Beginning of main content

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured St. Louis Business Hotels

See all 292 Hotels in St. Louis
Clayton Plaza Hotel

Clayton Plaza Hotel

7750 Carondelet Avenue, St. Louis
3.5 out of 5.0
4.1 out of 5 (2,953 reviews)
Comfortable and quietCame in late and left early. Nothing else to tell.
  Dec 8, 2017

$109

$109
City Place St. Louis - Downtown Hotel

City Place St. Louis - Downtown Hotel

200 North 4th Street, St. Louis
4.0 out of 5.0
3.3 out of 5 (3,684 reviews)
4th of JulyTraveled with my 2 kids- 11&12yo. Stayed 2 nights. July 3rd & 4th. Check in was quick & painless. They were quite busy, but didn't seem to rush me. Front desk was friendly. Requested a room facing the arch. Got a room on the 6th floor with a balcony. Valet parking was $20 or $10 to self park. Short ...
 Tim Jul 7, 2013

$79

$79
Wingate by Wyndham St. Charles MO

Wingate by Wyndham St. Charles MO

32 Research Park Circle, St. Charles
3.5 out of 5.0
4.3 out of 5 (891 reviews)
QuiteNot much to say. Very short stay to base a affluent opinion.
  Dec 10, 2017

$84

$84
The Westin St. Louis

The Westin St. Louis

811 Spruce St, St. Louis
5.0 out of 5.0
4.6 out of 5 (3,185 reviews)
Great! The room was exceptional!! I enjoyed it...........
  Dec 10, 2017

$119

$119
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

1820 Market Street, St. Louis
4.5 out of 5.0
4.3 out of 5 (1,789 reviews)
We had a lovely but quick stay. The Christmas decorations were absolutely beautiful! Wish we had more time to sight see. The staff was helpful and timely. Definitely would recommend this hotel.
  Dec 8, 2017

$106

$106
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

2 South 4th Street, St. Louis
3.0 out of 5.0
4.6 out of 5 (3,052 reviews)
Two days in JulyExperience was OK. Nice location, walking distance to the arch.Old style, might need some renovation (aka some kind of Chinese hotel of the 90s).Room proposed had a very small window, it felt like in a cave. The second room was better, with view on the arch, but in a secondary building to the main ...
 XD Jul 14, 2013

$120

$120
La Quinta Inn & Suites St. Louis Westport

La Quinta Inn & Suites St. Louis Westport

11805 Lackland Rd, Maryland Heights
2.5 out of 5.0
4.1 out of 5 (883 reviews)
Great service. Very friendly staff. Wish the rooms had queen beds instead of just doubles.
  Nov 19, 2017

$71

$71
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

315 Chestnut St, St. Louis
4.0 out of 5.0
4.3 out of 5 (4,990 reviews)
one of the best hotel i have stayed so far. Excellent service, clean rooms and restaurants were great.
  Dec 11, 2017

$79

$79
The Wildwood Hotel

The Wildwood Hotel

2801 Fountain Pl, Wildwood
3.5 out of 5.0
4.5 out of 5 (2,382 reviews)
Lovely hotelThis is a great hotel that just needs to be updated a bit. Had to give it 4/5 because the food on their breakfast buffet, while quite large, was cold.
  Dec 9, 2017

$95

$95
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights
4.0 out of 5.0
3.8 out of 5 (1,836 reviews)
We had an enjoyable night. Food at Final Cut was amazing. Enjoyed the gambling tables and the pillow top beds were very comfortable
  Dec 9, 2017

$87

$87
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St, St. Louis
4.5 out of 5.0
4.4 out of 5 (757 reviews)
Holiday Weekend GetawayGreat location downtown near Washington Street, easy to walk to the City Museum and the Arch. Good restaurants nearby and a grocery store a couple blocks away. Helpful and polite front desk staff. The room was clean other than two mold spots on our shower ceiling. The bed was comfortable but the ...
  Nov 27, 2017

$115

$115
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

2211 Market Street, St. Louis
3.5 out of 5.0
4.3 out of 5 (1,577 reviews)
Nice hotel conveniently located for our stay. Staff was very friendly and helpful. Would definitely recommend this hotel for the price.
  Dec 10, 2017

$95

$95
Missouri Athletic Club

Missouri Athletic Club

405 Washington Ave, St. Louis
4.0 out of 5.0
3.9 out of 5 (859 reviews)
Convenient location to metro. The hotel is only one block from the metro and two blocks from the convention center.
  Nov 21, 2017

$115

$115
Crowne Plaza St. Louis Airport

Crowne Plaza St. Louis Airport

11228 Lone Eagle Dr, Bridgeton
4.0 out of 5.0
4.1 out of 5 (908 reviews)
Close to airport and archVery nice hotel cost to airport, arch and other attractions. Only airport within short distance from Fort.
  Dec 9, 2017

$80

$80
Best Western St. Louis Inn

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr, St. Louis
3.0 out of 5.0
3.9 out of 5 (1,606 reviews)
The Room was fine, but the rate was high for the quality of the hotel.
  Nov 30, 2017

$72

$72
Days Inn St. Louis Westport MO

Days Inn St. Louis Westport MO

1970 Craig Rd, Maryland Heights
2.5 out of 5.0
3.7 out of 5 (1,560 reviews)
Very comfortable, quiet and convenient stay. Also very good value for the money. Haven’t stayed at a Days Inn for quite a while due to my thinking that the hotel had declined in quality but this experience has changed that. I would try another one to see if the quality has indeed changed ...
  Dec 7, 2017

$64

$64
Hilton Garden Inn St. Louis Airport

Hilton Garden Inn St. Louis Airport

4450 Evans Place, Berkeley
3.5 out of 5.0
4.2 out of 5 (1,049 reviews)
Won't be disappointedNice hotel, clean and comfortable. Front desk staff was nice. Only spent the night therefore didn't check everything out. Hotels in the area were competitively priced. The only negative is they should offer at least a complementary continental breakfast, a few of the other hotels in the area had ...
  Nov 22, 2017

$79

$79
The Cheshire

The Cheshire

6300 Clayton Rd, Richmond Heights
4.0 out of 5.0
4.2 out of 5 (1,367 reviews)
UK Museum and charmIt was so lovely for my kids and I to stay at the Cheshire. We were immersed into the charm and history of the experience. My kids were interested in the Queen of England and wanted to read the books provided by the hotel. I adored the old world paintings on the walls and the cozy feel of the lobby. ...
  Dec 5, 2017

$143

$143
Quality Inn St. Louis Airport Hotel

Quality Inn St. Louis Airport Hotel

10232 Natural Bridge Rd, St. Louis
3.0 out of 5.0
3.2 out of 5 (1,137 reviews)
Staff was great at check in. kind and courteous. Our room was warm . I didn’t care for the pillows, not comfortable.
  Nov 12, 2017

$52

$52
Airport Plaza Inn & Conference Center

Airport Plaza Inn & Conference Center

4534 Long Road, Bridgeton
3.5 out of 5.0
3.1 out of 5 (1,798 reviews)
Excellent price. Polite staff. Close to Airport. Price is affordable. Rooms are adequate. Staff was very polite. Shuttle to and from airport. Restaurant (India Place) was amazing.
  Nov 28, 2017

$62

$62
Map

Recently booked Business Hotels in St. Louis

Best Western Troy Hotel
2.5 out of 5.0
Last booking: 6 minutes ago
Drury Inn & Suites St. Louis St. Peters
3.5 out of 5.0
Last booking: 8 minutes ago
Hawthorn Suites by Wyndham St. Louis Westport Plaza
3.0 out of 5.0
Last booking: 19 minutes ago
Marriott St. Louis Grand
4.0 out of 5.0
Last booking: 21 minutes ago
City Place St. Louis - Downtown Hotel
4.0 out of 5.0
Last booking: 21 minutes ago
Drury Inn Airport - St. Louis, MO
3.5 out of 5.0
Last booking: 22 minutes ago
Extended Stay America - St. Louis - Airport - Central
3.0 out of 5.0
Last booking: 23 minutes ago
Missouri Athletic Club
4.0 out of 5.0
Last booking: 23 minutes ago
Hampton Inn by Hilton Wentzville
3.0 out of 5.0
Last booking: 24 minutes ago

Pocket Guide: Business Hotels in St. Louis

Search for hotels in St. Louis on Expedia. You can easily find your hotels in St. Louis using one of the methods below:

  • View our selection of featured hotels in St. Louis
  • Use the map to find hotels in the St. Louis neighborhood you prefer
  • Use the filters to see hotels in a specific area of St. Louis, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in St. Louis
  • Enter your travel dates to view the best deals on hotels in St. Louis - while they last