Cairo Vacations

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Your Cairo Vacation

The exciting city of Cairo is calling. Discover its hot spots and hidden treasures with a Cairo vacation package that's custom made for you. Need some ideas on what to do or see first during your trip to Cairo? Head straight for famous attractions like Fort Defiance State Park. No matter your travel plans or the size of your budget, putting together a tailored Cairo vacation is simple with Expedia.

Discover the most popular places to visit in Cairo

Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.

Fort Defiance State Park

Cairo Hotel Deals

Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 out of 5
13201 Kessler Road Cairo IL
Fully refundableReserve now, pay when you stay
$71 nightly
The price is $79 total per night from Jan 17 to Jan 18
$79 total
Jan 17 - Jan 18
Total with taxes and fees
6.4/10 (274 reviews)
Break fast was excellent

Reviewed on Sep 28, 2025

Quality Inn Cairo I-57
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
Fully refundableReserve now, pay when you stay
$62 nightly
The price is $69 total per night from Jan 4 to Jan 5
$69 total
Jan 4 - Jan 5
Total with taxes and fees
6.6/10 (614 reviews)
Thank you

Reviewed on Nov 7, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

Olive Branch IL
$133 nightly
The price is $140 total per night from Jan 4 to Jan 5
$140 total
Jan 4 - Jan 5
Total with taxes and fees
9.8/10 Exceptional! (34 reviews)
The cabin was great

Reviewed on Dec 1, 2025

Cozy cabins on beautiful Horseshoe Lake
See all 26 properties in Cairo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Cairo Vacation Packages

Cairo Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cape Girardeau Municipal Airport (CGI)
Population
2,500
Max Temp Winter
45ºF
Max Temp Summer
85ºF

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Frequently asked questions

How much does a Cairo vacation package cost?
Offering great value package deals on Expedia, you'll be pleasantly surprised at how much a vacation to Cairo costs! Expedia's packages simplify travel planning and maximize your savings.
What are the cheapest months to go to Cairo?
If you'd like to snag a cheap Cairo vacation package, consider planning a trip in December, January and February. You'll typically find lower prices on flights and accommodations during these quieter months — perfect for travelers wishing to save money.
How many days is enough for Cairo?
The ideal duration for your Cairo vacation depends on what you'd like to do. Generally, a few days to a week will give you plenty of time to go to all the major attractions and explore some hidden treasures along the way.
How to find the best Cairo package deals?
Landing a cheap Cairo package deal is a cinch with Expedia. Once you've entered your trip dates and destination under our "Packages" tab, set your budget range, apply some filters and see what's available. You can fine-tune your search by "Area," "Amenities," "Property type" and more. Sort the results by "Price: low to high" to view the most economical Cairo package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
Is it cheaper to book a Cairo vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to arranging accommodations and flights individually. Better still, you can customize your Cairo escape to match your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Cairo?
Score amazing discounts by reserving your flights in advance with Expedia. If spontaneity is more your style, snap up one of our last-minute deals for a spur-of-the-moment Cairo break.
Does Expedia offer Book Now, Pay Later Cairo vacation packages?
If you're anything like us, you love discovering new places but are not a fan of the price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can break down the overall cost of your Cairo vacation across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can secure great vacation packages with payment plans as soon as you spot them.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.