---
title: "Santa Cruz Vacation Rentals from $22: Search Short-Term Rentals | Expedia.com"
description: "Find the best deals on Santa Cruz vacation rentals with Expedia.com. We offer a huge selection of top vacation homes for rental in Santa Cruz. Book your next vacation with us!"
canonical: "https://www.expedia.com/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals"
language: en-US
market: US
currency: USD
prices_as_of: 2026-11-13T23:56:51Z
---

Plan your trip

- [Santa Cruz Travel Guide](https://www.expedia.com/Santa-Cruz.dx6053940)
- [Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)
- [Flights to Santa Cruz](https://www.expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)
- [Things to do in Santa Cruz](https://www.expedia.com/Things-To-Do-In-Santa-Cruz.d6053940.Travel-Guide-Activities)
- [Car Rentals in Santa Cruz](https://www.expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)
- [Santa Cruz Vacation Packages](https://www.expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides)

# Santa Cruz Vacation Rentals
![A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.](https://images.trvl-media.com/place/6053940/e3c01ff9-3345-4fe4-85dc-cd90529ccbe1.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

[Check prices for these dates, December 13 – 14, 2026](https://www.expedia.com/Hotel-Search?regionId=6053940&startDate=2026-12-13&endDate=2026-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&sort=VACATION%5FRENTAL)

[View in a map](https://www.expedia.com/Hotel-Search?regionId=6053940&stayLength=1&daysInFuture=30&pwaOverlay=map)

## Our top choices for Santa Cruz vacation rentals

### [1\. Apart Hotel Premium Suites Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

![A hotel room with a large bed, wooden headboard, bedside lamps, and a bedside phone.](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/16a8e9dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

- Location: Santa Cruz
- Guest rating: 8.6/10 (Excellent, 107 reviews)
- Price: $22 nightly, $22 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals
- Review: Great location., by Ruben

### [2\. Premium Suites Deluxe Aparthotel Equipetrol](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![A hotel room with a bed, bedside table, and a glass table with a vase of flowers.](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/972f9587.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Guest rating: 8.8/10 (Excellent, 121 reviews)
- Price: $46 nightly, $46 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals
- Review: great place to stay!, by Luisa

### [3\. AMERICA APARTMENTS](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

![A modern rooftop pool with a city view, wooden flooring, and a seating area.](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1510x0y0-a0234ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Guest rating: 10/10 (Exceptional, 3 reviews)
- Price: $27 nightly, $27 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals
- Review: Clean room, great staff , by Peter

### [4\. Terranova Suites](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

![An outdoor dining area with tables and chairs, surrounded by plants and palm trees.](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Guest rating: 8/10 (Very good, 91 reviews)
- Price: $48 nightly, $48 total, Nov 15 - Nov 16, for Our top choices for Santa Cruz vacation rentals
- Review: Easy to access, by Dorothy

### [5\. Equipetrol Suites Apart Hotel](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

![A hotel room with a large bed, a desk with a chair, a TV, and artwork on the wall.](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/74c8ede1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Guest rating: 8.8/10 (Excellent, 13 reviews)
- Price: $57 nightly, $57 total, Nov 15 - Nov 16, for Our top choices for Santa Cruz vacation rentals
- Review: Perfect hotel, by Yener

### [6\. 58" TV / Swimming Pool / Coworking Space / Fitness Center / Queen-Size Bed](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-And-Comfort-At-Equipetrol.h114470519.Hotel-Information)

![A rooftop pool with lounge chairs and a cityscape view at sunset.](https://images.trvl-media.com/lodging/115000000/114480000/114470600/114470519/6e34acbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Guest rating: 8.8/10 (Excellent, 3 reviews)
- Price: $49 nightly, $49 total, Nov 30 - Dec 1, for Our top choices for Santa Cruz vacation rentals

### [7\. Menacho Apartment - Mangales Blue - Norte](https://www.expedia.com/Santa-Cruz-Hotels-Menacho-Apartment-Mangales-Blue-Norte.h110945840.Hotel-Information)

![A rooftop swimming pool with a clear view of the city skyline and a partly cloudy sky.](https://images.trvl-media.com/lodging/111000000/110950000/110945900/110945840/89eb3c1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Guest rating: 10/10 (Exceptional, 1 review)
- Price: $26 nightly, $26 total, Nov 29 - Nov 30, for Our top choices for Santa Cruz vacation rentals
- Review: "We arrived at 12:30 am due to our flight and I let the host know of our late arrival time. He had no problem. When checking in I made an error and I couldn’t figure out how to get there. I called the host as late as it was, he answered no problem and was super nice and helpful. He was very communicative although out our stay. Room was fully functional. Had a kitchen with all the necessary utensils, living room area with a tv and a couch that became a bed for our kids. Private master bedroom..., by Evelyn

### [8\. Apart Hotel Toborochi](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

![A hotel with a pool, lounge chairs, and palm trees.](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/92d567f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Guest rating: 8.8/10 (Excellent, 61 reviews)
- Price: $73 nightly, $73 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals
- Review: Very comfortable and quiet place and very good location. , by Luis

### [9\. Comfort in the best neighborhood in Santa Cruz—perfect for business travelers and tourists!!](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h130844756.Hotel-Information)

![A modern kitchen with a black countertop, stainless steel appliances, and a built-in oven.](https://images.trvl-media.com/lodging/131000000/130850000/130844800/130844756/ba6dc77d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Price: $49 nightly, $49 total, Nov 20 - Nov 21, for Our top choices for Santa Cruz vacation rentals

### [10\. POX: 24th Floor, Green Tower | Luxury and Panoramic Views](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor.h122865145.Hotel-Information)

![A modern building with a glass facade, a pool area with sun loungers, and a clear blue sky.](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/1b6db924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Guest rating: 10/10 (Exceptional, 1 review)
- Price: $97 nightly, $97 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals
- Review: Very comfortable and nice view and the super clean, by Carlos

### [11\. Apartment with a balcony, pool, fitness center, and coworking space at Equipe](https://www.expedia.com/Santa-Cruz-Hotels-Modernity-And-Comfort-At-Equipe.h117789345.Hotel-Information)

![A rooftop pool with lounge chairs and a cityscape view at sunset.](https://images.trvl-media.com/lodging/118000000/117790000/117789400/117789345/00581056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Price: $47 nightly, $47 total, Nov 23 - Nov 24, for Our top choices for Santa Cruz vacation rentals

### [12\. A Must-See: Studio Apartment in Sirari-Equipetrol](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h112789864.Hotel-Information)

![A rooftop terrace with a pool, outdoor seating, and a view of surrounding buildings.](https://images.trvl-media.com/lodging/113000000/112790000/112789900/112789864/47db859c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Price: $50 nightly, $50 total, Nov 25 - Nov 26, for Our top choices for Santa Cruz vacation rentals

### [13\. Aqua: Loft Artistico Urbano](https://www.expedia.com/Santa-Cruz-Hotels-Aqua-Loft-Artistico-Urbano.h115983667.Hotel-Information)

![A modern bedroom with a large bed, bedside lamps, and a view into a kitchen area.](https://images.trvl-media.com/lodging/116000000/115990000/115983700/115983667/d03cfc37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Guest rating: 10/10 (Exceptional, 1 review)
- Price: $60 nightly, $60 total, Nov 30 - Dec 1, for Our top choices for Santa Cruz vacation rentals
- Review: Excellent atencion todo muy comodo bonito limpio gracias, by Nestor C.

### [14\. Apartment with a Balcony & View / Pool / Gym at Equipe](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-Apartment-Incredible-View.h117878252.Hotel-Information)

![A rooftop pool with clear blue water, surrounded by palm trees and plants, overlooking a cityscape with modern buildings.](https://images.trvl-media.com/lodging/118000000/117880000/117878300/117878252/067fea81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Price: $54 nightly, $54 total, Nov 23 - Nov 24, for Our top choices for Santa Cruz vacation rentals

### [15\. Enchanting studio with AC in Santa Cruz de la Sierra](https://www.expedia.com/Santa-Cruz-Hotels-Enchanting-Studio-With-AC-In-Santa-Cruz-De-La-Sierra.h120992266.Hotel-Information)

![A modern office space with glass walls, a long table with chairs, and several round ottomans.](https://images.trvl-media.com/lodging/121000000/121000000/120992300/120992266/84963eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Price: $39 nightly, $39 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals

### [16\. Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information)

![A rooftop pool with clear blue water, surrounded by palm trees and a cityscape in the background.](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/6663a26a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Price: $40 nightly, $40 total, Nov 14 - Nov 15, for Our top choices for Santa Cruz vacation rentals

### [17\. Inspiring Views • Enveloping Comfort](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h117979432.Hotel-Information)

![A rooftop pool with clear blue water, surrounded by lounge chairs and potted plants.](https://images.trvl-media.com/lodging/118000000/117980000/117979500/117979432/d8d972c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Price: $47 nightly, $47 total, Nov 23 - Nov 24, for Our top choices for Santa Cruz vacation rentals

### [18\. Patio-style apartment with a private garage](https://www.expedia.com/Santa-Cruz-Hotels-Apartment-In-Patio-Design-With-Private-Garage.h112789433.Hotel-Information)

![A modern pool area with a curved design, surrounded by wooden decking and lush greenery.](https://images.trvl-media.com/lodging/113000000/112790000/112789500/112789433/a38f024c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Price: $50 nightly, $50 total, Nov 18 - Nov 19, for Our top choices for Santa Cruz vacation rentals

### [19\. Apartment with a workspace / pool / gym / sleeper sofa](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h117979319.Hotel-Information)

![A rooftop pool with lounge chairs and a cityscape view at sunset.](https://images.trvl-media.com/lodging/118000000/117980000/117979400/117979319/a3a9d1ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Price: $47 nightly, $47 total, Nov 30 - Dec 1, for Our top choices for Santa Cruz vacation rentals

### [20\. Hermoso apartamento con dos habitaciones en la zona más segura de Santa Cruz.](https://www.expedia.com/Santa-Cruz-Hotels-Hermoso-Apartamento-Con-Dos-Habitaciones-En-La-Zona-Mas-Segura-De-Santa-Cruz.h108418487.Hotel-Information)

![A bedroom with a bed, a nightstand, a window with blinds, and a wooden wall panel.](https://images.trvl-media.com/lodging/109000000/108420000/108418500/108418487/e802fd77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz de la Sierra
- Price: $38 nightly, $38 total, Nov 18 - Nov 19, for Our top choices for Santa Cruz vacation rentals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://www.expedia.com/Hotel-Search?startDate=2026-11-27&endDate=2026-11-28&regionId=6053940&adults=2&sort=VACATION%5FRENTAL&openPlayBack=true)

## Find vacation rentals that suit your style

[Apartments](https://www.expedia.com/Hotel-Search?destination=Santa%20Cruz,%20Santa%20Cruz,%20Bolivia&regionId=6053940&latLong=-17.784489,-63.180824&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=APARTMENT)

[Aparthotels](https://www.expedia.com/Hotel-Search?destination=Santa%20Cruz,%20Santa%20Cruz,%20Bolivia&regionId=6053940&latLong=-17.784489,-63.180824&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=APART%5FHOTEL)

[Chalets](https://www.expedia.com/Hotel-Search?destination=Santa%20Cruz,%20Santa%20Cruz,%20Bolivia&regionId=6053940&latLong=-17.784489,-63.180824&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=CHALET)

[Condos](https://www.expedia.com/Hotel-Search?destination=Santa%20Cruz,%20Santa%20Cruz,%20Bolivia&regionId=6053940&latLong=-17.784489,-63.180824&adults=2&startDate=2026-11-20&d1=2026-11-20&endDate=2026-11-22&d2=2026-11-22&lodging=CONDO)

## Top Santa Cruz Hotel Reviews

### [Chairú Eco Hotel](https://www.expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information)

![A multi-level atrium with a central planter containing various plants, surrounded by glass railings and a brick wall.](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/bd6aa283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Review: Nice and clean, by Brian, October 28, 2026, rated 10/10 Excellent

### [Hotel Cortez](https://www.expedia.com/Santa-Cruz-Hotels-Hotel-Cortez.h13455822.Hotel-Information)

![A spacious lobby with high ceilings, wooden beams, and a large seating area with wicker chairs.](https://images.trvl-media.com/lodging/14000000/13460000/13455900/13455822/98bdb5e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Review: Great and modern with a touch of Traditional Tropical Bolivia., by Anonymous traveler, April 28, 2021, rated 10/10 Excellent

### [Alfonsina Hotel Boutique by Inboccaluppo](https://www.expedia.com/Santa-Cruz-Hotels-Inboccalupo-The-Hotel-Boutique.h10202755.Hotel-Information)

![An outdoor dining area with a brick wall, wooden shelves with plants, and a table set with plates of food and drinks.](https://images.trvl-media.com/lodging/11000000/10210000/10202800/10202755/a7124411.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Review: The hotel is gorgeous! A must stay, by Marianne, January 31, 2022, rated 10/10 Excellent

### [Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://www.expedia.com/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information)

![A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Review: The staff vwry friendly, the restaurant great and what a view, onlybissue was that it had no pool or sauna, by Anonymous traveler, May 5, 2019, rated 10/10 Excellent

### [Cosmopolitano Hotel Boutique](https://www.expedia.com/Santa-Cruz-Hotels-Cosmopolitano-Hotel-Boutique.h17512569.Hotel-Information)

![A multi-level indoor space with a pool, wooden flooring, and potted plants.](https://images.trvl-media.com/lodging/18000000/17520000/17512600/17512569/71ca5d29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Centro Histórico
- Review: Great place , great service, very cute and cozy . Highly recommended, by Hector, June 13, 2017, rated 10/10 Excellent

### [HOTEL OSHO](https://www.expedia.com/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information)

![A modern hotel building with a glass facade and a sign that reads 'OSHO HOTEL'.](https://images.trvl-media.com/lodging/76000000/75260000/75254900/75254801/785e8fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Review: Clean room, good staff,, by Neftali, November 5, 2026, rated 10/10 Excellent

### [TRYP by Wyndham Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information)

![A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/efaab5ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Review: Amazing place, benefit cost relationship 5 stars, by Marco, December 6, 2023, rated 10/10 Excellent

### [Hotel Maywa](https://www.expedia.com/Santa-Cruz-Hotels-Hotel-Maywa.h106727782.Hotel-Information)

![Room](https://images.trvl-media.com/lodging/107000000/106730000/106727800/106727782/5dec5cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Review: The structure and service was fantastic, by Alex, September 17, 2025, rated 10/10 Excellent

### [Marriott Santa Cruz de la Sierra Hotel](https://www.expedia.com/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information)

![A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/02f3d22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Review: I loved everything about this hotel. So accommodating, extremely clean and so friendly. I was able to get laundry service on a Sunday despite the service not usually being open on sundays and got my laundry within a couple hours, faster than the normal timing. The restaurant food was also amazing. Not a single complaint. I highly recommend this hotel to anyone!, by Lauren, May 9, 2023, rated 10/10 Excellent

### [Delfines Collection Hotel By Mercure](https://www.expedia.com/Santa-Cruz-Hotels-Delfines-Collection-Hotel-By-Mercure.h90301892.Hotel-Information)

![A modern hotel building with a prominent sign for Delfines Collection.](https://images.trvl-media.com/lodging/91000000/90310000/90301900/90301892/0e29e6d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Review: Todo muy bien, by lady, August 15, 2026, rated 10/10 Excellent

### [Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://www.expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information)

![A resort with a central swimming pool surrounded by lounge areas, palm trees, and multiple high-rise buildings in the background.](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/498d7028.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Equipetrol
- Review: Staff was friendly and accommodating. Very clean. A great breakfast! We loved The swimming pool., by Amy, October 24, 2023, rated 10/10 Excellent

### [Camino Real Hotel](https://www.expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information)

![A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/9d61826a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Location: Santa Cruz
- Review: Second time we've stayed here; great location, helpful staff, they came & picked us up at the airport, across the street from the Ventura mall, excellent restaurant., by Brian, November 6, 2022, rated 10/10 Excellent

### [Premium Suites Deluxe Aparthotel Equipetrol](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![A hotel room with a bed, bedside table, and a glass table with a vase of flowers.](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/972f9587.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: Calle Las Azucenas No. 127, Santa Cruz, Santa Cruz, BO
- Location: Santa Cruz
- Star rating: 3.5/5
- Guest rating: 8.8/10 (121 reviews)
- Review: Nice place very clean and spacious suites. I recommend highly this place, by Maria D, July 19, 2022, rated 10/10 Excellent

### [Equipetrol Suites Apart Hotel](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

![A hotel room with a large bed, a desk with a chair, a TV, and artwork on the wall.](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/74c8ede1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: Equipetrol, Santa Cruz, Departamento de Santa Cruz, BO
- Location: Santa Cruz
- Star rating: 2.5/5
- Guest rating: 8.8/10 (13 reviews)
- Review: Great Staff. Great Location, by Kairi, December 29, 2025, rated 10/10 Excellent

### [Apart Hotel Toborochi](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

![A hotel with a pool, lounge chairs, and palm trees.](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/92d567f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: Jaime Freyre 7, Santa Cruz, BO
- Location: Equipetrol
- Star rating: 3/5
- Guest rating: 8.8/10 (61 reviews)
- Review: The rooms are very spacious and the rest of the facilities are very well maintained, you feel like you are at home. The staff are very cordial and helpful. I will definitely stay at Suites Toborochi next time I'm in Santa Cruz, by Marce, March 20, 2016, rated 10/10 Excellent

### [Apart Hotel Premium Suites Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

![A hotel room with a large bed, wooden headboard, bedside lamps, and a bedside phone.](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/16a8e9dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)
- Address: Calle Las Begonias Nro 45, Santa Cruz, 2477, BO
- Location: Santa Cruz
- Star rating: 3.5/5
- Guest rating: 8.6/10 (107 reviews)
- Review: Great location., by Ruben, June 4, 2026, rated 10/10 Excellent

## Find out more about Santa Cruz

### Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

### Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $22 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

### How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Frequently Asked Questions

### Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

### What are some of the best vacation home rentals in Santa Cruz?

[Casa Vida](https://www.expedia.com/Santa-Cruz-Hotels-Casa-Vida.h15030862.Hotel-Information): This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are [Cozy 1-bedroom house in beautiful Santa Cruz de la Sierra with WiFi, AC](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-1-Bedroom-House-In-Beautiful-Santa-Cruz-De-La-Sierra-With-WiFi.h114525533.Hotel-Information) and [Seasonal House](https://www.expedia.com/Santa-Cruz-Hotels-Seasonal-House.h115106104.Hotel-Information).

### How many vacation rentals will I find in Santa Cruz?

With 23 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

### What can I see and do in Santa Cruz?

Enjoy the outdoors at Arenal Park and Guembe Biocenter, or simply take in cultural attractions like Ethno-folkloric Museum and Cine Center. Plaza 24 de Septiembre and Blacutt Square are other places to visit while you're in town.

### What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.

## Explore a world of travel with Expedia

- [Lodging](?equalTargetTab=tab-0)
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- [Rainforest & Jungle Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Jungle-Hotels.0-0-d6053940-tJungleHotels.Travel-Guide-Filter-Hotels)
- [Hotels with Hot Tubs in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Hotels-With-Hot-Tubs.0-0-d6053940-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
- [Hotels with a Lazy River in Santa Cruz](https://www.expedia.com/Destinations-In-Santa-Cruz-Hotels-With-A-Lazy-River.0-0-d6297178-tHotelswithaLazyRiver.Hotel-Filter-Destinations)
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- [Hotels with Laundry Facilities in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Hotels-With-Laundry-Facilities.0-0-d6053940-tHotelswithLaundryFacilities.Travel-Guide-Filter-Hotels)
- [Cabin Rentals in Santa Cruz](https://www.expedia.com/Santa-Cruz-Cabins.d6297178-aaCabins.Travel-Guide-Accommodation)
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- [Aparthotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Apart-Hotels.d6053940-aaApartHotels.Travel-Guide-Accommodation)
- [Safari Tentalow in Santa Cruz](https://www.expedia.com/Santa-Cruz-Safari-Tentalow.d6053940-aaSafariTentalow.Travel-Guide-Accommodation)
- [Hotels with Restaurants in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Hotels-With-Restaurants.0-0-d6053940-tHotelswithRestaurants.Travel-Guide-Filter-Hotels)
- [Santa Cruz Hotels](https://www.expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)
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- [Chalets in Santa Cruz](https://www.expedia.com/Santa-Cruz-Chalets.d6053940-aaChalets.Travel-Guide-Accommodation)
- [Best Western Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Best-Western.0-0-d6053940--bBestWestern.Travel-Guide-Filter-Hotels)
- [Hilton Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Hilton-Hotels.0-0-d6053940--bHiltonHotels.Travel-Guide-Filter-Hotels)
- [Condo Rentals in Santa Cruz](https://www.expedia.com/Santa-Cruz-Condos.d6053940-aaCondos.Travel-Guide-Accommodation)
- [Extended Stay Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Extended-Stay-Hotels.0-0-d6053940-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
- [Waterpark Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Waterpark-Hotels.0-0-d6053940-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Romantic Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Romantic-Hotel.0-0-d6053940-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Business Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Business-Hotel.0-0-d6053940-tBusinessHotel.Travel-Guide-Filter-Hotels)
- [Hotels with Kitchenettes in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Hotels-With-Kitchens.0-0-d6053940-tHotelswithKitchens.Travel-Guide-Filter-Hotels)
- [Yha Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-YHA.0-0-d6053940--bYHA.Travel-Guide-Filter-Hotels)
- [Houseboats in Santa Cruz](https://www.expedia.com/Santa-Cruz-Houseboats.d6053940-aaHouseboats.Travel-Guide-Accommodation)
- [Luxury Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-Hotel.0-0-d6053940-tLuxuryHotel.Travel-Guide-Filter-Hotels)
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- [Hotel Wedding Venues Hotels in Santa Cruz](https://www.expedia.com/Santa-Cruz-Hotels-Wedding-Hotels.0-0-d6053940-tWeddingHotels.Travel-Guide-Filter-Hotels)
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- [Pet-Friendly Hotels in Santa Cruz](https://www.expedia.com/Destinations-In-Santa-Cruz-Pet-Friendly-Hotel.0-0-d6297178-tPetfriendlyHotel.Hotel-Filter-Destinations)
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- [Hotels near Plaza 24 de Septiembre](https://www.expedia.com/Plaza-24-De-Septiembre-Hotels.0-l6098828-0.Travel-Guide-Filter-Hotels)
- [4 Star Hotels in Santa Cruz](https://www.expedia.com/4Star-Santa-Cruz-Hotels.s40-0-d6053940.Travel-Guide-Filter-Hotels)
- [Apartments in Santa Cruz](https://www.expedia.com/Santa-Cruz-Apartments.d6053940-aaApartments.Travel-Guide-Accommodation)
- [Flights to Santa Cruz](https://www.expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)
- [Flights from Santa Cruz](https://www.expedia.com/lp/flights/6053940/flights-from-santa-cruz)
- [Flights from Oakland (OAK) to Santa Cruz (SRZ)](https://www.expedia.com/lp/flights/oak/srz/oakland-to-santa-cruz)
- [Flights from Miami (MIA) to Santa Cruz (VVI)](https://www.expedia.com/lp/flights/mia/vvi/miami-to-santa-cruz)
- [Flights from Reno (RNO) to Santa Cruz (SRZ)](https://www.expedia.com/lp/flights/rno/srz/reno-to-santa-cruz)
- [Flights from El Trompillo](https://www.expedia.com/lp/airports/srz/flights-from-el-trompillo-airport)
- [Flights from Los Angeles (LAX) to Santa Cruz (SRZ)](https://www.expedia.com/lp/flights/lax/srz/los-angeles-to-santa-cruz)
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- [Santa Cruz Vacations](https://www.expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides)
- [Plaza 24 de Septiembre](https://www.expedia.com/Plaza-24-De-Septiembre-Santa-Cruz.d6098828.Vacation-Attraction)
- [Visit Santa Cruz](https://www.expedia.com/Santa-Cruz.dx6053940)
- [Santa Cruz Vacations](https://www.expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides)
- [La Recova Artisan Walk](https://www.expedia.com/La-Recova-Artisan-Walk-Santa-Cruz.d553248621532371683.Vacation-Attraction)
- [Visit Santa Cruz](https://www.expedia.com/Santa-Cruz.dx6297178)
- [Sacred Art Museum](https://www.expedia.com/Sacred-Art-Museum-Santa-Cruz.d553248621563217782.Vacation-Attraction)
- [Guarani Nandereko Nomai Art and Culture Center](https://www.expedia.com/Guarani-Nandereko-Nomai-Art-And-Culture-Center-Santa-Cruz.d553248621532371685.Vacation-Attraction)
- [Where to stay in Santa Cruz](https://www.expedia.com/Santa-Cruz.dx6053940.Where-To-Stay)
- [San Lorenzo Cathedral](https://www.expedia.com/San-Lorenzo-Cathedral-Santa-Cruz.d6098830.Vacation-Attraction)
- [Luxury Car Rentals in Santa Cruz](https://www.expedia.com/Luxury-Car-Rentals-In-Santa-Cruz.d6053940-tLuxury.Car-Rental-Guide-Class)
- [Minivan Car Rentals in Santa Cruz](https://www.expedia.com/Minivan-Car-Rentals-In-Santa-Cruz.d6053940-tMinivan.Car-Rental-Guide-Class)
- [Convertible Car Rentals in Santa Cruz](https://www.expedia.com/Convertible-Car-Rentals-In-Santa-Cruz.d6053940-tConvertible.Car-Rental-Guide-Class)
- [Dollar Rent A Car Rental Cars in Santa Cruz](https://www.expedia.com/Dollar-Rent-A-Car-Car-Rentals-In-Santa-Cruz.d6053940-c43.Car-Rental-Guide-Suppliers)
- [Alamo Rent A Car Rental Cars in Santa Cruz](https://www.expedia.com/Alamo-Rent-A-Car-Car-Rentals-In-Santa-Cruz.d6053940-c6.Car-Rental-Guide-Suppliers)
- [Thrifty Car Rental Rental Cars in Santa Cruz](https://www.expedia.com/Thrifty-Car-Rental-Car-Rentals-In-Santa-Cruz.d6053940-c45.Car-Rental-Guide-Suppliers)
- [Dollar Rental Cars in Santa Cruz](https://www.expedia.com/Dollar-Car-Rentals-In-Santa-Cruz.d6053940-c1091.Car-Rental-Guide-Suppliers)
- [Europcar Rental Cars in Santa Cruz](https://www.expedia.com/Europcar-Car-Rentals-In-Santa-Cruz.d6053940-c14.Car-Rental-Guide-Suppliers)
- [Hertz Rental Cars in Santa Cruz](https://www.expedia.com/Hertz-Car-Rentals-In-Santa-Cruz.d6053940-c40.Car-Rental-Guide-Suppliers)
- [Car rental Santa Cruz](https://www.expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)
- [Ace Rental Cars in Santa Cruz](https://www.expedia.com/Ace-Car-Rentals-In-Santa-Cruz.d6053940-c2.Car-Rental-Guide-Suppliers)
- [Santa Cruz Vacation Rentals](https://www.expedia.com/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)
- [Colinas del Urubo Vacation Rentals](https://www.expedia.com/Colinas-Del-Urubo-Vacation-Rentals.d6349680.Travel-Guide-VacationRentals)
- [El Torno Vacation Rentals](https://www.expedia.com/El-Torno-Vacation-Rentals.d3000419675.Travel-Guide-VacationRentals)
- [Warnes Vacation Rentals](https://www.expedia.com/Warnes-Vacation-Rentals.d6352296.Travel-Guide-VacationRentals)

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