Title: Lake City Vacation Rentals from $229: Search Short-Term Rentals | Expedia.com [Lake City Travel Guide](https://expedia.com/Lake-City.dx8506)[Hotels in Lake City](https://expedia.com/Lake-City-Hotels.d8506.Travel-Guide-Hotels)[Flights to Lake City](https://expedia.com/Cheap-Flights-To-Lake-City.d8506.Travel-Guide-Flights)[Car Rentals in Lake City](https://expedia.com/Car-Rentals-In-Lake-City.d8506.Car-Rental-Guide)[Lake City Vacation Packages](https://expedia.com/Lake-City.d8506.Destination-Travel-Guides) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates In two weeks [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=8506&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Lake City vacation rentals ![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/c148491e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/e827b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books, printers](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/24f777ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/80000000/79670000/79668500/79668437/d862c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walking distance from one of South Carolina's top Medical centers. [](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) Florence 9.8/10 Exceptional (47 reviews) "Everything was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debra B. $204 nightly $229 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Walking-Distance-From-One-Of-South-Carolinas-Top-Medical-Centers.h79668437.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/c3d44dee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/5d047f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/d9622cff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/124000000/123130000/123127500/123127484/25419117.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence. [](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information) Florence 8.8/10 Excellent (3 reviews) "Convenient location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Bonney W. $454 nightly $508 total Apr 6 - Apr 7 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Charming-3-Bedroom.h123127484.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/81b1f193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/a2a22dc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/d18e861f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/84000000/83970000/83966800/83966776/6be5fea4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Creekside Country Cottage- minutes away from I-95 [](https://www.expedia.com/Manning-Hotels-Creekside-Country-Cottage-Minutes-Away-From-I-95.h83966776.Hotel-Information) Manning 10/10 Exceptional (9 reviews) "Great place beautiful and the dogs loved it" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer T. [](https://www.expedia.com/Manning-Hotels-Creekside-Country-Cottage-Minutes-Away-From-I-95.h83966776.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/e85ce030.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/c362269a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/de384ec0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103870000/103861800/103861731/78ec87e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's [](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) Florence 10/10 Exceptional (49 reviews) "I would definitely stay again! Great location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LaDara D. $290 nightly $324 total Apr 5 - Apr 6 Total with taxes and fees [](https://www.expedia.com/Florence-Hotels-Take-A-Rest-In-Florence-Ideal-For-I95-Traveler-And-Florence-Center-And-Buc-Ees.h103861731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-17&endDate=2026-04-18®ionId=8506&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Lake+City%2C+South+Carolina%2C+United+States+of+America®ionId=8506&latLong=33.872719%2C-79.754379&adults=2&startDate=2026-07-02&d1=2026-07-02&endDate=2026-07-05&d2=2026-07-05&lodging=VACATION_HOME) Cottages [](https://www.expedia.com/Hotel-Search?destination=Lake+City%2C+South+Carolina%2C+United+States+of+America®ionId=8506&latLong=33.872719%2C-79.754379&adults=2&startDate=2026-07-02&d1=2026-07-02&endDate=2026-07-05&d2=2026-07-05&lodging=COTTAGE) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLake-City-Vacation-Rentals.d8506.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLake-City-Vacation-Rentals.d8506.Travel-Guide-VacationRentals) ## Top Lake City Hotel Reviews ![Days Inn by Wyndham Florence Near Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/1b5fb4c0_y.jpg) ### Days Inn by Wyndham Florence Near Civic Center 6/10 Okay "Breakfast items are very limited. Parking is safe." [](https://expedia.com/Florence-Hotels-Days-Inn-By-Wyndham-Florence-Near-Civic-Center.h11724.Hotel-Information) ![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/8dae8685_y.jpg) ### Quality Inn & Suites Florence Civic Center 6/10 Okay "Yes, Helpful, Good, Yes" [](https://expedia.com/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011_y.jpg) ### Comfort Inn & Suites Florence Center Area 2/10 Terrible "I booked three nights and checked out of the second day. When I checked in late at night the young lady at the front desk was not friendly at all not or welcoming. She made me feel like a was bothering her. When I checked out a day earlier the lady told me I would still be charged for three days with was absolutely crazy while she was checking me all a young lady comes out the back yelling at the other associate because she disappeared I felt so bad for the lady it was so disrespectful and unprofessional I will never return!!! Do not stay here!!! On top of that the room smelled horrible!!! " [](https://expedia.com/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![The Inn at the Crossroads](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76_y.jpg) ### The Inn at the Crossroads 10/10 Excellent "We came down for a funeral unfortunately and in spite of that we enjoyed our hotel stay " [](https://expedia.com/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Hilton Garden Inn Florence](https://images.trvl-media.com/lodging/2000000/1370000/1367300/1367205/ddbd2495_y.jpg) ### Hilton Garden Inn Florence 10/10 Excellent "Lovely, non-problematic, nice and quiet last minute overnight stop" [](https://expedia.com/Florence-Hotels-Hilton-Garden-Inn-Florence.h1367205.Hotel-Information) ![TownePlace Suites by Marriott Florence](https://images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/cd925f1d_y.jpg) ### TownePlace Suites by Marriott Florence 6/10 Okay "first room 104 smelled like cigarettes I asked front desk to move me she was insisting no one smokes in rooms but I told her she can go check buy she decided to change my room, next room it was kinda dirty dust and the air wasn't cooling down the temp in the room stayed 73 degrees and feels like hard to breath .. wasn't gonna move again and its late and just deal with it for one night was tired from my drive from Maryland " [](https://expedia.com/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![SpringHill Suites by Marriott Florence](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/bad3cc5c_y.jpg) ### SpringHill Suites by Marriott Florence 8/10 Good "Lovedddd the set up of the room! Staff were friendly, rooms were spotless. Pool was freezing & I wish they had a hot tub. Also, you basically have to make your own breakfast - didn’t enjoy that part. " [](https://expedia.com/Florence-Hotels-SpringHill-Suites-By-Marriott-Florence.h974962.Hotel-Information) ![Courtyard by Marriott Florence](https://images.trvl-media.com/lodging/1000000/90000/84600/84519/a3469465_y.jpg) ### Courtyard by Marriott Florence 8/10 Good "Rooms were clean for the most part, had an empty bag of chips & a bottle top on one of the nightstands. All of the food has to be paid for separately. & I really wish they had a hot tub!!!! " [](https://expedia.com/Florence-Hotels-Courtyard-By-Marriott-Florence.h84519.Hotel-Information) ![Florence Inn and Suites](https://images.trvl-media.com/lodging/1000000/30000/20300/20253/2aa0d516_y.jpg) ### Florence Inn and Suites 10/10 Excellent "The staff are friendly and vey helpful, last night the front desk lady assisted us with our request for a pet friendly room on the first floor, and just our luck, there’s an available one. Would recommend whether you have a pet or not." [](https://expedia.com/Florence-Hotels-Florence-Inn-And-Suites.h20253.Hotel-Information) ## Find out more about Lake City **Everything you need to know about Lake City vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lake City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lake City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Lake City vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Lake City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Lake City in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $229 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Lake City rentals** At Expedia, we put the best Lake City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Lake City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lake City vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lake City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Lake City ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals) - [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals) - [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals) - [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals) - [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals) - [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals) - [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals) - [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals) - [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals) - [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals) - [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals) - [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations) - [Vacation Homes in Lake City ](https://expedia.com/Lake-City-Private-Vacation-Homes.d8506-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Cottages in Lake City ](https://expedia.com/Lake-City-Cottages.d8506-aaCottages.Travel-Guide-Accommodation) - [Motels in Lake City ](https://expedia.com/Lake-City-Motels.d8506-aaMotels.Travel-Guide-Accommodation) - [Condo Rentals in Lake City ](https://expedia.com/Lake-City-Condos.d8506-aaCondos.Travel-Guide-Accommodation) - [Apartments in Lake City ](https://expedia.com/Lake-City-Apartments.d8506-aaApartments.Travel-Guide-Accommodation) - [RV Parks in Lake City ](https://expedia.com/Lake-City-RV-Parks.d8506-aaRVParks.Travel-Guide-Accommodation) - [Cabin Rentals in Lake City ](https://expedia.com/Lake-City-Cabins.d8506-aaCabins.Travel-Guide-Accommodation) ## Frequently asked questions ### Can I find a vacation rental in Lake City? 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