$379 Cheap Flights from Cusco (CUZ) to Chicago (ORD)

View $379 flight on Sun, Oct 25, 2026Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Chicago O'Hare Intl. Airport (ORD)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Cusco to Chicago (CUZ-ORD)

Prices were available within the past 7 days and start at $379 for one-way flights and $744 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Apr 15 - Mon, Apr 27
CUZ
Cusco
ORD
Chicago
$744 Roundtrip, found 2 days ago
$744
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Apr 15 from Cusco to Chicago, returning Mon, Apr 27, priced at $744 found 2 days ago
avianca
Mon, Sep 28 - Wed, Oct 14
CUZ
Cusco
ORD
Chicago
$772 Roundtrip, found 22 hours ago
$772
Roundtrip
found 22 hours ago
Select avianca flight, departing Mon, Sep 28 from Cusco to Chicago, returning Wed, Oct 14, priced at $772 found 22 hours ago
Delta
Wed, Aug 5 - Sat, Aug 22
CUZ
Cusco
ORD
Chicago
$779 Roundtrip, found 22 hours ago
$779
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Aug 5 from Cusco to Chicago, returning Sat, Aug 22, priced at $779 found 22 hours ago
avianca
Tue, May 26 - Fri, Jun 12
CUZ
Cusco
ORD
Chicago
$782 Roundtrip, found 22 hours ago
$782
Roundtrip
found 22 hours ago
Select avianca flight, departing Tue, May 26 from Cusco to Chicago, returning Fri, Jun 12, priced at $782 found 22 hours ago
Delta
Thu, Mar 12 - Thu, Mar 19
CUZ
Cusco
ORD
Chicago
$788 Roundtrip, found 4 days ago
$788
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Mar 12 from Cusco to Chicago, returning Thu, Mar 19, priced at $788 found 4 days ago
avianca
Tue, Nov 3 - Wed, Nov 4
CUZ
Cusco
ORD
Chicago
$797 Roundtrip, found 7 hours ago
$797
Roundtrip
found 7 hours ago
Select avianca flight, departing Tue, Nov 3 from Cusco to Chicago, returning Wed, Nov 4, priced at $797 found 7 hours ago
Delta
Tue, Nov 3 - Wed, Nov 4
CUZ
Cusco
ORD
Chicago
$800 Roundtrip, found 7 hours ago
$800
Roundtrip
found 7 hours ago
Select Delta flight, departing Tue, Nov 3 from Cusco to Chicago, returning Wed, Nov 4, priced at $800 found 7 hours ago
LATAM Airlines Group
Wed, Aug 5 - Wed, Aug 26
CUZ
Cusco
ORD
Chicago
$815 Roundtrip, found 22 hours ago
$815
Roundtrip
found 22 hours ago
Select LATAM Airlines Group flight, departing Wed, Aug 5 from Cusco to Chicago, returning Wed, Aug 26, priced at $815 found 22 hours ago
Aeromexico
Mon, Aug 24 - Thu, Sep 10
CUZ
Cusco
ORD
Chicago
$850 Roundtrip, found 22 hours ago
$850
Roundtrip
found 22 hours ago
Select Aeromexico flight, departing Mon, Aug 24 from Cusco to Chicago, returning Thu, Sep 10, priced at $850 found 22 hours ago
American Airlines
Mon, Jun 8 - Thu, Jun 25
CUZ
Cusco
ORD
Chicago
$1,108 Roundtrip, found 22 hours ago
$1,108
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Mon, Jun 8 from Cusco to Chicago, returning Thu, Jun 25, priced at $1,108 found 22 hours ago

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.
Book now

Alternative airports near Chicago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O'Hare Intl. ORD. Cheapest option available. Average driving time to city center is 23 minutes. Flights from $868
ORD
O'Hare Intl.
Cheapest
Average driving time to city center23 min
Flights from $868

Frequently asked questions

How much does a flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) cost?
You can find cheap one-way flights from $379 and cheap return flights from $744 Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) with Expedia. One-way flights generally range between $546 and $3125. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The cheapest month to fly from CUZ to ORD is April when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
Enter CUZ to ORD and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
LATAM Airlines Group, LAN Airlines and Avianca are just some of the carriers that fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.). Use Expedia's flight search tool to compare airlines on this route and find our cheapest option for your trip. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
To find a cheap flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The earliest flight from Cusco (CUZ) to Chicago (ORD) typically leaves at around 12:05 AM, operated by LATAM Airlines Group and Air Canada. This is a seasonal service active in March, and an early departure can help you maximize your time in Chicago. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
The most popular departure times for flights from Cusco (CUZ) to Chicago (ORD) are in the evening, from 6pm to 9pm. About 43% of passengers prefer this time window. Many major carriers, including LATAM Airlines and Delta Air Lines, offer flights during this window. This timing is popular because it allows travelers to enjoy their day in Cusco before heading to the airport.
How long does it take to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
A flight from CUZ to ORD with a layover takes around 25 hours, with the route covering approximately 3,968 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
Business class seats are offered on the CUZ to ORD route with Avianca.
How do I earn miles on a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight with Expedia?
It's easy to earn miles on a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Chicago from Alejandro Velasco Astete Intl. (CUZ)?
If you're planning to travel to Chicago from Alejandro Velasco Astete Intl. (CUZ), you can fly into O'Hare Intl. (ORD) Some flights may connect through major hubs like Jorge Chavez Intl. (LIM), El Dorado Intl. (BOG), El Alto Intl. (LPB) before reaching Chicago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) at the last minute?
Typically, booking a last minute flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight and hotel package?
Securing a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) Chicago Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.)?
If you booked your Cusco (CUZ-Alejandro Velasco Astete Intl.) to Chicago, IL (ORD-O'Hare Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
O'Hare Intl.
Airlines serving
Aeromexico, American Airlines, Delta, LATAM Airlines Group, avianca
Roundtrip price
$743
Distance
3967 mi

Book with confidence

Cusco to Chicago Flights

The cheapest times to fly from Cusco to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Chicago are during the month of April. You can find some of the cheapest flights from Cusco to Chicago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Chicago

Sunday is one of the best days to book for cheap flights from Cusco to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Chicago in 2026. You can also book with separate airlines for your outbound and return journeys, from $379 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to Chicago Flights

*Flight schedules are subject to change.

Explore a world of travel with Expedia

*Available to One Key members.