Find hotels in Grand Isle, Port St. Joe

Start date: Check-in selected.
To Date
End date: Check-out

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 2 - Dec 3
Tomorrow
Dec 3 - Dec 4
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Filter by

Guest rating
Guest rating
Star rating

Discover Grand Isle hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
The Port Inn and Cottages, an Ascend Collection Hotel

The Port Inn and Cottages, an Ascend Collection Hotel

3.5 star property
Downtown Port St. Joe, 11.1 mi from Grand Isle
9.0 out of 10, Wonderful, (401)
"Enjoyed our stay."
United States
Richard
$125 nightly
The price is $140
Dec 14 - Dec 15
Total with taxes and fees
The Port Inn and Cottages, an Ascend Collection Hotel
Suite, Multiple Beds, Accessible, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets
MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

2.5 star property
13.7 mi from Grand Isle
8.6 out of 10, Excellent, (694)
"Room was clean, kitchen very clean, hotel staff was very friendly "
United States
Donna
$110 nightly
The price is $123
Dec 14 - Dec 15
Total with taxes and fees
MainStay Suites Port Saint Joe South
Exterior
Candlewood Suites Panama City Tyndall AFB by IHG

Candlewood Suites Panama City Tyndall AFB by IHG

2.5 star property
17.8 mi from Grand Isle
9.6 out of 10, Exceptional, (33)
"The room was great, the staff was friendly and helpful. "
United States
Robert
$96 nightly
The price is $103
Dec 12 - Dec 13
Total with taxes and fees
Candlewood Suites Panama City Tyndall AFB by IHG
Laptop workspace, iron/ironing board, free cribs/infant beds, free WiFi
Days Inn by Wyndham Panama City/Callaway

Days Inn by Wyndham Panama City/Callaway

2.0 star property
18.3 mi from Grand Isle
6.8 out of 10, (476)
"Room was clean and the staff was friendly and helpful."
United States
Billie
$55 nightly
The price is $59
Dec 4 - Dec 5
Total with taxes and fees
Days Inn by Wyndham Panama City/Callaway
Exterior
Cape San Blas Inn

Cape San Blas Inn

3.0 star property
16.8 mi from Grand Isle
9.8 out of 10, Exceptional, (79)
"Great host excellent location we will be back"
United States
Tonianne
$334 nightly
The price is $374
Dec 3 - Dec 4
Total with taxes and fees
Cape San Blas Inn
Free buffet breakfast
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG

2.5 star property
18.1 mi from Grand Isle
8.4 out of 10, Very Good, (444)
"We enjoyed our stay."
United States
Lisa
$96 nightly
The price is $103
Dec 6 - Dec 7
Total with taxes and fees
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
Lobby
Comfort Suites

Comfort Suites

2.5 star property
18 mi from Grand Isle
8.6 out of 10, Excellent, (713)
"Very nice room. But the TV is in front of the bed instead of the couch. Terrible breakfast buffet. That was the major flaw. Slow to check us in but I can forgive that. "
United States
Deborah
$85 nightly
The price is $91
Jan 1 - Jan 2, 2026
Total with taxes and fees
Comfort Suites
Desk, laptop workspace, iron/ironing board, free WiFi
Extended Stay America Select Suites - Panama City - Callaway

Extended Stay America Select Suites - Panama City - Callaway

2.5 star property
18.7 mi from Grand Isle
6.2 out of 10, (493)
"great stay"
United States
Victor
$70 nightly
The price is $75
Dec 13 - Dec 14
Total with taxes and fees
Extended Stay America Select Suites - Panama City - Callaway
Aerial view
Cape Cottages by Panhandle Getaways

Cape Cottages by Panhandle Getaways

3.5 star property
14.2 mi from Grand Isle
10.0 out of 10, Exceptional, (4)
"Brand new, quaint spot with really comfortable beds. "
United States
Anonymous traveler
$472 nightly
The price is $529
Dec 6 - Dec 7
Total with taxes and fees
Cape Cottages by Panhandle Getaways
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Grand Isle

Find the best Grand Isle areas and neighborhoods for the activities you enjoy most.

Downtown Port St. Joe

While visiting Downtown Port St. Joe, you might make a stop by sights like Port Saint Joe City Hall and Port St. Joe Marina.

Cape Breezes

While Cape Breezes isn't home to many top sights, T.H. Stone Memorial St. Joseph Peninsula State Park and St. Joseph Peninsula State Park are some notable places to visit nearby.

Gulf Aire

While Gulf Aire isn't home to many top sights, Saint Joe Beach and Mexico Beach are some notable places to visit nearby.

Waterside Village

Though Waterside Village might not have many top sights, you can venture to the surrounding area to see attractions like Mexico Beach Marina and Mexico Beach.

Palms

While there might not be top attractions in Palms, you can explore the larger area and discover places like Mexico Beach and Mexico Beach Marina.

Top Grand Isle Hotel Reviews

MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

10/10 Excellent
"Everything was great. Friendly, accommodating staff. Awesome breakfast"
Theresa 7-night trip
Posted 2 days ago
MainStay Suites Port Saint Joe South

Frequently asked questions

Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Grand Isle.
How can I save on a Grand Isle hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Grand Isle hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Grand Isle hotel?
Hotel prices in Grand Isle often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia