Top 10 Hotels in Advance, MO (from $64) 2026 - Competitive Prices

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Our top choices for Advance hotels

A living room with a blue wall, a fireplace, a sofa, and a chair.

A bar area with stools and a counter where a bartender is serving drinks.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

1. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

$86 nightly

$93 total

Sep 6 - Sep 7

Total with taxes and fees

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

$98 nightly

$111 total

Sep 7 - Sep 8

Total with taxes and fees

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

3. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Raidas

$71 nightly

$80 total

Sep 7 - Sep 8

Total with taxes and fees

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

An outdoor patio with tables and chairs, a stone wall, and large windows.

4. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Shawn

$91 nightly

$99 total

Sep 2 - Sep 3

Total with taxes and fees

A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

A hotel lobby with a reception desk, a waiting area with a sofa and armchairs, and a patterned carpet.

A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.

A hotel room with two beds, a desk with a lamp, a chair, a dresser, and a door with a handle.

5. Dexter Inn

Dexter

Edward

$57 nightly

$64 total

Sep 2 - Sep 3

Total with taxes and fees

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

6. Drury Inn & Suites Jackson MO

Jackson

Jamie

$85 nightly

$90 total

Sep 22 - Sep 23

Total with taxes and fees

A modern hotel lobby with a bar area, seating, and artwork on the walls.

A modern hotel with a prominent sign, a covered entrance, and a well-lit exterior.

A swimming pool with clear blue water, surrounded by sun loungers and a lifeguard stand.

A reception desk with a wooden panel design, a white vase with flowers, and a 'Hilton HONOR' sign.

7. Hampton Inn By Hilton Dexter

Dexter

Joyce

$98 nightly

$110 total

Sep 7 - Sep 8

Total with taxes and fees

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

8. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Chevonne

$101 nightly

$114 total

Sep 3 - Sep 4

Total with taxes and fees

A hotel room with two beds, a TV, a mirror, a wardrobe, and a desk.

A bathroom with a bathtub, toilet, and a shower curtain.

A window with a view of a parking lot and buildings, a welcome sign, and a credit card machine.

A Hickory House Inn with a clear sky, a parking lot, and a covered entrance.

9. OYO Hickory House Inn

Dexter

Tammy

$59 nightly

$66 total

Sep 2 - Sep 3

Total with taxes and fees

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A multi-story hotel with a mix of brick and red facade, featuring a Holiday Inn Express sign.

Two patterned armchairs, a small round table with a lamp, and a staircase with decorative railings.

10. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

$99 nightly

$112 total

Sep 27 - Sep 28

Total with taxes and fees

A modern retail area with a display of local items and snacks.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

11. Tru By Hilton Cape Girardeau

Cape Girardeau

$89 nightly

$102 total

Sep 6 - Sep 7

Total with taxes and fees

A diner with booth seating, a checkered floor, and a counter with a cash register.

A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

A lobby with a round rug, two potted plants, three framed artworks, and two black leather chairs.

A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.

12. Travelodge by Wyndham Dexter

Dexter

Steven

$92 nightly

$103 total

Sep 10 - Sep 11

Total with taxes and fees

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

An outdoor patio with stone walls, wicker furniture, and large windows.

13. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

$106 nightly

$119 total

Sep 6 - Sep 7

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

A hotel reception area with a reception desk, framed certificates, and a painting on the wall.

A hotel with a brick facade, multiple windows, and a covered entrance area.

A living room with a sofa, a coffee table, a clock, and a painting on the wall.

14. Econo Lodge Dexter

Dexter

Herman

$49 nightly

$55 total

Sep 28 - Sep 29

Total with taxes and fees

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.

15. Town House Inn

Jackson

Taylor

$78 nightly

$84 total

Aug 31 - Sep 1

Total with taxes and fees

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

16. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Cheryl

$90 nightly

$102 total

Sep 6 - Sep 7

Total with taxes and fees

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.

17. Quality Inn Cape Girardeau North

Cape Girardeau

Stephen

$62 nightly

$70 total

Sep 6 - Sep 7

Total with taxes and fees

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

18. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

$101 nightly

$114 total

Sep 13 - Sep 14

Total with taxes and fees

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

19. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

$80 nightly

$86 total

Sep 22 - Sep 23

Total with taxes and fees

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A hotel room with a large bed, a nightstand with a lamp, a chair, and a desk with a lamp.

20. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

$99 nightly

$112 total

Sep 27 - Sep 28

Total with taxes and fees

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Top Advance Hotel Reviews

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"It was wonderful very clean and very nice staff."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Perfect place and location for our girls trip. The staff was excellent!"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Room and Public areas were all immaculate. Check-in was easy and quick."

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Wonderful stay. Clean, quiet, friendly staff. Will choose Candlewood again."

Tru By Hilton Cape Girardeau

8/10 Good

"Staff was friendly and welcoming."

Hampton Inn Sikeston

10/10 Excellent

"👍"

Hampton Inn By Hilton Dexter

10/10 Excellent

"Best Hampton Inn that I have ever stayed in. Excellent service and Wonderful staff. Extremely helpful with disabled husband."

Hampton Inn Cape Girardeau I 55 East

10/10 Excellent

"Good Job!"

Charming 3-bedroom house in delightful Advance with AC, WiFi

10/10 Excellent

"Our host was an excellent communicator who took great care of us. The place was immaculate and well cared for. We came back after having been here earlier in the year. 10/10 would recommend!"