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Check prices on hotels in South San Francisco

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Featured South San Francisco Independent Hotels

See all 719 Properties in South San Francisco
Hotel Whitcomb

Hotel Whitcomb

1231 Market St, San Francisco
  • Free Cancellation
  • Reserve now, pay when you stay
3.5 out of 5.0
 
 
3.2 out of 5 (8,805 reviews)
Old but nice In an older section of San Fran, walking from this hotel to sights, shopping, etc. is quick but req … - 

Hotel Whitcomb$129

Hotel Whitcomb$129
Hotel Spero

Hotel Spero

405 Taylor St, San Francisco
  • Free Cancellation
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4.0 out of 5.0
 
 
4.0 out of 5 (4,845 reviews)
Renovated One Bedroom Suite Awesome Hotel with newly renovated rooms in good condition. Not far away from Powell street. - 

Hotel Spero$135

Hotel Spero$135
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St, San Francisco
  • Free Cancellation
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3.5 out of 5.0
 
 
4.0 out of 5 (4,317 reviews)
Nice hotel in a great location. The staff, from the checking in to the painter applying wallpaper in the hallway - they were all su … - 

Handlery Union Square Hotel$178

Handlery Union Square Hotel$178
Hotel G San Francisco

Hotel G San Francisco

386 Geary Street, San Francisco
  • Free Cancellation
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4.0 out of 5.0
 
 
4.1 out of 5 (1,426 reviews)
average hotel (Overpriced) Staff is very nice and helpful Room is just average level Location is great - 

Hotel G San Francisco$153

Hotel G San Francisco$153
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

1550 Bayshore Hwy, Burlingame
  • Free Cancellation
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3.0 out of 5.0
 
 
4.5 out of 5 (3,918 reviews)
couldn't get much closer to SF airport All in all, this is a very nice hotel. Convenient to airport with shuttle. Only problem was a kid s … - 

Bay Landing San Francisco Airport Hotel$116

Bay Landing San Francisco Airport Hotel$116
The Pickwick Hotel

The Pickwick Hotel

85 5th St, San Francisco
  • Free Cancellation
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3.5 out of 5.0
 
 
3.5 out of 5 (1,967 reviews)
Close to everywhere Nice place and walking distance to Union Square, Chinatown, Lombard street, Pier39, Fisherman Wharf … - 

The Pickwick Hotel$149

The Pickwick Hotel$149
Hotel Focus SFO

Hotel Focus SFO

111 Mitchell Ave, South San Francisco
  • Free Cancellation
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3.0 out of 5.0
 
 
3.2 out of 5 (593 reviews)
convenient and clean close to airport, free shuttle, cute courtyard garden, clean - 

Hotel Focus SFO$88

Hotel Focus SFO$88
Hotel Zephyr

Hotel Zephyr

250 Beach Street, San Francisco
  • Free Cancellation
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3.5 out of 5.0
 
 
4.2 out of 5 (2,947 reviews)
Fun and Clean Lots to do in and around the Hotel the staff is extremely friendly and professional and the rooms a … - 
Oakland Airport Executive Hotel

Oakland Airport Executive Hotel

150 Hegenberger Rd, Oakland
  • Free Cancellation
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3.0 out of 5.0
 
 
3.6 out of 5 (1,635 reviews)
convenient hotel next yo airport my first time in this hotel. very convenient and easily accessible from airport. friendly staff. - 

Oakland Airport Executive Hotel$94

Oakland Airport Executive Hotel$94
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

433 Powell St, San Francisco
  • Free Cancellation
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3.5 out of 5.0
 
 
4.3 out of 5 (3,787 reviews)
Beautiful Hotel in the heart of San Fran Great hotel that was close to the center of San Fran. Easy access to public transit and all the ess … - 

Chancellor Hotel on Union Square$160

Chancellor Hotel on Union Square$160
The Dylan at SFO

The Dylan at SFO

110 S El Camino Real, Millbrae
  • Free Cancellation
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3.0 out of 5.0
 
 
4.2 out of 5 (2,767 reviews)
Comfy hotel close to airport My husband and I rested here after 48 hours of travel. The bed was very comfortable and the breakfa … - 

The Dylan at SFO$114

The Dylan at SFO$114
Park Pointe Hotel

Park Pointe Hotel

245 S Airport Blvd, South San Francisco
  • Free Cancellation
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2.0 out of 5.0
 
 
3.2 out of 5 (429 reviews)
What else can do you need Before I booked the hotel I read the reviews but because of the price I decided to book it. I read … - 

Park Pointe Hotel$97

Park Pointe Hotel$97
Kensington Park Hotel

Kensington Park Hotel

450 Post St, San Francisco
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3.5 out of 5.0
 
 
4.1 out of 5 (1,825 reviews)
Convenient old style hotel near Union Square Comfortable hotel with good service and good sized rooms. Tea and coffee and fridge in room. Ice an … - 
Calista Organic Hotel

Calista Organic Hotel

1485 Bush Street, San Francisco
  • Free Cancellation
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3.0 out of 5.0
 
 
3.6 out of 5 (280 reviews)
Walking distance to a lot Close to a lot of places. Very convenient. The rooms are really small nothing compared to what we o … - 

Calista Organic Hotel$111

Calista Organic Hotel$111
Grant Plaza Hotel

Grant Plaza Hotel

465 Grant Ave, San Francisco
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2.0 out of 5.0
 
 
3.2 out of 5 (2,103 reviews)
Value for money First the bad: no tea/coffee making kit in room, not many coat hangers, wardrobe space minimal. Roo … - 

Grant Plaza Hotel$114

Grant Plaza Hotel$114
Monarch Hotel

Monarch Hotel

1015 Geary St, San Francisco
  • Free Cancellation
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2.0 out of 5.0
 
 
3.0 out of 5 (1,951 reviews)
Pretty dirty Not happy. Rooms had a smell and it was very outdated. - 
Hotel Shattuck Plaza

Hotel Shattuck Plaza

2086 Allston Way, Berkeley
  • Free Cancellation
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4.0 out of 5.0
 
 
4.3 out of 5 (1,485 reviews)
Good 4-star in middle of Berkeley Great staff and location, excellent food, rooms are always a bit of a challenge in terms of structu … - 

Hotel Shattuck Plaza$132

Hotel Shattuck Plaza$132
Hotel Triton

Hotel Triton

342 Grant Ave, San Francisco
  • Free Cancellation
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3.0 out of 5.0
 
 
4.1 out of 5 (1,571 reviews)
Great location, surprisingly quiet...but dated A great spot in the city and in a reasonably quiet spot where I could open a window and not be over … - 

Hotel Triton$125

Hotel Triton$125
Hotel Fusion, a C-Two Hotel

Hotel Fusion, a C-Two Hotel

140 Ellis Street, San Francisco
  • Free Cancellation
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3.5 out of 5.0
 
 
3.7 out of 5 (2,008 reviews)
Great location - Friendly staff This hotel's location is it's selling point. It's very near Union Square and just a block from the … - 

Hotel Fusion, a C-Two Hotel$149

Hotel Fusion, a C-Two Hotel$149
The Marina Inn on San Francisco Bay

The Marina Inn on San Francisco Bay

68 Monarch Bay Dr, San Leandro
  • Free Cancellation
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2.5 out of 5.0
 
 
4.4 out of 5 (1,323 reviews)
Lovely Hotel This is a cozy hotel with a marina behind it. The lobby was lovely and rooms were comfortable. I wa … - 

The Marina Inn on San Francisco Bay$129

The Marina Inn on San Francisco Bay$129
Map

Recently booked South San Francisco hotels

Comfort Inn and Suites San Francisco Airport North
2.0 out of 5.0
Last booking: 16 hours ago
Holiday Inn Express San Francisco-Airport North
2.5 out of 5.0
Last booking: 16 hours ago
Travelodge by Wyndham San Francisco Airport North
2.0 out of 5.0
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La Quinta Inn & Suites San Francisco Airport North
2.5 out of 5.0
Last booking: 16 hours ago
Holiday Inn San Francisco International Airport
3.0 out of 5.0
Last booking: 24 hours ago
Best Western Plus Grosvenor Airport Hotel
3.0 out of 5.0
Last booking: 24 hours ago
Embassy Suites San Francisco Airport - South San Francisco
3.5 out of 5.0
Last booking: 25 hours ago
Park Pointe Hotel
2.0 out of 5.0
Last booking: 25 hours ago
Hotel Focus SFO
3.0 out of 5.0
Last booking: 25 hours ago

Independent South San Francisco Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in South San Francisco, San Francisco. Known for well-appointed rooms and friendly, personalized service, each of the top Independent South San Francisco hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some South San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.