A calm lake with mountains in the background.

Seneca Vacation Rentals

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Check prices for these dates

In two weeks
Oct 23 - Oct 25
In two months
Dec 4 - Dec 6
In three months
Jan 1 - Jan 3
In four months
Jan 29 - Jan 31

Our top choices for Seneca vacation rentals

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (109 reviews)
"Beautiful cabin, attentive hosts, and an overall great stay. I would definitely go back."
United States
Sebastian
$133 nightly
The price is $146
Oct 20 - Oct 21
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A living room with a large tiger mural, a fireplace, a sofa, and a coffee table.

2. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (22 reviews)
"Great host! We had a great experience during our stay. "
United States
David E.
$329 nightly
The price is $361
Oct 27 - Oct 28
Total with taxes and fees
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
A bedroom with a bed, a dresser, a nightstand, a lamp, and a painting on the wall.

3. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Fantastic location and really nicely done home. It was a perfect touch having a desk in one of the rooms to be able to get work done."
United States
Brenda B.
$335 nightly
The price is $368
Oct 11 - Oct 12
Total with taxes and fees
Renovated 3BR near Lake Keowee & Clemson
A modern kitchen with a central island, wooden cabinets, and a built-in refrigerator.

4. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (12 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
$334 nightly
The price is $367
Oct 11 - Oct 12
Total with taxes and fees
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
A modern kitchen with white cabinetry, a central island, and a large window.

5. The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Great house and host!"
United States
David E.
$549 nightly
The price is $603
Oct 27 - Oct 28
Total with taxes and fees
The Big Golf House- 10 miles to Clemson
A dining area with a wooden table, chairs, and a hanging light fixture.

6. Iroquois Crossroads - 10 min from Clemson & lakes

Iroquois Crossroads - 10 min from Clemson & lakes
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Couldn't have been an easier process. Place was immaculate. Would recommend."
United States
Steve M.
Iroquois Crossroads - 10 min from Clemson & lakes
A blue building with a wooden deck and two Adirondack chairs.

7. Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
10.0 out of 10, Exceptional, (3 reviews)
"The property was very clean and well maintained. The living space is large and the bathroom quite large as well. It was perfect for our needs. It is close to everything in the area. Jim was extremely helpful and super quick with his responses to our questions."
United States
Peter M.
$199 nightly
The price is $219
Oct 19 - Oct 20
Total with taxes and fees
Cozy Clemson TIny House Cabin
A bedroom with a bed, a nightstand, a lamp, a window with blinds, a ceiling fan, and a painting on the wall.

8. Peaceful 3-bedroom home 4 miles from Clemson.

Peaceful 3-bedroom home 4 miles from Clemson.
Seneca
$259 nightly
The price is $285
Oct 12 - Oct 13
Total with taxes and fees
Peaceful 3-bedroom home 4 miles from Clemson.
A modern kitchen with wooden cabinets, stainless steel appliances, granite countertops, and pendant lighting.

9. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
Seneca
$415 nightly
The price is $432
Oct 19 - Oct 20
Total with taxes and fees
Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
A wooden deck with a railing overlooking a forested area during sunset.

10. Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (16 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
$480 nightly
The price is $528
Oct 11 - Oct 12
Total with taxes and fees
Waterfront 3br home on Lake Hartwell near Clemson
A covered porch with wicker furniture, a wooden table, and a ceiling fan.

11. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.6 out of 10, Exceptional, (12 reviews)
"Everything was lovely."
United States
Allison C.
$657 nightly
The price is $695
Oct 12 - Oct 13
Total with taxes and fees
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
A bedroom with a wooden headboard, white bedding, and a dark blue throw blanket.

12. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (16 reviews)
"Perfect pet friendly spot to enjoy a weekend getaway! Quiet campground, homey vibe, and awesome location!"
United States
Josie G.
$183 nightly
The price is $201
Oct 12 - Oct 13
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
A spacious living room with a sofa, chairs, a wooden coffee table, and a fireplace.

13. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.0 out of 10, Very good, (7 reviews)
"Adorable and clean house! The yard is beautiful "
United States
Diana H.
$264 nightly
The price is $291
Oct 11 - Oct 12
Total with taxes and fees
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
A compact living space with a sofa, a chair, a coffee table, and a kitchenette area.

14. Camping on Fancy-Perfect for small family getaway or couples retreat!

Camping on Fancy-Perfect for small family getaway or couples retreat!
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Perfect space for me and my husband to stay for family weekend at Clemson. Perfectly located, comfortable, and the hostess was incredibly kind and thoughtful.We will definitely be staying here again."
United States
Regina J.
$220 nightly
The price is $242
Oct 13 - Oct 14
Total with taxes and fees
Camping on Fancy-Perfect for small family getaway or couples retreat!
A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.

15. Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.6 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay, it was the perfect size for our family of four. "
United States
Ashley
$214 nightly
The price is $238
Oct 11 - Oct 12
Total with taxes and fees
Clemson Memorabilia House
A forest clearing with a central fire pit surrounded by logs.

16. Tiny House - Slice of Heaven Walhalla

Tiny House - Slice of Heaven Walhalla
Walhalla
9.4 out of 10, Exceptional, (33 reviews)
"Our stay was great! Our family had everything we needed, we loved how clean the place was, how friendly our host was, and how easy check-in and check-out was. Thanks, Tom!"
United States
L W.
$203 nightly
The price is $223
Oct 11 - Oct 12
Total with taxes and fees
Tiny House - Slice of Heaven Walhalla
A white house with a sloped roof, surrounded by trees and a garden.

17. Clemson Game Day Cottage w/ Fire Pit

Clemson Game Day Cottage w/ Fire Pit
3.0 star property
Clemson
10.0 out of 10, Exceptional, (1 review)
$242 nightly
The price is $268
Oct 12 - Oct 13
Total with taxes and fees
Clemson Game Day Cottage w/ Fire Pit
A two-story wooden cabin with a balcony on the upper floor, surrounded by trees.

18. Keowee Key ~ Cozy Condo ~ Golf Course View - Amenities

Keowee Key ~ Cozy Condo ~ Golf Course View - Amenities
Salem
10.0 out of 10, Exceptional, (84 reviews)
"Clean with cute thoughtful little snacks and clear directions for navigating your stay . Bed was a little hard but they had a softer option in another room. Very nice stay"
United States
Mary L.
$360 nightly
The price is $396
Nov 1 - Nov 2
Total with taxes and fees
Keowee Key ~ Cozy Condo ~ Golf Course View - Amenities
A lakeside cabin with a dock, a floating platform, and a house in the background.

19. Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option

Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option
West Union
9.6 out of 10, Exceptional, (17 reviews)
"Great home. Neat and Clean. We had family 3-70 and there was something for everyone to do and enjoy during our stay. Host was very prompt with communication and answering my questions. Would stay here again."
United States
April O.
$1,194 nightly
The price is $1,313
Oct 27 - Oct 28
Total with taxes and fees
Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option
A cozy interior with a sofa, a small round table with a vase, and a staircase leading to an upper level.

20. The Pendle-Tin

The Pendle-Tin
Pendleton
9.8 out of 10, Exceptional, (13 reviews)
"Property was cute, cozy and perfect for our short 2 night stay! Clean and distance to campus was great! "
United States
Cindy L.
$214 nightly
The price is $237
Oct 13 - Oct 14
Total with taxes and fees
The Pendle-Tin
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Beautiful cabin, attentive hosts, and an overall great stay. I would definitely go back."
Sebastian 2-night trip
Posted 8 hours ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $146 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water: This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You can relax into your vacation with a garden and a selection of games. Some other homes for rent in Seneca include Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub and New to VRBO! Big water views, private dock, pool table, 15 min Clemson!.

How many vacation rentals are there in Seneca?

Choose from 217 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Lake Keowee and Lake Hartwell are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Oconee County Library Seneca Branch are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.