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Featured Syracuse Luxury Hotels

See all 687 Hotels in Syracuse
Des Etrangers Hotel & SPA

Des Etrangers Hotel & SPA

Passeggio Adorno 10/12, Syracuse
5.0 out of 5.0
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12, Syracuse
5.0 out of 5.0
Grand Hotel Minareto

Grand Hotel Minareto

Via del Faro Massolivieri 26, Syracuse
5.0 out of 5.0
Eureka Palace Hotel Spa Resort

Eureka Palace Hotel Spa Resort

Strada Spinagallo 50, Syracuse
5.0 out of 5.0
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93, Syracuse
4.0 out of 5.0
Hotel Livingston Siracusa

Hotel Livingston Siracusa

Via Nizza, 17, Syracuse
4.5 out of 5.0
Hotel Parco delle Fontane

Hotel Parco delle Fontane

Viale Scala Greca, 325, Syracuse
Grande Albergo Alfeo

Grande Albergo Alfeo

Via Nino Bixio 5, Syracuse
4.5 out of 5.0
Villa Felicia

Villa Felicia

Contrada Falconara snc, Noto
Charme Hotel Henry's House

Charme Hotel Henry's House

Via del Castello Maniace n. 68, Syracuse
4.5 out of 5.0
Antico Hotel Roma 1880

Antico Hotel Roma 1880

Via Roma 66, Syracuse
4.5 out of 5.0
L'Approdo delle Sirene

L'Approdo delle Sirene

Riva Giuseppe Garibaldi 15, Syracuse
3.5 out of 5.0
Alla Giudecca

Alla Giudecca

Via Alagona 52, Ortigia, Syracuse
3.5 out of 5.0
Grand Hotel Villa Politi

Grand Hotel Villa Politi

Via Maria Politi Laudien 2, Syracuse
4.0 out of 5.0
Royal Maniace Hotel

Royal Maniace Hotel

Lungomare di Ortigia,13, Syracuse
4.5 out of 5.0
Hotel dei Coloniali

Hotel dei Coloniali

Via Del Porto Grande 46, Syracuse
3.5 out of 5.0
Piccolo Hotel Casa Mia

Piccolo Hotel Casa Mia

Corso Umberto, 112, Syracuse
Hotel Cavalieri

Hotel Cavalieri

V MALTA 42,, SIRACUSA
4.5 out of 5.0
Domus Mariae Benessere

Domus Mariae Benessere

Via Vittorio Veneto, 89, Syracuse
3.0 out of 5.0
Borgo Pantano

Borgo Pantano

Traversa Fontana Mortella, 13 int. 4, Syracuse
4.5 out of 5.0
Map

Recently booked Luxury Hotels in Syracuse

Algila' Ortigia Charme Hotel
4.0 out of 5.0
Last booking: 12 minutes ago
Borgo Pantano
4.5 out of 5.0
Last booking: 19 hours ago
Grand Hotel Minareto
5.0 out of 5.0
Last booking: 26 hours ago

A weekend away keeps your stress at bay, especially when you're enjoying a stay in Syracuse. Divine eats, fascinating sites, and the most breathtaking photo opportunities: these are just some of the reasons to take a vacation to Syracuse. Where else would you stay but a luxury hotel? Anything less than the best is for the birds. While you're in town, you'll also treat yourself to the city's best food, marvel at the best points of interest in the region, and grab tickets to the most sought-after shows. Book your elegant hotel in Syracuse on Expedia.com today and start your trip off on the right (well-dressed) foot.

5-Star Vacations in Syracuse

It turns out plenty of folks have decided to call it home -- how is that for proof that Syracuse is full of an intoxicating assortment of activities? Whether you’re looking to spend your vacation dining on the best regional fare or exploring museums in Syracuse, you'll never be disappointed. Syracuse is full of impressive hotels on top of appealing attractions, so you can count on a marvelous stay. Book well in advance to get a room with a view!

An upscale vacation is your chance to live your best life, including eating at 5-star restaurants and getting the VIP treatment. When you're smart enough to book travel on Expedia.com, you can enjoy it all. Thanks to our great rates on hotels, you'll still have plenty of cash for the most popular activities. After an eventful day of adventure, your luxury suite awaits. Don't fall asleep before soaking in your over-sized tub or sipping on a glass of fine wine. The luxury hotels in Syracuse will lull you into a state of tranquility in the blink of an eye.

Luxury Syracuse Hotels

There's no better time than right now to book your getaway in Syracuse, and Expedia.com is here to help. Browse the bounty of real traveler reviews on dozens of hotels to find an accommodation that suits your needs. 5-Star hotels treat you right, offering things like high end bath amenities and private kitchens. Many high-end accommodations in Syracuse even feature gigantic suites, and it's not uncommon to find a sauna and heated swimming pool in your hotel. Book your dream hotel in Syracuse now, and before you know it you'll be getting pampered in paradise!