South Eastern Region Vacations & Trips from $267

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your South Eastern Region Vacation

With a South Eastern Region vacation package, you can forget about the stress of planning and just focus on experiencing all this lively destination has on offer. You'll have a long to-do list during your trip to South Eastern Region. One top city you'll want to explore is Valletta. Expedia has flights, hotels and everything else you need to help you create your own customized South Eastern Region vacation today.

Top destinations in South Eastern Region

A cityscape with prominent domed buildings and a historic church.

Valletta

Valletta
A nighttime cityscape with illuminated buildings reflecting on the water.

Floriana

Floriana
An aerial view of a city with a prominent cathedral featuring a large red dome, surrounded by urban buildings and streets.

Zabbar

Zabbar
A harbor with numerous boats, a historic cityscape, and a clear sky.

Birgu

Birgu
A coastal cityscape with historic buildings, a fortified harbor, and a calm sea at dusk.

Senglea

Senglea
A marina with various boats docked, a large stone wall, and buildings in the background.

Kalkara

Kalkara

The Latest South Eastern Region Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Park Heights by the Warren Collection

Park Heights by the Warren Collection

$267
per person
Nov 6 - Nov 9
just found
Roundtrip flight included
Birmingham (BHX) to Luqa (MLA)
9.4/10 Exceptional! (169 reviews)
Valletta Lucente

Valletta Lucente

$443
per person
Nov 6 - Nov 9
just found
Roundtrip flight included
Birmingham (BHX) to Luqa (MLA)
9.6/10 Exceptional! (220 reviews)
First time in Malta. Specifically chose this hotel as I wanted accommodation in Valetta close to St John's Cathedral and Valetta Harbour, though Valetta is only 1km x 1km so any accommodation within the city walls would have been sufficient. This hotel is on a very popular street with several restaurants all with tables and chairs in the street and all competing with each other to play the loudest music. This is no unusual in Valetta but it is excessive. Although local signage asks for quiet after 11pm this happened once, on Sunday, Monday and Tuesday and Wednesday exessive noise went on until after midday, on Thursday and Friday it was after 1am, my 1st Saturday excessive noise went on until 3am.

Reviewed on Sep 27, 2026

Squadron Base

Squadron Base

$307
per person
Nov 6 - Nov 9
just found
Roundtrip flight included
Birmingham (BHX) to Luqa (MLA)
7.8/10 Good! (7 reviews)
Land's End Boutique Hotel

Land's End Boutique Hotel

$372
per person
Nov 6 - Nov 9
just found
Roundtrip flight included
Birmingham (BHX) to Luqa (MLA)
9.6/10 Exceptional! (310 reviews)
We happened to visit during the heat wave and power outages this July. The hotel was well prepared and extremely helpful. The view was lovely and the room was clean and comfortable. Very good price point for the experience.

Reviewed on Oct 1, 2026

Palazzino Nina Boutique Hotel

Palazzino Nina Boutique Hotel

$386
per person
Nov 6 - Nov 9
just found
Roundtrip flight included
Birmingham (BHX) to Luqa (MLA)
9/10 Wonderful! (11 reviews)

Where to stay in South Eastern Region

Find the best South Eastern Region areas and neighborhoods for the activities you enjoy most.

San Tumas

When in San Tumas, you can plan a visit to St. Peter's Pool and Pretty Bay, some noteworthy sights in the nearby area.

Bellavista

While Bellavista might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Marsaxlokk Bay and Grand Harbour.

Misraħ Strejnu

While there might not be top attractions in Misraħ Strejnu, you can explore the larger area and discover places like Marsaxlokk Bay and St. Peter's Pool.

Tal-Plier

While Tal-Plier might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Grand Harbour and Inquisitor's Palace.

Zejtun Center

While there might not be top attractions in Zejtun Center, you can explore the larger area and discover places like Marsaxlokk Bay and Hal Saflieni Hypogeum.

Find the Best South Eastern Region Vacation Packages

South Eastern Region Essential Information

Language
Maltese
Currency
Euros
Local Welcome
Hawn
Local Goodbye
Ċaw
Top Sights
Upper Barrakka Gardens, Lower Barrakka Gardens and Marsaxlokk Bay

South Eastern Region Hotel Deals

Grand Hotel Excelsior

Grand Hotel Excelsior

Great Siege Road Floriana Malta
Fully refundableReserve now, pay when you stay
$184 nightly
$200 total
Nov 2 - Nov 3
Total with taxes and fees
8.8/10 Excellent! (1,002 reviews)
"We absolutely love coming to this hotel, the staff are great, facilities are great. Can’t wait to come back."

Reviewed on Oct 1, 2026

Grand Hotel Excelsior
The Phoenicia Malta - The Leading Hotels of the World

The Phoenicia Malta - The Leading Hotels of the World

The Mall Floriana Malta
Fully refundableReserve now, pay when you stay
$486 nightly
$523 total
Nov 1 - Nov 2
Total with taxes and fees
The Phoenicia Malta - The Leading Hotels of the World
Tritoni Valletta Boutique Hotel

Tritoni Valletta Boutique Hotel

33 Triq Vincenzo Dimech Floriana
Fully refundableReserve now, pay when you stay
$103 nightly
$114 total
Nov 1 - Nov 2
Total with taxes and fees
8.6/10 Excellent! (260 reviews)
"Hotel is in the Middle of everything, and short distance to the bus terminal,clean and quiet, but the best thing about the hotel is the staff, specially the front desk, thank you all for all the help"

Reviewed on Sep 24, 2026

Tritoni Valletta Boutique Hotel
See all 1,043 properties in South Eastern Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Eastern Region attractions

An aerial view of a coastal city with dense urban architecture, a prominent church, and a marina filled with boats.

Malta Experience

8.8/10 (1,972 reviews)
Enjoy a show at Malta Experience, a storied theater in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties
A stone bridge with arches and people sitting on benches.

Upper Barrakka Gardens

9.0/10 (1,783 reviews)
Perched above Valletta's Grand Harbour is an exquisite park of flowers and statues, from where a cannon salute is fired every day.
See properties
An ornate altar with a large chandelier, golden decorations, and a detailed ceiling fresco.
Photo by Robby Delaware

St. Johns Co - Cathedral

9.4/10 (738 reviews)
After visiting St. Johns Co - Cathedral, make a plan to see the other sights and activities in Valletta. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
See properties
A historic stone wall with greenery growing on it, a building with green shutters, and a clear blue sky.

Fort St. Elmo

8.8/10 (1,361 reviews)
This battle-scared fortress has stood watch over Malta’s capital city for more than 400 hundred years. Learn about the historic sieges that took place here through dramatic reenactments.
See properties
A waterfront promenade at night with illuminated buildings and a boat docked by the water.
Photo by Rosmarie Danz

The Valletta Waterfront

9.4/10 (144 reviews)
After visiting The Valletta Waterfront, make a plan to see the other sights and activities in Floriana. Stroll along the seaside in this family-friendly area, or check out its lively bars.
See properties
A street with parked cars and people walking. There is a banner hanging from a building that reads "Casa Rocca Piccola 16th Century Palazzo Open".

Casa Rocca Piccola

9.0/10 (69 reviews)
Get a glimpse into the lives of an aristocratic Maltese family when you tour this 16th-century palace.
See properties

Mediterranean Conference Centre

8.2/10 (138 reviews)
Mediterranean Conference Centre is just one of the places to see in Valletta, so why not enjoy the other things to explore during your travels? Wander the area's seaside or simply enjoy one of its top-notch restaurants.
See properties

Grand Masters Palace

8.6/10 (45 reviews)
After visiting Grand Masters Palace, make a plan to see the other sights and activities in Valletta. Stroll along the area's seaside, or simply savor its top-notch restaurants.
See properties

What to do in South Eastern Region

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour

$37
per adult
88% of travellers recommend
Malta: Gozo & Comino Islands, Blue Lagoon & Seacaves Tour
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour

$34
per adult
90% of travellers recommend
Comino: Blue Lagoon, Crystal Lagoon, and Seacaves Tour
Malta Boat: Comino Blue Lagoon,Crystal Lagoon, Gozo & Caves

Malta Boat: Comino Blue Lagoon, Crystal Lagoon, Gozo & Caves

$40
per adult
98% of travellers recommend
Malta Boat: Comino Blue Lagoon, Crystal Lagoon, Gozo & Caves
See all activities in South Eastern Region
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.