No Smoking Policy in Upstate South Carolina

Browse for Upstate South Carolina Non-Smoking Hotels from $59

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Featured Upstate South Carolina Non-Smoking Hotels

Historic Charmer 3 Blocks From Main St!!!
5/5Exceptional! (27 reviews)

"It was spacious, clean and an excellent place to stay! Five stars!!!"…"

Reviewed on Sep 8, 2019

Historic Charmer 3 Blocks From Main St!!!
4 Bedroom Ranch With Deep-water Dock, Kayaks, Game Tables, Close to Hwy 85
4.7/5Exceptional! (34 reviews)
Girls week

"Loved home. We had a great time We were 5 older women for a girls getaway"…"

Reviewed on Sep 17, 2019

4 Bedroom Ranch With Deep-water Dock, Kayaks, Game Tables, Close to Hwy 85
7mi to Clemson New Custom Luxury Lakehome 4BR 4BA Shuffleboard + Fire Pit
4.9/5Exceptional! (19 reviews)
Everything Fantastic

"Everything was great for our Labor Day weekend. Very nice home inside and out and a perfect setup for multiple families. So close to everything in Seneca and Clemson. We would definitely rent again."…"

Reviewed on Sep 2, 2019

7mi to Clemson New Custom Luxury Lakehome 4BR 4BA Shuffleboard + Fire Pit
AC Hotel by Marriott Spartanburg
3.5 out of 5
225 West Main Street, Spartanburg, SC
Free CancellationReserve now, pay when you stay
$116
per night
Nov 24 - Nov 25
4.7/5Exceptional! (122 reviews)

"My stay was amazing!!! Staff were all professional & it smelled wonderful."…"

Reviewed on Oct 26, 2019

AC Hotel by Marriott Spartanburg
Aloft Greenville Downtown
3 out of 5
5 North Laurens Street, Greenville, SC
Free CancellationReserve now, pay when you stay
$114
per night
Nov 24 - Nov 25
4.5/5Wonderful! (439 reviews)

"Elevators , Are slow and hard to understand where you are on the property"…"

Reviewed on Nov 7, 2019

Aloft Greenville Downtown
Americas Best Value Inn Anderson, SC
2 out of 5
4020 Clemson Blvd, Anderson, SC
Free CancellationReserve now, pay when you stay
$66
per night
Nov 14 - Nov 15
2.4/5 (70 reviews)

"Convenient to Clemson Property was good asked on price point. We weren’t looking for luxury as we weren’t spending time at the property."…"

Reviewed on Sep 23, 2019

Americas Best Value Inn Anderson, SC
Best Western Executive Inn
2.5 out of 5
511 Bypass Highway 123, Seneca, SC
Free CancellationReserve now, pay when you stay
$89
per night
Nov 28 - Nov 29
4.2/5Very Good! (335 reviews)

"Friendly staff was a positive. Did not get a paper copy of receipt was not a positive"…"

Reviewed on Nov 4, 2019

Best Western Executive Inn
Best Western Plus Greenville South
2.5 out of 5
70 Kalyns Way, Piedmont, SC
Free CancellationReserve now, pay when you stay
$83
per night
Nov 24 - Nov 25
4.1/5Very Good! (298 reviews)

"Elevator always had a "funky" smell to it. Other than that, everything was great!"…"

Reviewed on Nov 1, 2019

Best Western Plus Greenville South
Best Western Travelers Rest Greenville
2.5 out of 5
110 Hawkins Rd, Travelers Rest, SC
Free CancellationReserve now, pay when you stay
$76
per night
Nov 20 - Nov 21
4.2/5Very Good! (416 reviews)

"Jhhhhhsjjjhjswookdjdjeieisjdhehjejheudeuhehedhehhwjhdheejdh"…"

Reviewed on Nov 10, 2019

Best Western Travelers Rest Greenville
Candlewood Suites Greenville
2.5 out of 5
25 Green Heron Road, Greenville, SC
Free Cancellation
$79
per night
Nov 24 - Nov 25
4.6/5Wonderful! (126 reviews)

"Good access to Woodruff Rd. Good price and no frills."…"

Reviewed on Oct 27, 2019

Candlewood Suites Greenville
Charming Secluded, Lakefront Home on Lake Hartwell
4.8/5Exceptional! (57 reviews)
Will Definitely Return

"This is our second stay at this property. The owners are very nice and welcoming. The house is perfect and the lake is just so relaxing. Close enough to Clemson but far enough away to be able to unwind too. We will definitely return. Extra bonus are the cats. They stay away if you don't approach ..."…"

Reviewed on Sep 23, 2019

Charming Secluded, Lakefront Home on Lake Hartwell
Clemson University's James F. Martin Inn
3 out of 5
240 Madren Center Drive, Clemson, SC
Free CancellationReserve now, pay when you stay
$129
per night
Nov 24 - Nov 25
4.6/5Exceptional! (205 reviews)

"The Martin Inn is perfectly situated on the Clemson Campus ten minutes from the stadium. It overlooks Lake Hartwell and the Walker Course. Beautiful from sunrise to sunset! Special Clemson touches everywhere including their signature citrus toiletries."…"

Reviewed on Sep 21, 2019

Clemson University's James F. Martin Inn
Comfort Inn & Suites at I-85
2 out of 5
154 Candlenut Ln, Spartanburg, SC
Free CancellationReserve now, pay when you stay
$76
per night
Nov 27 - Nov 28
3.9/5Very Good! (320 reviews)

"We have stayed here twice now and Tara has checked us in both times. She is amazing. Helpful, sweet, friendly, and professional to everyone!! Love this place."…"

Reviewed on Oct 20, 2019

Comfort Inn & Suites at I-85
Comfort Inn Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
Free CancellationReserve now, pay when you stay
$80
per night
Nov 20 - Nov 21
3.9/5Very Good! (431 reviews)

"Very good value! Property is convenient, clean, and well-maintained. Staff is nice too."…"

Reviewed on Nov 7, 2019

Comfort Inn Clemson - University Area
Comfort Suites
2.5 out of 5
12865 Hwy 56 N, Clinton, SC
Free CancellationReserve now, pay when you stay
$89
per night
Nov 14 - Nov 15
4.2/5Excellent! (247 reviews)

"The water in the shower took an extremely long time to get hot. Then, in the middle of the shower it cooled down for a few minutes before it got warm again. It was around 5pm so I doubt a lot of other rooms were using their showers at that time."…"

Reviewed on Oct 31, 2019

Comfort Suites
Comfort Suites
2.5 out of 5
458 West Blackstock Road, Spartanburg, SC
Free CancellationReserve now, pay when you stay
$80
per night
Nov 24 - Nov 25
4.4/5Excellent! (427 reviews)

"Cleanliness, no ghettoness, classy, great customer service,"…"

Reviewed on Sep 30, 2019

Comfort Suites
Comfort Suites Anderson
2.5 out of 5
118 Interstate Blvd, Anderson, SC
Free CancellationReserve now, pay when you stay
$59
per night
Dec 8 - Dec 9
4.2/5Excellent! (527 reviews)

"Some of staff could be a little more friendly. Rooms need maintenance... clog drains."…"

Reviewed on Nov 4, 2019

Comfort Suites Anderson
Comfort Suites Greenville South
2.5 out of 5
10 Kalyns Way, Piedmont, SC
Free CancellationReserve now, pay when you stay
$94
per night
Nov 29 - Nov 30
4.5/5Wonderful! (264 reviews)

"Very clean and quiet. Excellent. helpful and vary friendly staff."…"

Reviewed on Nov 2, 2019

Comfort Suites Greenville South
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Pocket Guide: Non-Smoking Hotels in Upstate South Carolina

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