Find hotels in Louisiana, MO from $65

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Compare 82 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

River's Edge Motel

2.0 star property
Louisiana
9.0 out of 10, Wonderful, (355)
"Excellent stay !!! Quite "
United States
Bradley
$80 nightly
The price is $91
Dec 19 - Dec 20
Total with taxes and fees
River's Edge Motel

The Eagles Nest Inn

3.0 star property
Louisiana
9.4 out of 10, Exceptional, (19)
"The room was great. Large and attractive!! Nice bathroom. Had all the convenience you need from TV to mini frig. "
United States
Judith
$96 nightly
The price is $109
Dec 10 - Dec 11
Total with taxes and fees
The Eagles Nest Inn

Quality Inn & Suites Hannibal West

2.5 star property
Hannibal
8.0 out of 10, Very Good, (1003)
"Very nice place to stay during a snow storm. "
United States
Teresa
$79 nightly
The price is $92
Jan 2 - Jan 3, 2026
Total with taxes and fees
Quality Inn & Suites Hannibal West

Best Western On The River

2.5 star property
Hannibal
8.6 out of 10, Excellent, (1003)
"Great stay! Clean and cozy!!"
United States
Courtney
$100 nightly
The price is $115
Dec 10 - Dec 11
Total with taxes and fees
Best Western On The River

Sleep Inn & Suites Hannibal West

2.5 star property
Hannibal
9.6 out of 10, Exceptional, (1005)
"Great area"
United States
kelvin
$101 nightly
The price is $117
Jan 2 - Jan 3, 2026
Total with taxes and fees
Sleep Inn & Suites Hannibal West

Comfort Inn & Suites - Hannibal

2.5 star property
Hannibal
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
$83 nightly
The price is $96
Jan 2 - Jan 3, 2026
Total with taxes and fees
Comfort Inn & Suites - Hannibal

Baymont by Wyndham Hannibal

2.5 star property
Hannibal
6.4 out of 10, (735)
" There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. "
United States
Thomas
$65 nightly
The price is $75
Dec 10 - Dec 11
Total with taxes and fees
Baymont by Wyndham Hannibal

Motel 6 Hannibal, MO

2.0 star property
Hannibal
7.4 out of 10, Good, (1000)
"Very clean rooms and staff is very friendly "
United States
Sherrie
$58 nightly
The price is $67
Dec 19 - Dec 20
Total with taxes and fees
Motel 6 Hannibal, MO

Days Inn by Wyndham Hannibal

2.0 star property
Hannibal
7.4 out of 10, Good, (214)
"Left before breakfast great cup of coffee"
United States
David
$65 nightly
The price is $74
Dec 28 - Dec 29
Total with taxes and fees
Days Inn by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2.0 star property
Hannibal
7.2 out of 10, Good, (1000)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
$68 nightly
The price is $78
Dec 12 - Dec 13
Total with taxes and fees
Super 8 by Wyndham Hannibal

Rodeway Inn

2.0 star property
Pittsfield
6.8 out of 10, (125)
"Air conditioning | Pet-friendly | Clean room | Staf"
United States
Anonymous traveler
$62 nightly
The price is $68
Dec 14 - Dec 15
Total with taxes and fees
Rodeway Inn

William Watson Hotel

3.0 star property
Pittsfield
9.2 out of 10, Wonderful, (345)
"Great location, restaurant downstairs, friendly staff, microwaves and refrigerator in room, historic significance "
United States
Druann
$82 nightly
The price is $91
Dec 10 - Dec 11
Total with taxes and fees
William Watson Hotel

Lighthouse Inn & Suites

4.0 star property
Hannibal
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
$188 nightly
The price is $215
Dec 10 - Dec 11
Total with taxes and fees
Lighthouse Inn & Suites

Howard Johnson BY Wyndham Hannibal

2.0 star property
Hannibal
7.2 out of 10, Good, (152)
"The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three months.!"
United States
Shawn
$56 nightly
The price is $65
Dec 28 - Dec 29
Total with taxes and fees
Howard Johnson BY Wyndham Hannibal

Garden House Bed and Breakfast

2.0 star property
Hannibal
8.6 out of 10, Excellent, (36)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
$109 nightly
The price is $125
Jan 3 - Jan 4, 2026
Total with taxes and fees
Garden House Bed and Breakfast

Green Acres Hotel

2.5 star property
Pittsfield
8.6 out of 10, Excellent, (141)
"Great stay"
United States
Jeramy
$107 nightly
The price is $118
Dec 10 - Dec 11
Total with taxes and fees
Green Acres Hotel

Monroe Street Suites

2.5 star property
Pittsfield
9.6 out of 10, Exceptional, (57)
"We had a great stay and would recommend others to stay here!"
United States
Brady
$86 nightly
The price is $95
Jan 1 - Jan 2, 2026
Total with taxes and fees
Monroe Street Suites

Riverside Inn Hannibal

2.5 star property
Hannibal
9.4 out of 10, Exceptional, (164)
"Great place to stay!"
United States
Sandy
$197 nightly
The price is $226
Dec 13 - Dec 14
Total with taxes and fees
Riverside Inn Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Louisiana

Like rivers? Get away to relaxing Louisiana!

Open swing span of Louisiana railroad bridge across the upper Mississippi near the town of Louisiana in Missouri

Top Louisiana Hotel Reviews

More cheap stays in Louisiana

Hotels in Louisiana with star-rating

Find out more about Louisiana

Top reasons to visit Louisiana

  • Outdoor Adventures: Louisiana, Missouri, boasts scenic trails and captivating caves, perfect for nature enthusiasts.
  • Romantic Getaways: The charming atmosphere and tranquil river make it an ideal destination for couples.
  • Vibrant Nightlife: Enjoy live jazz performances and a lively local scene for a fun night out.
  • Family-Friendly Activities: The local amusement park and recreational areas cater to families seeking adventure.
  • Diverse Accommodations: From cozy bed & breakfasts to pet-friendly hotels, there’s something for everyone.

Find great hotels in and around Louisiana

Discover the charm of Louisiana, Missouri, with a variety of accommodation options that cater to every traveler's needs. From cozy bed & breakfasts to pet-friendly hotels, you'll find the perfect place to unwind after a day of exploring. Experience the unique blend of adventure and history that this quaint town offers, all while enjoying top-notch services and amenities. Your ideal getaway awaits in Louisiana.

  • Super 8 by Wyndham Bowling Green: Located a short drive of 10 miles from Louisiana, Super 8 by Wyndham Bowling Green offers a cozy and welcoming atmosphere for travelers. This hotel is ideal for those looking to start their day with a hearty meal, featuring complimentary breakfast options including a daily breakfast buffet and to-go breakfast. Entertainment is abundant with amenities such as a DVD player, satellite TV, and premium channels, ensuring guests can unwind after a day of exploring the area.
  • River's Edge Motel: Nestled in the heart of Louisiana, River's Edge Motel is the perfect choice for pet lovers seeking a comfortable and accommodating stay. This motel welcomes certain pets, making it a convenient option for those traveling with furry friends. Guests appreciate the friendly pet policy, allowing for a stress-free vacation experience. The motel’s location offers easy access to local attractions, ensuring you enjoy the natural beauty of Louisiana.
  • Rodeway Inn: Situated 16 miles from Louisiana, Rodeway Inn is tailored for adventure seekers and pet owners alike. This hotel provides an array of adventure sports and recreational activities nearby, including hunting opportunities. The pet-friendly policy allows dogs and cats, ensuring that your beloved pets can accompany you on your travels. Guests can enjoy the rustic charm of the inn while engaging in exciting outdoor activities, making it a well-rounded choice for an adventurous getaway.

Where to stay in and around Louisiana

Louisiana, Missouri, offers a charming blend of outdoor adventures and scenic beauty perfect for a romantic getaway or family vacation. Explore the friendly atmosphere of the city, where you can unwind in recreational areas or indulge in local excursions. Nearby cities provide trendy and luxurious experiences, ensuring a memorable stay. Whether you’re enjoying the rich local culture or the vibrant community, Louisiana is a delightful destination for all types of travelers.

  • Ashburn: Nestled within the Louisiana area, Ashburn is a charming village that attracts visitors year-round, although it sees a surge in activity during the summer months from June to August. Travelers flock here primarily for sports-related experiences, enjoying the local sports facilities and stadiums. Despite its small size, Ashburn offers a welcoming atmosphere where you can engage in various sports activities and enjoy the friendly community spirit.
  • Rockport: Located just 7 miles from Louisiana, Rockport is a vibrant city known for its cultural and city-themed experiences. This charming destination experiences seasonal visitor patterns, with peak months in May, July, and September. Visitors can immerse themselves in the local culture by exploring historic places and buildings that reflect the rich heritage of the area. Educational activities are also popular here, making it a perfect spot for those looking to blend leisure with learning.
  • Bowling Green: A city located 11 miles from Louisiana, Bowling Green offers a delightful mix of outdoor, family, and romantic experiences. With visitor numbers peaking in the summer and early fall, this city is perfect for those looking to enjoy recreational activities, shopping, and theaters. The presence of a lovely lake, historic places, and urban parks provides ample opportunities for relaxation and exploration, making Bowling Green an excellent choice for families and couples alike.

Things to do near Louisiana

Louisiana, Missouri, offers a delightful mix of outdoor adventures and romantic getaways. Enjoy scenic trails, visit the local amusement park, and immerse yourself in the vibrant nightlife with live jazz performances. Whether you're seeking leisurely activities or a cozy escape, Louisiana provides a charming backdrop for your vacation, making it an ideal spot for both relaxation and fun.

Shopping

In Louisiana, visit local shops along Main Street for unique gifts and souvenirs. If you're up for a drive, check out the Oakwood Shopping Center, located 12 miles away, featuring a mix of retail stores and dining options for a fun shopping experience.

Recreation

Experience the scenic Old Orchard Country Club, where you can enjoy a round of golf amidst beautiful landscapes and vibrant outdoor vibes. For a more relaxing atmosphere, head to McCully Heritage Project, offering a peaceful setting perfect for unwinding and rejuvenation.

Adventure

Explore the picturesque Mark Twain Lake, offering water activities like fishing, boating, and swimming. For hiking enthusiasts, the nearby Mark Twain State Park features scenic trails and stunning views of the Lake's shoreline, perfect for a day of adventure in nature.

Nightlife

For a vibrant nightlife experience in Louisiana, consider catching a show at the Planters Barn Theater or the Bluff City Theater, both located 24 miles away. These venues offer a delightful mix of culture, romance, and family-friendly entertainment to ensure a memorable evening.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Louisiana

For a budget-friendly trip to Louisiana, Missouri, consider visiting from November to January when prices are lower, especially on Mondays. Avoid Saturdays for the best rates. Use Expedia to compare hotel prices and customize your search for affordable options, including eco-friendly stays. Booking a package that combines hotels, flights, and activities can yield additional savings. Join Expedia’s One Key membership for exclusive discounts and the chance to earn OneKeyCash for future bookings. Explore free local attractions and utilize public transport for economical travel around the area.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Louisiana are November to January, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Louisiana is Monday. The most expensive day to stay in Louisiana is Saturday.
  • Find cheap hotels on Expedia: Expedia's search tool enables you to customize your travel preferences, including your budget and preferred destination. You can easily arrange your search results by price, starting with the most affordable hotels. Additionally, you have the option to refine your choices by hotel category; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are available for booking.
  • Consider bundling your trip: You can save money by combining your Louisiana hotel reservations with your flights and activities by booking a package through Expedia.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Louisiana

Louisiana, Missouri, is perfect for outdoor enthusiasts and those seeking romantic getaways, offering breathtaking scenery and numerous attractions. Visitors can explore captivating caves, enjoy the tranquil river, and stroll through urban parks. The local points of interest cater to travelers looking for adventure, culture, and unique experiences, making Louisiana an ideal destination for anyone seeking to immerse themselves in nature and local charm.

  • Mississippi River: Experience the breathtaking scenery and outdoor vibes of the iconic Mississippi River, located 9 miles from Louisiana. Enjoy activities like fishing, boating, or simply taking in the beautiful views along the riverbanks.
  • Clarksville State Game Refuge: Just 8 miles away, this serene reserve offers a relaxing atmosphere perfect for family-friendly excursions. Encounter friendly locals and explore the diverse wildlife, making it an ideal spot for nature lovers and outdoor enthusiasts.
  • Clarksville Riverfront Park: Situated 9 miles from Louisiana, this urban park is a great place for families to gather. Enjoy outdoor activities, picnics, and the vibrant city vibe while taking in lovely views of the river.

Best time to go to Louisiana

The best time to visit Louisiana can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Louisiana falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature in Louisiana falls in January, visitor numbers are slightly low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January28.6°F (-1.9°C)Light RainMostly CloudySlightly LowSlightly Low
February31.6°F (-0.2°C)Light RainMostly SunnyAverageAverage
March44.1°F (6.7°C)Light RainMostly SunnyAverageAverage
April53.8°F (12.1°C)Light RainMostly SunnySlightly HighAverage
May64.0°F (17.8°C)Light RainMostly SunnyAverageSlightly High
June73.8°F (23.2°C)Light RainMostly SunnyAverageSlightly High
July76.6°F (24.8°C)Light RainMostly SunnySlightly HighSlightly High
August75.0°F (23.9°C)Light RainMostly SunnyAverageAverage
September69.1°F (20.6°C)Light RainMostly SunnySlightly HighAverage
October56.3°F (13.5°C)Light RainMostly SunnyAverageAverage
November44.1°F (6.7°C)Light RainMostly SunnySlightly LowSlightly Low
December35.1°F (1.7°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Louisiana

For your visit to Louisiana, Missouri, you have a couple of major airports to consider. St. Louis Lambert International Airport (STL) is situated 61 miles away, with nearby accommodation options like The Ritz-Carlton, St. Louis, and Ameristar Casino Resort and Spa, both about 7 miles from the airport. Quincy Regional Airport (UIN) is closer at 34 miles, offering hotels such as Holiday Inn Quincy East, located 8 miles away. Another option is Spirit of St. Louis Airport (SUS), 58 miles from Louisiana, with nearby hotels like DoubleTree by Hilton Hotel St. Louis - Chesterfield just 4 miles away. Each airport provides convenient access to these comfortable lodging choices.

Frequently asked questions

What are the best family hotels in Louisiana?
The Eagles Nest Inn in Louisiana is a charming family-friendly hotel great for those traveling with children. With thoughtful amenities like a dedicated Kids Meal program and convenient in-room microwaves, this hotel ensures that families can enjoy meals tailored to their little ones while also having the flexibility to prepare snacks or quick bites. Find more child-friendly accommodations in Louisiana.
What are the best budget hotels in Louisiana?
River's Edge Motel is an excellent choice for budget-conscious travelers seeking comfort and convenience in Louisiana, MO. With an excellent review score of 8.8, guests appreciate the inviting space and thoughtful amenities, including free toiletries and in-room WiFi, superb for staying connected while on the go. View all budget hotels in Louisiana.
When is the best time to go to Louisiana?
The most popular time to visit Louisiana is during April, when the weather is pleasantly warm and vibrant festivals fill the calendar. With temperatures averaging in the low to mid-70s Fahrenheit, this month invites you to immerse yourself in the lively atmosphere of New Orleans and experience the rich culture that defines the region.

From April to June, Louisiana enjoys its peak tourist season, drawing visitors eager to partake in outdoor activities and sightseeing. The charming streets of the French Quarter come alive with music, art, and culinary delights, making it an ideal time for travelers who appreciate attentive service and great experiences. Strolling through the historic districts or enjoying a steamboat cruise along the Mississippi River becomes a delightful adventure in this inviting climate.

For couples and friends looking to indulge in the local scene, April is particularly special due to events like the New Orleans Jazz & Heritage Festival. This celebrated festival showcases incredible music, food, and crafts, offering a fantastic way to connect with the local culture while creating unforgettable memories together.

If you're seeking a quieter experience, consider visiting in November. While temperatures begin to cool down, this month often features fewer crowds, allowing for a more intimate exploration of Louisiana's charm. You can still enjoy access to local attractions, delicious cuisine, and the warm hospitality the state is known for.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Louisiana hotel for you.
How can I save on a Louisiana hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Louisiana hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Louisiana hotel?
Prices for hotels in Louisiana often vary, but you can find a great deal from $65 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia