A calm lake with mountains in the background.

Seneca Vacation Rentals

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Check prices for these dates

In two weeks
Sep 11 - Sep 13
In two months
Oct 23 - Oct 25
In three months
Nov 20 - Nov 22
In four months
Dec 18 - Dec 20

Our top choices for Seneca vacation rentals

A cabin with a large window, surrounded by trees.

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (101 reviews)
"Me and my family had a great time"
United States
Nirumol
$141 nightly
The price is $155
Sep 24 - Sep 25
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A living room with a sofa, a coffee table, and a TV mounted on the wall.

2. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Seneca
10.0 out of 10, Exceptional, (28 reviews)
"Great place to stay. The rooms were clean and we had plenty of space. Definitely would come back!"
United States
Brandon P.
$312 nightly
The price is $343
Aug 26 - Aug 27
Total with taxes and fees
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
A blue building with a wooden deck and two Adirondack chairs.

3. Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
10.0 out of 10, Exceptional, (3 reviews)
"The property was very clean and well maintained. The living space is large and the bathroom quite large as well. It was perfect for our needs. It is close to everything in the area. Jim was extremely helpful and super quick with his responses to our questions."
United States
Peter M.
$199 nightly
The price is $219
Aug 26 - Aug 27
Total with taxes and fees
Cozy Clemson TIny House Cabin
A covered porch with wicker furniture, a stone pillar, and a small garden.

4. Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"Beautiful home, no complaints."
United States
Brenda
$295 nightly
The price is $324
Aug 29 - Aug 30
Total with taxes and fees
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
A bedroom with a wooden headboard, white bedding, and a dark blue throw blanket.

5. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (15 reviews)
"Perfect pet friendly spot to enjoy a weekend getaway! Quiet campground, homey vibe, and awesome location!"
United States
Josie G.
$182 nightly
The price is $200
Aug 26 - Aug 27
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
A dining area with a wooden table, chairs, and a hanging light fixture.

6. Iroquois Crossroads - 10 min from Clemson & lakes

Iroquois Crossroads - 10 min from Clemson & lakes
Seneca
$305 nightly
The price is $336
Sep 9 - Sep 10
Total with taxes and fees
Iroquois Crossroads - 10 min from Clemson & lakes
A modern kitchen with wooden cabinets, granite countertops, a refrigerator, stove, and a sink.

7. Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"We were very pleased with our stay. Four bedrooms was perfect for us. The little coffee bar was an enjoyable perk!"
United States
Karen S.
$305 nightly
The price is $335
Sep 6 - Sep 7
Total with taxes and fees
Carolina Cottage Retreat-12 Minutes from Clemson University
A living room with a large tiger mural, a fireplace, a sofa, and a coffee table.

8. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (21 reviews)
"Great host! We had a great experience during our stay. "
United States
David E.
$347 nightly
The price is $381
Aug 30 - Aug 31
Total with taxes and fees
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

9. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Fantastic location and really nicely done home. It was a perfect touch having a desk in one of the rooms to be able to get work done."
United States
Brenda B.
$348 nightly
The price is $382
Aug 26 - Aug 27
Total with taxes and fees
Renovated 3BR near Lake Keowee & Clemson
A modern kitchen with a central island, wooden cabinets, and a built-in refrigerator.

10. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (12 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
$334 nightly
The price is $367
Aug 26 - Aug 27
Total with taxes and fees
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
A wooden deck overlooking a calm lake with boats docked, surrounded by dense trees.

11. Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Seneca
9.8 out of 10, Exceptional, (66 reviews)
"This property was very clean and we loved the convenience of being so close to town."
United States
Kathleen A.
$477 nightly
The price is $525
Aug 27 - Aug 28
Total with taxes and fees
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
A spacious living room with a sofa, chairs, a wooden coffee table, and a fireplace.

12. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.0 out of 10, Very Good, (7 reviews)
"Adorable and clean house! The yard is beautiful "
United States
Diana H.
$268 nightly
The price is $295
Aug 30 - Aug 31
Total with taxes and fees
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
A wooden deck with a railing overlooking a forested area during sunset.

13. Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (14 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
$477 nightly
The price is $525
Aug 26 - Aug 27
Total with taxes and fees
Waterfront 3br home on Lake Hartwell near Clemson
A modern kitchen with white cabinetry, a central island, and a large window.

14. The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Great house and host!"
United States
David E.
$567 nightly
The price is $623
Aug 26 - Aug 27
Total with taxes and fees
The Big Golf House- 10 miles to Clemson
A bedroom with a bed, bench, bedside table, and a view of a lake.

15. Johnsons Cove - Lakefront Retreat With EV Charger

Johnsons Cove - Lakefront Retreat With EV Charger
Seneca
10.0 out of 10, Exceptional, (1 review)
"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."
United States
Rebecca G.
$719 nightly
The price is $764
Sep 8 - Sep 9
Total with taxes and fees
Johnsons Cove - Lakefront Retreat With EV Charger
A covered porch with wicker furniture, a wooden table, and a ceiling fan.

16. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.6 out of 10, Exceptional, (11 reviews)
"Everything was lovely."
United States
Allison C.
$652 nightly
The price is $689
Aug 26 - Aug 27
Total with taxes and fees
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
A forest clearing with a central fire pit surrounded by logs.

17. Tiny House - Slice of Heaven Walhalla

Tiny House - Slice of Heaven Walhalla
Walhalla
9.4 out of 10, Exceptional, (32 reviews)
"Our stay was great! Our family had everything we needed, we loved how clean the place was, how friendly our host was, and how easy check-in and check-out was. Thanks, Tom!"
United States
L W.
$191 nightly
The price is $210
Aug 26 - Aug 27
Total with taxes and fees
Tiny House - Slice of Heaven Walhalla
A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.

18. Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.6 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay, it was the perfect size for our family of four. "
United States
Ashley
$212 nightly
The price is $236
Aug 30 - Aug 31
Total with taxes and fees
Clemson Memorabilia House
A cozy interior with a sofa, a small round table with a vase, and a staircase leading to an upper level.

19. The Pendle-Tin

The Pendle-Tin
Pendleton
9.8 out of 10, Exceptional, (12 reviews)
"Cozy, clean & close to campus "
United States
INGRID S.
$175 nightly
The price is $195
Aug 31 - Sep 1
Total with taxes and fees
The Pendle-Tin
A cozy living room with a fireplace, a dining area with a table and chairs, and a kitchen in the background.

20. Clemson Memorabilia House Frank Howard III’s Home

Clemson Memorabilia House Frank Howard III’s Home
Clemson
8.4 out of 10, Very Good, (20 reviews)
"It’s a great location and size for us. I did notice the bathroom wasn’t as clean as in the past…fyi. Everything else was great and we would definitely stay again! "
United States
Christy L.
$238 nightly
The price is $264
Aug 26 - Aug 27
Total with taxes and fees
Clemson Memorabilia House Frank Howard III’s Home
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent
"Always my favorite in the area"
TRISHA 1-night trip
Posted 14 hours ago
Lakeside Lodge Clemson

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $155 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!: This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade game room. Some other homes for rent in Seneca include Lakefront home with private beach & unbelievable sunsets on Lake Keowee and New to VRBO! Big water views, private dock, pool table, 15 min Clemson!.

How many vacation rentals are there in Seneca?

Choose from 217 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Lake Keowee and Lake Hartwell are a couple of picturesque spots to enjoy the outdoors. While here, Oconee County Library Seneca Branch and Keowee Key Golf Course are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.