$449 Cheap Flights from Santa Cruz (SRZ) to Panama City (PTY)

View $449 flight on Wed, Aug 6, 2025Opens in a new window

Popular airlines from Santa Cruz (SRZ-El Trompillo) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Santa Cruz to Panama City (SRZ-PTY)

Prices were available within the past 7 days and start at $449 for one-way flights and $657 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Tue, Nov 11 - Sun, Nov 16
VVI
Santa Cruz
PTY
Panama City
$657 Roundtrip, found 1 day ago
$657
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, Nov 11 from Santa Cruz to Panama City, returning Sun, Nov 16, priced at $657 found 1 day ago
Copa
Mon, Aug 18 - Fri, Aug 22
VVI
Santa Cruz
PTY
Panama City
$677 Roundtrip, found 16 hours ago
$677
Roundtrip
found 16 hours ago
Select Copa flight, departing Mon, Aug 18 from Santa Cruz to Panama City, returning Fri, Aug 22, priced at $677 found 16 hours ago
Copa
Mon, Aug 18 - Thu, Aug 21
VVI
Santa Cruz
PTY
Panama City
$705 Roundtrip, found 1 day ago
$705
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Aug 18 from Santa Cruz to Panama City, returning Thu, Aug 21, priced at $705 found 1 day ago
Copa
Tue, Jan 13 - Fri, Jan 30
VVI
Santa Cruz
PTY
Panama City
$742 Roundtrip, found 5 days ago
$742
Roundtrip
found 5 days ago
Select Copa flight, departing Tue, Jan 13 from Santa Cruz to Panama City, returning Fri, Jan 30, priced at $742 found 5 days ago
Copa
Sat, Nov 15 - Wed, Nov 19
VVI
Santa Cruz
PTY
Panama City
$744 Roundtrip, found 2 days ago
$744
Roundtrip
found 2 days ago
Select Copa flight, departing Sat, Nov 15 from Santa Cruz to Panama City, returning Wed, Nov 19, priced at $744 found 2 days ago
Copa
Fri, Dec 26 - Sun, Dec 28
VVI
Santa Cruz
PTY
Panama City
$762 Roundtrip, found 2 days ago
$762
Roundtrip
found 2 days ago
Select Copa flight, departing Fri, Dec 26 from Santa Cruz to Panama City, returning Sun, Dec 28, priced at $762 found 2 days ago
Copa
Sun, Aug 10 - Fri, Aug 15
VVI
Santa Cruz
PTY
Panama City
$763 Roundtrip, found 4 days ago
$763
Roundtrip
found 4 days ago
Select Copa flight, departing Sun, Aug 10 from Santa Cruz to Panama City, returning Fri, Aug 15, priced at $763 found 4 days ago
Copa
Thu, Jul 31 - Thu, Aug 7
VVI
Santa Cruz
PTY
Panama City
$772 Roundtrip, found 1 day ago
$772
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, Jul 31 from Santa Cruz to Panama City, returning Thu, Aug 7, priced at $772 found 1 day ago
Copa
Tue, Jan 13 - Fri, Jan 23
VVI
Santa Cruz
PTY
Panama City
$779 Roundtrip, found 5 days ago
$779
Roundtrip
found 5 days ago
Select Copa flight, departing Tue, Jan 13 from Santa Cruz to Panama City, returning Fri, Jan 23, priced at $779 found 5 days ago
avianca
Fri, Aug 1 - Wed, Aug 6
VVI
Santa Cruz
PTY
Panama City
$853 Roundtrip, found 5 hours ago
$853
Roundtrip
found 5 hours ago
Select avianca flight, departing Fri, Aug 1 from Santa Cruz to Panama City, returning Wed, Aug 6, priced at $853 found 5 hours ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $853
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $853
Flights from Santa Cruz (VVI) to Panama City (PTY)
Origin airport
Viru Viru Intl.
Destination airport
Tocumen Intl.
Roundtrip price
$657
Distance
2153 mi

Santa Cruz to Panama City Flights

The cheapest times to fly from Santa Cruz to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santa Cruz to Panama City are during the month of November. You can find some of the cheapest flights from Santa Cruz to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santa Cruz to Panama City

Sunday is one of the best days to book for cheap flights from Santa Cruz to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santa Cruz to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santa Cruz to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $449 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santa Cruz to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santa Cruz to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from SRZ to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SRZ to PTY?
The cheapest flights from SRZ to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY)?
Although Santa Cruz (SRZ-El Trompillo) doesn't have any direct flights to Tocumen Intl. Airport (PTY), other airports have nonstop routes. Flying from Viru Viru Intl. Airport (VVI) will get you to Panama City without any layovers.
What is the cheapest airline that flies from SRZ to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from SRZ to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY)?
You'll have to catch a flight with a layover when traveling from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from SRZ to PTY?
Typically you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY)?
Select a flight from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the likelihood of delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY) last-minute?
Holding off until right before your break to book a flight from SRZ to PTY often results in higher prices. Although you may find some last-minute offers, there's no guarantee. Keep your travel plans flexible for the best chance of getting a bargain.
Is it cheaper to book a SRZ to PTY flight and hotel package?
Booking a SRZ to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our impressive range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from El Trompillo Airport (SRZ) to Tocumen Intl. Airport (PTY)?
It's usually possible to cancel or reschedule your SRZ to PTY flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.