Title: Seneca Vacation Rentals from $120: Search Short-Term Rentals | Expedia.com

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![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

## Check prices for these dates

In two weeks

[Mar 6 - Mar 8](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-03-06&endDate=2026-03-08&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Seneca vacation rentals

![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Queen Bed (View) | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/e935ccb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/cf119645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/ec2a8fca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

Seneca

9.8/10

Exceptional

(60 reviews)

"Excellent stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beonca

$109 nightly

$120 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/w1536h2048x0y0-6998e207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/405dd7c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/c9812bb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/ad885ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Clemson TIny House Cabin

[](https://www.expedia.com/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information)

Seneca

$200 nightly

$220 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/40d3b059.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/89ea8ad4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/ec808a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/45872750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Clemson Cottage - 3.6 mi. to Memorial Stadium

[](https://www.expedia.com/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information)

Seneca

10/10

Exceptional

(14 reviews)

"Adorable and clean home convenient to Clemson’s campus. We enjoyed our stay and Tyler was an exceptional host! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mandy H.

$360 nightly

$396 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/67979a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/c5a2afe0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/e2588273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/4513793e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

[](https://www.expedia.com/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information)

Seneca

10/10

Exceptional

(12 reviews)

"Very clean and comfortable - very close to Clemson and easy access. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jim A.

$183 nightly

$201 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/fbb953e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/2d71c6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/a6445e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/b464b65a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 1-bedroom house in lovely Seneca. 5 miles from Clemson University

[](https://www.expedia.com/Seneca-Hotels-Charming-1-Bedroom-House-In-Lovely-Seneca-5-Miles-From-Clemson-University.h125624500.Hotel-Information)

Seneca

$77 nightly

$85 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Charming-1-Bedroom-House-In-Lovely-Seneca-5-Miles-From-Clemson-University.h125624500.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/e032590e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/8a811318.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/9b29fdfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/518d0c67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell

[](https://www.expedia.com/Charming-3-Bedroom-House-With-WiFi-And-AC-In-Serene-Seneca-On-Lake-Hartwell.h114542071.Hotel-Information)

Seneca

10/10

Exceptional

(9 reviews)

"Very easy check in and check out. It had everything we needed including wonderful views at the dock. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lance A.

$480 nightly

$528 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Charming-3-Bedroom-House-With-WiFi-And-AC-In-Serene-Seneca-On-Lake-Hartwell.h114542071.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/0834ba3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/e2e2f98a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/51bdec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/c941d493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

[](https://www.expedia.com/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information)

Seneca

8.6/10

Excellent

(4 reviews)

"Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alisa W.

$268 nightly

$295 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games, stereo](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/735219a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/91ac5b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

[](https://www.expedia.com/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information)

Serenity Bay

9.8/10

Exceptional

(130 reviews)

"A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

stacy s.

$646 nightly

$711 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/c027128d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/1ece8b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/84d2a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/9e13146e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Big Golf House- 10 miles to Clemson

[](https://www.expedia.com/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information)

Seneca

10/10

Exceptional

(2 reviews)

"Absolutely! Perfect space for our needs, so for accommodating for our family & pet. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gennifer Q.

$498 nightly

$541 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/7bfcd263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/8d32bcc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/fa054611.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/1692b12e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

[](https://www.expedia.com/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information)

Seneca

10/10

Exceptional

(5 reviews)

"Great place with a lot close by"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Aldor D.

$289 nightly

$317 total

Feb 24 - Feb 25

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/fc891652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d33a6537.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d37b415d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/98c8974f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

[](https://www.expedia.com/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information)

Seneca

9.6/10

Exceptional

(8 reviews)

"Very accommodating host. Property is a great location and very clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Craig F.

$657 nightly

$695 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information)

![4 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/41018e46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/50a9d9d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/aad65738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/3ef9dbf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Johnsons Cove - Lakefront Retreat With EV Charger

[](https://www.expedia.com/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger-Family-And-Pet-Friendly.h114843702.Hotel-Information)

Seneca

10/10

Exceptional

(1 review)

"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rebecca G.

$741 nightly

$786 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger-Family-And-Pet-Friendly.h114843702.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/8cc7e5ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/9b67ec16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, stereo](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/061a9e84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/dbdc80ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Timber Trail Estate: Stunning Views + Waterfront

[](https://www.expedia.com/Seneca-Hotels-Lake-Keowee-Retreat-4BR-With-Hot-Tub-Dock.h106116530.Hotel-Information)

Seneca

6.4/10

(5 reviews)

"Main floor was clean but basement and loft, cleaners missed a lot. It was very dusty with lots of cobwebs. Cleaners have missed a lot of places over and over again. The downstairs deck was full of pollen and so dirty we couldn’t sit out there. Wish there was an umbrella on top deck- no shade or cover when rains. Wish there was somewhere to put suitcases but w no closet space and no dresser tops, suitcases were all over floors. Was just hoping for a cleaner space for what we paid. Overall it was...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristen F.

$419 nightly

$476 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Lake-Keowee-Retreat-4BR-With-Hot-Tub-Dock.h106116530.Hotel-Information)

![Full-size fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/31949138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/0073b890.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/989adbff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, hair dryer, towels, soap](https://images.trvl-media.com/lodging/88000000/87140000/87136100/87136049/14b6ef24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Pendle-Tin

[](https://www.expedia.com/Pendleton-Hotels-The-Pendle-Tin.h87136049.Hotel-Information)

Pendleton

9.8/10

Exceptional

(9 reviews)

"Property was cute, cozy and perfect for our short 2 night stay! Clean and distance to campus was great! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cindy L.

$179 nightly

$199 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Pendleton-Hotels-The-Pendle-Tin.h87136049.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/8bba3903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/d70b5cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/0f807340.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/bd6f0d56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Glamping with a partial lake view, 30 minutes to Clemson University

[](https://www.expedia.com/Westminster-Hotels-Glamping-With-A-Partial-Lake-View.h105489096.Hotel-Information)

Westminster

9.4/10

Exceptional

(14 reviews)

"The camper was very clean and the set up was very nice. Didn’t have a view of the lake, but all in all had a very nice stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott S.

$189 nightly

$208 total

Mar 2 - Mar 3

Total with taxes and fees

[](https://www.expedia.com/Westminster-Hotels-Glamping-With-A-Partial-Lake-View.h105489096.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/125000000/124350000/124344900/124344869/dad69d7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/125000000/124350000/124344900/124344869/a835e91e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/125000000/124350000/124344900/124344869/a8fabef4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/125000000/124350000/124344900/124344869/628046d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy RV in a vacation community on Lake Hartwell

[](https://www.expedia.com/Westminster-Hotels-Cozy-RV-In-A-Vacation-Community-On-Lake-Hartwell.h124344869.Hotel-Information)

Westminster

$127 nightly

$139 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Westminster-Hotels-Cozy-RV-In-A-Vacation-Community-On-Lake-Hartwell.h124344869.Hotel-Information)

![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/afe0f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/b26b87ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Bedroom, Courtyard View | Front of property](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/f825207a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, in-room safe, individually furnished, laptop workspace](https://images.trvl-media.com/lodging/123000000/122100000/122099800/122099740/4d5d913d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Carolina Camp Cedar

[](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information)

Pickens

10/10

Exceptional

(1 review)

"This place was super clean and super cute! Convenient to everything I needed. I enjoyed the quietness."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Julie

$176 nightly

$195 total

Mar 4 - Mar 5

Total with taxes and fees

[](https://www.expedia.com/Pickens-Hotels-Carolina-Camp-Cedar.h122099740.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/23000000/22130000/22120400/22120360/w799h599x1y1-a20a5639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/23000000/22130000/22120400/22120360/72ad9aac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/23000000/22130000/22120400/22120360/ff8007fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/23000000/22130000/22120400/22120360/83b0dc9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peace-in-the-Forest Retreat - Singles, Couples, Artists, Forest Lovers

[](https://www.expedia.com/Pickens-Hotels-Peace-In-The-Forest-Retreat-Singles.h22120360.Hotel-Information)

Pickens

10/10

Exceptional

(276 reviews)

"We really enjoyed our stay. Close to town, easy to get around."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angie E.

$180 nightly

$200 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Pickens-Hotels-Peace-In-The-Forest-Retreat-Singles.h22120360.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/efec02d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/fc94d8c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, table tennis](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/1a5c9883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/67000000/66030000/66026900/66026894/69fcdbfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxury Vacation Mountain Home

[](https://www.expedia.com/Pickens-Hotels-Luxury-Vacation-Mtn-Home.h66026894.Hotel-Information)

Pickens

9.8/10

Exceptional

(25 reviews)

"Everything was perfect from the hot tub to the comfort of the beds!!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly C.

$297 nightly

$329 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Pickens-Hotels-Luxury-Vacation-Mtn-Home.h66026894.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/111000000/110820000/110812100/110812036/f95c7c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/111000000/110820000/110812100/110812036/5ca265fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110820000/110812100/110812036/2eb8978f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/111000000/110820000/110812100/110812036/3a781422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Broyles Landing Cottage at Lake Hartwell SC

[](https://www.expedia.com/Townville-Hotels-Broyles-Landing-Cottage-At-Lake-Hartwell-SC.h110812036.Hotel-Information)

Townville

10/10

Exceptional

(19 reviews)

"Very clean cottage, convenient to Saddlers’ Creek State Park. Appreciated the goodies provided for guests."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beverly F.

$178 nightly

$198 total

Feb 23 - Feb 24

Total with taxes and fees

[](https://www.expedia.com/Townville-Hotels-Broyles-Landing-Cottage-At-Lake-Hartwell-SC.h110812036.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09&regionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=CABIN)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=COTTAGE)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=VACATION_HOME)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=APART_HOTEL)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=VILLA)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=HOUSE_BOAT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-05-23&d1=2026-05-23&endDate=2026-05-26&d2=2026-05-26&lodging=CHALET)

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## Top Seneca Hotel Reviews

![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg)

### Tru by Hilton Seneca Clemson

10/10 Excellent

"Always clean and friendly! "

[](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information)

![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg)

### Lakeside Lodge Clemson

10/10 Excellent

"Wonderful! Clean and comfortable room. Great staff!"

[](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information)

![Perfect Lake Hartwell Getaway - Gorgeous Lake Views!](https://images.trvl-media.com/lodging/38000000/37750000/37749500/37749425/391b1689_y.jpg)

### Perfect Lake Hartwell Getaway - Gorgeous Lake Views!

10/10 Excellent

"Host was very responsive. House was clean. Would stay here again. "

[](https://expedia.com/Anderson-Hotels-Perfect-Lake-Hartwell-Getaway-Gorgeous-Lake-Views.h37749425.Hotel-Information)

![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg)

### Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent

"yes"

[](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information)

![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg)

### Quality Inn Seneca Clemson Area US-123

10/10 Excellent

"Everting was good"

[](https://expedia.com/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information)

![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg)

### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"THE ABSOLUTE BEST from the staff that accommodated every request I had, the views, the welcoming kit, very very clean. Perfect getaway with the kids. Can’t wait to go back for an adult weekend! "

[](https://expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

![Days Inn by Wyndham Seneca / Clemson Area](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/9f69229a_y.jpg)

### Days Inn by Wyndham Seneca / Clemson Area

10/10 Excellent

"Room was very clean and the staff are great. "

[](https://expedia.com/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information)

![5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!](https://images.trvl-media.com/lodging/62000000/61020000/61010400/61010330/fa789e5c_y.jpg)

### 5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

10/10 Excellent

"Nick, the host, was helpful and prompt to respond. The home was beautiful and was perfect for our corporate event. "

[](https://expedia.com/Seneca-Hotels-Modern-Lakefront-Luxury-Oasis-270-Lake-Views-WDock.h61010330.Hotel-Information)

![Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock](https://images.trvl-media.com/lodging/28000000/27120000/27118400/27118346/67cc829e_y.jpg)

### Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock

10/10 Excellent

"We will definitely be booking this property again. We usually have family gathering inJanuary and I think this will be our new location. It accommodated those lodging with us and who came to visit while we were there. The flow of the house and outdoors was so convenient especially for our large gathering when we roasted oysters. "

[](https://expedia.com/Seneca-Hotels-Quiet-Cove.h27118346.Hotel-Information)

## Find out more about Seneca

**Everything you need to know about Seneca vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Seneca vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $120 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Seneca rentals**

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Seneca ](https://expedia.com/Seneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Seneca ](https://expedia.com/Seneca-Cottages.d6548-aaCottages.Travel-Guide-Accommodation)
- [Cabin Rentals in Seneca ](https://expedia.com/Seneca-Cabins.d6548-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Seneca ](https://expedia.com/Seneca-Apartments.d6548-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Seneca ](https://expedia.com/Seneca-Condos.d6548-aaCondos.Travel-Guide-Accommodation)
- [Villas in Seneca ](https://expedia.com/Seneca-Villas.d6548-aaVillas.Travel-Guide-Accommodation)
- [Motels in Seneca ](https://expedia.com/Seneca-Motels.d6548-aaMotels.Travel-Guide-Accommodation)
- [Farmstay in Seneca ](https://expedia.com/Seneca-Agritourism.d6548-aaAgritourism.Travel-Guide-Accommodation)
- [Lodges in Seneca ](https://expedia.com/Seneca-Lodges.d6548-aaLodges.Travel-Guide-Accommodation)
- [RV Parks in Seneca ](https://expedia.com/Seneca-RV-Parks.d6548-aaRVParks.Travel-Guide-Accommodation)
- [B&B in Seneca ](https://expedia.com/Seneca-Bed-And-Breakfast.d6548-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Guest Houses in Seneca ](https://expedia.com/Seneca-Guest-Houses.d6548-aaGuestHouses.Travel-Guide-Accommodation)
- [Chalets in Seneca ](https://expedia.com/Seneca-Chalets.d6548-aaChalets.Travel-Guide-Accommodation)
- [Houseboats in Seneca ](https://expedia.com/Seneca-Houseboats.d6548-aaHouseboats.Travel-Guide-Accommodation)
- [Condo Resorts in Seneca ](https://expedia.com/Seneca-Condominium-Resort.d6548-aaCondominiumResort.Travel-Guide-Accommodation)

## Frequently asked questions

### Are there vacation rentals in Seneca?

### What's the top vacation rental in Seneca?

### How many vacation rentals are there in Seneca?

### What’s there to see and do in Seneca?

### What’s a vacation rental in Seneca like?

### Expedia's Latest Trends

Hotels

- [Charleston Oceanfront Hotels](https://expedia.com/Charleston-Hotels-Oceanfront-Hotels.0-0-d179997-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Mount Pleasant](https://expedia.com/Mount-Pleasant-Hotels.d8675.Travel-Guide-Hotels)
- [Charleston Cheap Hotels](https://expedia.com/Charleston-Hotels-Cheap-Hotels.0-0-d179997-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Summerville](https://expedia.com/Summerville-Hotels.d6992.Travel-Guide-Hotels)
- [Best Hotels in Myrtle Beach](https://expedia.com/Myrtle-Beach-Hotels.d601685.Travel-Guide-Hotels)
- [Myrtle Beach All-inclusive Resorts](https://expedia.com/Myrtle-Beach-Hotels-All-Inclusive-Hotel.0-0-d601685-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Best Hotels in North Myrtle Beach](https://expedia.com/North-Myrtle-Beach-Hotels.d8929.Travel-Guide-Hotels)
- [Best Hotels in Greenville](https://expedia.com/Greenville-Hotels.d1388.Travel-Guide-Hotels)
- [Myrtle Beach Oceanfront Hotels](https://expedia.com/Myrtle-Beach-Hotels-Oceanfront-Hotels.0-0-d601685-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Hilton Head Island](https://expedia.com/Hilton-Head-Island-Hotels.d601684.Travel-Guide-Hotels)
- [Hilton Head Island Oceanfront Hotels](https://expedia.com/Hilton-Head-Island-Hotels-Oceanfront-Hotels.0-0-d601684-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Columbia](https://expedia.com/Columbia-Hotels.d764.Travel-Guide-Hotels)
- [Best Hotels in Florence](https://expedia.com/Florence-Hotels.d1221.Travel-Guide-Hotels)
- [Myrtle Beach Cheap Hotels](https://expedia.com/Myrtle-Beach-Hotels-Cheap-Hotels.0-0-d601685-tCheapHotels.Travel-Guide-Filter-Hotels)
- [North Myrtle Beach Oceanfront Hotels](https://expedia.com/North-Myrtle-Beach-Hotels-Oceanfront-Hotels.0-0-d8929-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Best Hotels in Charleston](https://expedia.com/Charleston-Hotels.d179997.Travel-Guide-Hotels)
- [Myrtle Beach Pet-friendly Hotels](https://expedia.com/Myrtle-Beach-Hotels-Pet-Friendly-Hotel.0-0-d601685-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Folly Beach Oceanfront Hotels](https://expedia.com/Folly-Beach-Hotels-Oceanfront-Hotels.0-0-d7217-tOceanfrontHotels.Travel-Guide-Filter-Hotels)

Flights

- [Flights to CAE](https://expedia.com/Cheap-Flights-To-Columbia.d764.Travel-Guide-Flights)
- [Flights to CHS](https://expedia.com/Cheap-Flights-To-Charleston.d179997.Travel-Guide-Flights)
- [Flights to SAV](https://expedia.com/Cheap-Flights-To-Hilton-Head-Island.d601684.Travel-Guide-Flights)
- [Flights to MYR](https://expedia.com/Cheap-Flights-To-Myrtle-Beach.d601685.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d764.Car-Rental-Guide)
- [Car rentals in Charleston](https://expedia.com/Car-Rentals-In-Charleston.d179997.Car-Rental-Guide)
- [Car rentals in Myrtle Beach](https://expedia.com/Car-Rentals-In-Myrtle-Beach.d601685.Car-Rental-Guide)
- [Car rentals in Greenville](https://expedia.com/Car-Rentals-In-Greenville.d1388.Car-Rental-Guide)

Cruises

- [Cruises from Charleston](https://expedia.com/Cruises-from-Charleston.d179997.Cruise-Departure-Port)

Activities

- [Things to do in Myrtle Beach](https://expedia.com/Things-To-Do-In-Myrtle-Beach.d601685.Travel-Guide-Activities)

Packages

- [Myrtle Beach Vacation Packages](https://expedia.com/Myrtle-Beach.d601685.Destination-Travel-Guides)

Vacation Rentals

- [Vacation Rentals Myrtle Beach](https://expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)