$104 Cheap Flights from Panama City (ECP) to St. Louis (STL)

View $104 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Panama City to St. Louis (ECP-STL)

Prices were available within the past 7 days and start at $104 for one-way flights and $207 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$207 Roundtrip, found 6 days ago
$207
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $207 found 6 days ago
American Airlines
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$207 Roundtrip, found 6 days ago
$207
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $207 found 6 days ago
Delta
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$209 Roundtrip, found 6 days ago
$209
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $209 found 6 days ago
Delta
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$210 Roundtrip, found 6 days ago
$210
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $210 found 6 days ago
Southwest Airlines
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$212 Roundtrip, found 6 days ago
$212
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $212 found 6 days ago
Southwest Airlines
Fri, Dec 12 - Sun, Dec 14
ECP
Panama City
STL
St. Louis
$214 Roundtrip, found 6 days ago
$214
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Fri, Dec 12 from Panama City to St. Louis, returning Sun, Dec 14, priced at $214 found 6 days ago
Southwest Airlines
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$242 Roundtrip, found 6 days ago
$242
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $242 found 6 days ago
Southwest Airlines
Fri, Dec 12 - Sun, Dec 14
ECP
Panama City
STL
St. Louis
$244 Roundtrip, found 6 days ago
$244
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Fri, Dec 12 from Panama City to St. Louis, returning Sun, Dec 14, priced at $244 found 6 days ago
Delta
Fri, Dec 5 - Mon, Dec 8
ECP
Panama City
STL
St. Louis
$245 Roundtrip, found 6 days ago
$245
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Dec 5 from Panama City to St. Louis, returning Mon, Dec 8, priced at $245 found 6 days ago
United
Fri, Nov 21 - Fri, Nov 28
ECP
Panama City
STL
St. Louis
$289 Roundtrip, found 2 days ago
$289
Roundtrip
found 2 days ago
Select United flight, departing Fri, Nov 21 from Panama City to St. Louis, returning Fri, Nov 28, priced at $289 found 2 days ago

Find the cheapest month to fly from Panama City (ECP) to St. Louis (STL)

September is typically the cheapest month to fly

From $151 - $415 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $453
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $453

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) cost?
Snag a cheap one-way flight from $104 or cheap return flight from $207 from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
Flying in December may help you find better deals, as it's the cheapest month for flights between ECP and STL. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest ECP to STL flight.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
You'll have to catch a flight with a layover when traveling from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from ECP to STL?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can change based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
Select a flight from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) that leaves before 3 PM to reduce the risk of cancellations and delays. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Waiting until just before your departure to book a ticket from ECP to STL generally means paying more. Although you may find some last-minute offers, they aren't always guaranteed. Keep your travel plans flexible for a better chance of landing a bargain.
Is it cheaper to book an ECP to STL flight and hotel package?
Compared with arranging flights and hotels separately, booking an ECP to STL flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place will take the stress out of travel planning. Just pick your flights and choose from our wide range of stays, then personalize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your ECP to STL flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

Travel information

Origin airport
Northwest Florida Beaches Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$201
Distance
634 mi

Book with confidence

Panama City to St. Louis Flights

The cheapest times to fly from Panama City to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to St. Louis are during the month of December. You can find some of the cheapest flights from Panama City to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to St. Louis

Sunday is one of the best days to book for cheap flights from Panama City to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $104 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to St. Louis Flights

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*Available to One Key members.