Search 590,000 properties worldwide.
Search over a million flights, hotels, packages, and more
No Expedia cancellation fee to change or cancel almost any hotel reservation.
Handlery Union Square Hotel$178Handlery Union Square Hotel$178
Bay Landing San Francisco Airport Hotel$116Bay Landing San Francisco Airport Hotel$116
Oakland Airport Executive Hotel$94Oakland Airport Executive Hotel$94
Chancellor Hotel on Union Square$160Chancellor Hotel on Union Square$160
Hotel Fusion, a C-Two Hotel$149Hotel Fusion, a C-Two Hotel$149
The Marina Inn on San Francisco Bay$129The Marina Inn on San Francisco Bay$129
Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in South San Francisco, San Francisco. Known for well-appointed rooms and friendly, personalized service, each of the top Independent South San Francisco hotels guarantees an unparalleled level of comfort and quality.
You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some South San Francisco Independent locations may even offer extra little benefits and discounts for frequent travelers.