A coastal cityscape with a prominent dome and spires, a fortified wall, and a calm sea reflecting the buildings.

South Eastern Region Vacations from $1,382

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Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A person sitting by a pool with a cityscape in the background.
    Jan 18 - Jan 24

    Ta' Tereza In Manwel Dimech + Flight

    Sliema
    5 nights
    3.5 star property
    9.2/10 - Wonderful (255 reviews)
    "The pool area was closed..the weather was cooling down so fair enough."
    Reviewed November 8, 2026
    Roundtrip • New York (EWR) - Luqa (MLA)
    EWR - MLA • 1 stop MLA - EWR • 2 stops
    $1,675
    $1,382
    per traveler
    found 11 hours ago
    Ta' Tereza In Manwel Dimech
  • A stone-walled spa area with a hot tub, candles, and a tray with champagne and strawberries.
    Jan 18 - Jan 24

    Lulu Boutique Hotel + Flight

    Zebbug
    5 nights
    4.0 star property
    10/10 - Exceptional (56 reviews)
    "Love this hotel! We stayed 2 nights at the start of our visit and came back for our last night in Malta. The town is small but it’s so easy to use Bolt (like Uber) to travel around to see the sites. It’s a small boutique hotel and each room is unique. Super comfortable with a lot of eclectic objects that the owner has acquired. There is a lovely plunge pool by the bar area. The breakfast was perfect. They made us porridge and a full English. The staff go above and beyond and the owners are super..."
    Reviewed October 17, 2026
    Roundtrip • New York (EWR) - Luqa (MLA)
    EWR - MLA • 1 stop MLA - EWR • 2 stops
    $1,859
    $1,488
    per traveler
    found 11 hours ago
    Lulu Boutique Hotel
  • A couple in a swimming pool with a view of the ocean and resort buildings.
    Jan 18 - Jan 24

    voco Malta by IHG + Flight

    Paceville
    5 nights
    5.0 star property
    9.4/10 - Exceptional (127 reviews)
    "Our stay was lovely. The staff were helpful and friendly throughout our stay. The cleanliness of the room was a bit of a miss, not quite the five star as there were dried pasta on the floor, couldn’t see it unless stepped on, however even the room clean days it had not been dealt with. The balcony was facing the pool, the view was nice. We didn’t have breakfast, tried out the Italian food in the evening on the top floor of the hotel, the food was average and it was very windy. Lots of nice..."
    Reviewed November 8, 2026
    Roundtrip • New York (EWR) - Luqa (MLA)
    EWR - MLA • 1 stop MLA - EWR • 2 stops
    $1,800
    $1,450
    per traveler
    found 11 hours ago
    voco Malta by IHG
  • A spa area with a pool, stone walls, and seating.
    Jan 18 - Jan 24

    Iniala Valletta + Flight

    Valletta
    5 nights
    5.0 star property
    9.8/10 - Exceptional (128 reviews)
    Roundtrip • New York (EWR) - Luqa (MLA)
    EWR - MLA • 1 stop MLA - EWR • 2 stops
    $2,432
    $1,980
    per traveler
    found 11 hours ago
    Iniala Valletta
  • Pool
    Jan 19 - Jan 24

    The Westin Dragonara Resort, Malta + Flight

    Paceville
    4 nights
    5.0 star property
    9.6/10 - Exceptional (1,030 reviews)
    Roundtrip • New York (EWR) - Luqa (MLA)
    EWR - MLA • 1 stop MLA - EWR • 1 stop
    $2,961
    $2,474
    per traveler
    found 1 hour ago
    The Westin Dragonara Resort, Malta

Discover the most popular places to visit in South Eastern Region

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
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What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$27
per adult
86% of travelers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
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South Eastern Region Hotel Deals

A rooftop pool area with lounge chairs and umbrellas, surrounded by greenery and a view of the cityscape.

St Anne Palace by Tritoni Prestige

St Anne Palace by Tritoni Prestige
3.5 star property
2.3 mi from South Eastern Region
10.0 out of 10, Exceptional, (7 reviews)
"The hotel is only a short walk from Valletta. It is situated in an historic area of Malta with lots to do and see nearby. The roof terrace is a wonderful space to relax and enjoy the sunshine and sunset. The true heroes though are the team. Everyone makes it their mission to look after you and make you feel special. We will be back. Thank you."
$117 nightly
The price is $129
Dec 1 - Dec 2
Total with taxes and fees
St Anne Palace by Tritoni Prestige
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.