Title: Mesilla Vacation Rentals from $133: Search Short-Term Rentals | Expedia.com [Mesilla Travel Guide](https://expedia.com/Mesilla.dx132684)[Hotels in Mesilla](https://expedia.com/Mesilla-Hotels.d132684.Travel-Guide-Hotels)[Flights to Mesilla](https://expedia.com/Cheap-Flights-To-Mesilla.d132684.Travel-Guide-Flights)[Car Rentals in Mesilla](https://expedia.com/Car-Rentals-In-Mesilla.d132684.Car-Rental-Guide)[Mesilla Vacation Packages](https://expedia.com/Mesilla.d132684.Destination-Travel-Guides) ![Red chile doorway Mesilla NM](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/132684/621c4b20-e7ee-452c-9495-0ec62a9d9908.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ## Check prices for these dates In two weeks [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-03-27&endDate=2026-03-29&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [May 8 - May 10](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Jun 5 - Jun 7](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-06-05&endDate=2026-06-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [Jul 3 - Jul 5](https://www.expedia.com/Hotel-Search?regionId=132684&startDate=2026-07-03&endDate=2026-07-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mesilla vacation rentals ![Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/798477c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/262fc47e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/c977937e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/120000000/119930000/119923800/119923794/ccb4ff70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Las Cruces Home w/ Fenced Yard: Recently Remodeled [](https://www.expedia.com/Las-Cruces-Home-W-Fenced-Yard-Recently-Remodeled.h119923794.Hotel-Information) Las Cruces $223 nightly $256 total Mar 16 - Mar 17 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Home-W-Fenced-Yard-Recently-Remodeled.h119923794.Hotel-Information) ![House, 2 Bedrooms | Living area | Smart TV, streaming services](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/043ded28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, 2 Bedrooms | Private kitchen | Fridge, oven, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/6fad21b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, 2 Bedrooms | Interior](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/a0826640.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, 2 Bedrooms | Living area | Smart TV, streaming services](https://images.trvl-media.com/lodging/121000000/120410000/120402300/120402249/097df6e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Desert Haven Cozy 2-Bedroom Mobile Home Near NMSU 2 Home [](https://www.expedia.com/Las-Cruces-Hotels-Desert-Haven-Cozy-2-Bedroom-Mobile-Home-Near-NMSU-2-Home.h120402249.Hotel-Information) Las Cruces $337 nightly $385 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Las-Cruces-Hotels-Desert-Haven-Cozy-2-Bedroom-Mobile-Home-Near-NMSU-2-Home.h120402249.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-28&endDate=2026-03-29®ionId=132684&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=VR_SPRING_PROMO_132684) ## Find vacation rentals that suit your style Private vacation homes [](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-12&d1=2026-06-12&endDate=2026-06-15&d2=2026-06-15&lodging=VACATION_HOME) Apartments [](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-12&d1=2026-06-12&endDate=2026-06-15&d2=2026-06-15&lodging=APARTMENT) Cottages [](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-12&d1=2026-06-12&endDate=2026-06-15&d2=2026-06-15&lodging=COTTAGE) Villas [](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-12&d1=2026-06-12&endDate=2026-06-15&d2=2026-06-15&lodging=VILLA) Condos [](https://www.expedia.com/Hotel-Search?destination=Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=132684&latLong=32.270096%2C-106.800835&adults=2&startDate=2026-06-12&d1=2026-06-12&endDate=2026-06-15&d2=2026-06-15&lodging=CONDO) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMesilla-Vacation-Rentals.d132684.Travel-Guide-VacationRentals) ## Top Mesilla Hotel Reviews ![Hampton Inn & Suites Las Cruces I-10](https://images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/dec3042f_y.jpg) ### Hampton Inn & Suites Las Cruces I-10 10/10 Excellent "We Stayed here for one nite in early March heading to Texas, and had a pleasant stay. Plenty of towels, comfy room, plenty of parking. Being able to have free breakfast before we left that next morning was great! Breakfast started at 6am which was perfect! " [](https://expedia.com/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](https://images.trvl-media.com/lodging/1000000/80000/75400/75365/e54f14db_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 6/10 Okay "There are no usb plugs. It just seemed very old" [](https://expedia.com/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-25](https://images.trvl-media.com/lodging/2000000/1670000/1665200/1665185/fc08ee64_y.jpg) ### Hampton Inn & Suites Las Cruces I-25 10/10 Excellent "Nice place " [](https://expedia.com/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-25.h1665185.Hotel-Information) ![Best Western Mission Inn](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/798cead2_y.jpg) ### Best Western Mission Inn 10/10 Excellent "Everyone was friendly, and welcoming. The room was very nice. The breakfast was delicious." [](https://expedia.com/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![Hotel Encanto de Las Cruces](https://images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 8/10 Good "Nice hotel. Pleasant stay. " [](https://expedia.com/Las-Cruces-Hotels-Hotel-Encanto-De-Las-Cruces.h21267.Hotel-Information) ![Drury Inn & Suites Las Cruces](https://images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/46263956_y.jpg) ### Drury Inn & Suites Las Cruces 10/10 Excellent "All was good " [](https://expedia.com/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Days Inn by Wyndham Las Cruces](https://images.trvl-media.com/lodging/1000000/20000/15100/15035/b4a415ed_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent "King Room was spacious and clean!" [](https://expedia.com/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Super 8 by Wyndham Las Cruces/White Sands Area](https://images.trvl-media.com/lodging/1000000/50000/42400/42327/8d2f8dc0_y.jpg) ### Super 8 by Wyndham Las Cruces/White Sands Area 10/10 Excellent "I have stayed here several times and it has always been a good visit." [](https://expedia.com/Las-Cruces-Hotels-Super-8-By-Wyndham-Las-CrucesWhite-Sands-Area.h42327.Hotel-Information) ![Comfort Suites University Las Cruces](https://images.trvl-media.com/lodging/1000000/50000/43200/43179/3f986bbe_y.jpg) ### Comfort Suites University Las Cruces 8/10 Good "The staff were extremely nice and helpful. The room was nice except that my husband figured out that the AC cool light was broken so that’s why we weren’t cooling down. And the bed was very comfortable " [](https://expedia.com/Las-Cruces-Hotels-Comfort-Suites-University-Las-Cruces.h43179.Hotel-Information) ## Find out more about Mesilla **Everything you need to know about Mesilla vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mesilla vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on. There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mesilla vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. **Mesilla vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in Mesilla. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Mesilla in high season. Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $133 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals! **How to find incredible deals on Mesilla rentals** At Expedia, we put the best Mesilla vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. To find some top Mesilla rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mesilla vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mesilla. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. ## Explore a world of travel with Expedia - Trending destinations on Expedia.com - All accommodation types in Mesilla ### Trending destinations on Expedia.com - [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals) - [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals) - [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals) - [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals) - [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals) - [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals) - [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals) - [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals) - [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals) - [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals) - [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals) - [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals) - [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals) - [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals) - [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals) - [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals) - [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals) - [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals) - [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations) - [Vacation Homes in Mesilla ](https://expedia.com/Mesilla-Private-Vacation-Homes.d132684-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Apartments in Mesilla ](https://expedia.com/Mesilla-Apartments.d132684-aaApartments.Travel-Guide-Accommodation) - [Cottages in Mesilla ](https://expedia.com/Mesilla-Cottages.d132684-aaCottages.Travel-Guide-Accommodation) - [Condo Rentals in Mesilla ](https://expedia.com/Mesilla-Condos.d132684-aaCondos.Travel-Guide-Accommodation) - [Villas in Mesilla ](https://expedia.com/Mesilla-Villas.d132684-aaVillas.Travel-Guide-Accommodation) - [Guest Houses in Mesilla ](https://expedia.com/Mesilla-Guest-Houses.d132684-aaGuestHouses.Travel-Guide-Accommodation) - [Motels in Mesilla ](https://expedia.com/Mesilla-Motels.d132684-aaMotels.Travel-Guide-Accommodation) - [Farmstay in Mesilla ](https://expedia.com/Mesilla-Agritourism.d132684-aaAgritourism.Travel-Guide-Accommodation) ## Frequently asked questions ### Can I find a vacation rental in Mesilla? 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