South Eastern Region Vacations & Trips from $1,258

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

A cityscape with prominent domed buildings and a historic church.

Valletta

Valletta
A nighttime cityscape with illuminated buildings reflecting on the water.

Floriana

Floriana
A harbor with numerous boats, a historic cityscape, and a clear sky.

Birgu

Birgu
An aerial view of a city with a prominent cathedral featuring a large red dome, surrounded by urban buildings and streets.

Zabbar

Zabbar
A coastal cityscape with historic buildings, a fortified harbor, and a calm sea at dusk.

Senglea

Senglea

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Lulu Boutique Hotel

Lulu Boutique Hotel

$1,258
per person
Oct 15 - Oct 19
found 21 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
10/10 Exceptional! (50 reviews)
This is an excellent little hotel, that’s uniquely brought to life by its owners. As it’s small, the owners and their staff are way more attentive than would be possible in a large hotel, including giving tips on things to do and where to go to us Malta first timers. Zebbug itself is a small village, but bars and restaurants are a short walk away. Though the streets around the hotel are tight and the bolt/uber drivers we used occasionally struggled to find us. That said, the area is centrally located and a great base to visit places like Rabat, Mdina, Blue Grotto and Valletta (once we were more confident in directing the taxi drivers) . Highly recommended if you want somewhere with personality and hosts who genuinely care.

Reviewed on Aug 30, 2026

Iniala Valletta

Iniala Valletta

Save 100% on your flight
$2,400
per person
Oct 26 - Oct 30
found 13 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.8/10 Exceptional! (121 reviews)
I've stayed in many luxury hotels and Iniala Valletta is at the top of the list!!! I'm so happy I didn't stay in the St. Julian area. This was a beautiful view of the grand Harbour... quiet and elegant. I cannot compliment the staff and hotel enough.

Reviewed on Aug 25, 2026

Hard Rock Hotel Malta

Hard Rock Hotel Malta

$1,412
per person
Oct 26 - Oct 30
found 13 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
No reviews
Awesome hotel, even though they were still working. Hands down best place to stay in Malta!

Reviewed on Aug 31, 2026

Corinthia Palace Malta

Corinthia Palace Malta

$1,376
per person
Oct 15 - Oct 19
found 21 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.4/10 Exceptional! (1,006 reviews)
Nice luxury hotel. Small bathrooms though

Reviewed on Sep 2, 2026

Avalon Boutique

Avalon Boutique

$1,824
per person
Oct 17 - Oct 24
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Luqa (MLA)
9.2/10 Wonderful! (15 reviews)
This was a lovely stay in the heart of Valletta (which is a tiny city). Irregardless, it is super close to excellent food and many of the points of interest. Staff was friendly, room was very nice.

Reviewed on Apr 4, 2026

Where to stay in South Eastern Region

Find the best South Eastern Region areas and neighborhoods for the activities you enjoy most.

San Tumas

When in San Tumas, you can plan a visit to St. Peter's Pool and Pretty Bay, some noteworthy sights in the nearby area.

Bellavista

While Bellavista might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Marsaxlokk Bay and Grand Harbour.

Misraħ Strejnu

While there might not be top attractions in Misraħ Strejnu, you can explore the larger area and discover places like Marsaxlokk Bay and St. Peter's Pool.

Ħal Bisbut

Though Ħal Bisbut might not have many top sights, you can venture to the surrounding area to see attractions like Marsaxlokk Bay and Pretty Bay.

Tal-Plier

While Tal-Plier might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Grand Harbour and Inquisitor's Palace.

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$351 nightly
$379 total
Oct 1 - Oct 2
Total with taxes and fees
8.8/10 Excellent! (1,002 reviews)
"Starting from checking in, guest relations Janette, event planning Aleksandra, all front and dining staff, pool staff. Everyone is very friendly and helpful. All cleaning staff as well are amazing. Nothing but excellent reviews all over."

Reviewed on Sep 2, 2026

Grand Hotel Excelsior
The Phoenicia Malta - The Leading Hotels of the World

The Phoenicia Malta - The Leading Hotels of the World

The Mall Floriana Malta
Fully refundableReserve now, pay when you stay
$631 nightly
$678 total
Sep 8 - Sep 9
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
"Romantic place with amazing service"

Reviewed on Aug 25, 2026

The Phoenicia Malta - The Leading Hotels of the World
Tritoni Valletta Boutique Hotel

Tritoni Valletta Boutique Hotel

33 Triq Vincenzo Dimech Floriana
Fully refundableReserve now, pay when you stay
$136 nightly
$149 total
Sep 13 - Sep 14
Total with taxes and fees
8.4/10 Very Good! (248 reviews)
"Not a boutique hotel. Check in was uncomfortable due to an angry and eccentric staff member. AC cooled the room but made strange noises all night. Poor amenities. Bed squeaked all night and we discovered it was built on plywood boards. Toilet paper forgotten during housekeeping. Pool is a murky hole ..."

Reviewed on Sep 1, 2026

Tritoni Valletta Boutique Hotel
See all 1,009 properties in South Eastern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Eastern Region attractions

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties
A stone bridge with arches and people sitting on benches.

Upper Barrakka Gardens

9.0/10 (1,783 reviews)
Perched above Valletta's Grand Harbour is an exquisite park of flowers and statues, from where a cannon salute is fired every day.
See properties
An ornate altar with a large chandelier, golden decorations, and a detailed ceiling fresco.
Photo by Robby Delaware

St. Johns Co - Cathedral

9.4/10 (738 reviews)
After visiting St. Johns Co - Cathedral, make a plan to see the other sights and activities in Valletta. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
See properties
A historic stone wall with greenery growing on it, a building with green shutters, and a clear blue sky.

Fort St. Elmo

8.8/10 (1,361 reviews)
This battle-scared fortress has stood watch over Malta’s capital city for more than 400 hundred years. Learn about the historic sieges that took place here through dramatic reenactments.
See properties
A waterfront promenade at night with illuminated buildings and a boat docked by the water.
Photo by Rosmarie Danz

The Valletta Waterfront

9.4/10 (144 reviews)
After visiting The Valletta Waterfront, make a plan to see the other sights and activities in Floriana. Stroll along the seaside in this family-friendly area, or check out its top-notch restaurants.
See properties
A bustling street lined with historic buildings, a clear blue sky, and pedestrians walking along.
Photo by Algirdas Sidiskis

Merchant Street Market

8.8/10 (65 reviews)
During your trip to Valletta, you can search for that perfect souvenir at Merchant Street Market. While you're in the area, stroll along the waterfront.
See properties

Grand Masters Palace

8.6/10 (45 reviews)
After visiting Grand Masters Palace, make a plan to see the other sights and activities in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties

Mediterranean Conference Centre

8.2/10 (138 reviews)
Mediterranean Conference Centre is just one of the places to see in Valletta, so why not enjoy the other things to explore during your travels? Wander the area's seaside or simply enjoy one of its top-notch restaurants.
See properties

What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$47
per adult
86% of travellers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

$35
per adult
90% of travellers recommend
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour
Malta Boat: Comino Blue Lagoon,Crystal Lagoon, Gozo & Caves

Malta Boat: Comino Blue Lagoon, Crystal Lagoon, Gozo & Caves

$40
per adult
96% of travellers recommend
Malta Boat: Comino Blue Lagoon, Crystal Lagoon, Gozo & Caves
See all activities in South Eastern Region
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.