Top 10 Hotels in Advance, MO (from $65) 2026 - Competitive Prices

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Our top choices for Advance hotels

A living room with a blue wall, a fireplace, a sofa, and a chair.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A brick building with a sign reading "Mercantile & Hotel".

1. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

$86 nightly

$93 total

Sep 6 - Sep 7

Total with taxes and fees

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

$100 nightly

$113 total

Sep 6 - Sep 7

Total with taxes and fees

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

3. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Raidas

$72 nightly

$81 total

Sep 6 - Sep 7

Total with taxes and fees

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

4. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Shawn

$91 nightly

$99 total

Sep 7 - Sep 8

Total with taxes and fees

A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

A hotel room with two beds, a desk with a lamp, a chair, a dresser, and a door with a handle.

A hotel lobby with a reception desk, a waiting area with a sofa and armchairs, and a patterned carpet.

A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.

5. Dexter Inn

Dexter

Edward

$58 nightly

$65 total

Aug 31 - Sep 1

Total with taxes and fees

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

6. Drury Inn & Suites Jackson MO

Jackson

Jamie

$83 nightly

$88 total

Sep 21 - Sep 22

Total with taxes and fees

A modern hotel lobby with a bar area, seating, and artwork on the walls.

A swimming pool with clear blue water, surrounded by sun loungers and a lifeguard stand.

A reception desk with a wooden panel design, a white vase with flowers, and a 'Hilton HONOR' sign.

A modern kitchen with a large island, bar stools, wine bottles, and a built-in TV.

7. Hampton Inn By Hilton Dexter

Dexter

Joyce

$98 nightly

$110 total

Sep 7 - Sep 8

Total with taxes and fees

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

8. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Chevonne

$101 nightly

$114 total

Sep 6 - Sep 7

Total with taxes and fees

A hotel room with two beds, a TV, a mirror, a wardrobe, and a desk.

A row of single-story brick buildings with attached garages, likely a motel or small hotel, with a parking lot in front and a grassy area with a gazebo.

A bathroom with a bathtub, toilet, and a shower curtain.

A Hickory House Inn with a clear sky, a parking lot, and a covered entrance.

9. OYO Hickory House Inn

Dexter

Tammy

$61 nightly

$67 total

Aug 31 - Sep 1

Total with taxes and fees

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.

A multi-story hotel with a mix of brick and red facade, featuring a Holiday Inn Express sign.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

10. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

ELAINE

$105 nightly

$118 total

Sep 3 - Sep 4

Total with taxes and fees

A modern retail area with a display of local items and snacks.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

11. Tru By Hilton Cape Girardeau

Cape Girardeau

Darlene

$89 nightly

$102 total

Sep 6 - Sep 7

Total with taxes and fees

A diner with booth seating, a checkered floor, and a counter with a cash register.

A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.

A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

A lobby with a round rug, two potted plants, three framed artworks, and two black leather chairs.

12. Travelodge by Wyndham Dexter

Dexter

Steven

$92 nightly

$103 total

Sep 10 - Sep 11

Total with taxes and fees

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

13. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

$106 nightly

$119 total

Sep 6 - Sep 7

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

A living room with a sofa, a coffee table, a clock, and a painting on the wall.

A hotel with a brick facade, multiple windows, and a covered entrance area.

A kitchen with wooden cabinets, a stainless steel sink, a microwave, and a dishwasher.

14. Econo Lodge Dexter

Dexter

Herman

$49 nightly

$55 total

Sep 30 - Oct 1

Total with taxes and fees

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.

A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

15. Town House Inn

Jackson

Taylor

$78 nightly

$84 total

Aug 31 - Sep 1

Total with taxes and fees

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

16. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Cheryl

$90 nightly

$102 total

Sep 6 - Sep 7

Total with taxes and fees

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.

A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

17. Quality Inn Cape Girardeau North

Cape Girardeau

Stephen

$62 nightly

$70 total

Sep 7 - Sep 8

Total with taxes and fees

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

18. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

$101 nightly

$114 total

Sep 13 - Sep 14

Total with taxes and fees

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.

19. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

$80 nightly

$87 total

Sep 28 - Sep 29

Total with taxes and fees

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

20. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

$105 nightly

$119 total

Sep 20 - Sep 21

Total with taxes and fees

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Top Advance Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"I've never stayed at a Drury Hotel before. This was my first experience, and I have to say it was a wonderful one. I would highly recommend this hotel to travelers!"

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"It was wonderful very clean and very nice staff."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Perfect place and location for our girls trip. The staff was excellent!"

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Room and Public areas were all immaculate. Check-in was easy and quick."

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Wonderful stay. Clean, quiet, friendly staff. Will choose Candlewood again."

Tru By Hilton Cape Girardeau

8/10 Good

"Staff was friendly and welcoming."

Hampton Inn Sikeston

10/10 Excellent

"👍"

Hampton Inn By Hilton Dexter

10/10 Excellent

"Best Hampton Inn that I have ever stayed in. Excellent service and Wonderful staff. Extremely helpful with disabled husband."

Charming 3-bedroom house in delightful Advance with AC, WiFi

10/10 Excellent

"Our host was an excellent communicator who took great care of us. The place was immaculate and well cared for. We came back after having been here earlier in the year. 10/10 would recommend!"