Title: Santa Cruz Vacation Rentals from $27: Search Short-Term Rentals | Expedia.com

[Santa Cruz Travel Guide](https://expedia.com/Santa-Cruz.dx6053940)[Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)[Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)[Things to do in Santa Cruz](https://expedia.com/Things-To-Do-In-Santa-Cruz.d6053940.Travel-Guide-Activities)[Car Rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)[Santa Cruz Vacation Packages](https://expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides)

![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 13 - Mar 15](https://www.expedia.com/Hotel-Search?regionId=6053940&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 24 - Apr 26](https://www.expedia.com/Hotel-Search?regionId=6053940&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=6053940&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=6053940&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santa Cruz vacation rentals

![Standard Suite, 1 Queen Bed | Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e2b53d65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e1ac9300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/6f15dda8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/3e13fa51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

9.0/10

Wonderful

(12 reviews)

"Perfect hotel"

![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg)

Yener

$47 nightly

$47 total

Mar 1 - Mar 2

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1510x0y0-a0234ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1500x0y7-eed47d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/c3714572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/1c1dec0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

10/10

Exceptional

(1 review)

"Clean room, great staff "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Peter

$55 nightly

$55 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/47df2d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge, microwave, electric kettle, cookware/dishes/utensils](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/6fc90c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/1f2b7f07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

8.0/10

Very Good

(90 reviews)

"Easy to access"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dorothy

$48 nightly

$48 total

Mar 10 - Mar 11

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

![Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b86b5103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/0144c46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b5037c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Apartment, 1 King Bed with Sofa bed, Terrace | Premium bedding, down comforters, Tempur-Pedic beds, in-room safe](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/3e7101b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

9.0/10

Wonderful

(86 reviews)

"Good price, great hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

$39 nightly

$39 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/9c745b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/ee5e58e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/af761024.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/91978058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

$55 nightly

$55 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/9a481119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/3d263a1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, Terrace (Plus) | Terrace/patio](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/b0eabde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

8.6/10

Excellent

(99 reviews)

"Yes, staff were very friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

veronica

$27 nightly

$27 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/w1290h2293x0y251-5b08e5b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/21992b29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels, toilet paper](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f6e53b9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f8f1dd6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

8.0/10

Very Good

(1 review)

"Muy buen departamento, bien ubicado"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elva

$59 nightly

$59 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/83c0e879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/2d334027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/809a343e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/c0d4ffcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

8.8/10

Excellent

(60 reviews)

"Very comfortable and quiet place and very good location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/fdb44263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/080d90c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1927x0y24-b8c75958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1583x0y0-5b3fde27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

$65 nightly

$65 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/494b7af9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Children's area](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/81a819db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/bc52c455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/6649134a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Chalet in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Chalet-Indept.h102550831.Hotel-Information)

$35 nightly

$35 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Chalet-Indept.h102550831.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/1b6db924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/55cf49f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/d11c7efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/85781538.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

$83 nightly

$83 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/0f570e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/2254dc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/09ebee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/5af8579d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

$42 nightly

$42 total

Mar 1 - Mar 2

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/206167b0_edited_22cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/32a88bcf_edited_de17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/e59e23c9_edited_fb52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/0c7b09d8_edited_c88f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Tranquil-Apartment-With-WiFi-In-Santa-Cruz-De-La-Sierra.h112222028.Hotel-Information)

10/10

Exceptional

(2 reviews)

"Zona tranquila y todo cerca supermercados tiendas etc"

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Fabricio O.

$60 nightly

$60 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Tranquil-Apartment-With-WiFi-In-Santa-Cruz-De-La-Sierra.h112222028.Hotel-Information)

![1 bedroom, free WiFi](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/9c6cc778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/b5dde86c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/99089910.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/ada57e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information)

10/10

Exceptional

(1 review)

"The place was cozy, neat, and th host was very attentive and supportive. I recomend this place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mauricio O.

$76 nightly

$76 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/w689h954x0y0-7d2c5be0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, oven, dishwasher, electric kettle](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/7272b045.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/af1568a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/bde12cb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

$52 nightly

$52 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/6d55bdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, electric kettle](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/d7013903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/9a14a6db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/1c0d3586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Condo in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

$67 nightly

$67 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/6663a26a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/20029dec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/w1257h960x23y0-1ca3484e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/f8c2e918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information)

$48 nightly

$48 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/89a86d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/80f980e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/5c4a14d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/08ad0327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

$50 nightly

$50 total

Mar 1 - Mar 2

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/fbbf5c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/a66dc8d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/2b7e7464.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/e8ecf36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

$60 nightly

$60 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-11&endDate=2026-03-12&regionId=6053940&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## Find vacation rentals that suit your style

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=VACATION_HOME)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CONDO)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=APART_HOTEL)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=HOUSE_BOAT)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CABIN)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=CHALET)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Santa+Cruz%2C+Bolivia&regionId=6053940&latLong=-17.784489%2C-63.180824&adults=2&startDate=2026-05-26&d1=2026-05-26&endDate=2026-05-29&d2=2026-05-29&lodging=COTTAGE)

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## Top Santa Cruz Hotel Reviews

![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg)

### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent

"Lovely staff. Great buffets. "

[](https://expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information)

![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg)

### Chairú Eco Hotel

10/10 Excellent

"The room was 👌 perfect!!!The staff was perfect,especially front desc -Alvaro and Francisco!They gave me free earlier check in,send me location when I was late outside ,help for my safe and etc. These people deserve something more in the hotel business!!!"

[](https://expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information)

![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/53c67151_y.jpg)

### Ibis Santa Cruz DE LA Sierra

10/10 Excellent

"Great value "

[](https://expedia.com/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information)

![Premium Suites Deluxe Aparthotel Equipetrol](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/12ef5e8d_y.jpg)

### Premium Suites Deluxe Aparthotel Equipetrol

10/10 Excellent

"Clean rooms, friendly people who work there. Parking always a plus "

[](https://expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Delfines Collection Hotel By Mercure](https://images.trvl-media.com/lodging/91000000/90310000/90301900/90301892/fd3e0846_y.jpg)

### Delfines Collection Hotel By Mercure

10/10 Excellent

"Yes room was tidy and clean. Beds were very comfortable "

[](https://expedia.com/Santa-Cruz-Hotels-Delfines-Collection-Hotel-By-Mercure.h90301892.Hotel-Information)

![Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765_y.jpg)

### Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

10/10 Excellent

"Clean room "

[](https://expedia.com/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information)

![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418_y.jpg)

### Camino Real Hotel

10/10 Excellent

"Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options."

[](https://expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information)

![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/d021f216_y.jpg)

### Sun Hotel

10/10 Excellent

"Awesome place "

[](https://expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information)

![HOTEL OSHO](https://images.trvl-media.com/lodging/76000000/75260000/75254900/75254801/286f65b1_y.jpg)

### HOTEL OSHO

10/10 Excellent

"Room was great and staff were very accommodating!"

[](https://expedia.com/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information)

## Find out more about Santa Cruz

**Everything you need to know about Santa Cruz vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Santa Cruz vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $27 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Santa Cruz rentals**

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in Santa Cruz

### Trending destinations on Expedia.com

- [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals)
- [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals)
- [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals)
- [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals)
- [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals)
- [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals)
- [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals)
- [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals)
- [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)
- [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals)
- [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals)
- [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals)
- [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals)
- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Apartments in Santa Cruz ](https://expedia.com/Santa-Cruz-Apartments.d6053940-aaApartments.Travel-Guide-Accommodation)
- [Vacation Homes in Santa Cruz ](https://expedia.com/Santa-Cruz-Private-Vacation-Homes.d6053940-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Aparthotels in Santa Cruz ](https://expedia.com/Santa-Cruz-Apart-Hotels.d6053940-aaApartHotels.Travel-Guide-Accommodation)
- [Hostels in Santa Cruz ](https://expedia.com/Santa-Cruz-Hostels.d6053940-aaHostels.Travel-Guide-Accommodation)
- [Condo Rentals in Santa Cruz ](https://expedia.com/Santa-Cruz-Condos.d6053940-aaCondos.Travel-Guide-Accommodation)
- [Chalets in Santa Cruz ](https://expedia.com/Santa-Cruz-Chalets.d6053940-aaChalets.Travel-Guide-Accommodation)
- [Houseboats in Santa Cruz ](https://expedia.com/Santa-Cruz-Houseboats.d6053940-aaHouseboats.Travel-Guide-Accommodation)
- [Resorts in Santa Cruz ](https://expedia.com/Santa-Cruz-Resorts.d6053940-aaResorts.Travel-Guide-Accommodation)
- [Guest Houses in Santa Cruz ](https://expedia.com/Santa-Cruz-Guest-Houses.d6053940-aaGuestHouses.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find a vacation rental in Santa Cruz?

### What are some of the best vacation home rentals in Santa Cruz?

### How many vacation rentals will I find in Santa Cruz?

### What can I see and do in Santa Cruz?

### What are vacation rentals like in Santa Cruz?

### Expedia's Latest Trends

Hotels

- [Hotels in Vallegrande](https://expedia.com/Vallegrande-Hotels.d6350207.Travel-Guide-Hotels)
- [Hotels in La Guardia](https://expedia.com/La-Guardia-Hotels.d6347124.Travel-Guide-Hotels)
- [Hotels in Sucre](https://expedia.com/Sucre-Hotels.d3261.Travel-Guide-Hotels)
- [Hotels in Estancia Bella Vista](https://expedia.com/Estancia-Bella-Vista-Hotels.d6350895.Travel-Guide-Hotels)
- [Hotels in Colinas del Urubo](https://expedia.com/Colinas-Del-Urubo-Hotels.d6349680.Travel-Guide-Hotels)
- [Hotels in Samaipata](https://expedia.com/Samaipata-Hotels.d6200976.Travel-Guide-Hotels)

Flights

- [Cheap Flights to Uyuni](https://expedia.com/Cheap-Flights-To-Uyuni.d6139345.Travel-Guide-Flights)
- [Roboré Flights](https://expedia.com/lp/flights/3000408084/flights-from-robore)
- [Cheap Flights to Copacabana](https://expedia.com/Cheap-Flights-To-Copacabana.d6048577.Travel-Guide-Flights)
- [Cheap Flights to Sucre](https://expedia.com/Cheap-Flights-To-Sucre.d3261.Travel-Guide-Flights)

Cars

- [Car rentals in Sucre](https://expedia.com/Car-Rentals-In-Sucre.d3261.Car-Rental-Guide)
- [Car rentals in Uyuni](https://expedia.com/Car-Rentals-In-Uyuni.d6139345.Car-Rental-Guide)
- [Car rental Santa Cruz Airport (VVI)](https://expedia.com/Car-Rentals-In-Viru-Viru-Intl.d6033004.Car-Rental-Guide)
- [Car rentals in Reyes](https://expedia.com/Car-Rentals-In-Reyes.d3000400289.Car-Rental-Guide)
- [Car rentals in Puerto Suarez](https://expedia.com/Car-Rentals-In-Puerto-Suarez.d3000470804.Car-Rental-Guide)

Activities

- [Things to do in Sucre](https://expedia.com/Things-To-Do-In-Sucre.d3261.Travel-Guide-Activities)
- [Things to do in Isla del Sol](https://expedia.com/Things-To-Do-In-Isla-Del-Sol.d6141339.Travel-Guide-Activities)
- [Things to do in Copacabana](https://expedia.com/Things-To-Do-In-Copacabana.d6048577.Travel-Guide-Activities)

Packages

- [Guembe Biocenter](https://expedia.com/Guembe-Biocenter-Santa-Cruz.d553248621532465358.Vacation-Attraction)
- [Santa Cruz Zoo](https://expedia.com/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Vacation-Attraction)
- [Ethno-folkloric Museum](https://expedia.com/Ethno-Folkloric-Museum-Santa-Cruz.d6098834.Vacation-Attraction)
- [Cine Center](https://expedia.com/Cine-Center-Santa-Cruz.d6126769.Vacation-Attraction)
- [Uyuni Vacation](https://expedia.com/Uyuni.d6139345.Destination-Travel-Guides)

Vacation Rentals

- [Camiri Vacation Rentals](https://expedia.com/Camiri-Vacation-Rentals.d770.Travel-Guide-VacationRentals)

General

- [Visit Sucre](https://expedia.com/Sucre.dx3261)
- [Visit Puerto Quijarro](https://expedia.com/Puerto-Quijarro.dx3000389058)
- [Visit Puerto Suarez](https://expedia.com/Puerto-Suarez.dx3000470804)
- [Visit Tiwanaku](https://expedia.com/Tiwanaku.dx6251815)
- [Visit San Jose de Chiquitos](https://expedia.com/San-Jose-De-Chiquitos.dx6344854)
- [Visit Villa Tunari](https://expedia.com/Villa-Tunari.dx6350212)

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