South Eastern Region Vacations & Trips from $1,191

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Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

A cityscape with prominent domed buildings and a historic church.

Valletta

Valletta
A nighttime cityscape with illuminated buildings reflecting on the water.

Floriana

Floriana
A harbor with numerous boats, a historic cityscape, and a clear sky.

Birgu

Birgu
An aerial view of a city with a prominent cathedral featuring a large red dome, surrounded by urban buildings and streets.

Zabbar

Zabbar
A coastal cityscape with historic buildings, a fortified harbor, and a calm sea at dusk.

Senglea

Senglea
A marina with various boats docked, a large stone wall, and buildings in the background.

Kalkara

Kalkara

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Valletta Lucente

Valletta Lucente

$1,191
per person
Oct 8 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.6/10 Exceptional! (210 reviews)
Absolutely loved our stay in the Penthouse suite , Staff were lovely and very helpful. All amenities you need , kettle, fridge, air con and a iron. Even better ilwe got engaged there x

Reviewed on Jul 20, 2026

Iniala Valletta

Iniala Valletta

Save 100% on your flight
$3,941
per person
Oct 8 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
9.8/10 Exceptional! (119 reviews)
Fantastic hotel with amazing staff!

Reviewed on Jul 5, 2026

Lulu Boutique Hotel

Lulu Boutique Hotel

Save 100% on your flight
$1,825
per person
Oct 13 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
10/10 Exceptional! (48 reviews)
We were wow’d the moment we stepped into this gorgeous, unique property. The owners, Lulu and Clive were so hospitable and you could tell the attention to detail from the unique, eclectic lobby to the courtyard with swimming pool. Out room was equally stunning. We booked the one with a jacuzzi- a small living area, separate bedroom area, and spiral staircase to a surprise cavernous room w a jacuzzi! Everything was perfect! Bathrobes, fluffy towels and luxury bath products, this hotel was better than most of the 5 star hotels we stayed at! And it’s only 10 minutes to Mdina and 15 mins to the airport. We absolutely loved it !!!

Reviewed on Jul 15, 2026

Il Palazzin Hotel

Il Palazzin Hotel

Qawra
$2,667
per person
Sep 13 - Sep 18
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Luqa (MLA)
8/10 Very Good! (392 reviews)
Pool was good. Upstairs pool would need a little care. Staff excellent

Reviewed on May 20, 2026

Radisson Blu Resort, Malta St. Julian's

Radisson Blu Resort, Malta St. Julian's

$1,638
per person
Oct 13 - Oct 21
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Luqa (MLA)
8.8/10 Excellent! (1,002 reviews)

Where to stay in South Eastern Region

Find the best South Eastern Region areas and neighborhoods for the activities you enjoy most.

San Tumas

When in San Tumas, you can plan a visit to St. Peter's Pool and Pretty Bay, some noteworthy sights in the nearby area.

Bellavista

While Bellavista might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Marsaxlokk Bay and Hal Saflieni Hypogeum.

Misraħ Strejnu

While there might not be top attractions in Misraħ Strejnu, you can explore the larger area and discover places like Marsaxlokk Bay and St. Peter's Pool.

Ħal Bisbut

Though Ħal Bisbut might not have many top sights, you can venture to the surrounding area to see attractions like Marsaxlokk Bay and Pretty Bay.

Zejtun Center

While there might not be top attractions in Zejtun Center, you can explore the larger area and discover places like Marsaxlokk Bay and Hal Saflieni Hypogeum.

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$331 nightly
$358 total
Aug 30 - Aug 31
Total with taxes and fees
Grand Hotel Excelsior
The Phoenicia Malta - The Leading Hotels of the World

The Phoenicia Malta - The Leading Hotels of the World

The Mall Floriana Malta
Fully refundableReserve now, pay when you stay
$504 nightly
$543 total
Aug 24 - Aug 25
Total with taxes and fees
The Phoenicia Malta - The Leading Hotels of the World
Tritoni Valletta Boutique Hotel

Tritoni Valletta Boutique Hotel

33 Triq Vincenzo Dimech Floriana
$131 nightly
$144 total
Aug 30 - Aug 31
Total with taxes and fees
8.6/10 Excellent! (243 reviews)
"Pool was closed for maintenance and will not be repaired for months, hot tub was old and not well maintained, breakfast looked horrible and not worth the extra cost."

Reviewed on Jul 22, 2026

Tritoni Valletta Boutique Hotel
See all 1,019 properties in South Eastern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Eastern Region attractions

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's marina, or simply savor its top-notch restaurants.
See properties
A stone bridge with arches and people sitting on benches.

Upper Barrakka Gardens

9.0/10 (1,783 reviews)
Perched above Valletta's Grand Harbour is an exquisite park of flowers and statues, from where a cannon salute is fired every day.
See properties
An ornate altar with a large chandelier, golden decorations, and a detailed ceiling fresco.
Photo by Robby Delaware

St. Johns Co - Cathedral

9.4/10 (738 reviews)
After visiting St. Johns Co - Cathedral, make a plan to see the other sights and activities in Valletta. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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A historic stone wall with greenery growing on it, a building with green shutters, and a clear blue sky.

Fort St. Elmo

8.8/10 (1,361 reviews)
This battle-scared fortress has stood watch over Malta’s capital city for more than 400 hundred years. Learn about the historic sieges that took place here through dramatic reenactments.
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A waterfront promenade at night with illuminated buildings and a boat docked by the water.
Photo by Rosmarie Danz

The Valletta Waterfront

9.4/10 (144 reviews)
After visiting The Valletta Waterfront, make a plan to see the other sights and activities in Floriana. Stroll along the seaside in this family-friendly area, or check out its lively bars.
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Mediterranean Conference Centre

8.2/10 (138 reviews)
Mediterranean Conference Centre is just one of the places to see in Valletta, so why not enjoy the other things to explore during your travels? Wander the area's seaside or simply enjoy one of its top-notch restaurants.
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Grand Masters Palace

8.6/10 (45 reviews)
After visiting Grand Masters Palace, make a plan to see the other sights and activities in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
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St George Square

9.2/10 (81 reviews)
You can find out about the history of Valletta with a stop at St George Square. Stroll along the beautiful beaches or attend a sporting event in this romantic area.
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What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$34
per adult
88% of travellers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

$34
per adult
90% of travellers recommend
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour
Sea Bird

Comino Island: including Blue Lagoon, Crystal Lagoon & sea caves

$34
per adult
88% of travellers recommend
Comino Island: including Blue Lagoon, Crystal Lagoon & sea caves
See all activities in South Eastern Region
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