South Eastern Region Vacations & Trips from $923

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Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

A cityscape with prominent domed buildings and a historic church.

Valletta

Valletta
A nighttime cityscape with illuminated buildings reflecting on the water.

Floriana

Floriana
A harbor with numerous boats, a historic cityscape, and a clear sky.

Birgu

Birgu
An aerial view of a city with a prominent cathedral featuring a large red dome, surrounded by urban buildings and streets.

Zabbar

Zabbar
A coastal cityscape with historic buildings, a fortified harbor, and a calm sea at dusk.

Senglea

Senglea

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Island Guesthouse

Island Guesthouse

$923
per person
Oct 29 - Nov 4
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
8.4/10 Very Good! (103 reviews)
I had a great experience at the Island Guest House! I would definitely stay there again and recommend. It was a great value. If you book through Expedia though I recommend that you confirm DIRECTLY with the Island Guest House. There was an issue with Expedia, but they righted it for me. What a pleasure! Thanks again!!

Reviewed on Jan 3, 2026

Lulu Boutique Hotel

Lulu Boutique Hotel

$1,296
per person
Nov 2 - Nov 6
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
10/10 Exceptional! (48 reviews)
We were wow’d the moment we stepped into this gorgeous, unique property. The owners, Lulu and Clive were so hospitable and you could tell the attention to detail from the unique, eclectic lobby to the courtyard with swimming pool. Out room was equally stunning. We booked the one with a jacuzzi- a small living area, separate bedroom area, and spiral staircase to a surprise cavernous room w a jacuzzi! Everything was perfect! Bathrobes, fluffy towels and luxury bath products, this hotel was better than most of the 5 star hotels we stayed at! And it’s only 10 minutes to Mdina and 15 mins to the airport. We absolutely loved it !!!

Reviewed on Jul 15, 2026

Iniala Valletta

Iniala Valletta

Save 100% on your flight
$3,296
per person
Sep 23 - Sep 27
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.8/10 Exceptional! (119 reviews)
Fantastic hotel with amazing staff!

Reviewed on Jul 5, 2026

SU29 Boutique Hotel

SU29 Boutique Hotel

$1,333
per person
Oct 29 - Nov 4
found 14 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.2/10 Wonderful! (200 reviews)
This is a great place with very nice staff, well appointed rooms and generous breakfast.

Reviewed on Aug 18, 2026

Ramla Bay Resort

Ramla Bay Resort

$2,075
per person
Oct 24 - Oct 31
found 16 hours ago
Roundtrip flight included
Dallas (DFW) to Luqa (MLA)
8.6/10 Excellent! (794 reviews)
Absolutely stunning hotel. Very clean and nice decorations. Beautiful shape outside and surroundings. Choice of a number of pools and a little private beach or swimming in a rocky cove area. Remote place so access to recommended sites takes transport but well worth it. Staff friendly and so helpful. They couldnt give us a late check out but offered a courtesy room for our late flight. Food was great well cooked and vast to fit all needs and taste.

Reviewed on Aug 10, 2026

Where to stay in South Eastern Region

Find the best South Eastern Region areas and neighborhoods for the activities you enjoy most.

San Tumas

When in San Tumas, you can plan a visit to St. Peter's Pool and Pretty Bay, some noteworthy sights in the nearby area.

Bellavista

While Bellavista might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Marsaxlokk Bay and Hal Saflieni Hypogeum.

Misraħ Strejnu

While there might not be top attractions in Misraħ Strejnu, you can explore the larger area and discover places like Marsaxlokk Bay and St. Peter's Pool.

Tal-Plier

While Tal-Plier might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Grand Harbour and Hal Saflieni Hypogeum.

Ħal Bisbut

Though Ħal Bisbut might not have many top sights, you can venture to the surrounding area to see attractions like Marsaxlokk Bay and Pretty Bay.

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$354 nightly
$383 total
Aug 26 - Aug 27
Total with taxes and fees
Grand Hotel Excelsior
The Phoenicia Malta - The Leading Hotels of the World

The Phoenicia Malta - The Leading Hotels of the World

The Mall Floriana Malta
Fully refundableReserve now, pay when you stay
$459 nightly
$495 total
Aug 24 - Aug 25
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
"Many thanks! All was the best from check in till check out. Kitchen, SPA, Service, silence- all on the top level."

Reviewed on Aug 17, 2026

The Phoenicia Malta - The Leading Hotels of the World
Tritoni Valletta Boutique Hotel

Tritoni Valletta Boutique Hotel

33 Triq Vincenzo Dimech Floriana
Fully refundableReserve now, pay when you stay
$125 nightly
$137 total
Aug 23 - Aug 24
Total with taxes and fees
8.6/10 Excellent! (244 reviews)
"Very nice friendly staff and they did a good job with keeping the rooms fresh and clean everyday"

Reviewed on Aug 14, 2026

Tritoni Valletta Boutique Hotel
See all 1,007 properties in South Eastern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Eastern Region attractions

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties
A stone bridge with arches and people sitting on benches.

Upper Barrakka Gardens

9.0/10 (1,783 reviews)
Perched above Valletta's Grand Harbour is an exquisite park of flowers and statues, from where a cannon salute is fired every day.
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An ornate altar with a large chandelier, golden decorations, and a detailed ceiling fresco.
Photo by Robby Delaware

St. Johns Co - Cathedral

9.4/10 (738 reviews)
After visiting St. Johns Co - Cathedral, make a plan to see the other sights and activities in Valletta. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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A historic stone wall with greenery growing on it, a building with green shutters, and a clear blue sky.

Fort St. Elmo

8.8/10 (1,361 reviews)
This battle-scared fortress has stood watch over Malta’s capital city for more than 400 hundred years. Learn about the historic sieges that took place here through dramatic reenactments.
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A waterfront promenade at night with illuminated buildings and a boat docked by the water.
Photo by Rosmarie Danz

The Valletta Waterfront

9.4/10 (144 reviews)
After visiting The Valletta Waterfront, make a plan to see the other sights and activities in Floriana. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.
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Mediterranean Conference Centre

8.2/10 (138 reviews)
Mediterranean Conference Centre is just one of the places to see in Valletta, so why not enjoy the other things to explore during your travels? Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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St George Square

9.2/10 (81 reviews)
You can find out about the history of Valletta with a stop at St George Square. Stroll along the beautiful beaches or attend a sporting event in this romantic area.
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Grand Masters Palace

8.6/10 (45 reviews)
After visiting Grand Masters Palace, make a plan to see the other sights and activities in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
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What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$34
per adult
88% of travellers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

$34
per adult
90% of travellers recommend
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour
An afternoon sunset cruise to the Blue Lagoon

An afternoon sunset cruise to the Blue Lagoon

$34
per adult
100% of travellers recommend
An afternoon sunset cruise to the Blue Lagoon
See all activities in South Eastern Region
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