Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Roundtrip flights from Sioux Fa... to Denver starting at $107


Roundtrip flights from Sioux Fa... to Seattle starting at $308


Roundtrip flights from Sioux Fa... to Orlando starting at $304


Roundtrip flights from Sioux Fa... to Chicago starting at $251


Roundtrip flights from Sioux Fa... to Minneapo... starting at $219


Roundtrip flights from Sioux Fa... to Cancun starting at $538


Roundtrip flights from Sioux Fa... to Los Cabo... starting at $360


Roundtrip flights from Sioux Fa... to Portland starting at $243


Roundtrip flights from Sioux Fa... to Phoenix starting at $213


Roundtrip flights from Sioux Fa... to Los Ange... starting at $224