Can I rent a car with a debit card?
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It depends on the company you are planning to rent the car with a debit card with.
For Reserve now, pay now bookings, you'll see the accepted debit / credit cards on the Expedia checkout page.
For Reserve now, pay later bookings, the accepted debit / credit cards vary by car rental company. In this case it's a good idea to give them a call ahead of time to make sure they accept your card!