$28 Cheap Flights to De Soto, MO

View $28 flight on Wed, May 20, 2026Opens in a new window

Popular airlines to De Soto

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How much is the cheapest flight to De Soto?

Prices were available within the past 7 days and start at $28 for one-way flights and $56 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, May 13 - Wed, May 20
ATL
Atlanta
STL
St. Louis
$56 Roundtrip, found 3 hours ago
$56
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Wed, May 13 from Atlanta to St. Louis, returning Wed, May 20, priced at $56 found 3 hours ago
Delta
Tue, May 12 - Tue, Jun 2
ATL
Atlanta
STL
St. Louis
$177 Roundtrip, found 4 hours ago
$177
Roundtrip
found 4 hours ago
Select Delta flight, departing Tue, May 12 from Atlanta to St. Louis, returning Tue, Jun 2, priced at $177 found 4 hours ago
Southwest Airlines
Tue, May 12 - Tue, Jun 2
ATL
Atlanta
STL
St. Louis
$177 Roundtrip, found 4 hours ago
$177
Roundtrip
found 4 hours ago
Select Southwest Airlines flight, departing Tue, May 12 from Atlanta to St. Louis, returning Tue, Jun 2, priced at $177 found 4 hours ago
American Airlines
Tue, May 12 - Tue, Jun 2
ATL
Atlanta
STL
St. Louis
$197 Roundtrip, found 4 hours ago
$197
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, May 12 from Atlanta to St. Louis, returning Tue, Jun 2, priced at $197 found 4 hours ago
United
Tue, May 12 - Tue, Jun 2
ATL
Atlanta
STL
St. Louis
$197 Roundtrip, found 4 hours ago
$197
Roundtrip
found 4 hours ago
Select United flight, departing Tue, May 12 from Atlanta to St. Louis, returning Tue, Jun 2, priced at $197 found 4 hours ago

Frequently asked questions

What month is the cheapest to fly to De Soto?
May is the cheapest month to travel to De Soto. Demand is lower then, so you're likely to score a great deal. Organizing your trip outside of school and public holidays can also help you save.
Which US cities have the cheapest flights to De Soto?
Land cheap flights to De Soto from Chicago, Dallas and Denver. These cities usually offer the lowest fares to this popular destination. But remember that holiday periods, demand and stopovers also influence rates, so remain flexible and book when you see a bargain.
Which US cities fly direct to De Soto?
There are 55 US cities you're able to fly to De Soto directly from. Explore the options by selecting the "Direct flights only" filter on Expedia and pick the best departure point for you. Here are a handful of the leading cities to take off from:

  • Chicago
  • Dallas
  • Denver
  • New York
  • Atlanta

How to find a cheap flight to De Soto?
Book early or search for cheap flights to De Soto during off-peak months like October and December. Jetting off on a Thursday could also save you 16% on average compared to a Sunday departure.* The Expedia app makes it even easier to know the right time to book. Just activate the toggle for "Watch prices" and get notified as soon as there's a better deal.*Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.
How to get a cheap last-minute flight to De Soto?
Although booking in advance is typically the best way to save cash, don't panic if your De Soto getaway is last minute. You can still find cheap flights to De Soto, especially if your plans have some flexibility. Try switching up your travel dates, exploring different ticket options or flying out of another airport.
How far in advance should I book a flight to De Soto?
Book your flight to De Soto two to four months ahead if you're taking off from an international destination. For domestic travel, the usual timeframe is 28 days in advance. Cheaper tickets and a wider variety of travel dates, schedules and seating options are some of the great reasons to book early.**Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.
Which day of the week is the cheapest day to buy a plane ticket to De Soto?
Sundays are typically the best day to book a cheap flight to De Soto, with savings of about 8% on average compared to a Friday. If you choose to purchase on a Friday, be ready to pay a higher price as this is typically the most expensive day.**Best day of the week to book, depart and ideal booking window recommendations based on average round-trip ticket prices for January through August 2023, sourced from Airline Reporting Corporation's (ARC) global airline sales database. Percentages noted are averages.
Which airlines fly to De Soto?
There are 10 airlines that connect De Soto with 33 airports across the world. The major entry point to this city is Lambert-St. Louis Intl. Airport (STL). Travel with any of these top airlines to De Soto:

  • Delta Air Lines
  • American Airlines
  • United Airlines
  • Southern Airways Express

Where do you fly into De Soto?
If you're flying to De Soto, the main hub to disembark at is Lambert-St. Louis Intl. Airport (STL). You could also fly to De Soto via Spirit of St. Louis Airport (SUS).
How far is the airport from central De Soto?
Landing at Lambert-St. Louis Intl. Airport (STL) puts you approximately 45 mi north of central De Soto.
Can I save money by booking a De Soto trip package?
Book a De Soto flight and hotel package deal on Expedia, and you can make significant savings. It's easy to bundle your accommodations and flights, and you can add tours and car rentals to create your own personalized De Soto trip. Plus, there's nothing like the convenience of booking everything in the same place.
Can I change or cancel my flight to De Soto?
It's usually possible to change or cancel your flight to De Soto. Many airlines allow you to cancel your flights for free within 24 hours of making your booking. However, some flights are non-refundable, and airlines may offer you a credit toward a future trip rather than a direct refund. To find cheap flights to De Soto with flexible change policies, check "No cancel fee" or "Changes included" when you search. Looking for more information? Visit our Customer Service Portal.

*Flight schedules are subject to change.

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Travel information

Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Destination city name
St. Louis
Roundtrip price
$56

Trending flights to De Soto

Prices were available within the past 7 days and start at $28 for one-way flights and $56 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, May 13 - Wed, May 20
ATL
Atlanta
STL
St. Louis
$56 Roundtrip, found 3 hours ago
$56
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Wed, May 13 from Atlanta to St. Louis, returning Wed, May 20, priced at $56 found 3 hours ago

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