$337 Cheap Flights from Medford (MFR) to Key West (EYW)

View $337 flight on Wed, Feb 18, 2026Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW)

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Cheap Flights from Medford to Key West (MFR-EYW)

Prices were available within the past 7 days and start at $337 for one-way flights and $406 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Feb 25 - Tue, Mar 10
MFR
Medford
EYW
Key West
$406 Roundtrip, found 4 days ago
$406
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Feb 25 from Medford to Key West, returning Tue, Mar 10, priced at $406 found 4 days ago
Delta
Mon, Jan 26 - Tue, Feb 10
MFR
Medford
EYW
Key West
$416 Roundtrip, found 4 days ago
$416
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Jan 26 from Medford to Key West, returning Tue, Feb 10, priced at $416 found 4 days ago
Delta
Mon, Jan 26 - Fri, Feb 6
MFR
Medford
EYW
Key West
$426 Roundtrip, found 4 days ago
$426
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Jan 26 from Medford to Key West, returning Fri, Feb 6, priced at $426 found 4 days ago
Delta
Tue, Feb 10 - Tue, Feb 24
MFR
Medford
EYW
Key West
$431 Roundtrip, found 4 days ago
$431
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 10 from Medford to Key West, returning Tue, Feb 24, priced at $431 found 4 days ago
Delta
Tue, Feb 3 - Thu, Feb 19
MFR
Medford
EYW
Key West
$441 Roundtrip, found 4 days ago
$441
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 3 from Medford to Key West, returning Thu, Feb 19, priced at $441 found 4 days ago
Delta
Tue, Feb 24 - Tue, Mar 10
MFR
Medford
EYW
Key West
$446 Roundtrip, found 4 days ago
$446
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 24 from Medford to Key West, returning Tue, Mar 10, priced at $446 found 4 days ago
Delta
Mon, Feb 2 - Thu, Feb 19
MFR
Medford
EYW
Key West
$451 Roundtrip, found 4 days ago
$451
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Feb 2 from Medford to Key West, returning Thu, Feb 19, priced at $451 found 4 days ago
Delta
Tue, Mar 10 - Tue, Mar 24
MFR
Medford
EYW
Key West
$456 Roundtrip, found 4 days ago
$456
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Mar 10 from Medford to Key West, returning Tue, Mar 24, priced at $456 found 4 days ago
United
Sat, Jan 10 - Tue, Jan 27
MFR
Medford
EYW
Key West
$590 Roundtrip, found 4 days ago
$590
Roundtrip
found 4 days ago
Select United flight, departing Sat, Jan 10 from Medford to Key West, returning Tue, Jan 27, priced at $590 found 4 days ago
American Airlines
Wed, Apr 1 - Wed, Apr 8
MFR
Medford
EYW
Key West
$727 Roundtrip, just found
$727
Roundtrip
just found
Select American Airlines flight, departing Wed, Apr 1 from Medford to Key West, returning Wed, Apr 8, priced at $727 just found

Alternative airports near Key West

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Key West Intl. EYW. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $496
EYW
Key West Intl.
CheapestClosest
Average driving time to city center8 min
Flights from $496

Frequently asked questions

How much does a flight from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW) cost?
Lock in a cheap one-way flight from $337 or cheap return flight from $406 from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW)?
February is the cheapest month to fly from MFR to EYW. Avoiding peak travel times is often the key to finding better fares.
What is the cheapest airline that flies from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from MFR to EYW. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW)?
You'll have to catch a flight with a layover if you're traveling from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from MFR to EYW?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* But this can change depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW)?
Select a flight from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW) last-minute?
Last-minute fares from MFR to EYW are typically more expensive. For the lowest prices, start looking for flights as soon as possible. That being said, if you're flexible with your travel dates, you may score a cheap ticket right before you leave.
Is it cheaper to book a MFR to EYW flight and hotel package?
You'll generally save money by securing a MFR to EYW flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. After selecting your preferred flights and accommodations, consider adding extras like car rentals, tours and activities.
Can I cancel or change the date of my flight from Rogue Valley Intl. Airport (MFR) to Key West Intl. Airport (EYW)?
If you booked your MFR to EYW flight in the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

Travel information

Origin airport
Rogue Valley Intl.
Destination airport
Key West Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$405
Distance
2636 mi

Book with confidence

Medford to Key West Flights

The cheapest times to fly from Medford to Key West

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to Key West are during the month of February. You can find some of the cheapest flights from Medford to Key West with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to Key West

Sunday is one of the best days to book for cheap flights from Medford to Key West: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to Key West

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to Key West in 2025. You can also book with separate airlines for your outbound and return journeys, from $337 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to Key West flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to Key West airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medford to Key West Flights

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*Available to One Key members.