Find Luxury Hotels in Upstate South Carolina, SC

Search over 1 million properties and 550 airlines worldwide.

Members save 10% more on select hotels, cars, activities and vacation rentals. Sign up.

Most hotels are fully refundable. Because flexibility matters.

Top Upstate South Carolina Luxury Hotels

The Bleckley Inn
3.5 out of 5
151 E Church St, Anderson, SC
The price is $145 per night from Sep 23 to Sep 23
4.8/5Exceptional! (296 reviews)
"Very nice Hotel - Will stay again if in the area"

Reviewed on Sep 13, 2021

The Bleckley Inn
Hampton Inn & Suites Greenville-Downtown-RiverPlace
2.5 out of 5
171 Riverplace, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $178 per night from Sep 28 to Sep 28
4.6/5Exceptional! (837 reviews)
"Great hotel… the staff was very friendly and our room was awesome. Beds are so comfy cozy. Our front desk clerk, Tammy, was so accommodating and so very nice. I would stay here again in a skinny minute!"

Reviewed on Sep 18, 2021

Hampton Inn & Suites Greenville-Downtown-RiverPlace
Drury Inn & Suites Greenville
3 out of 5
10 Carolina Point Pkwy, Greenville, SC
The price is $99 per night from Oct 3 to Oct 3
4.6/5Exceptional! (969 reviews)
"Liked the hot breakfast and coffeeThought it was a good value Clean and comfortable Staff was very pleasant Location was very good"

Reviewed on Sep 14, 2021

Drury Inn & Suites Greenville
You could be seeing lower prices

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
The Westin Poinsett Greenville
4 out of 5
120 South Main St, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $209 per night from Sep 26 to Sep 26
4.5/5Wonderful! (987 reviews)
"Staff was lovely However, no housekeeping services were available We made our own bed daily and had to rquest towels, shampoo, conditioner and body wash"

Reviewed on Sep 17, 2021

The Westin Poinsett Greenville
Embassy Suites Greenville Golf Resort & Conference Center
3.5 out of 5
670 Verdae Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $121 per night from Oct 10 to Oct 10
4.4/5Wonderful! (824 reviews)
"I Love everything. The staff was amazing!"

Reviewed on Sep 7, 2021

Embassy Suites Greenville Golf Resort & Conference Center
La Quinta Inn & Suites by Wyndham Greenville Haywood
2.5 out of 5
65 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $74 per night from Sep 28 to Sep 28
4.4/5Excellent! (973 reviews)
"Check in was easy; staff was SO friendly!! Beds were very comfortable!"

Reviewed on Sep 19, 2021

La Quinta Inn & Suites by Wyndham Greenville Haywood
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
Fully refundable
The price is $161 per night from Oct 3 to Oct 3
4.3/5Excellent! (982 reviews)
"Great staff! Great location!"

Reviewed on Sep 11, 2021

Hyatt Regency Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
3.5 out of 5
851 Congaree Rd, Greenville, SC
Fully refundable
The price is $101 per night from Oct 3 to Oct 3
4.2/5Excellent! (693 reviews)
"Clean property and friendly staff"

Reviewed on Aug 23, 2021

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
Best Western Plus Spartanburg
2.5 out of 5
125 Sloane Garden Rd, Spartanburg, SC
Fully refundableReserve now, pay when you stay
The price is $85 per night from Sep 27 to Sep 27
4.2/5Excellent! (536 reviews)
"I love this hotel , when i go to south carolina this is my hotel, never change"

Reviewed on Sep 14, 2021

Best Western Plus Spartanburg
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $128 per night from Oct 3 to Oct 3
4.1/5Very Good! (976 reviews)
"The whole experience was great"

Reviewed on Sep 8, 2021

Hilton Greenville
Best Western Travelers Rest Greenville
2.5 out of 5
110 Hawkins Rd, Travelers Rest, SC
Fully refundableReserve now, pay when you stay
The price is $72 per night from Sep 27 to Sep 27
4/5Very Good! (628 reviews)
"Stay was great"

Reviewed on Sep 11, 2021

Best Western Travelers Rest Greenville
Comfort Inn Greenville - Haywood Mall
2.5 out of 5
246 Congaree Road, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $71 per night from Sep 28 to Sep 28
4/5Very Good! (980 reviews)
"Nice, friendly, family hotel."

Reviewed on Aug 8, 2021

Comfort Inn Greenville - Haywood Mall
Sleep Inn at Greenville Convention Cente
2.5 out of 5
231 N Pleasantburg Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $69 per night from Oct 3 to Oct 3
3.9/5Good! (608 reviews)
"TV didn’t work, and in the breakfast bag, the Applesauce had a curly black hair in it. Wasn’t my hair, all of mine is gray."

Reviewed on Sep 19, 2021

Sleep Inn at Greenville Convention Cente
Best Western Greenville Airport Inn
2.5 out of 5
5009 Pelham Road, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $78 per night from Sep 26 to Sep 26
3.8/5Good! (972 reviews)
"I didn’t like the room location outside entrance"

Reviewed on Sep 6, 2021

Best Western Greenville Airport Inn
Baymont by Wyndham Anderson Clemson
2.5 out of 5
128 Interstate Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
The price is $59 per night from Oct 3 to Oct 3
3.7/5Good! (532 reviews)
"Great affordable option!"

Reviewed on Aug 14, 2021

Baymont by Wyndham Anderson Clemson
Quality Inn Clemson near University
2.5 out of 5
3430 Clemson Blvd, Anderson, SC
The price is $63 per night from Oct 3 to Oct 3
3.6/5Good! (653 reviews)
"Lobby was very nice and customer service was great at check-in. The rooms cleanliness was not good. Carpeting was torn, fridge was dirty and the bathroom was terrible. No water pressure in shower and there were all kinds of hair in tub and around sink area. Caulking around tub had mold. Would not ..."

Reviewed on Jul 10, 2021

Quality Inn Clemson near University
Baymont by Wyndham Greenville Woodruff Rd
2.5 out of 5
31 Old Country Rd, Greenville, SC
Fully refundable
The price is $50 per night from Oct 22 to Oct 22
3.6/5Good! (974 reviews)
"Nice"

Reviewed on Sep 17, 2021

Baymont by Wyndham Greenville Woodruff Rd
Red Roof Inn Spartanburg
2 out of 5
6765 Pottery Rd, Spartanburg, SC
Fully refundableReserve now, pay when you stay
The price is $69 per night from Sep 22 to Sep 22
3.5/5Good! (568 reviews)
"Basic room nothing fancy. Iron didn't work but front desk brought one up as soon as I called."

Reviewed on Jul 31, 2021

Red Roof Inn Spartanburg
Days Inn by Wyndham Greenville
2 out of 5
60 Roper Mountain Rd, Greenville, SC
Fully refundableReserve now, pay when you stay
The price is $75 per night from Sep 22 to Sep 22
3.2/5 (987 reviews)
"Property is in great condition. Easy access to rooms all around."

Reviewed on Aug 9, 2021

Days Inn by Wyndham Greenville
Days Inn by Wyndham Clemson
2 out of 5
1387 Tiger Blvd, Clemson, SC
The price is $79 per night from Sep 22 to Sep 22
3/5 (607 reviews)
"Close to everything in Clemson"

Reviewed on Jul 27, 2021

Days Inn by Wyndham Clemson
Don't see what you're looking for?
We've got more Luxury Hotels. Find the right one for you.
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top 4 Star Hotels in Upstate South Carolina

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More trip options

Recent reviews of Upstate South Carolina hotels