Luxury in Upstate South Carolina

Upstate South Carolina Luxury Hotels & Resorts $50

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Search over a million flights, hotels, packages, and more

Featured Upstate South Carolina Luxury Hotels

The Westin Poinsett Greenville
4 out of 5
120 South Main St, Greenville, SC
Free CancellationReserve now, pay when you stay
$179
per night
Nov 3 - Nov 4
4.4/5Wonderful! (897 reviews)

"Beautiful hotel, very nice, extremely clean, conveniently located! All employees were over and above helpful, friendly! Highly recommend!"…"

Reviewed on Oct 16, 2019

The Westin Poinsett Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
Free Cancellation
$145
per night
Nov 11 - Nov 12
4.2/5Excellent! (988 reviews)

"Great location and setup. Excellent access to restaurants and shops and they have an on premise Starbucks. The only downside was we made our reservations late and paid a premium for a room that had our door facing the elevators and our window facing the garage. Not really their problem but it was ..."…"

Reviewed on Oct 18, 2019

Hyatt Regency Greenville
Sleep Inn at Greenville Convention Cente
2.5 out of 5
231 N Pleasantburg Dr, Greenville, SC
Free CancellationReserve now, pay when you stay
$67
per night
Oct 27 - Oct 28
3.8/5Good! (510 reviews)

"customer service. Suggest replacing hall carpet. Jean was very nice and approachable."…"

Reviewed on Oct 2, 2019

Sleep Inn at Greenville Convention Cente
The Bleckley Inn
3.5 out of 5
151 E Church St, Anderson, SC
$125
per night
Oct 24 - Oct 25
4.8/5Exceptional! (227 reviews)

"Amazing breakfast!!! We drive out of our way to stay here whenever we can,"…"

Reviewed on Oct 9, 2019

The Bleckley Inn
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd
3.5 out of 5
851 Congaree Rd, Greenville, SC
Free Cancellation
$93
per night
Oct 27 - Oct 28
4.2/5Excellent! (439 reviews)

"It is the superb comfort and convenience that this hotel always provides. It was excellent"…"

Reviewed on Oct 7, 2019

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd
Red Roof Inn Spartanburg
2 out of 5
6765 Pottery Rd, Spartanburg, SC
Free CancellationReserve now, pay when you stay
$65
per night
Oct 22 - Oct 23
3.5/5Good! (473 reviews)

"From the minute we walked in the door it was like running into old friends. Your front desk staff were exceptional specially the lady as she was training a young man that day. We hit it off and laughed and were made to feel very at ease and when we walked into our room it was a good feeling. The ..."…"

Reviewed on Oct 14, 2019

Red Roof Inn Spartanburg
Quality Inn Clemson near University
2 out of 5
3430 Clemson Blvd, Anderson, SC
Free CancellationReserve now, pay when you stay
$58
per night
Oct 27 - Oct 28
3.6/5Good! (568 reviews)

"The location was near where I needed to be. The room was clean the breakfast was good."…"

Reviewed on Sep 26, 2019

Quality Inn Clemson near University
La Quinta Inn & Suites by Wyndham Greenville Haywood
2.5 out of 5
65 W Orchard Park Dr, Greenville, SC
Free CancellationReserve now, pay when you stay
$94
per night
Nov 3 - Nov 4
4.4/5Excellent! (1,440 reviews)

"Quiet, clean, good breakfast. Price was good, short drive to downtown."…"

Reviewed on Oct 18, 2019

La Quinta Inn & Suites by Wyndham Greenville Haywood
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Free CancellationReserve now, pay when you stay
$105
per night
Nov 3 - Nov 4
4.2/5Very Good! (699 reviews)

"Pleasant Hotel Staff, wonderful site, decent fitness center."…"

Reviewed on Sep 30, 2019

Hilton Greenville
Best Western Travelers Rest Greenville
2.5 out of 5
110 Hawkins Rd, Travelers Rest, SC
Free CancellationReserve now, pay when you stay
$75
per night
Nov 4 - Nov 5
4.2/5Very Good! (401 reviews)

"A good basic hotel for a one night stopover. No problems. Not fancy, but a good stop for a night. Good breakfast"…"

Reviewed on Oct 15, 2019

Best Western Travelers Rest Greenville
Embassy Suites Greenville Golf Resort & Conference Center
3.5 out of 5
670 Verdae Blvd, Greenville, SC
Free CancellationReserve now, pay when you stay
$141
per night
Nov 3 - Nov 4
4.5/5Wonderful! (627 reviews)

"It was a very lovely hotel and the staff was amazing. The buffet was everything"…"

Reviewed on Oct 6, 2019

Embassy Suites Greenville Golf Resort & Conference Center
Comfort Inn Greenville - Haywood Mall
2.5 out of 5
246 Congaree Road, Greenville, SC
Free CancellationReserve now, pay when you stay
$80
per night
Oct 27 - Oct 28
4.1/5Very Good! (1,697 reviews)

"Rooms a little small for the price. Felt safe and close to everything."…"

Reviewed on Oct 1, 2019

Comfort Inn Greenville - Haywood Mall
Drury Inn & Suites - Greenville, SC
3 out of 5
10 Carolina Point Pkwy, Greenville, SC
Free CancellationReserve now, pay when you stay
$90
per night
Nov 3 - Nov 4
4.7/5Exceptional! (1,010 reviews)

"Property was well maintained and staff was pleasant."…"

Reviewed on Oct 17, 2019

Drury Inn & Suites - Greenville, SC
Days Inn by Wyndham Greenville
2 out of 5
60 Roper Mountain Rd, Greenville, SC
Free CancellationReserve now, pay when you stay
$50
per night
Nov 6 - Nov 7
3.3/5 (1,494 reviews)

"Nice beds and free breakfast. But the lady at the front desk was very rude and she was the manager. So her attitude started my stay here on an uneasy note."…"

Reviewed on Sep 23, 2019

Days Inn by Wyndham Greenville
Baymont by Wyndham Anderson Clemson
2.5 out of 5
128 Interstate Blvd, Anderson, SC
$50
per night
Oct 27 - Oct 28
3.7/5Good! (397 reviews)

"It's a pet friendly property but no pet waste bags or receptacles are available."…"

Reviewed on Oct 18, 2019

Baymont by Wyndham Anderson Clemson
Best Western Plus Spartanburg
2.5 out of 5
125 Sloane Garden Rd, Spartanburg, SC
Free CancellationReserve now, pay when you stay
$73
per night
Nov 3 - Nov 4
4.3/5Excellent! (294 reviews)

"Modern decor and exceptional cleanliness. Staff was personable and friendly."…"

Reviewed on Sep 30, 2019

Best Western Plus Spartanburg
Days Inn by Wyndham Clemson
2 out of 5
1387 Tiger Blvd, Clemson, SC
Free CancellationReserve now, pay when you stay
$67
per night
Oct 27 - Oct 28
3.1/5 (524 reviews)

"The bed was comfortable. It was nice and dark for sleeping in."…"

Reviewed on Aug 24, 2019

Days Inn by Wyndham Clemson
Hampton Inn & Suites Greenville-Downtown-RiverPlace
2.5 out of 5
171 Riverplace, Greenville, SC
Free CancellationReserve now, pay when you stay
$153
per night
Oct 27 - Oct 28
4.6/5Exceptional! (645 reviews)

"Friendly staff, early check in, convenient parking, reat location, complimentary breakfast, room very comfortable but bed was not as comfortable as I had hoped for. Everything else was terrific. I would stay at this location again."…"

Reviewed on Oct 13, 2019

Hampton Inn & Suites Greenville-Downtown-RiverPlace
Don't see what you're looking for?
See all available properties in Upstate South Carolina
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Pocket Guide: Luxury Hotels in Upstate South Carolina

Search for hotels in Upstate South Carolina on Expedia. You can easily find your hotels in Upstate South Carolina using one of the methods below:

  • View our selection of featured hotels in Upstate South Carolina
  • Use the map to find hotels in the Upstate South Carolina neighborhood you prefer
  • Use the filters to see hotels in a specific area of Upstate South Carolina, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Upstate South Carolina
  • Enter your travel dates to view the best deals on hotels in Upstate South Carolina - while they last

More trip options

Travelers Loved These Luxury Hotels