$1,565 Cheap KLM flights Rome (FCO) to San Diego (SAN)

Finding cheap one-way KLM flights from FCO to SAN from $1,565 on Expedia is a breeze — just filter by "Price (lowest to highest)." Alternatively, check out our affordable round-trip fares from $951 for your next exciting vacation.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Getting the best KLM deals from FCO to SAN often comes down to timing. You can save 17% on international flights when you book 18 to 29 days before takeoff instead of four to five months ahead. Better yet, you can pocket 17% on average by buying your fare on a Sunday rather than a Friday, which is often the most expensive day to book.* It's a good idea to start searching for flights about one month before you plan to travel.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to see the earliest departures from FCO to SAN. Setting off early means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.

A 4-star airline rating and the ability to rack up points through KLM Flying Blue are the start of the reasons to depart from FCO to SAN with KLM. Plus, when you join our One Key™ program, you can receive OneKeyCash™* alongside KLM's loyalty program earnings. It's yours to spend on your next adventure.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.