Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured St. Louis Business Hotels

See all 265 Hotels in St. Louis
City Place St. Louis - Downtown Hotel

City Place St. Louis - Downtown Hotel

200 North 4th Street, St. Louis
3.5 out of 5.0
3.2 out of 5 (1,248 reviews)
Great location near the Arch and downtownOverall this was a fine place to stay. It is not a four or five star place but the rooms are HUGE and have all the basics in them. Beds were comfy, big screen TV, etc. The front desk staff were very nice and put us in a room with a view of the Arch. We did have a problem with our room that took a ...
  Sep 18, 2017

$93

$93
Wingate by Wyndham St. Charles MO

Wingate by Wyndham St. Charles MO

32 Research Park Circle, St. Charles
3.0 out of 5.0
4.3 out of 5 (234 reviews)
Quiet location near i64. I enjoyed coffee on the patio in the morning before eating scrambled eggs and a sausage potato scramble. The kitchen crew teased each other as they worked. I had the impression they were family since I heard one call the older man Grandpa. How nice I thought, breakfast with a family touch. This was ...
  Sep 16, 2017

$93

$93
The Wildwood Hotel, BW Premier Collection

The Wildwood Hotel, BW Premier Collection

2801 Fountain Pl, Wildwood
3.5 out of 5.0
4.4 out of 5 (612 reviews)
Can't wait to come back!My fiance and I stayed at the Wildwood this past Aug for the eclipse. We had such a great experience, we're coming back for our honeymoon! First off, the staff was amazing, Every single person we encountered was warm, friendly, and they seemed genuinely concerned about their guests. Secondly, there's ...
  Sep 18, 2017

$81

$81
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights
3.5 out of 5.0
3.7 out of 5 (478 reviews)
Great Time.Enjoyed playing the games and listening ,watching the awesome performance of the Platinum Rock Legends Band at the Boogie Nights Club.
  Sep 18, 2017

$103

$103
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St, St. Louis
4.0 out of 5.0
4.3 out of 5 (197 reviews)
Beautiful St Louis Hotel The hotel is a beautiful boutique. Our room was very comfortable and quiet. It was a just a short walk to Bush Stadium and may be our new St. Louis regular hotel!
  Sep 15, 2017

$159

$159
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

2211 Market Street, St. Louis
3.0 out of 5.0
4.3 out of 5 (500 reviews)
Good location, downtown.This was so much better than the last place I stayed in St. Louis. Good location just north of Union Station, and a parking garage. Rooms were nice, couch, desk, besides the basics, tv, bed, etc. Would definitely use again. Breakfast, and cocktail hour included.
  Sep 18, 2017

$120

$120
Crowne Plaza St. Louis Airport

Crowne Plaza St. Louis Airport

11228 Lone Eagle Dr, Bridgeton
3.5 out of 5.0
4.1 out of 5 (280 reviews)
SERVICE, FACILITIESEXCELLENT SERVICE, RESPONSIVE STAFF, COMFORTABLE. 'HARD TO ACCESS AND FIND HOTEL LOCATION... ROOM WAS LARGE, EXEMPLARY, COMFORTABLE
  Sep 14, 2017

$110

$110
Days Inn St. Louis Westport MO

Days Inn St. Louis Westport MO

1970 Craig Rd, Maryland Heights
2.5 out of 5.0
3.6 out of 5 (398 reviews)
It was great! Will definitely stay here again! Nice hotel!!
  Sep 16, 2017

$59

$59
The Cheshire

The Cheshire

6300 Clayton Rd, Richmond Heights
4.0 out of 5.0
4.0 out of 5 (391 reviews)
Enjoyable stay. Very convenient. Staff very helpful. Location very good just adjacent to Forest Park. Nice facility with the best "free" breakfast of any of the hotel in which we have stayed. Easy parking in protected garage. Would stay here again when in the area.
  Sep 3, 2017

$152

$152
Airport Plaza Inn & Conference Center

Airport Plaza Inn & Conference Center

4534 Long Road, Bridgeton
3.0 out of 5.0
3.1 out of 5 (771 reviews)
Stayed for one night, easy check in, check out. Room was clean, staff was very nice, breakfast was below average.
  Sep 11, 2017

$69

$69
Map

Recently booked Business Hotels in St. Louis

Moonrise Hotel
4.0 out of 5.0
Last booking: 5 minutes ago
Drury Inn Airport - St. Louis, MO
3.0 out of 5.0
Last booking: 16 minutes ago
Hilton St. Louis Frontenac
3.5 out of 5.0
Last booking: 18 minutes ago
Hyatt Regency St. Louis at The Arch
4.0 out of 5.0
Last booking: 29 minutes ago
Pear Tree Inn St. Louis Near Union Station
3.0 out of 5.0
Last booking: 41 minutes ago
Days Inn St. Louis North
1.5 out of 5.0
Last booking: 1 hour ago
La Quinta Inn & Suites Collinsville
2.5 out of 5.0
Last booking: 1 hour ago
Marriott St. Louis Airport
3.5 out of 5.0
Last booking: 1 hour ago
Hilton St. Louis Airport
3.5 out of 5.0
Last booking: 1 hour ago

St. Louis Business Hotel Information

Work hard and play harder when you reserve a business hotel in St. Louis.
  • Make a business savvy move and browse our vast selection of choices
  • Don’t forget about our convenient mobile booking options
  • Reserve a hotel today and save yourself time and money

Be the boss, call the shots, and make your reservations on the ideal business hotel today. Because when you’re traveling on a work trip, you need to get down to business.

Business Hotels

Instead of booking a traditional hotel and dealing with potential inconveniences, reserve a business hotel in St. Louis, which is specifically designed with the business traveler in mind. These accommodations provide a strong Wi-Fi signal and quiet areas where you and your coworkers can focus on the task at hand without disturbances. Fuel up on the hotel’s freshly brewed coffee for a caffeine kick and don’t forget about the around-the-clock business center for printing, faxing, and photocopying.

Seminar Rooms

Executive St. Louis business hotels feature the ideal venue space for hosting seminars or teambuilding events. These spacious facilities are also perfect for training rooms, as they offer large areas with tables and chairs. Furthermore, these seminar rooms provide all the amenities you need for conducting a successful meeting, from whiteboards to Wi-Fi. Round up your staff for a training session or a company presentation, and don’t forget the catering.

Meeting Space

During your stay at a business hotel in St. Louis, practice your big pitch for the bigwigs in a presentation room or take advantage of the video conferencing tools to touch base with your boss back home. If you’re a business traveler journeying solo or with a handful of employees, these hotels feature day office and coworking floor space to accommodate your smaller-scale needs. Whether you’re looking for deposition space or a private business suite, make a hotel with meeting rooms in St. Louis your go-to choice.

When you book reservations for a business hotel on Expedia, you can leave your negotiating skills at work because we offer the lowest rates around. We simply cut to the chase and provide you with our unbeatable discounts from the start. When it’s time to book a hotel with a office center or executive suite, browse our selection to find the ideal place suiting all your work trip needs.