Find spa resorts & hotels in Berkeley, St. Louis from $153
Check availability on Berkeley Resorts & Hotels with Spas
Our top choices for Berkeley hotels with a spa

Ameristar Casino Resort and Spa
St. Charles
8.4 out of 10, Very Good, (1001)
$166 nightly
The price is $194
Dec 14 - Dec 15
Total with taxes and fees

21C Museum Hotel St Louis
Downtown West
9.0 out of 10, Wonderful, (1489)
$131 nightly
The price is $153
Jan 4 - Jan 5, 2026
Total with taxes and fees

Four Seasons Hotel St Louis
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
$415 nightly
The price is $485
Jan 1 - Jan 2, 2026
Total with taxes and fees

The Ritz-Carlton, St. Louis
Clayton
9.2 out of 10, Wonderful, (553)
$499 nightly
The price is $583
Dec 21 - Dec 22
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Berkeley Hotel Reviews

Drury Inn & Suites St. Louis Union Station
10/10 Excellent
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