South Eastern Region Vacations & Trips from $1,283

Book a Hotel + Flight or Car together to unlock savings

Photo by Michael Camilleri
  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
SU29 Boutique Hotel
Iniala Harbour House
InterContinental Malta by IHG
Rosselli
Palais Le Brun

Where to stay in South Eastern Region

Get a lay of the land and find the perfect place to stay Learn more about South Eastern Region

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

5 out of 5
Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$158 nightly
The price is $170 total per night from Mar 22 to Mar 23
$170 total
Mar 22 - Mar 23
Total with taxes and fees
8.8/10 Excellent! (1,008 reviews)
Excellent stay, good old fashioned polite service. Tasty food with plenty of choice.

Reviewed on Mar 19, 2026

Grand Hotel Excelsior
The Gomerino Hotel

The Gomerino Hotel

4 out of 5
247 St Paul St Valletta
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $231 total per night from Mar 31 to Apr 1
$231 total
Mar 31 - Apr 1
Total with taxes and fees
9.6/10 Exceptional! (1,001 reviews)
Wonderful hotel and the staff were all extremely friendly and helpful! Perfect location in the centre of Valletta meaning you can easily get around everywhere! Breakfast was really nice - and the pool was a great way to relax at the end of the day! If the weather is nice I’d highly recommend the ...

Reviewed on Mar 20, 2026

The Gomerino Hotel
Palais Le Brun

Palais Le Brun

4.5 out of 5
101 old bakery street Valletta
Fully refundableReserve now, pay when you stay
$192 nightly
The price is $207 total per night from Mar 22 to Mar 23
$207 total
Mar 22 - Mar 23
Total with taxes and fees
9.6/10 Exceptional! (841 reviews)
Exceptionally clean room, spacious bathroom, EASY to operate shower. Firm matress. Quaint and elegant. Breakfast buffett very nice, great choice of complimentary hot dishes. Staff was super-attentive, friendly, and polite.

Reviewed on Mar 20, 2026

Palais Le Brun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in South Eastern Region

What to do in South Eastern Region

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.