Texas Medical Center Vacations from $257

Book a Hotel + Flight or Car together to unlock savings

Looking for sports, concerts, or music festivals? Opens in a new windowSearch event tickets

    Plan, book, travel with confidence
  • payments icon
    Better together
    Save up to $580 when you book a flight and hotel together*
  • lob hotels icon
    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • lob packages icon
    Rest easy
    Plan, book, and manage your trip all in one place

Your Texas Medical Center Vacation

Our Texas Medical Center vacation packages are a speedy and practical way to plan and reserve your next adventure. Discover the true character of this unique neighborhood without the pressure of planning it all yourself. Start your trip to Texas Medical Center by heading to nearby attractions such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. No matter what your dream Texas Medical Center vacation may look like, you can turn it into reality with Expedia.

The Latest Texas Medical Center Vacation Packages

C. Baldwin, Curio Collection by Hilton

C. Baldwin, Curio Collection by Hilton

4 out of 5
Downtown Houston
Save 100% on your flight
per person
Jun 16 - Jun 19
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (602 reviews)
Really hated the expensive valet parking. We used the shuttle service and our driver was a delight! But holey moley the cost to park was ridiculous. It appears to be like this all over Houston but come on.

Reviewed on Apr 18, 2024

The Lancaster Hotel

The Lancaster Hotel

4 out of 5
Downtown Houston
Save 100% on your flight
per person
May 24 - May 27
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.8/10 Exceptional! (1,495 reviews)
Great welcome and friendly staff. The welcome pack in the hotel far exceeds what is offered in similar hotels.

Reviewed on Apr 16, 2024

Thompson Houston, by Hyatt

Thompson Houston, by Hyatt

4 out of 5
Fourth Ward
Save 100% on your flight
per person
Jun 16 - Jun 19
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.6/10 Exceptional! (7 reviews)
This is my first time treating myself to a realllly nice hotel and when I say they didn’t disappoint.. this was a great experience. Extra clean, smelled great, lots of amenities, friendly staff, easy check in & out process. The bathrooms were so luxurious I spent most of my time in there. Obsessed is an understatement.

Reviewed on Mar 16, 2024

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
Greater Uptown
Save 100% on your flight
per person
Jun 16 - Jun 19
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
7.6/10 Good! (1,003 reviews)
The property was nice and clean. It was conveniently located with many things around it for food, shopping and all in walking distance. The staff was pleasant.

Reviewed on Apr 19, 2024

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria

4 out of 5
The Galleria
Save 100% on your flight
per person
Jun 16 - Jun 19
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,005 reviews)
Over all the hotel is okay and bo specific issues other than just kind of old stuff. Needs a little upgrade

Reviewed on Apr 17, 2024

Prices and availability subject to change. Additional terms may apply.

Where to stay in Texas Medical Center

Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotel + flight trips in Downtown Houston

Texas Medical Center Hotel Deals

Blossom Hotel Houston
Blossom Hotel Houston
4 out of 5
7118 Bertner Ave, Houston, TX
Fully refundableReserve now, pay when you stay
The price is $170 per night from May 1 to May 2
$170
$199 total
includes taxes & fees
May 1 - May 2
9.2/10 Wonderful! (2,049 reviews)
"I truly loved my stay here it was a beautiful quiet stay here I have to travel back again."

Reviewed on Apr 19, 2024

Blossom Hotel Houston
Hyatt Place Houston Medical Center
Hyatt Place Houston Medical Center
3 out of 5
7329 FANNIN STREET Building 2, Houston, TX
Fully refundable
The price is $126 per night from Apr 21 to Apr 22
$126
$147 total
includes taxes & fees
Apr 21 - Apr 22
9/10 Wonderful! (588 reviews)
"Super nice hotel for a great price."

Reviewed on Apr 17, 2024

Hyatt Place Houston Medical Center
DoubleTree by Hilton Houston Medical Center Hotel & Suites
DoubleTree by Hilton Houston Medical Center Hotel & Suites
4 out of 5
6800 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
The price is $127 per night from May 12 to May 13
$127
$148 total
includes taxes & fees
May 12 - May 13
8.6/10 Excellent! (44 reviews)
Great room in very quiet area.
"Great room in perfect conditions."

Reviewed on Apr 15, 2024

DoubleTree by Hilton Houston Medical Center Hotel & Suites
See all 6,641 properties in Texas Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Explore other types of vacation packages

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Frequently asked questions

How much does a Texas Medical Center vacation package cost?
Much less than you might think — from only $257, in fact! By bundling flights, hotels and car rentals into a tailor-made vacation package, your getaway to Texas Medical Center is just a few clicks away.
How do I get a cheap travel package to Texas Medical Center?
Browse and lock in everything in the one place with our Texas Medical Center vacation packages. You’ll discover bargains on flights, hotels, tours and more that’ll keep your hip pocket happy and your adventurous spirit alive. And, with more than 550 airlines and 1,000,000 properties all over the world to select from, you’ll have the flexibility to mix and match as you please.
Where should I stay in Texas Medical Center?
Choose a place close to Houston Zoo. This famous sight is in the middle of the action and on the must-see lists of many travelers.
What are the top hotels in Texas Medical Center?
Hilton Garden Inn Houston Medical Center, TX and Home2 Suites by Hilton Houston Medical Center, TX are two of the most well-known hotels in Texas Medical Center. Why not have a look at the rates and amenities at each and then decide?
How far in advance should I book my Texas Medical Center vacation?
Browse Expedia to compare international flights as soon as you know your travel dates. You can normally purchase a ticket up to a year in advance. If it’s too early for your preferred air carrier, or you have to book last minute, don’t stress. Low prices to Texas Medical Center occasionally appear just weeks before the date of departure.
What does an Expedia Texas Medical Center travel package include?
Expedia has all you need to lock in Texas Medical Center trip, but how your package is structured is your choice. Choose from a combination of rental cars, flights and hotels. In search of a few activities to keep you busy? Once you’ve made your booking, you can add them too. Whatever your style or budget, there’s a package deal to match your needs.
What should I know before booking a Texas Medical Center travel package?
Our prices are already low. However, you’ll snap up even more savings when you book your flights, hotels and car rentals together. With an Expedia travel package, you’ll get transparent pricing and a terrific range of choice.
Can I choose my airline with a Texas Medical Center Expedia vacation package?
Yes — and it’s easy too. Expedia has access to more than 550 partner airlines around the world. Our packages give you the flexibility to pick from available flights, hotels and activities that fit your needs.
If I'm not able to travel, can I cancel my Texas Medical Center vacation package?
It’s difficult to predict what tomorrow might bring, so it’s good to know that you can change or cancel your Texas Medical Center vacation package. If you made your booking in the last 24 hours, you may be eligible for a refund. If your booking is older, your airline, hotel or car rental company may charge a fee. Check our Customer Service Portal to learn more.

Discover the most popular places to visit in Texas Medical Center

Image for George R. Brown Convention Center

George R. Brown Convention Center

4/5(961 reviews)

During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and acclaimed art scene in this vibrant area.

George R. Brown Convention Center
Image for Toyota Center

Toyota Center

4/5(967 reviews)

Catch an event at Toyota Center during your trip to Houston. Experience the entertainment choices and acclaimed art scene in this vibrant area.

Toyota Center
Image for Minute Maid Park

Minute Maid Park

4.5/5(907 reviews)

Catch an event at Minute Maid Park during your trip to Houston. Experience the lively festivals and great live music in this vibrant area.

Minute Maid Park

Other vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.