Unfortunately a really disappointing end to a great holiday purely due to the hotel.
Firstly, we were put in a room about 50m down the road from the main hotel in a room that looked nothing like the pictures on hotels.com. We were told we could check in at 12pm. On arrival at 1pm we checked into our room to find it not having been cleaned from the previous guests. Not a good start.
The worst part is the annex we were put in effectively didn't have a space between the roof of our room and the floor of the room above which was made of wood. It is impossible to demonstrate how loud and creaky this was when walked on from above. Furthermore, the inhabitants of this room was a private flat, who proceeded to have a great party on our last night meaning we got no sleep after 1am. With the hotel not having a 24hr reception there was nothing we could do. We knocked on the door if the flat but were ignored. When we mentioned this to reception in the morning it was greeted with a chuckle and a 'what-do-you-expect-me-to-do-about-it' attitude.
Lastly, when trying to pay the city tax, they demanded cash payment. Since we weren't notified of this at check in and was our last day in italy we had no cash. In another example of extreme unhelpfulness, we were forced to run around the island looking for a cash machine, meaning we missed our boat to the airport.
Murano is a wonderful island, but I would urge you to book at another hotel.