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Find Resorts & Hotels with Spas in Clarksville, IN

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Check availability on Clarksville Resorts & Hotels with Spas

Our top choices for Clarksville hotels with a spa

4 restaurants, breakfast, lunch, dinner served; American cuisine
Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (3845)
"Beautiful room and great hospitality. "
United States
Chase
$133 nightly
The price is $157
Dec 15 - Dec 16
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham
Indoor pool
Caesars Southern Indiana - A Caesars Rewards Destination

Caesars Southern Indiana - A Caesars Rewards Destination

3.5 star property
Elizabeth
8.2 out of 10, Very Good, (1008)
"The room was very clean, the staff was very friendly and helpful."
United States
Judy
$89 nightly
The price is $99
Dec 10 - Dec 11
Total with taxes and fees
Caesars Southern Indiana - A Caesars Rewards Destination
Sauna, body treatments, aromatherapy, hot stone massages
Omni Louisville Hotel

Omni Louisville Hotel

4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1714)
"Clean room, friendly staff"
United States
Jill
$167 nightly
The price is $197
Jan 1 - Jan 2, 2026
Total with taxes and fees
Omni Louisville Hotel
Full-size fridge, microwave, oven, stovetop
The Reserve on Main

The Reserve on Main

4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
$190 nightly
The price is $213
Dec 14 - Dec 15
Total with taxes and fees
The Reserve on Main
Front of property
21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1002)
" Loved our stay, would definitely plan to come back if we are ever in the area again."
United States
Erica
$143 nightly
The price is $169
Jan 1 - Jan 2, 2026
Total with taxes and fees
21c Museum Hotel Louisville
Exterior detail
Central Park Bed & Breakfast

Central Park Bed & Breakfast

4.0 star property
Old Louisville
9.4 out of 10, Exceptional, (56)
"The room was phenomenal and breakfast was even better! The whole place is adorable!"
United States
Cher
$134 nightly
The price is $156
Dec 15 - Dec 16
Total with taxes and fees
Central Park Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Clarksville Hotel Reviews

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

10/10 Excellent
"It sucks waiting on the elevator "
Rob 2-night trip
Posted 15 hours ago
Galt House Hotel Trademark Collection by Wyndham

Frequently asked questions

Looking for a spa hotel in Clarksville?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Travelers recommend the gourmet restaurants in Clarksville. Enjoy the shopping and waterfalls during your vacation. Hotels with spas are a great way to break out of your daily routine and add a layer of luxury to your vacation.
What's there to see and do in Clarksville?
When you're in Clarksville, enjoy exploring the sights and attractions here including Derby Dinner Playhouse, Falls of the Ohio State Park, and Ohio River Valley. If you have a little extra time during your trip, you might want to check out Atlantis Waterpark and Old Clarksville Site.
What is a Clarksville spa hotel?
Spa hotels in Clarksville provide lodging and have a full on-site spa which offers services such as couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

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