Title: Lake City Vacation Rentals from $194: Search Short-Term Rentals | Expedia.com

[Lake City Travel Guide](https://expedia.com/Lake-City.dx8506)[Hotels in Lake City](https://expedia.com/Lake-City-Hotels.d8506.Travel-Guide-Hotels)[Flights to Lake City](https://expedia.com/Cheap-Flights-To-Lake-City.d8506.Travel-Guide-Flights)[Car Rentals in Lake City](https://expedia.com/Car-Rentals-In-Lake-City.d8506.Car-Rental-Guide)[Lake City Vacation Packages](https://expedia.com/Lake-City.d8506.Destination-Travel-Guides)

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## Check prices for these dates

In two weeks

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-03-06&endDate=2026-03-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Lake City vacation rentals

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/ad5ff8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Walking distance from one of South Carolina's top Medical centers.

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

Florence

9.8/10

Exceptional

(43 reviews)

"Everything was great!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Debra B.

$174 nightly

$194 total

Feb 18 - Feb 19

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/c3d44dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/25419117.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/d9622cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/93bab7ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

[](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

Florence

8.8/10

Excellent

(3 reviews)

"Convenient location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bonney W.

$422 nightly

$473 total

Feb 18 - Feb 19

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/78ec87e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/f2cc1121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

[](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

Florence

10/10

Exceptional

(46 reviews)

"I would definitely stay again! Great location."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

LaDara D.

$229 nightly

$257 total

Feb 18 - Feb 19

Total with taxes and fees

[](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/81b1f193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/6be5fea4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/d18e861f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/a2a22dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Creekside Country Cottage- minutes away from I-95

[](https://www.expedia.com/Manning-Hotels-Creekside-Country-Cottage-Minutes-Away-From-I-95.h83966776.Hotel-Information)

Manning

10/10

Exceptional

(9 reviews)

"Great place beautiful and the dogs loved it"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer T.

$394 nightly

$437 total

Feb 18 - Feb 19

Total with taxes and fees

[](https://www.expedia.com/Manning-Hotels-Creekside-Country-Cottage-Minutes-Away-From-I-95.h83966776.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-03&endDate=2026-03-04&regionId=8506&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## 

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## Find vacation rentals that suit your style

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Lake+City%2C+South+Carolina%2C+United+States+of+America&regionId=8506&latLong=33.872719%2C-79.754379&adults=2&startDate=2026-05-17&d1=2026-05-17&endDate=2026-05-20&d2=2026-05-20&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Lake+City%2C+South+Carolina%2C+United+States+of+America&regionId=8506&latLong=33.872719%2C-79.754379&adults=2&startDate=2026-05-17&d1=2026-05-17&endDate=2026-05-20&d2=2026-05-20&lodging=COTTAGE)

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## Top Lake City Hotel Reviews

![Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG](https://images.trvl-media.com/lodging/2000000/1510000/1509700/1509674/17df73d5_y.jpg)

### Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

10/10 Excellent

"Room was spotless!!"

[](https://expedia.com/Florence-Hotels-Holiday-Inn-Ex-Hotel-Suites-Florence-I-95-I-20-Civic-Ctr.h1509674.Hotel-Information)

![Home2 Suites by Hilton Florence, SC](https://images.trvl-media.com/lodging/8000000/7280000/7271300/7271220/25ce2409_y.jpg)

### Home2 Suites by Hilton Florence, SC

10/10 Excellent

"Very surprised with how spaciouse and comfortable it all was! Had a full kitchen too big fridge big microwave all the utensils really happy with my stay"

[](https://expedia.com/Florence-Hotels-Home2-Suites-By-Hilton-Florence.h7271220.Hotel-Information)

![Hilton Garden Inn Florence](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/8b770330_y.jpg)

### Hilton Garden Inn Florence

10/10 Excellent

"Clean, and great staff"

[](https://expedia.com/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information)

![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg)

### TownePlace Suites by Marriott Florence

10/10 Excellent

"The cleanliness of the rooms, lobby, and the grounds. Staff was very helpful."

[](https://expedia.com/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information)

![Fairfield Inn & Suites by Marriott Florence I-20](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5dc20640_y.jpg)

### Fairfield Inn & Suites by Marriott Florence I-20

10/10 Excellent

"This is a WONDERFUL hotel! Everything here is fantastic! From Jalen, to Lauren, to Kim, and whatever other employees we encountered, the courtesy and care from them was above and beyond! I even said they must’ve been through an amazing customer service training program because I have never experienced that level of professionalism mixed with kindness that I did here. They also have the most comfortable beds and the pillows are amazing, so much so that I may be ordering a couple off the website. It is clean, it is decorated and/or updated with a cute modern aesthetic and the continental breakfast is quite good enough! My only wish is that they had bacon available more mornings. This was our second trip there and we were in and out from day to day as we dealt with a loved one in the hospital who ultimately passed away. I just can’t say enough good things. Stay here, I do not think you’ll regret it. Thank you guys for being so kind and understanding of why we were there. ❤️"

[](https://expedia.com/Florence-Hotels-Fairfield-Inn-Suites-By-Marriott-Florence-I-20.h17035960.Hotel-Information)

![Hampton Inn & Suites Florence Center](https://images.trvl-media.com/lodging/1000000/50000/42900/42876/e1b59003_y.jpg)

### Hampton Inn & Suites Florence Center

10/10 Excellent

"Friendly staff and clean"

[](https://expedia.com/Florence-Hotels-Hampton-Inn-Suites-Florence-Center.h42876.Hotel-Information)

![Residence Inn Marriott Florence](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb_y.jpg)

### Residence Inn Marriott Florence

10/10 Excellent

"The room was large and clean. New. The breakfast was great. I've stayed at Residence Inns a few times and have always had excellent experiences."

[](https://expedia.com/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information)

![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc_y.jpg)

### Quality Inn & Suites Florence Civic Center

10/10 Excellent

"Quiet clean and many options local for food etc Good for a night or two stay Bed was comfortable "

[](https://expedia.com/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information)

![SpringHill Suites by Marriott Florence](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/90a03799_y.jpg)

### SpringHill Suites by Marriott Florence

10/10 Excellent

"Krystal was great!!"

[](https://expedia.com/Florence-Hotels-SpringHill-Suites-By-Marriott-Florence.h974962.Hotel-Information)

## Find out more about Lake City

**Everything you need to know about Lake City vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Lake City vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Lake City in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $194 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Lake City rentals**

At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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- [Vacation Homes in Lake City ](https://expedia.com/Lake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Lake City ](https://expedia.com/Lake-City-Cottages.d8506-aaCottages.Travel-Guide-Accommodation)
- [Motels in Lake City ](https://expedia.com/Lake-City-Motels.d8506-aaMotels.Travel-Guide-Accommodation)
- [Condo Rentals in Lake City ](https://expedia.com/Lake-City-Condos.d8506-aaCondos.Travel-Guide-Accommodation)
- [Cabin Rentals in Lake City ](https://expedia.com/Lake-City-Cabins.d8506-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Lake City ](https://expedia.com/Lake-City-Apartments.d8506-aaApartments.Travel-Guide-Accommodation)
- [RV Parks in Lake City ](https://expedia.com/Lake-City-RV-Parks.d8506-aaRVParks.Travel-Guide-Accommodation)

## Frequently asked questions

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### What are some of the best vacation rentals that Lake City has to offer?

### What can I see and do in Lake City?

### What are vacation rentals like in Lake City?

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Hotels

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Flights

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- [Flights to Charleston](https://expedia.com/Cheap-Flights-To-Charleston.d179997.Travel-Guide-Flights)
- [Flights to Hilton Head Island](https://expedia.com/Cheap-Flights-To-Hilton-Head-Island.d601684.Travel-Guide-Flights)
- [Flights to Myrtle Beach](https://expedia.com/Cheap-Flights-To-Myrtle-Beach.d601685.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d764.Car-Rental-Guide)
- [Car rentals in Charleston](https://expedia.com/Car-Rentals-In-Charleston.d179997.Car-Rental-Guide)
- [Car rentals in Myrtle Beach](https://expedia.com/Car-Rentals-In-Myrtle-Beach.d601685.Car-Rental-Guide)
- [Car rentals in Greenville](https://expedia.com/Car-Rentals-In-Greenville.d1388.Car-Rental-Guide)

Cruises

- [Cruises from Charleston](https://expedia.com/Cruises-from-Charleston.d179997.Cruise-Departure-Port)

Activities

- [Things to do in Myrtle Beach](https://expedia.com/Things-To-Do-In-Myrtle-Beach.d601685.Travel-Guide-Activities)

Packages

- [Myrtle Beach Vacation](https://expedia.com/Myrtle-Beach.d601685.Destination-Travel-Guides)

Vacation Rentals

- [Myrtle Beach Vacation Rentals](https://expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)

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