokk Bay and Grand Harbour.

Misraħ Strejnu

While there might not be top attractions in Misraħ Strejnu, you can explore the larger area and discover places like Marsaxlokk Bay and St. Peter's Pool.

Ħal Bisbut

Though Ħal Bisbut might not have many top sights, you can venture to the surrounding area to see attractions like Marsaxlokk Bay and Pretty Bay.

Tal-Plier

While Tal-Plier might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Grand Harbour and Inquisitor's Palace.

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$354 nightly
$383 total
Aug 28 - Aug 29
Total with taxes and fees
8.8/10 Excellent! (1,000 reviews)
"The staff at the Concierge desk was great but that's where it ended. Check in room almost an hour. A cruise ship we came in on all departed at the same time and the most of the passengers all succeed at the and Unfortunately there is a lot wrong with this property. The rooms"

Reviewed on Aug 25, 2026

Grand Hotel Excelsior
The Phoenicia Malta - The Leading Hotels of the World

The Phoenicia Malta - The Leading Hotels of the World

The Mall Floriana Malta
Fully refundableReserve now, pay when you stay
$493 nightly
$531 total
Aug 31 - Sep 1
Total with taxes and fees
9.4/10 Exceptional! (1,005 reviews)
"Romantic place with amazing service"

Reviewed on Aug 25, 2026

The Phoenicia Malta - The Leading Hotels of the World
Tritoni Valletta Boutique Hotel

Tritoni Valletta Boutique Hotel

33 Triq Vincenzo Dimech Floriana
Fully refundableReserve now, pay when you stay
$134 nightly
$146 total
Aug 27 - Aug 28
Total with taxes and fees
8.6/10 Excellent! (244 reviews)
"Very nice friendly staff and they did a good job with keeping the rooms fresh and clean everyday"

Reviewed on Aug 14, 2026

Tritoni Valletta Boutique Hotel
See all 1,009 properties in South Eastern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Eastern Region attractions

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties
A stone bridge with arches and people sitting on benches.

Upper Barrakka Gardens

9.0/10 (1,783 reviews)
Perched above Valletta's Grand Harbour is an exquisite park of flowers and statues, from where a cannon salute is fired every day.
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An ornate altar with a large chandelier, golden decorations, and a detailed ceiling fresco.
Photo by Robby Delaware

St. Johns Co - Cathedral

9.4/10 (738 reviews)
After visiting St. Johns Co - Cathedral, make a plan to see the other sights and activities in Valletta. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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A historic stone wall with greenery growing on it, a building with green shutters, and a clear blue sky.

Fort St. Elmo

8.8/10 (1,361 reviews)
This battle-scared fortress has stood watch over Malta’s capital city for more than 400 hundred years. Learn about the historic sieges that took place here through dramatic reenactments.
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A waterfront promenade at night with illuminated buildings and a boat docked by the water.
Photo by Rosmarie Danz

The Valletta Waterfront

9.4/10 (144 reviews)
After visiting The Valletta Waterfront, make a plan to see the other sights and activities in Floriana. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.
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Mediterranean Conference Centre

8.2/10 (138 reviews)
Mediterranean Conference Centre is just one of the places to see in Valletta, so why not enjoy the other things to explore during your travels? Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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St George Square

9.2/10 (81 reviews)
You can find out about the history of Valletta with a stop at St George Square. Stroll along the beautiful beaches or attend a sporting event in this romantic area.
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Grand Masters Palace

8.6/10 (45 reviews)
After visiting Grand Masters Palace, make a plan to see the other sights and activities in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties

What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$34
per adult
88% of travellers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

$34
per adult
90% of travellers recommend
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour
An afternoon sunset cruise to the Blue Lagoon

An afternoon sunset cruise to the Blue Lagoon

$34
per adult
100% of travellers recommend
An afternoon sunset cruise to the Blue Lagoon
See all activities in South Eastern Region
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