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Find luxury hotels in South San Francisco, CA

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Our top choices for South San Francisco luxury hotels

Travelodge by Wyndham San Francisco Airport North

2.0 star property
South San Francisco
5.8 out of 10, (2901)
"Price and location were great"
United States
Tiber A.
$60 nightly
The price is $72
Dec 14 - Dec 15
Total with taxes and fees
Travelodge by Wyndham San Francisco Airport North

Hotel Focus SFO

3.0 star property
The East Side
7.6 out of 10, Good, (1523)
"Good hotel."
United States
Peter
$86 nightly
The price is $101
Dec 29 - Dec 30
Total with taxes and fees
Hotel Focus SFO

Comfort Inn and Suites San Francisco Airport North

2.5 star property
The East Side
7.8 out of 10, Good, (1002)
"Very nice room and staff "
United States
Robert
$93 nightly
The price is $109
Jan 3 - Jan 4, 2026
Total with taxes and fees
Comfort Inn and Suites San Francisco Airport North

Embassy Suites by Hilton San Francisco Airport Oyster Point

3.5 star property
The East Side
8.6 out of 10, Excellent, (1231)
"Everything was just great the amenities the staff the cleanliness the breakfast I had a very relaxing and great time "
United States
Lily
$106 nightly
The price is $125
Jan 9 - Jan 10, 2026
Total with taxes and fees
Embassy Suites by Hilton San Francisco Airport Oyster Point

Hilton Garden Inn San Francisco Arpt North

3.0 star property
The East Side
8.4 out of 10, Very Good, (1009)
"Staff, amenities, clean rooms "
United States
ROMEO JR
$91 nightly
The price is $107
Dec 20 - Dec 21
Total with taxes and fees
Hilton Garden Inn San Francisco Arpt North

Larkspur Landing Extended Stay Suites South San Francisco

3.0 star property
The East Side
7.8 out of 10, Good, (1002)
"The staff and the area is safe and clean"
United States
Em
$94 nightly
The price is $112
Dec 13 - Dec 14
Total with taxes and fees
Larkspur Landing Extended Stay Suites South San Francisco

Park Pointe Hotel

2.0 star property
South San Francisco
5.8 out of 10, (1005)
"Great place to stay "
United States
shamika
$67 nightly
The price is $79
Dec 10 - Dec 11
Total with taxes and fees
Park Pointe Hotel

La Quinta Inn & Suites by Wyndham San Francisco Airport N

3.0 star property
Downtown South San Francisco
8.0 out of 10, Very Good, (2007)
"Breakfast is great. Staff is great."
United States
Trina
$112 nightly
The price is $131
Dec 20 - Dec 21
Total with taxes and fees
La Quinta Inn & Suites by Wyndham San Francisco Airport N

Hampton Inn San Francisco Airport

2.5 star property
The East Side
8.8 out of 10, Excellent, (1005)
"Amazing place, 100% recommend "
United States
Ana catherine
$107 nightly
The price is $127
Jan 1 - Jan 2, 2026
Total with taxes and fees
Hampton Inn San Francisco Airport

Days Inn by Wyndham San Francisco S/Oyster Point Airport

2.0 star property
Paradise Valley
6.4 out of 10, (1000)
"Rooms were wonderfully maintained!!"
United States
Thomas
$84 nightly
The price is $101
Dec 12 - Dec 13
Total with taxes and fees
Days Inn by Wyndham San Francisco S/Oyster Point Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about South San Francisco

South San Franciscoand its attractions for luxury travelers

South San Francisco offers a unique blend of luxury and convenience for travelers. Begin your stay by exploring the stunning Bayfront Park, where you can enjoy picturesque views of the San Francisco skyline and indulge in a leisurely stroll along the waterfront, perfect for families seeking both relaxation and adventure. For a taste of local culture, visit the South San Francisco Historical Society Museum, which offers insights into the city's rich heritage and charming past, making it an enjoyable stop for parents and children alike. Take a short drive to the nearby San Bruno Mountain State Park, where upscale hiking trails lead to breathtaking vistas of the Bay Area, ideal for families looking to bond over outdoor activities. After a day of exploration, unwind at the luxurious Grand Hyatt at SFO, famous for its exquisite amenities and exceptional guest service, ensuring your family feels pampered throughout your stay. With its close nearby the airport and top dining options, including gourmet restaurants like the renowned Koi Palace for authentic dim sum, South San Francisco presents an ideal base for luxury travelers seeking quality experiences.

Find the best luxury hotels and resorts in South San Francisco

For travelers seeking a luxurious stay in South San Francisco, these top hotels offer exceptional amenities and service, ensuring a refined experience throughout your visit.

AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront

  • Why it's great for a luxury retreat: A perfect choice for travelers, the AC Hotel by Marriott San Francisco Airport Oyster Point/Waterfront boasts a remarkable guest review rating of 9.2. This hotel features a dedicated concierge service, ensuring that guests receive personalized attention and assistance during their stay, adding a touch of luxury to every interaction. Enjoy a refreshing dip in the indoor pool, or maintain your fitness routine in the 24-hour fitness center, designed for those who appreciate convenience and quality.
  • Other amenities: Additional amenities include accessible parking options, free daily housekeeping, and free toiletries that elevate the stay. Guests will also appreciate the serene garden setting, electric car charging stations, and the option of rollaway beds for added comfort. With self-parking and van parking available, travelers can enjoy easy access to their vehicles while savoring the upscale atmosphere of this waterfront hotel.
  • Neighborhood: Oyster Point
  • Nearby attractions: South San Francisco Convention Center - 1.59 miles, San Francisco Baking Institute - 1.9 miles, San Francisco Bay - 1.77 miles

Embassy Suites by Hilton San Francisco Airport Oyster Point

  • Why it's great for a luxury retreat: With a solid guest review rating of 8.6, the Embassy Suites by Hilton San Francisco Airport Oyster Point stands out as a luxury option for travelers. This hotel is known for its spacious suites and executive rooms, providing guests with ample space and comfort. The concierge service is dedicated to helping guests make the most of their stay, whether it's dining recommendations or local attractions, ensuring a tailored experience.
  • Other amenities: Guests can enjoy the complimentary buffet breakfast, perfect for starting the day off right. The hotel also offers an indoor pool, fitness facilities that are accessible 24/7, and convenient airport transportation services. Additional features include self-parking, a garden for relaxation, and shopping options both on-site and nearby. With a focus on premium bedding and spacious living areas, guests are sure to feel pampered and well taken care of.
  • Neighborhood: The East Side
  • Nearby attractions: South San Francisco Convention Center - 0.96 miles, SFO Museum - 1.71 miles, San Francisco Baking Institute - 1.28 miles

DoubleTree by Hilton San Francisco South Airport Blvd

  • Why it's great for a luxury retreat: Guests will find a luxurious escape at the DoubleTree by Hilton San Francisco South Airport Blvd, where an impressive review rating of 8.4 reflects the quality of service and comfort provided. The hotel features convenient amenities like a dedicated concierge and air conditioning throughout, ensuring a pleasant and personalized experience. The inviting atmosphere is complemented by a scheduled airport shuttle service, making travel seamless for guests arriving or departing.
  • Other amenities: In addition to luxury amenities, the hotel offers flexible check-in and check-out options, as well as express services for those on a tight schedule. Guests can unwind at the accessible pool or enjoy the fitness center, with options for early check-in to maximize their stay. The presence of a grocery store on-site and shopping opportunities nearby make it convenient for guests to indulge in leisure activities, while free internet access ensures connectivity throughout their visit.
  • Nearby attractions: South San Francisco Convention Center - 0.06 miles, SFO Museum - 0.85 miles, San Francisco Baking Institute - 1.58 miles

Top South San Francisco Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to South San Francisco?
Let Expedia help you arrange your flight to San Francisco Intl. Airport (SFO) airport or Oakland Intl. Airport (OAK) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay special. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can assist you in finding the best luxury hotel experience that South San Francisco offers. During your visit, you might want to enjoy the sightseeing and tours which South San Francisco is known for.
When can I expect good weather in South San Francisco?
Planning for the weather is an important factor for making your trip to South San Francisco a success, especially when you're splurging. The hottest months are usually September and August with an average temp of 62°F, while the coldest months are February and January with an average of 53°F. Average annual precipitation for South San Francisco is 23 inches.
What's there to see and do in South San Francisco?
Take in some sights and attractions while you're in South San Francisco by visiting San Francisco Bay, Santa Cruz Mountains, and See's Candies. If you have spare time during your trip, you might want to make a stop at San Bruno Point Park and K1 Speed.
How can I get around South San Francisco?
It's easier to get around town in style when you know your options. Make your way to South San Francisco Metro Station to catch metro. To see more of the larger area, hop on a train at South San Francisco Station.

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