Charleston Vacation Rentals

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Our top choices for Charleston vacation rentals

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very Good, (56 reviews)
"Great cute place. "
United States
Jeremy W.
$101 nightly
The price is $108
May 23 - May 24
Total with taxes and fees
Little Blue Cottage on Spanish

Tranquil charming Tiny House in Clinton

Tranquil charming Tiny House in Clinton
Clinton
10.0 out of 10, Exceptional, (2 reviews)
"It is clean and comfortable. Would definitely stay again if ever in the area."
United States
Jennifer M.
$145 nightly
The price is $155
May 20 - May 21
Total with taxes and fees
Tranquil charming Tiny House in Clinton

Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (27 reviews)
"The place was quiet, clean and secluded. Exactly what my wife and I were looking for. Thanks for having us!"
United States
Andy I.
$175 nightly
The price is $185
May 19 - May 20
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
$166 nightly
The price is $174
Jun 18 - Jun 19
Total with taxes and fees
Studio Apt | King Bed, Full Kitchen · By KeenStays

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays
Cape Girardeau
$198 nightly
The price is $207
May 19 - May 20
Total with taxes and fees
Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Modern Boho Getaway · 1BR Apartment · By KeenStays

Modern Boho Getaway · 1BR Apartment · By KeenStays
Cape Girardeau
$160 nightly
The price is $167
May 31 - Jun 1
Total with taxes and fees
Modern Boho Getaway · 1BR Apartment · By KeenStays

The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"It’s very nice and comfortable "
United States
John S.
$133 nightly
The price is $140
May 25 - May 26
Total with taxes and fees
The Rested Duck Mallard Room

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (39 reviews)
"Peaceful and suited our needs perfectly."
United States
Matthew
$133 nightly
The price is $140
May 24 - May 25
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake

Vacation rental attached to our house out in the country.

Vacation rental attached to our house out in the country.
Union City
10.0 out of 10, Exceptional, (3 reviews)
"The home was spotless, very comfortable and a great location for what we needed."
United States
Sherrie S.
$145 nightly
The price is $162
May 19 - May 20
Total with taxes and fees
Vacation rental attached to our house out in the country.

Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
10.0 out of 10, Exceptional, (23 reviews)
"We enjoyed staying here very much. Clean and close to where we wanted to be!"
United States
Becky C.
$165 nightly
The price is $187
May 21 - May 22
Total with taxes and fees
Charming Home just minutes from Interstate and Mall

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (155 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
$229 nightly
The price is $248
May 19 - May 20
Total with taxes and fees
Serenity South -- Gardens, River-Views, and Refreshing Space

Welcoming 4-bedroom house with AC in charming La Center

Welcoming 4-bedroom house with AC in charming La Center
La Center
10.0 out of 10, Exceptional, (1 review)
"We stayed here while working on a project, and it was honestly one of the best stays I’ve had. The house was super clean, the beds were very comfortable, and the air conditioning worked great. The neighborhood felt safe, the neighbors were friendly, and the location was very convenient with a grocery store just a couple blocks away and a great pizza place nearby.I would definitely stay here again. Highly recommend!"
United States
Tom R.
$229 nightly
The price is $245
May 26 - May 27
Total with taxes and fees
Welcoming 4-bedroom house with AC in charming La Center

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (40 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
$302 nightly
The price is $317
May 26 - May 27
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
$571 nightly
The price is $620
May 19 - May 20
Total with taxes and fees
Building at Cape Girardeau Regional Airport

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
$529 nightly
The price is $555
May 26 - May 27
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid
10.0 out of 10, Exceptional, (1 review)
"The host was very quick to respond and so great to work with for on our stay. "
United States
Jessica S.
$343 nightly
The price is $369
May 19 - May 20
Total with taxes and fees
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Charleston Hotel Reviews

Find out more about Charleston

Everything you need to know about Charleston vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Charleston vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Charleston vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Charleston vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Charleston. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Charleston in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $108 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Charleston rentals

At Expedia, we put the best Charleston vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Charleston rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Charleston vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Charleston. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Charleston?

Yes, we have vacation rentals close to the most popular sights in Charleston, or you can go with a secluded option if you want a relaxing place to stay. Our travelers say Charleston has a good selection of restaurants. Make sure you have time to check out the entertainment choices and theaters during your trip.

What are some of the best vacation rentals that Charleston has to offer?

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau: Visitors like this Charleston vacation home rental. It is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

What can I see and do in Charleston?

Mississippi River and Ohio River are a couple of lovely local spots to get outside and enjoy nature. Sikeston Depot Museum and Ballard Wildlife Management Area are a couple of places you'll find in the larger area.

What are vacation rentals like in Charleston?

Vacation rentals are private accommodations you can book for a few days or a quick weekend in Charleston. Vacation rentals feature extras like WiFi and washers and dryers so you'll feel just like you're at home. If you're concerned about a sanitized environment, vacation rentals can offer a sense of security away from shared hotel elevators and bustling concierge desks while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which makes a vacation rental a great choice for family trips.