Title: The Best 4 Star Hotels in Santee, SC  | Expedia.com

[Santee Travel Guide](https://expedia.com/Santee.dx9953)[Hotels in Santee](https://expedia.com/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.com/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.com/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Car Rentals in Santee](https://expedia.com/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.com/Santee.d9953.Destination-Travel-Guides)

![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Santee 4 Star Hotels

Tonight

[Feb 23 - Feb 24](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-02-23&endDate=2026-02-24&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 24 - Feb 25](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-02-24&endDate=2026-02-25&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-02-27&endDate=2026-03-01&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=9953&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santee 4-star hotels

![Exterior](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, DVD player](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/d97d64ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/cf50a6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Balcony](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/17d2f4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wyndham Vacation Resorts Lake Marion

[](https://www.expedia.com/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information)

Santee

9.4/10

Exceptional

(24 reviews)

"Excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

[](https://www.expedia.com/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information)

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## Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

[See all hotels in Santee](https://www.expedia.com/Hotel-Search?startDate=2026-03-10&endDate=2026-03-11&adults=2&regionId=9953)

![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=899&h=634&p=1&q=high)

## Top Santee Hotel Reviews

![Wyndham Vacation Resorts Lake Marion](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8_y.jpg)

### Wyndham Vacation Resorts Lake Marion

10/10 Excellent

"The room was spacious and very clean. The front desk person was friendly and they did try to sell my fiance some things, but he wasn't interested. Once we kindly said no they understood and wasn't being pushy which we greatly appreciated. My family and I will stay here each time. My fiance and I dropped my niece off to college which is about 30 min away. She was able to have her own room and bathroom in addition to us. It was very safe and comfortable around the resort."

[](https://expedia.com/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information)

## Find out more about Santee

## Santee Four Star Hotel Information

When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Santee, South Carolina are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Santee 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.

Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Santee. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Santee, South Carolina, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.

Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Santee hotels offer everything your heart desires.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Santee?

> - Search for the lowest price

### What's the difference between 5-star and 4-star hotels in Santee?

### Does Santee have any 4-star all-inclusive resorts?

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