Title: 20 Best B&B in Seneca, SC - Bed and Breakfast from $213 | Expedia.com

[Seneca Travel Guide](https://expedia.com/Seneca.dx6548)[Hotels in Seneca](https://expedia.com/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.com/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.com/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Car Rentals in Seneca](https://expedia.com/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.com/Seneca.d6548.Destination-Travel-Guides)

![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

## Check prices for these dates

Next weekend

[Feb 13 - Feb 15](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-02-13&endDate=2026-02-15&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-02-20&endDate=2026-02-22&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In one month

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-03&endDate=2026-04-05&adults=2&lodging=BED_AND_BREAKFAST&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Seneca bed & breakfast

![Front of property](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7ccc39b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/679dc208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/286fc023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Double Room | Premium bedding, memory foam beds, individually decorated](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/bd9ed0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Liberty Hall Bed and Breakfast

[](https://www.expedia.com/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information)

Pendleton

10/10

Exceptional

(78 reviews)

"The owners are amazing. Comfy rooms, stellar breakfast and good people. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee

$192 nightly

$213 total

Feb 10 - Feb 11

Total with taxes and fees

[](https://www.expedia.com/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Seneca Hotel Reviews

![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg)

### Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"Yes"

[](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information)

![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg)

### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Very clean! Cozy space. Great 24 hour getaway! "

[](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg)

### Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent

"Woman at the front desk "

[](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information)

![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg)

### Lakeside Lodge Clemson

10/10 Excellent

"Spotless room, great staff, and amenities"

[](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information)

![5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/fa789e5c_y.jpg)

### 5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10/10 Excellent

"What a wonderful place for our family gathering. The large commons area provided beautiful views of the lake. There were a variety of places to play games and enjoy our time together."

[](https://expedia.com/Seneca-Hotels-Modern-Lakefront-Luxury-Oasis-270-Lake-Views-WDock.h61010330.Hotel-Information)

![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg)

### Quality Inn Seneca Clemson Area US-123

10/10 Excellent

"Our stay was very nice. Clean room. The outside was clean. "

[](https://expedia.com/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information)

![Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/67cc829e_y.jpg)

### Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock

10/10 Excellent

"We will definitely be booking this property again. We usually have family gathering inJanuary and I think this will be our new location. It accommodated those lodging with us and who came to visit while we were there. The flow of the house and outdoors was so convenient especially for our large gathering when we roasted oysters. "

[](https://expedia.com/Seneca-Hotels-Quiet-Cove.h27118346.Hotel-Information)

![Fairfield Inn & Suites Seneca Clemson Univ Area    ](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/9fe06894_y.jpg)

### Fairfield Inn & Suites Seneca Clemson Univ Area 

10/10 Excellent

"Spotless, friendly staff, great location. "

[](https://expedia.com/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information)

![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg)

### Tru by Hilton Seneca Clemson

10/10 Excellent

"The staff here are top tier! We had to be at a meet at the university by 6am and they made breakfast early so our kids could eat before the meet! Genuine care for their guest! Love it here! "

[](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information)

## Find out more about Seneca

## Seneca B&B information

| Number of reviews | 78    |
| ----------------- | ----- |
| Accommodation     | 3 B&B |
| Lowest Price      | $213  |
| Highest Price     | $213  |

## Frequently asked questions

### What are the most popular Seneca B&Bs?

> For those traveling with friends or family, the Boutique Hotel also offers another lovely room option with a queen/king combo. This setup is great for accommodating multiple guests while enjoying the same delightful atmosphere and easy access to downtown attractions. The convenience of air conditioning ensures everyone stays comfortable, allowing for a laid-back getaway.

### What is the nightly rate for a Bed & Breakfast in Seneca?

### When is the best time to book a Bed and Breakfast in Seneca?

> July marks the height of tourist activity, characterized by warm temperatures typically ranging from the mid-60s to low 80s Fahrenheit. During this time, visitors can fully enjoy the region's pristine lakes and trails, making it superb for those who appreciate a confident, stress-free outdoor experience. The vibrant atmosphere during these months is enhanced by various local events that showcase the community spirit and cultural heritage of Seneca.
> 
>   
> For those looking for a more tranquil experience, consider planning your visit in September. As the summer crowds begin to thin, this month offers a fantastic opportunity to enjoy the beautiful fall foliage without the bustle of peak season. The temperatures remain mild, often in the 50s to 70s Fahrenheit, allowing for comfortable hiking and exploration of the area's scenic spots.
> 
>   
> If you're seeking a budget-friendly option, December is typically the low season in Seneca. While the weather may be cooler, ranging from the low 30s to mid-40s Fahrenheit, this time can offer unique winter experiences like cozy B&B stays and quiet reflection by the lakeside.

### What is the difference between a Seneca Bed & Breakfast and a hotel?

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