Boutique Hotel in Upstate South Carolina

Browse for Upstate South Carolina Boutique Hotels from $89

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Search over a million flights, hotels, packages, and more

Featured Upstate South Carolina Boutique Hotels

Hotel Domestique
4 out of 5
10 Road of Vines, Travelers Rest, SC
$246
per night
Oct 23 - Oct 24
4.7/5Exceptional! (10 reviews)
Two day getaway

"First impression was good! Pool was excellent. Dinner the first night was average and it is pricey. Better the next night. Waiter was great. Would have liked better service in the bar. Outdoor construction repair left undone. Not enough areas to sit, if you’re not eating. Informed that it’s mostly ..."…"

Reviewed on Jul 3, 2019

Hotel Domestique
Hotel Tillman
2.5 out of 5
1303 Tiger Blvd, Clemson, SC
Free CancellationReserve now, pay when you stay
$89
per night
Oct 22 - Oct 23
4/5Very Good! (745 reviews)

"Clean property, great location for Clemson activities. Price was right. Free breakfast a bit limited on options, and fitness area tiny, but minor complaints in the overall experience. I would stay there again for sure !"…"

Reviewed on Oct 16, 2019

Hotel Tillman
The Bleckley Inn
3.5 out of 5
151 E Church St, Anderson, SC
$125
per night
Oct 24 - Oct 25
4.8/5Exceptional! (227 reviews)

"Amazing breakfast!!! We drive out of our way to stay here whenever we can,"…"

Reviewed on Oct 9, 2019

The Bleckley Inn
Hyatt Place Greenville/Haywood
3 out of 5
40 W Orchard Park Dr, Greenville, SC
Free Cancellation
$91
per night
Nov 3 - Nov 4
4.3/5Excellent! (1,672 reviews)

"This was a very nice hotel but some of the front desk staff not all that friendly"…"

Reviewed on Oct 17, 2019

Hyatt Place Greenville/Haywood
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pocket Guide: Boutique Hotels in Upstate South Carolina

Search for hotels in Upstate South Carolina on Expedia. You can easily find your hotels in Upstate South Carolina using one of the methods below:

  • View our selection of featured hotels in Upstate South Carolina
  • Use the map to find hotels in the Upstate South Carolina neighborhood you prefer
  • Use the filters to see hotels in a specific area of Upstate South Carolina, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Upstate South Carolina
  • Enter your travel dates to view the best deals on hotels in Upstate South Carolina - while they last

More trip options

Travelers Loved These Boutique Hotels