Find 4 Star Hotels in Defiance, MO from $127
Check availability on Defiance 4 Star Hotels
Compare Defiance 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Hilton St. Louis Frontenac
Frontenac
8.8 out of 10, Excellent, (1002)
"Very nice hotel. Friendly and helpful staff. "
Andrew
$112 nightly
The price is $130
Dec 20 - Dec 21
Total with taxes and fees
Ameristar Casino Resort and Spa
St. Charles
8.4 out of 10, Very Good, (1007)
"Beautiful hotel, spacious guestroom, comfortable beds, kind and helpful staff! "
Heather
$157 nightly
The price is $184
Dec 7 - Dec 8
Total with taxes and fees
DoubleTree by Hilton St. Louis - Westport
Maryland Heights
8.2 out of 10, Very Good, (1004)
"Stayed one night felt very safe here"
William
$110 nightly
The price is $127
Dec 28 - Dec 29
Total with taxes and fees
DoubleTree by Hilton Hotel St. Louis - Chesterfield
Chesterfield
8.6 out of 10, Excellent, (1006)
"Great hotel!"
John
$122 nightly
The price is $142
Dec 20 - Dec 21
Total with taxes and fees
The Inn at Elijah McLeans
Washington
8.8 out of 10, Excellent, (133)
"Modern"
Susan
$131 nightly
The price is $150
Dec 28 - Dec 29
Total with taxes and fees
Historic Main Street Heritage Retreat
St. Charles Historic District
9.4 out of 10, Exceptional, (37)
"No complaints here, would definitely stay here again! "
Adrienne R.
Landing Apartments - Eureka
Eureka
Save an average of 15% on thousands of hotels when you're signed in
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.
Top Defiance Hotel Reviews
Hilton St. Louis Frontenac
10/10 Excellent
Find out more about Defiance
Defiance Four Star Hotel Information
When you need to book a room with luxurious amazing amenities and the best rates, the 4 star hotels in Defiance, St. Louis are incredible options. Known for their extra perks, first-rate service, and fantastic locations, each of the Defiance 4 star hotels offers the ultimate experience for globe-trotting travelers. Relax in your expertly designed room. Kick back with around-the-clock room service.
Get a good night’s sleep with the ultra-plush bedding, and freshen up in the morning with designer-inspired body products. It’s all available when you stay at one of the top book a four star hotels in Defiance. What’s more, thanks to Expedia you might even score a cheap great deal on a 4 star hotel in Defiance, St. Louis, areas near the hottest attractions, so you can plan a sightseeing adventure and take advantage of unbeatable discounts in one fell swoop.
Whether you’re putting together a serene getaway or want to revel in the most vibrant entertainment district, 4 star Defiance hotels offer everything your heart desires.
Frequently asked questions
Explore a world of travel with Expedia
- Hotels near Yellow Farmhouse Winery
- Hotels near Chandler Hill Vineyards
- Hotels near Sugar Creek Winery
- Hamburg Hotels
- Saint Albans Hotels
- Villas in Saint Albans
- Vacation Homes in Saint Albans
- Cottages in Saint Albans
- Hotels near Historic Daniel Boone Home and Heritage Center
- Hotels near Babler State Park
- Hotels near Dr. Edmund A. Babler Memorial State Park
- Hotels near Weldon Spring Site Interpretive Center
- Hotels near Montelle Winery
- Hotels near August A. Busch Memorial Conservation Area
- Hotels near Broemmelsiek Park
- 5 Star Hotels in Augusta
- 3 Star Hotels in Augusta
- 4 Star Hotels in Weldon Spring Heights
- 3 Star Hotels in Weldon Spring Heights
- Augusta Hotels
- B&B in Augusta
- Cottages in Augusta
- RV Parks in Augusta
- Romantic Hotels in Augusta
- Cabin Rentals in Augusta
- Hotels with Hot Tubs in Augusta
- Drury Inn & Suites Hotels in Augusta
- Lodges in Augusta
- Resorts & Hotels with Spas in Augusta
- Chalets in Augusta
- Hotels & Resorts for Couples in Augusta
- Historic Hotels in Augusta
- Motels in Augusta
- Villas in Augusta
- Winery Hotels in Augusta
- Guest Houses in Augusta
- Hotels near St. Louis Premium Outlets
- Weldon Spring Heights Hotels
- B&B in Weldon Spring Heights
- Chalets in Weldon Spring Heights
- Motels in Weldon Spring Heights
- Cabin Rentals in Weldon Spring Heights
- Wyndham Hotels in Weldon Spring Heights
- Villas in Weldon Spring Heights
- Hotels near Missouri Bluffs Golf Course
- Hotels near Augusta Winery
- Weldon Spring Hotels
- Hotels near Spirit of St. Louis
- Hotels near Noboleis Vineyard
- Flights from Saint Albans
- Flights from Augusta
- Flights to Weldon Spring Heights
- Flights from Spirit of St. Louis
- Flights from Poplar Bluff (POF) to St. Louis (SUS)
- Flights from St. Louis (STL) to St. Louis (SUS)
- Flights from Mount Vernon (MVN) to St. Louis (SUS)
- Flights from Grand Rapids (GRR) to St. Louis (SUS)
- Flights from Los Angeles (LAX) to St. Louis (SUS)
- Flights from Joplin (JLN) to St. Louis (SUS)
- Flights from Atlanta (ATL) to St. Louis (SUS)
- Flights from Enid (WDG) to St. Louis (SUS)
- Flights from Minneapolis (MSP) to St. Louis (SUS)
- Flights from Detroit (DTW) to St. Louis (SUS)
- Flights from Las Vegas (LAS) to St. Louis (SUS)
- Flights from Lexington (LEX) to St. Louis (SUS)
- Flights from Chicago (ORD) to St. Louis (SUS)
- Flights from Kansas City (MCI) to St. Louis (SUS)
- Flights from Nashville (BNA) to St. Louis (SUS)
- Flights from Philadelphia (PHL) to St. Louis (SUS)
- Flights from Cincinnati (CVG) to St. Louis (SUS)
- Flights from Denver (DEN) to St. Louis (SUS)
- Yellow Farmhouse Winery
- Chandler Hill Vineyards
- Sugar Creek Winery
- Visit Saint Albans
- Historic Daniel Boone Home and Heritage Center
- Babler State Park
- Dr. Edmund A. Babler Memorial State Park
- Weldon Spring Site Interpretive Center
- Montelle Winery
- August A. Busch Memorial Conservation Area
- Broemmelsiek Park
- Augusta Vacations
- Visit Weldon Spring Heights
- St. Louis Premium Outlets
- Missouri Bluffs Golf Course
- Augusta Winery
- Car rentals near Hamburg
- Car rentals near Saint Albans
- Car rentals near Babler State Park
- Car rentals near Augusta
- Midway Car Rental Rental Cars in Augusta
- Car rentals near Weldon Spring Heights
- Car rentals near Weldon Spring
- Car rental St. Louis Airport (SUS)
- Enterprise Rental Cars in Spirit of St. Louis
- Budget Rental Cars in Spirit of St. Louis