--- title: "Indianapolis to Florence cheap flights from $287 (IND to FLO) - Expedia" description: "Cheap Flights from Indianapolis (IND) to Florence (FLO) start at $287 for one-way and for round trip. Earn your airline miles on top of our rewards!" canonical: "https://www.expedia.com/lp/flights/ind/flo/indianapolis-to-florence" language: en-US market: US currency: USD prices_as_of: 2026-11-13T11:13:06Z --- # $287 Cheap Flights from Indianapolis (IND) to Florence (FLO) ![A shopping mall with a Magnolia Mall sign and a Burlington store across the street.](https://images.trvl-media.com/place/6165602/4392990f-7038-4d9a-a654-83ae3a3dcd0f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) [View $287 flight on Sun, Apr 4, 2027](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:4/4/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:286.20&airProductToken=AQpmCjEIwYIBEgQyODgzGKgbIOKaASiryKkDMJTJqQM4T0AAWAFqBE1BSU5yCE9XQVhaTk4xCjEIwYIBEgQ1ODkzGOKaASDlcijqyakDMK3KqQM4T0ABWAFqBE1BSU5yCE9XQVhaTk4xEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) ## Popular airlines from Indianapolis Intl. Airport (IND) to Florence, SC (FLO-Florence Regional) [American Airlines](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:11/27/2026TANYT&leg2=from:FLO,to:IND,departure:12/4/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) ### Be in the know Get alerts if flight prices drop or rise\* ### Book smarter Save up to 30% on select hotels after you book a flight\* ### Earn twice Earn your airline miles on top of our OneKeyCash [Learn about One Key](https://www.expedia.com/welcome-one-key) Find the cheapest flights on Expedia from (IND) to (FLO). Flight ticket prices change frequently based on availability and demand. We send price‑drop alerts to make air travel simple and flexible. The lowest one-way fare found on Expedia for this route in the past 7 days starts at $287 for travel on April 4, 2027. ## Cheap Flights from Indianapolis to Florence (IND-FLO) Prices were available within the past 7 days and start at $287 for one-way flights, for the period specified. Prices and availability are subject to change. One way [Select American Airlines flight, departing Sun, Apr 4 from Indianapolis to Florence, priced at $287 Found 1 day ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:4/4/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:286.20&airProductToken=AQpmCjEIwYIBEgQyODgzGKgbIOKaASiryKkDMJTJqQM4T0AAWAFqBE1BSU5yCE9XQVhaTk4xCjEIwYIBEgQ1ODkzGOKaASDlcijqyakDMK3KqQM4T0ABWAFqBE1BSU5yCE9XQVhaTk4xEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAL) IND · FLO · One way [Select American Airlines flight, departing Sun, Apr 4 from Indianapolis to Florence, priced at $292 Found 12 hours ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:4/4/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:291.20&airProductToken=AQpmCjEIwYIBEgQ1NjMxGKgbIOKaASi9x6kDMKvIqQM4T0AAWAFqBE1BSU5yCE9XQVhaTk4xCjEIwYIBEgQ1ODkzGOKaASDlcijqyakDMK3KqQM4T0ABWAFqBE1BSU5yCE9XQVhaTk4xEgwIARABGAEqAkFBMgAYASIECAEQASgCKAMoBDAB) IND · FLO · One way [Select American Airlines flight, departing Thu, Dec 31 from Indianapolis to Florence, priced at $329 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:12/31/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:328.10&airProductToken=AQqbAQoxCMGCARIEMTE5MRioGyCMAijsoaEDMKOjoQM4QkAAWAFqBUJBU0lDcghPVkZKWU5CWAoyCMGCARIEMTAxMRiMAiDimgEokqahAzCep6EDOEJAAVgBagVCQVNJQ3IIT1dGV1pOQloKMgjBggESBDU4OTMY4poBIOVyKOaooQMwqamhAzhCQAFYAWoFQkFTSUNyCE9XRldaTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Fri, Nov 27 from Indianapolis to Florence, priced at $347 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:11/27/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:346.81&airProductToken=AQpoCjIIwYIBEgQyODg3GKgbIOKaASj5pZ4DMOCmngM4QkAAWAFqBUJBU0lDcghPMEFXWlNCWgoyCMGCARIENTg5MxjimgEg5XIopqqeAzDmqp4DOEJAAVgBagVCQVNJQ3IITzBBV1pTQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) IND · FLO · One way [Select American Airlines flight, departing Wed, Dec 2 from Indianapolis to Florence, priced at $395 Found 6 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:12/2/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:394.10&airProductToken=AQqaAQoxCMGCARIENDU0MRioGyCuHCia3Z4DMPXdngM4QkAAWAFqBUJBU0lDcghPVkFJVVNCWgoxCMGCARIDODY0GK4cIOKaASiV4J4DMJjhngM4QkABWAFqBUJBU0lDcghPMEFXVU5CWgoyCMGCARIENTg5MxjimgEg5XIoiuKeAzDL4p4DOEJAAVgBagVCQVNJQ3IITzBBV1VOQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) IND · FLO · One way [Select American Airlines flight, departing Sat, Jan 2 from Indianapolis to Florence, priced at $426 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/2/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:425.10&airProductToken=AQqbAQoxCMGCARIENDc5NxioGyDLASiPuKEDMJW5oQM4QkAAWAFqBUJBU0lDcghOVUZIWk5CWgoyCMGCARIEMTA4NBjLASDimgEo5byhAzDkvaEDOEJAAVgBagVCQVNJQ3IITjBGV1VOQloKMgjBggESBDU4OTMY4poBIOVyKKa%5FoQMw6b-hAzhCQAFYAWoFQkFTSUNyCE4wRldVTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Thu, Dec 31 from Indianapolis to Florence, priced at $428 Found 9 hours ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:12/31/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:427.50&airProductToken=AQqYAQowCMGCARIEMTI5NBioGyCMAijHoKEDMP2hoQM4T0AAWAFqBE1BSU5yCE9VRkpZTk0zCjEIwYIBEgQzMTk4GIwCIOKaASjNoqEDMNijoQM4UUABWAFqBE1BSU5yCFEwRldaTk4xCjEIwYIBEgQ1OTg0GOKaASDlciidpKEDMN6koQM4UUABWAFqBE1BSU5yCFEwRldaTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwAQ) IND · FLO · One way [Select American Airlines flight, departing Fri, Jan 1 from Indianapolis to Florence, priced at $430 Found 1 day ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/1/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:429.10&airProductToken=AQqbAQoxCMGCARIENDYzMRioGyCpUSiSraEDMKKuoQM4QkAAWAFqBUJBU0lDcghRVkZIWk5CWgoyCMGCARIEMTc4NxipUSDimgEonrChAzCdsaEDOEJAAVgBagVCQVNJQ3IIUTBGV1pOQloKMgjBggESBDU4OTMY4poBIOVyKOmxoQMwrLKhAzhCQAFYAWoFQkFTSUNyCFEwRldaTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Sat, Jan 2 from Indianapolis to Florence, priced at $450 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/2/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:449.50&airProductToken=AQqbAQoxCMGCARIENDU1MhioGyDLASjkuqEDMOy7oQM4QkAAWAFqBUJBU0lDcghRVkZIWk5CWgoyCMGCARIEMTA4NBjLASDimgEo5byhAzDkvaEDOEJAAVgBagVCQVNJQ3IITjBGV1VOQloKMgjBggESBDU4OTMY4poBIOVyKKa%5FoQMw6b-hAzhCQAFYAWoFQkFTSUNyCE4wRldVTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Wed, Dec 2 from Indianapolis to Florence, priced at $459 Found 6 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:12/2/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:458.10&airProductToken=AQqXAQowCMGCARIENDU0MRioGyCuHCia3Z4DMPXdngM4T0AAWAFqBE1BSU5yCE9WQUlVU00xCjAIwYIBEgM4NjQYrhwg4poBKJXgngMwmOGeAzhPQAFYAWoETUFJTnIITzBBV1pOTjEKMQjBggESBDU4OTMY4poBIOVyKIringMwy-KeAzhPQAFYAWoETUFJTnIITzBBV1pOTjESCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) IND · FLO · One way [Select American Airlines flight, departing Fri, Jan 1 from Indianapolis to Florence, priced at $461 Found 3 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/1/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:460.50&airProductToken=AQqYAQowCMGCARIEMTE5MRioGyCMAiiMraEDMMOuoQM4T0AAWAFqBE1BSU5yCE9WRkpZTk0zCjEIwYIBEgQzMTA0GIwCIOKaASjhr6EDMOmwoQM4U0ABWAFqBE1BSU5yCFMwRldaTk4xCjEIwYIBEgQ1ODkzGOKaASDlcijpsaEDMKyyoQM4U0ABWAFqBE1BSU5yCFMwRldaTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Fri, Jan 1 from Indianapolis to Florence, priced at $467 Found 1 day ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/1/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:466.10&airProductToken=AQqYAQowCMGCARIEMTI5NBioGyCMAijnq6EDMJ2toQM4T0AAWAFqBE1BSU5yCE9WRkpZTk0zCjEIwYIBEgQzMTA0GIwCIOKaASjhr6EDMOmwoQM4U0ABWAFqBE1BSU5yCFMwRldaTk4xCjEIwYIBEgQ1ODkzGOKaASDlcijpsaEDMKyyoQM4U0ABWAFqBE1BSU5yCFMwRldaTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Tue, Nov 17 from Indianapolis to Florence, priced at $469 Found 3 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:11/17/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:468.20&airProductToken=AQpmCjEIwYIBEgQyODg3GKgbIOKaASjktp0DMMy3nQM4U0AAWAFqBE1BSU5yCFMwQVdVTk4xCjEIwYIBEgQ1ODkzGOKaASDlciivuZ0DMO-5nQM4U0ABWAFqBE1BSU5yCFMwQVdVTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Wed, Dec 2 from Indianapolis to Florence, priced at $474 Found 9 hours ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:12/2/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:473.20&airProductToken=AQpmCjEIwYIBEgQzMjUzGKgbIOKaASiO3Z4DMPTdngM4U0AAWAFqBE1BSU5yCFMwQVdVTk4xCjEIwYIBEgQ1OTg0GOKaASDlcii63p4DMPzengM4U0ABWAFqBE1BSU5yCFMwQVdVTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwAQ) IND · FLO · One way [Select American Airlines flight, departing Fri, Jan 1 from Indianapolis to Florence, priced at $484 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/1/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:483.11&airProductToken=AQqYAQowCMGCARIEMjM2NhioGyCuHCj0q6EDMMWsoQM4UUAAWAFqBE1BSU5yCFFWQUlZU00xCjEIwYIBEgQyNTE0GK4cIOKaASiAsKEDMP6woQM4T0ABWAFqBE1BSU5yCE8wQVdaTk4xCjEIwYIBEgQ1ODkzGOKaASDlcijpsaEDMKyyoQM4T0ABWAFqBE1BSU5yCE8wQVdaTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Tue, Nov 17 from Indianapolis to Florence, priced at $485 Found 3 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:11/17/2026TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:484.12&airProductToken=AQpmCjEIwYIBEgQzMjUzGKgbIOKaASirtJ0DMJG1nQM4U0AAWAFqBE1BSU5yCFMwQVdVTk4xCjEIwYIBEgQ1OTg0GOKaASDlcijhtZ0DMKC2nQM4U0ABWAFqBE1BSU5yCFMwQVdVTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Sat, Jan 2 from Indianapolis to Florence, priced at $495 Found 1 day ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/2/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:494.10&airProductToken=AQqbAQoxCMGCARIENDc5NxioGyDLASiPuKEDMJW5oQM4QkAAWAFqBUJBU0lDcghOVUZIWk5CWgoyCMGCARIEMTA4NBjLASDimgEo5byhAzDkvaEDOEJAAVgBagVCQVNJQ3IIUzBGV1VOQloKMgjBggESBDU4OTMY4poBIOVyKKa%5FoQMw6b-hAzhCQAFYAWoFQkFTSUNyCFMwRldVTkJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Sun, Apr 4 from Indianapolis to Florence, priced at $524 Found 1 day ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:4/4/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:523.19&airProductToken=AQpmCjEIwYIBEgQzMTY2GKgbIOKaASj9wqkDMOjDqQM4U0AAWAFqBE1BSU5yCFMwQVdaTk4xCjEIwYIBEgQ1OTg0GOKaASDlciihxakDMODFqQM4U0ABWAFqBE1BSU5yCFMwQVdaTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Sun, Jan 3 from Indianapolis to Florence, priced at $554 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/3/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:553.20&airProductToken=AQpmCjEIwYIBEgQxNjk4GKgbIOKaASjOw6EDML%5FEoQM4U0AAWAFqBE1BSU5yCFMwQVdaTk4xCjEIwYIBEgQ1OTg0GOKaASDlcij9xaEDML7GoQM4U0ABWAFqBE1BSU5yCFMwQVdaTk4xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) IND · FLO · One way [Select American Airlines flight, departing Sat, Jan 2 from Indianapolis to Florence, priced at $569 Found 4 days ago](https://www.expedia.com/Flights-Search?leg1=from:IND,to:FLO,departure:1/2/2027TANYT&trip=oneway&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&flp=mdl:flights-flex-module,price:568.19&airProductToken=AQpqCjMIwYIBEgQxNjk4GKgbIOKaASisuKEDMJq5oQM4U0AAWAFqBk1BSU5GTHIIUzBBV1VSUzEKMwjBggESBDU5ODQY4poBIOVyKN26oQMwnruhAzhTQAFYAWoGTUFJTkZMcghTMEFXVVJTMRIKCAEQARgBKgJBQRgBIgQIARABKAIoBCgGMAs) IND · FLO · One way ## Book with confidence ### Indianapolis to Florence Flights #### The cheapest times to fly from Indianapolis to Florence On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Indianapolis to Florence are during the month of . You can find some of the cheapest flights from Indianapolis to Florence with Expedia's search tool and vast selection of airlines. #### The best time to book a flight from Indianapolis to Florence Sunday is one of the best days to book for cheap flights from Indianapolis to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance. #### How to find cheap round-trip tickets from Indianapolis to Florence Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Indianapolis to Florence in 2026\. You can also book with separate airlines for your outbound and return journeys, from $287 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference\*. This is available for a small fee, and is free to One Key Gold and Platinum tier members. Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Indianapolis to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps. You could also save big by booking one of Expedia's [vacation packages](https://www.expedia.com/package-deals). Bundling together your Indianapolis to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures. *\*Terms apply.* *Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023\. The percentages you see are averages.* ## Frequently Asked Questions ### How much does a flight from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) cost? You can find cheap one-way flights from $287 and cheap return flights Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) with Expedia. Return flights often range between $476 and $1030\. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) ticket fares go up or down. *\*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.* ### What is the cheapest month to fly from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? The cheapest month to fly from IND to FLO is when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route. ### Which airlines fly direct from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? Enter IND to FLO and your travel dates, then apply the 'Nonstop' filter to see only direct flights. ### What is the cheapest airline that flies from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? American Airlines is one of the cheapest airlines offering connecting flights from Indianapolis Intl. (IND) to Florence Regional (FLO) with a layover in O'Hare Intl. (ORD), starting from around $447\. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget. *\*Prices based on flights available on Expedia in the last year.* ### How do I find cheap flights from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? To find a cheap flight from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up [Price Tracking](https://www.expedia.com/why/price-tracking) and receive alerts when fares go up or down. ### What is the best time to fly from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience. ### What is the earliest flight from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from IND to FLO. To compare more early flights, use the "Early Morning" and "Morning" filters in your search. ### What are the most popular departure times for flights from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? The most popular departure times for flights from Indianapolis (IND) to Florence (FLO) are in the morning, from 6am to 9am. About 40% of passengers prefer this time window. Many major carriers, including American Airlines, operate flights during this period. This timing works well because it allows you to arrive in Florence with plenty of time to explore the area. ### How long does it take to fly from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? A flight from IND to FLO with a layover takes around 4 hours, with the route covering approximately 526 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic. ### Can you fly business or first class from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? Select the "Business class" and "First class" filters when looking for IND to FLO flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip. ### How do I earn miles on a Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) flight with Expedia? It's easy to earn miles on a Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of [One Key™](https://www.expedia.com/welcome-one-key), you can also earn OneKeyCash™\* on top of your airline miles when you book with Expedia. \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands. ### What airports do you fly into for Florence from Indianapolis Intl. (IND)? From Indianapolis Intl. (IND), you can fly into Florence Regional (FLO) and Peretola (FLR) in Florence. Some flights may connect through major hubs like O'Hare Intl. (ORD), Dallas-Fort Worth Intl. (DFW), Ronald Reagan Washington National (DCA) before reaching Florence. Compare routes and airports on Expedia to find the best flight options for your travel plans. ### Is it cheaper to buy a plane ticket from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) at the last minute? Typically, booking a last minute flight from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare. ### Is it cheaper to book a Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package? Securing a Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars. ### Can I cancel or change the date of my flight from Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional)? If you booked your Indianapolis, IN (IND-Indianapolis Intl.) to Florence, SC (FLO-Florence Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in [your itinerary](https://www.expedia.com/trips) or confirmation email. Or, head to our [Customer Service portal](https://www.expedia.com/helpcenter/) if you'd like more information. ## Travel information | Origin airport | Indianapolis Intl. Airport | | ------------------- | -------------------------- | | Destination airport | Florence, SC | | Distance | 526 miles away | | Airlines serving | American Airlines | | Popular airline | American Airlines | | Roundtrip price | $287 | ## Explore a world of travel with Expedia - [Flights](?equalTargetTab=tab-0) - [Flights from Augusta (AGS) to Florence (FLO)](https://www.expedia.com/lp/flights/ags/flo/augusta-to-florence) - [Flights from Tulsa (TUL) to Florence (FLO)](https://www.expedia.com/lp/flights/tul/flo/tulsa-to-florence) - [Flights from Portland (PDX) to Florence (FLO)](https://www.expedia.com/lp/flights/pdx/flo/portland-to-florence) - [Flights from Birmingham (BHM) to Florence (FLO)](https://www.expedia.com/lp/flights/bhm/flo/birmingham-to-florence) - [Flights from Providence (PVD) to Florence (FLO)](https://www.expedia.com/lp/flights/pvd/flo/providence-to-florence) - [Flights from Chicago (ORD) to Florence (FLO)](https://www.expedia.com/lp/flights/ord/flo/chicago-to-florence) - 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Airport (EWR) to Florence (FLO)](https://www.expedia.com/lp/flights/ewr/flo/newark-liberty-intl-airport-to-florence) - [Flights from Rzeszow (RZE) to Florence (FLO)](https://www.expedia.com/lp/flights/rze/flo/rzeszow-to-florence) - [Flights from Boston (BOS) to Florence (FLO)](https://www.expedia.com/lp/flights/bos/flo/boston-to-florence) - [Flights from Miami (MIA) to Florence (FLO)](https://www.expedia.com/lp/flights/mia/flo/miami-to-florence) - [Flights from Boston (BOS) to Myrtle Beach (MYR)](https://www.expedia.com/lp/flights/bos/myr/boston-to-myrtle-beach) - [Flights from Minneapolis (MSP) to Florence (FLO)](https://www.expedia.com/lp/flights/msp/flo/minneapolis-to-florence) - [Flights from Dayton (DAY) to Florence (FLO)](https://www.expedia.com/lp/flights/day/flo/dayton-to-florence) - [Flights from Chattanooga (CHA) to Florence (FLO)](https://www.expedia.com/lp/flights/cha/flo/chattanooga-to-florence) - [Flights from Colorado Springs (COS) to Florence (FLO)](https://www.expedia.com/lp/flights/cos/flo/colorado-springs-to-florence) - 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[Flights from Fort Myers (RSW) to Florence (FLO)](https://www.expedia.com/lp/flights/rsw/flo/fort-myers-to-florence) - [Flights from Cleveland (CLE) to Florence (FLO)](https://www.expedia.com/lp/flights/cle/flo/cleveland-to-florence) - [Flights from Charlotte (CLT) to Florence (FLO)](https://www.expedia.com/lp/flights/clt/flo/charlotte-to-florence) - [Flights from Memphis (MEM) to Florence (FLO)](https://www.expedia.com/lp/flights/mem/flo/memphis-to-florence) - [Flights from Los Angeles (LAX) to Florence (FLO)](https://www.expedia.com/lp/flights/lax/flo/los-angeles-to-florence) - [Flights from Fresno (FAT) to Florence (FLO)](https://www.expedia.com/lp/flights/fat/flo/fresno-to-florence) - [Flights from South Bend (SBN) to Florence (FLO)](https://www.expedia.com/lp/flights/sbn/flo/south-bend-to-florence) - [Flights from Dothan (DHN) to Florence (FLO)](https://www.expedia.com/lp/flights/dhn/flo/dothan-to-florence) - [Flights from Newburgh (SWF) to Florence (FLO)](https://www.expedia.com/lp/flights/swf/flo/newburgh-to-florence) - [Flights from El Paso (ELP) to Florence (FLO)](https://www.expedia.com/lp/flights/elp/flo/el-paso-to-florence) - [Flights from Fort Lauderdale (FLL) to Florence (FLO)](https://www.expedia.com/lp/flights/fll/flo/fort-lauderdale-to-florence) - [Flights from Little Rock (LIT) to Florence (FLO)](https://www.expedia.com/lp/flights/lit/flo/little-rock-to-florence) - [Flights from Detroit (DTW) to Florence (FLO)](https://www.expedia.com/lp/flights/dtw/flo/detroit-to-florence) - [Flights from Greenville (GSP) to Florence (FLO)](https://www.expedia.com/lp/flights/gsp/flo/greenville-to-florence) - [Flights from Sacramento (SMF) to Florence (FLO)](https://www.expedia.com/lp/flights/smf/flo/sacramento-to-florence) \*Available to One Key members. ## Other language versions ```yaml hreflang: x-default: https://www.expedia.com/lp/flights/ind/flo/indianapolis-to-florence en-US: https://www.expedia.com/lp/flights/ind/flo/indianapolis-to-florence fr-FR: https://www.expedia.fr/lp/vols/ind/flo/indianapolis-a-florence ar: https://www.expedia.sa/lp/flights/ind/flo/indianapolis-to-florence es: https://www.expedia.com/es/lp/vuelos/ind/flo/indianapolis-a-florence ```