$329 Cheap Flights from Detroit (DTW) to Panama City (PTY)

View $329 flight on Sun, Mar 15, 2026Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Detroit to Panama City (DTW-PTY)

Prices were available within the past 7 days and start at $329 for one-way flights and $599 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sun, Mar 15 - Mon, Mar 23
DTW
Detroit
PTY
Panama City
$599 Roundtrip, found 1 hour ago
$599
Roundtrip
found 1 hour ago
Select Delta flight, departing Sun, Mar 15 from Detroit to Panama City, returning Mon, Mar 23, priced at $599 found 1 hour ago
United
Wed, Mar 25 - Wed, Apr 1
DTW
Detroit
PTY
Panama City
$599 Roundtrip, found 4 hours ago
$599
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Mar 25 from Detroit to Panama City, returning Wed, Apr 1, priced at $599 found 4 hours ago
United
Sun, Mar 15 - Mon, Mar 23
DTW
Detroit
PTY
Panama City
$603 Roundtrip, found 1 hour ago
$603
Roundtrip
found 1 hour ago
Select United flight, departing Sun, Mar 15 from Detroit to Panama City, returning Mon, Mar 23, priced at $603 found 1 hour ago
United
Wed, Mar 25 - Wed, Apr 1
DTW
Detroit
PTY
Panama City
$607 Roundtrip, found 4 hours ago
$607
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Mar 25 from Detroit to Panama City, returning Wed, Apr 1, priced at $607 found 4 hours ago
Delta
Sun, Feb 22 - Mon, Mar 2
DTW
Detroit
PTY
Panama City
$608 Roundtrip, found 19 hours ago
$608
Roundtrip
found 19 hours ago
Select Delta flight, departing Sun, Feb 22 from Detroit to Panama City, returning Mon, Mar 2, priced at $608 found 19 hours ago
Delta
Sun, Feb 22 - Mon, Mar 2
DTW
Detroit
PTY
Panama City
$618 Roundtrip, found 2 days ago
$618
Roundtrip
found 2 days ago
Select Delta flight, departing Sun, Feb 22 from Detroit to Panama City, returning Mon, Mar 2, priced at $618 found 2 days ago
American Airlines
Mon, Feb 2 - Tue, Feb 24
DTW
Detroit
PTY
Panama City
$619 Roundtrip, found 4 days ago
$619
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Feb 2 from Detroit to Panama City, returning Tue, Feb 24, priced at $619 found 4 days ago
American Airlines
Fri, Feb 27 - Sat, Mar 7
DTW
Detroit
PTY
Panama City
$623 Roundtrip, found 1 day ago
$623
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Feb 27 from Detroit to Panama City, returning Sat, Mar 7, priced at $623 found 1 day ago
American Airlines
Tue, Feb 17 - Tue, Feb 24
DTW
Detroit
PTY
Panama City
$626 Roundtrip, found 11 hours ago
$626
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Tue, Feb 17 from Detroit to Panama City, returning Tue, Feb 24, priced at $626 found 11 hours ago
Copa
Mon, Dec 29 - Sat, Jan 17
DTW
Detroit
PTY
Panama City
$752 Roundtrip, just found
$752
Roundtrip
just found
Select Copa flight, departing Mon, Dec 29 from Detroit to Panama City, returning Sat, Jan 17, priced at $752 just found

Find the cheapest month to fly from Detroit (DTW) to Panama City (PTY)

October is typically the cheapest month to fly

From $507 - $1,175 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $812
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $812

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) cost?
Grab a cheap one-way flight from $329 or cheap return flight from $599 from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
March is the most affordable month to fly from DTW to PTY. Traveling during quieter months is often the key to finding a great deal.
What is the cheapest airline that flies from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DTW to PTY flight.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
Nonstop flights from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DTW to PTY?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
To reach Tocumen Intl. Airport (PTY) on time, choose a flight that takes off from Detroit Metropolitan Wayne County Airport (DTW) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY) last-minute?
Waiting until right before your break to book a ticket from DTW to PTY often results in higher prices. While you might find some last-minute offers, they're not always guaranteed. Allow some flexibility in your schedule to boost your chances of scoring a bargain.
Is it cheaper to book a DTW to PTY flight and hotel package?
You can save money by securing a DTW to PTY flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've chosen your ideal accommodations and flights, consider adding extras such as tours, activities and car rentals.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to Tocumen Intl. Airport (PTY)?
If you reserved your DTW to PTY flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Origin airport
Detroit Metropolitan Wayne County
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$598
Distance
2303 mi

Book with confidence

Detroit to Panama City Flights

The cheapest times to fly from Detroit to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Panama City are during the month of March. You can find some of the cheapest flights from Detroit to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to Panama City

Sunday is one of the best days to book for cheap flights from Detroit to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $329 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Detroit to Panama City Flights

Explore a world of travel with Expedia

*Available to One Key members.