Southeast Houston Vacations

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Your Southeast Houston Vacation

Take the fuss out of planning your next adventure by booking a Southeast Houston vacation package. Immerse yourself in the sights and sounds of this appealing neighborhood and experience everything it has to offer. When the time comes to sightsee during your trip to Southeast Houston, don't miss nearby attractions such as 1940 Air Terminal Museum. Expedia will help put your plans into action. Book your ultimate Southeast Houston vacation now.

Where to stay in Southeast Houston

Find the best Southeast Houston areas and neighborhoods for the activities you enjoy most. Learn more about Southeast Houston
Illuminated paths and modern buildings create a vibrant atmosphere at Discovery Green in Houston, Texas during the evening

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,329 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

Southeast Houston Hotel Deals

The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District

4 out of 5
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$214 nightly
The price is $248 total per night from Mar 29 to Mar 30
$248 total
Mar 29 - Mar 30
Total with taxes and fees
9.2/10 Wonderful! (1,132 reviews)
Daniel who was the bartender on duty when we checked in could not have been nicer. Room was more than fine. Clean hotel. One thing that did bother us from a security standpoint: anyone without a key can access any floor in the hotel. This is a big security concern.

Reviewed on Mar 20, 2026

The Westin Houston Medical Center/Museum District
Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel

2.5 out of 5
14402 Old Chocolate Bayou Road Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $104 total per night from Mar 28 to Mar 29
$104 total
Mar 28 - Mar 29
Total with taxes and fees
9.2/10 Wonderful! (189 reviews)
Great location. Clean room! Friendly staff

Reviewed on Mar 23, 2026

Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Hobby Airport Inn & Suites

Best Western Plus Hobby Airport Inn & Suites

2.5 out of 5
8778 Airport Blvd Houston TX
Fully refundableReserve now, pay when you stay
$76 nightly
The price is $89 total per night from Apr 1 to Apr 2
$89 total
Apr 1 - Apr 2
Total with taxes and fees
8.8/10 Excellent! (1,473 reviews)
Very comfortable room and clean

Reviewed on Mar 24, 2026

Best Western Plus Hobby Airport Inn & Suites
See all 1,116 properties in Southeast Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Southeast Houston

Houston Zoo

Houston Zoo

4.5/5(1,018 reviews)

Feed a giraffe, catch a 4-D movie or cool off in the water park at this extraordinary zoo.

Houston Zoo
Overcast view of the campus of University of Houston

University of Houston

4/5(397 reviews)

Enjoy the collegiate vibe when you visit University of Houston, during your travels in Houston. Experience the great live music and lively festivals in this vibrant area.

University of Houston
Houston Natural Science Museum featuring heritage elements and interior views

Houston Natural Science Museum

4.5/5(811 reviews)

You can spend time studying the exhibits at Houston Natural Science Museum in Houston. Experience the area's great live music and acclaimed theater scene.

Houston Natural Science Museum

Things to do

Astroville Tunnel Tour of Downtown Houston

Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)

$25
per adult
100% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston Museum of Natural Science: Cockrell Butterfly Center

Houston Museum of Natural Science: Butterfly Center Ticket

$15
per adult
100% of travellers recommend
Houston Museum of Natural Science: Butterfly Center Ticket
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

$12
per adult
80% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
See all activities in Houston
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.