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Find luxury hotels in Clarksdale, MS

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Top Clarksdale Luxury Hotels

Quality Inn

2.5 star property
Clarksdale
7.4 out of 10, Good, (705)
"Room was great! Staff is always nice and sociable."
United States
LaVonda
$80 nightly
The price is $87
Jan 5 - Jan 6, 2026
Total with taxes and fees
Quality Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Clarksdale

Clarksdaleand its attractions for luxury travelers

Clarksdale, Mississippi, is a paradise for luxury travelers seeking an authentic Southern experience infused with rich culture and music. Start your journey at the Delta Blues Museum, where you can immerse yourself in the history of blues music, featuring exhibits that showcase legendary artists and the region's musical heritage. Next, enjoy a stroll through the vibrant downtown area where you can find upscale boutiques and art galleries, perfect for an afternoon of shopping and cultural exploration. The historic Crossroads, where blues legend Robert Johnson famously sold his soul, offers a unique photo opportunity and a taste of local lore. For a taste of local flavors, indulge in fine dining at acclaimed restaurants like Ground Zero Blues Club, known for its vibrant ambiance and live music, ensuring a memorable meal. Finally, consider staying at a luxury boutique hotel that offers personalized service and unique character, like the locally owned and operated hotels that reflect the spirit of the Delta. This area provides a rich backdrop for your stay, with easy access to local attractions, ensuring convenience and a truly pampered experience.

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Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Clarksdale?
Use Expedia to arrange your flight to Tunica, MS (UTM-Tunica Municipal) airport or Greenville, MS (GLH-Mid Delta Regional) airport, and then choose from a variety of places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Clarksdale has to offer. During your visit, you might want to enjoy the restaurants which Clarksdale is known for.
When can I expect good weather in Clarksdale?
Planning for the weather is an important factor for making your trip to Clarksdale a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 79°F, while the coldest months are January and February with an average of 47°F. Average annual precipitation for Clarksdale is 55 inches.
What's there to see and do in Clarksdale?
Enjoy all that Clarksdale has to offer when you visit Delta Blues Museum, Red's Lounge, and Mississippi River. If you have spare time during your trip, you might want to make a stop at The Holy Moly Theatre and Ground Zero Blues Club.

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