$130 Cheap Flights from Santa Fe (SAF) to Knoxville (TYS)

View $130 flight on Thu, Dec 25, 2025Opens in a new window

Popular airlines from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS)

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Cheap Flights from Santa Fe to Knoxville (SAF-TYS)

Prices were available within the past 7 days and start at $130 for one-way flights and $394 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Fri, Jan 9 - Sat, Jan 17
SAF
Santa Fe
TYS
Knoxville
$394 Roundtrip, found 6 days ago
$394
Roundtrip
found 6 days ago
Select United flight, departing Fri, Jan 9 from Santa Fe to Knoxville, returning Sat, Jan 17, priced at $394 found 6 days ago
American Airlines
Sun, Jan 11 - Thu, Jan 29
SAF
Santa Fe
TYS
Knoxville
$414 Roundtrip, found 6 days ago
$414
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Jan 11 from Santa Fe to Knoxville, returning Thu, Jan 29, priced at $414 found 6 days ago
United
Wed, Jan 7 - Fri, Jan 9
SAF
Santa Fe
TYS
Knoxville
$444 Roundtrip, found 6 days ago
$444
Roundtrip
found 6 days ago
Select United flight, departing Wed, Jan 7 from Santa Fe to Knoxville, returning Fri, Jan 9, priced at $444 found 6 days ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$588 Roundtrip, found 11 hours ago
$588
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $588 found 11 hours ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$688 Roundtrip, found 11 hours ago
$688
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $688 found 11 hours ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$722 Roundtrip, found 11 hours ago
$722
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $722 found 11 hours ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$726 Roundtrip, found 11 hours ago
$726
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $726 found 11 hours ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$729 Roundtrip, found 11 hours ago
$729
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $729 found 11 hours ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$776 Roundtrip, found 11 hours ago
$776
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $776 found 11 hours ago
American Airlines
Fri, Jan 2 - Wed, Jan 7
SAF
Santa Fe
TYS
Knoxville
$785 Roundtrip, found 11 hours ago
$785
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Fri, Jan 2 from Santa Fe to Knoxville, returning Wed, Jan 7, priced at $785 found 11 hours ago
Flights from Santa Fe (SAF) to Knoxville (TYS)
Origin airport
Santa Fe Municipal
Destination airport
McGhee Tyson
Roundtrip price
$394
Distance
1236 mi

Santa Fe to Knoxville Flights

The cheapest times to fly from Santa Fe to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santa Fe to Knoxville are during the month of January. You can find some of the cheapest flights from Santa Fe to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santa Fe to Knoxville

Sunday is one of the best days to book for cheap flights from Santa Fe to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santa Fe to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santa Fe to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $130 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santa Fe to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santa Fe to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS) cost?
Lock in a cheap one-way flight from $130 or cheap return flight from $394 from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS)?
January is the cheapest month to fly from SAF to TYS. Avoiding peak travel times is often the key to landing a great deal.
What is the cheapest airline that flies from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll fly you from SAF to TYS. Then, sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS)?
You'll need to catch a flight with a layover if you're traveling from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from SAF to TYS?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS)?
To arrive at McGhee Tyson Airport (TYS) on time, pick a flight that takes off from Santa Fe Municipal Airport (SAF) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS) last-minute?
Last-minute bookings from SAF to TYS are generally more expensive. To secure the best rates, start looking for flights ahead of time. That said, if you're flexible with your travel dates, you may score a cheap ticket right before you leave.
Is it cheaper to book a SAF to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking a SAF to TYS flight and hotel package with Expedia could lead to significant savings. Better yet, having it all in one place will take the stress out of travel planning. Just pick your flights and select from our wide range of stays, then customize your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Santa Fe Municipal Airport (SAF) to McGhee Tyson Airport (TYS)?
It's usually possible to cancel or reschedule your SAF to TYS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.