A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals
  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings
  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Santa Cruz vacation rentals

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (112 reviews)
"Great Location"
United States
Blanca
$44 nightly
The price is $44
Aug 26 - Aug 27
Premium Suites Deluxe Aparthotel Equipetrol

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.8 out of 10, Excellent, (103 reviews)
"Great location."
United States
Ruben
$27 nightly
The price is $27
Jul 27 - Jul 28
Apart Hotel Premium Suites Santa Cruz

Terranova Suites

Terranova Suites
3.5 star property
Santa Cruz
8.0 out of 10, Very Good, (91 reviews)
"Easy to access"
United States
Dorothy
$52 nightly
The price is $52
Jul 28 - Jul 29
Terranova Suites

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
8.8 out of 10, Excellent, (13 reviews)
"Perfect hotel"
Turkey
Yener
$47 nightly
The price is $47
Jul 30 - Jul 31
Equipetrol Suites Apart Hotel

Apart Hotel Toborochi

Apart Hotel Toborochi
3.0 star property
Santa Cruz
8.8 out of 10, Excellent, (60 reviews)
"Very comfortable and quiet place and very good location. "
United States
Luis
$117 nightly
The price is $117
Aug 26 - Aug 27
Apart Hotel Toborochi

POX: Green Tower 16th floor : Luxury and elegance - 2H

POX: Green Tower 16th floor : Luxury and elegance - 2H
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1 review)
"Beautiful place, excellent location."
United States
Ruben
$110 nightly
The price is $110
Jul 27 - Jul 28
POX: Green Tower 16th floor : Luxury and elegance - 2H

AMERICA APARTMENTS

AMERICA APARTMENTS
3.0 star property
Santa Cruz
10.0 out of 10, Exceptional, (2 reviews)
"Clean room, great staff "
Canada
Peter
$34 nightly
The price is $34
Aug 1 - Aug 2
AMERICA APARTMENTS

Tranquil apartment with WiFi in Santa Cruz de la Sierra

Tranquil apartment with WiFi in Santa Cruz de la Sierra
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (2 reviews)
"Zona tranquila y todo cerca supermercados tiendas etc"
Mexico
Fabricio O.
$60 nightly
The price is $60
Jul 27 - Jul 28
Tranquil apartment with WiFi in Santa Cruz de la Sierra

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
Santa Cruz de la Sierra
$67 nightly
The price is $67
Jul 27 - Jul 28
COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

Charming 1-bedroom apartment in brilliant Santa Cruz with AC, WiFi

Charming 1-bedroom apartment in brilliant Santa Cruz with AC, WiFi
Santa Cruz de la Sierra
$49 nightly
The price is $49
Jul 28 - Jul 29
Charming 1-bedroom apartment in brilliant Santa Cruz with AC, WiFi

Beautiful Loft in a brand new Condo, 10 minutes from business center.

Beautiful Loft in a brand new Condo, 10 minutes from business center.
Santa Cruz de la Sierra
$57 nightly
The price is $57
Jul 27 - Jul 28
Beautiful Loft in a brand new Condo, 10 minutes from business center.

SC Apartments

SC Apartments
Santa Cruz de la Sierra
$57 nightly
The price is $61
Aug 2 - Aug 3
SC Apartments

Menacho Apartment - Mangales Blue - Norte

Menacho Apartment - Mangales Blue - Norte
Santa Cruz de la Sierra
$32 nightly
The price is $32
Jul 27 - Jul 28
Menacho Apartment - Mangales Blue - Norte

Enchanting studio with AC in Santa Cruz de la Sierra

Enchanting studio with AC in Santa Cruz de la Sierra
Santa Cruz de la Sierra
$47 nightly
The price is $47
Jul 27 - Jul 28
Enchanting studio with AC in Santa Cruz de la Sierra

Hermoso Departamento 4 Habitaciones con Baño a 10 min del Aeropuerto

Hermoso Departamento 4 Habitaciones con Baño a 10 min del Aeropuerto
Santa Cruz de la Sierra
$87 nightly
The price is $87
Jul 27 - Jul 28
Hermoso Departamento 4 Habitaciones con Baño a 10 min del Aeropuerto

Elegante departamento Sirari Equipetrol

Elegante departamento Sirari Equipetrol
Santa Cruz de la Sierra
$67 nightly
The price is $67
Jul 27 - Jul 28
Elegante departamento Sirari Equipetrol

1-bedroom Modern Apartment in Sirari, Equipetrol

1-bedroom Modern Apartment in Sirari, Equipetrol
Santa Cruz de la Sierra
$47 nightly
The price is $50
Jul 27 - Jul 28
1-bedroom Modern Apartment in Sirari, Equipetrol

Aqua: Loft Artistico Urbano

Aqua: Loft Artistico Urbano
Santa Cruz de la Sierra
$68 nightly
The price is $68
Jul 27 - Jul 28
Aqua: Loft Artistico Urbano

Apartment in Patio Design with private garage

Apartment in Patio Design with private garage
Santa Cruz de la Sierra
$58 nightly
The price is $58
Aug 24 - Aug 25
Apartment in Patio Design with private garage

A must-see studio apartment in Sirari-Equipetrol

A must-see studio apartment in Sirari-Equipetrol
Santa Cruz de la Sierra
$58 nightly
The price is $58
Aug 2 - Aug 3
A must-see studio apartment in Sirari-Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $27 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

What are some of the best vacation home rentals in Santa Cruz?

Casa Vida: This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC and Seasonal House.

How many vacation rentals will I find in Santa Cruz?

With 22 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

What can I see and do in Santa Cruz?

Enjoy the outdoors at Arenal Park and Guembe Biocenter, or simply take in cultural attractions like Cine Center and Ethno-folkloric Museum. Plaza 24 de Septiembre and Blacutt Square are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.