Top 10 Hotels in Advance, MO (from $58) 2026 - Competitive Prices

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Our top choices for Advance hotels

A living room with a blue wall, a fireplace, a sofa, and a chair.

A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

A bar area with stools and a counter where a bartender is serving drinks.

A brick building with a sign reading "Mercantile & Hotel".

1. EC Reed's Mercantile and Hotel

Marble Hill

JANEEN

$117 nightly

$127 total

Oct 7 - Oct 8

Total with taxes and fees

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

A hotel room with two beds, a brick wall, and a wooden headboard.

2. Drury Inn & Suites Jackson MO

Jackson

Thomas

$80 nightly

$85 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

3. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

$72 nightly

$81 total

Oct 11 - Oct 12

Total with taxes and fees

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

$100 nightly

$113 total

Oct 11 - Oct 12

Total with taxes and fees

A modern retail area with a display of local items and snacks.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

5. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

$89 nightly

$102 total

Oct 12 - Oct 13

Total with taxes and fees

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

6. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

$101 nightly

$115 total

Oct 15 - Oct 16

Total with taxes and fees

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

7. Hampton Inn Sikeston

Sikeston

Carolyn

$105 nightly

$120 total

Oct 18 - Oct 19

Total with taxes and fees

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.

A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

8. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

Rebecca

$101 nightly

$115 total

Oct 11 - Oct 12

Total with taxes and fees

A wheelchair-accessible shower stall with a grab bar, a bench, and a hand-held showerhead.

A hotel room with two beds, a nightstand, a lamp, and a chair.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

$81 nightly

$87 total

Nov 1 - Nov 2

Total with taxes and fees

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

10. The Riverview

Cape Girardeau

Alyssa

$100 nightly

$113 total

Oct 14 - Oct 15

Total with taxes and fees

A modern hotel lobby with a bar area, seating, and artwork on the walls.

A modern hotel with a prominent sign, a covered entrance, and a well-lit exterior.

A modern kitchen with a large island, bar stools, wine bottles, and a built-in TV.

A reception desk with a wooden panel design, a white vase with flowers, and a 'Hilton HONOR' sign.

11. Hampton Inn By Hilton Dexter

Dexter

Kendall

$98 nightly

$111 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

12. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

$90 nightly

$102 total

Oct 11 - Oct 12

Total with taxes and fees

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

13. TownePlace Suites by Marriott Sikeston

Sikeston

Stacy

$105 nightly

$119 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

A hotel patio with a gazebo, outdoor seating, and a view of the road.

A hotel room with a bed, a TV, a desk, and a chair.

14. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

Samuel

$85 nightly

$101 total

Oct 11 - Oct 12

Total with taxes and fees

A coffee shop with a coffee machine, espresso cups, a sink, and a trash bin.

A hotel room with two beds, a desk with a lamp, a chair, a dresser, and a door with a handle.

A hotel lobby with a reception desk, a waiting area with a sofa and armchairs, and a patterned carpet.

A kitchen with a white microwave, a fruit basket, a coffee maker, and a storage container.

15. Dexter Inn

Dexter

Edward

$69 nightly

$78 total

Oct 7 - Oct 8

Total with taxes and fees

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

16. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

$101 nightly

$114 total

Oct 15 - Oct 16

Total with taxes and fees

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.

A gym with exercise equipment, a treadmill, and a wall-mounted TV.

17. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

Rebekah

$106 nightly

$119 total

Oct 18 - Oct 19

Total with taxes and fees

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

A buffet with various food items, including omelets and baked goods, served in metal containers.

18. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

$101 nightly

$115 total

Oct 18 - Oct 19

Total with taxes and fees

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

19. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

$76 nightly

$82 total

Oct 29 - Oct 30

Total with taxes and fees

A hotel room with a bed, a desk, a chair, a bathroom with a bathtub, and a patterned floor.

A hotel with a brick facade, multiple windows, and a covered entrance area.

A hotel reception area with a reception desk, framed certificates, and a painting on the wall.

A kitchen with wooden cabinets, a stainless steel sink, a microwave, and a dishwasher.

20. Econo Lodge Dexter

Dexter

Herman

$51 nightly

$58 total

Nov 5 - Nov 6

Total with taxes and fees

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Top Advance Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Nice property"

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Wonderful. Very clean, spacious and lovely staff. Breakfast was delicious also."

Drury Inn & Suites Jackson MO

10/10 Excellent

"We were only there for one night, but we SO grateful for a clean, safe and lovely stay! Would recommend it highly!"

Hampton Inn Sikeston

10/10 Excellent

"Clean, safe, quiet and a very good breakfast."

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Candlewood Suites Cape Girardeau by IHG

8/10 Good

"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."

Hampton Inn Cape Girardeau I 55 East

8/10 Good

"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Very nice! Bed was comfortable and room had a very large bathroom and shower. Towels were thick and fluffy. Enjoyed having a bar downstairs with a fun friendly staff. Will stay there again when I’m coming through."

Charming 3-bedroom house in delightful Advance with AC, WiFi

10/10 Excellent

"The house was so charming! It was immaculate! It had all the amenities needed. Lots of parking area and great neighborhood. Communication with our wonderful host was so prompt! We hope to stay there again!!"

More cheap stays in Advance

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

$72 nightly

$81 total

Oct 11 - Oct 12

Total with taxes and fees

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

$85 nightly

$101 total

Oct 11 - Oct 12

Total with taxes and fees

8/10 Very Good! (1,001 reviews)

Tru By Hilton Cape Girardeau

2520 Veterans Memorial Dr Cape Girardeau MO

$89 nightly

$102 total

Oct 12 - Oct 13

Total with taxes and fees

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

$101 nightly

$115 total

Oct 18 - Oct 19

Total with taxes and fees

8.8/10 Excellent! (515 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

$101 nightly

$115 total

Oct 11 - Oct 12

Total with taxes and fees

9.4/10 Exceptional! (1,005 reviews)

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

$105 nightly

$120 total

Oct 18 - Oct 19

Total with taxes and fees

9/10 Wonderful! (629 reviews)

Hotels in Advance with star-rating

Frequently asked questions

What is the best area to stay in Advance?

Given the size and nature of Advance, Missouri, the best area to stay is generally within the town limits, focusing on accommodations that offer convenient access to local amenities and the main thoroughfares.Advance is a small, rural town, and visitors typically prioritize convenience and practicality. Staying near Highway 25 or Highway 91 puts you close to the few local businesses, including gas stations and small eateries. This central area allows for easy navigation whether you're visiting for local events, family, or as a stopover.Travelers looking for a quiet, straightforward stay will find the general area of Advance suitable. Accommodations here are usually no-frills, providing a comfortable place to rest.

When is the best time to go to Advance?

The best times to visit Advance, Missouri, are during the spring (April to May) and fall (September to October) when the weather is most pleasant.During these months, you'll experience mild temperatures, making it comfortable for outdoor activities like exploring local parks or attending community events. Spring brings blooming dogwoods and redbuds, while fall offers scenic foliage as the leaves change color.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Advance.

How much is the nightly rate at a Advance hotel?

Prices for hotels in Advance often vary, but you can find a great deal from $58 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Find hotels in Advance, MO from $58

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Advance

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Advance hotels

1. EC Reed's Mercantile and Hotel

2. Drury Inn & Suites Jackson MO

3. Pear Tree Inn Cape Girardeau West

4. Drury Plaza Hotel Cape Girardeau Conference Center

5. Tru By Hilton Cape Girardeau

6. Fairfield Inn & Suites by Marriott Sikeston

7. Hampton Inn Sikeston

8. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10. The Riverview

11. Hampton Inn By Hilton Dexter

12. Drury Inn & Suites Cape Girardeau

13. TownePlace Suites by Marriott Sikeston

14. Candlewood Suites Cape Girardeau by IHG

15. Dexter Inn

16. Fairfield Inn & Suites by Marriott Cape Girardeau

17. Hampton Inn Cape Girardeau I 55 East

18. Holiday Inn Express & Suites Sikeston Southwest by IHG

19. Comfort Suites Jackson-Cape Girardeau

20. Econo Lodge Dexter

Top Advance Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Jackson MO

Hampton Inn Sikeston

Drury Inn & Suites Cape Girardeau

Candlewood Suites Cape Girardeau by IHG

Hampton Inn Cape Girardeau I 55 East

Courtyard by Marriott Cape Girardeau Downtown

Charming 3-bedroom house in delightful Advance with AC, WiFi

More cheap stays in Advance

Pear Tree Inn Cape Girardeau West

Candlewood Suites Cape Girardeau by IHG

Tru By Hilton Cape Girardeau

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Sikeston

Hotels in Advance with star-rating

Frequently asked questions

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