Find 4 Star Hotels in Panama City from $49

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Our top choices for Panama City 4-star hotels

Crowne Plaza Panama Airport by IHG

4.0 star property
Tocumen
8.4 out of 10, Very Good, (2310)
"The room was clean and the staff were nice! "
United States
CECILIA
$110 nightly
The price is $121
Dec 23 - Dec 24
Total with taxes and fees
Crowne Plaza Panama Airport by IHG

Megapolis Hotel Panamá

4.5 star property
San Francisco
8.4 out of 10, Very Good, (1261)
"Clean rooms, staff was amazing!!"
United States
Christopher
$131 nightly
The price is $144
Dec 10 - Dec 11
Total with taxes and fees
Megapolis Hotel Panamá

Las Americas Golden Tower Panama

4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1004)
"Wonderful stay!"
United States
Martha
$149 nightly
The price is $167
Dec 17 - Dec 18
Total with taxes and fees
Las Americas Golden Tower Panama

Marriott Panama Hotel

4.0 star property
Panama City
9.0 out of 10, Wonderful, (1002)
"Great breakfast "
United States
Amina
$142 nightly
The price is $156
Dec 12 - Dec 13
Total with taxes and fees
Marriott Panama Hotel

Novotel Panama City

4.0 star property
Bella Vista
9.2 out of 10, Wonderful, (1016)
"Great service, big room, solid breakfasts.. all at good price."
Canada
Nicholas
$106 nightly
The price is $117
Dec 13 - Dec 14
Total with taxes and fees
Novotel Panama City

Studio Coliving

4.5 star property
Bella Vista
7.8 out of 10, Good, (578)
"Not much different than a basic hotel"
United States
Jeremy
$44 nightly
The price is $49
Dec 10 - Dec 11
Total with taxes and fees
Studio Coliving

Decapolis Hotel Panama City

4.0 star property
San Francisco
8.6 out of 10, Excellent, (1435)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
$112 nightly
The price is $123
Dec 10 - Dec 11
Total with taxes and fees
Decapolis Hotel Panama City

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1103)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
$119 nightly
The price is $131
Dec 24 - Dec 25
Total with taxes and fees
Ramada Plaza by Wyndham Panama Punta Pacifica

American Trade Hotel

4.5 star property
Casco Viejo
9.4 out of 10, Exceptional, (601)
"Excellent service and great rooms on a beautiful and historical building"
Canada
Manuel
$233 nightly
The price is $258
Jan 8 - Jan 9, 2026
Total with taxes and fees
American Trade Hotel

Sheraton Grand Panama

4.0 star property
San Francisco
8.6 out of 10, Excellent, (989)
"Was amazing food was delicious and stay was great "
United States
Amanda
$134 nightly
The price is $148
Jan 9 - Jan 10, 2026
Total with taxes and fees
Sheraton Grand Panama

Waymore Hotel Spa & Casino

4.0 star property
Bella Vista
9.0 out of 10, Wonderful, (618)
"Friwndly staff, clean rooms and a very convenient location."
United States
Alisa
$88 nightly
The price is $97
Dec 14 - Dec 15
Total with taxes and fees
Waymore Hotel Spa & Casino

Courtyard by Marriott Panama Metromall

4.0 star property
Cerro Viento
8.8 out of 10, Excellent, (1005)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
$101 nightly
The price is $111
Jan 5 - Jan 6, 2026
Total with taxes and fees
Courtyard by Marriott Panama Metromall

Holiday Inn Panama Distrito Financiero by IHG

4.0 star property
Bella Vista
8.8 out of 10, Excellent, (1004)
"The staff members are amazing!!"
United States
Cherisse
$91 nightly
The price is $100
Dec 30 - Dec 31
Total with taxes and fees
Holiday Inn Panama Distrito Financiero by IHG

Central Hotel Panama Casco Viejo

4.0 star property
Casco Viejo
9.0 out of 10, Wonderful, (1004)
"Excellent hotel , good breakfast, great location, would highly recommend "
United States
Glen
$202 nightly
The price is $222
Dec 12 - Dec 13
Total with taxes and fees
Central Hotel Panama Casco Viejo

Courtyard by Marriott Panama Multiplaza Mall

4.0 star property
San Francisco
8.8 out of 10, Excellent, (1000)
"Staff was very helpful. Great location."
United States
John
$114 nightly
The price is $125
Jan 3 - Jan 4, 2026
Total with taxes and fees
Courtyard by Marriott Panama Multiplaza Mall

Residence Inn by Marriott Panama City

4.0 star property
San Francisco
9.0 out of 10, Wonderful, (535)
"Amazing hotel amazing view service great location perfect "
United States
Melissa
$152 nightly
The price is $167
Jan 2 - Jan 3, 2026
Total with taxes and fees
Residence Inn by Marriott Panama City

Hyatt Regency Panama City

4.5 star property
Bella Vista
10.0 out of 10, Exceptional, (121)
"Great hotel fair price"
United States
Santiago
$135 nightly
The price is $149
Dec 13 - Dec 14
Total with taxes and fees
Hyatt Regency Panama City

Hotel San Felipe

4.0 star property
Casco Viejo
9.4 out of 10, Exceptional, (244)
"Really nice staff and property is in amazing location "
United States
Michael
$122 nightly
The price is $134
Dec 10 - Dec 11
Total with taxes and fees
Hotel San Felipe

Hotel La Compañía Casco Antiguo

4.5 star property
Casco Viejo
9.8 out of 10, Exceptional, (258)
"Great location!"
United States
Erik
$322 nightly
The price is $354
Dec 23 - Dec 24
Total with taxes and fees
Hotel La Compañía Casco Antiguo

Radisson Hotel Panama Canal

4.5 star property
Amador
8.6 out of 10, Excellent, (1002)
"Wonderful staff and easy checkin!"
United States
Kristin
$70 nightly
The price is $77
Dec 22 - Dec 23
Total with taxes and fees
Radisson Hotel Panama Canal
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Panama City.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama City

The gleaming skyscrapers of this cosmopolitan capital stand in striking contrast to the colonial charm of Casco Viejo. Watch massive ships navigate the Canal locks, then sample ceviche at the seafood market where local fishermen bring their daily catch.

Panoramic view at the Downtown of Panama City - Panama

Top Panama City Hotel Reviews

Price trends for properties with 4 Stars in Panama City

Less expensive
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This month
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January
November
$103
$101
Month
Price
January
$101
February
$102
March
$108
April
$118
May
$123
June
$120
July
$117
August
$125
September
$120
October
$120
November
$128
December
$103
Price trend information excludes taxes and fees and is based on base rates for a nightly stay for 2 adults found in the last 7 days on our site and averaged for commonly viewed properties with 4 stars in Panama City. Select dates and complete search for nightly totals inclusive of taxes and fees.

Find out more about Panama City

The outset of any much-needed trip kicks off with choosing a great destination. Panama City is a popular option with guests because it offers so much. Location is everything, but that applies to more than the area you are flying into. Now that you have a feel for this city, it is time you to get to know your home away from home.

Hotels as Picturesque as Panama City

Panama City saw its fair share of visitors last year. Expedia's comment section contains comments that highlight how astounding these hotels are. The resorts found here aim to make your stay as pleasant as your nights checking out Panama City. These hotels aim to make the grounds and facilities pleasing from the time you step onto the property. You'll never need to search long for an invigorating dip, gourmet lunch, or to keep up with your workout routine during your vacation with all that they offer.

Rooms have been configured to keep you as comfortable as possible, with amenities like in-room tea or coffee, designer bathroom products, and, premium bedding. So, sit back and relax. Moreover, if you find yourself in need of anything else, you can trust the staff will do their best to ensure you continue to be satisfied during your stay. These accommodations are so lovely that you'll regret the day you have to leave.

Book a 4-Star Hotel in Panama City Today!

A getaway to Panama City should be one that you'll recall for years to come, and booking a 4-star hotel will help make those memories nothing but incredible. Review Expedia's wide selection of 4-star hotels in Panama City that will take your trip to greater heights.

Frequently asked questions

What are the best 4-star hotels in Panama City?
Continental Hotel Panamá is a 4-star hotel in Panama City that ranks highly among Expedia travelers. A sauna and dining romance packages are just a couple of its amenities. Travelers also recommend Hotel El Panama by Faranda Grand, a member of Radisson Individuals. From premium bedding to Egyptian-cotton sheets, it offers conveniences that cater to every aspect of your relaxation and enjoyment.
How much does it cost to stay in a 4-star hotel in Panama City?
With Expedia's search and sort filters, scoring an awesome deal on a 4-star hotel in Panama City just got simpler. Start by keying in your chosen travel dates and length of your getaway. Then list the results by price and choose the option that best fits your style and budget.

  • Search for the lowest price from $135

What's the difference between 5-star and 4-star hotels in Panama City?
Treat yourself to luxury during your Panama City getaway by checking in to a 4-star hotel. As well as featuring upscale accommodations, these properties are usually packed with amenities, including large beds, complimentary bathrobes and more. A 5-star hotel will go above and beyond to make your trip an even more lavish and special one. Concierge assistance, elegant décor and world-class dining are just the start of the superior conveniences and services you'll likely get access to.

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