$216 Cheap Flights from Panama City (PTY) to Mexico City (MEX)

Bundle Your Flight + Hotel & Save!

Featured airlines

Top nine airline logos for desktop

    Plan, book, fly with confidence
    trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
    bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
    one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Panama City to Mexico City (PTY-MEX)

Prices were available within the past 7 days and start at $216 for one-way flights and $397 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Wed, Oct 16 - Sat, Oct 19
PTY
Panama City
MEX
Mexico City
$397 Roundtrip, found 4 days ago
$397
Roundtrip
found 4 days ago
Select avianca flight, departing Wed, Oct 16 from Panama City to Mexico City, returning Sat, Oct 19, priced at $397 found 4 days ago
avianca
Tue, May 7 - Fri, May 10
PTY
Panama City
MEX
Mexico City
$412 Roundtrip, just found
$412
Roundtrip
just found
Select avianca flight, departing Tue, May 7 from Panama City to Mexico City, returning Fri, May 10, priced at $412 just found
avianca
Mon, Oct 14 - Fri, Oct 18
PTY
Panama City
MEX
Mexico City
$416 Roundtrip, found 15 hours ago
$416
Roundtrip
found 15 hours ago
Select avianca flight, departing Mon, Oct 14 from Panama City to Mexico City, returning Fri, Oct 18, priced at $416 found 15 hours ago
avianca
Sun, Sep 1 - Sun, Sep 15
PTY
Panama City
MEX
Mexico City
$423 Roundtrip, just found
$423
Roundtrip
just found
Select avianca flight, departing Sun, Sep 1 from Panama City to Mexico City, returning Sun, Sep 15, priced at $423 just found
avianca
Wed, May 15 - Sun, May 26
PTY
Panama City
MEX
Mexico City
$425 Roundtrip, found 1 hour ago
$425
Roundtrip
found 1 hour ago
Select avianca flight, departing Wed, May 15 from Panama City to Mexico City, returning Sun, May 26, priced at $425 found 1 hour ago
avianca
Tue, Oct 1 - Fri, Oct 4
PTY
Panama City
MEX
Mexico City
$427 Roundtrip, found 14 hours ago
$427
Roundtrip
found 14 hours ago
Select avianca flight, departing Tue, Oct 1 from Panama City to Mexico City, returning Fri, Oct 4, priced at $427 found 14 hours ago
avianca
Wed, May 8 - Wed, May 15
PTY
Panama City
MEX
Mexico City
$431 Roundtrip, found 1 hour ago
$431
Roundtrip
found 1 hour ago
Select avianca flight, departing Wed, May 8 from Panama City to Mexico City, returning Wed, May 15, priced at $431 found 1 hour ago
avianca
Fri, May 17 - Wed, May 22
PTY
Panama City
MEX
Mexico City
$434 Roundtrip, just found
$434
Roundtrip
just found
Select avianca flight, departing Fri, May 17 from Panama City to Mexico City, returning Wed, May 22, priced at $434 just found
avianca
Sun, Jun 2 - Fri, Jun 14
PTY
Panama City
MEX
Mexico City
$435 Roundtrip, found 4 days ago
$435
Roundtrip
found 4 days ago
Select avianca flight, departing Sun, Jun 2 from Panama City to Mexico City, returning Fri, Jun 14, priced at $435 found 4 days ago
avianca
Wed, Oct 16 - Sat, Oct 19
PTY
Panama City
MEX
Mexico City
$435 Roundtrip, found 4 days ago
$435
Roundtrip
found 4 days ago
Select avianca flight, departing Wed, Oct 16 from Panama City to Mexico City, returning Sat, Oct 19, priced at $435 found 4 days ago
Flights from Panama City (PTY) to Mexico City (MEX)
Origin airport
Tocumen Intl.
Destination airport
Mexico City Intl.
Airlines serving
Air Canada, American Airlines, Copa, Delta, Iberia, United, avianca
Roundtrip price
$397
Distance
1498 mi
Average flight time
2 hours 57 mins

Panama City to Mexico City Flights

Whether you’re looking for a grand adventure or just want to get away for a last-minute break, flights from Panama City to Mexico City offer the perfect respite. Not only does exploring Mexico City provide the chance to make some magical memories, dip into delectable dishes, and tour the local landmarks, but the cheap airfare means you won’t bust your budget. So no matter whether your ideal itinerary involves flying one way, non-stop, or round trip, you’re bound to find flights that match your schedule on Expedia, and at prices that won’t shock your wallet.

Bagging a cheap flight from Panama City to Mexico City may mean more dollars to spend on for one-of-a-kind souvenirs when you arrive, but it doesn’t mean you have to skimp on your travel experience, as Expedia offers a sizzling selection of cheap airlines that’ll put you in your happy place on their planes, whether that’s getting lost in a hair-raising airport thriller, dreaming on the passing landscape over a glass of bubbly, or jotting down your vacation bucket list at 38,000 feet. There’s also bound to be plenty of opportunities to snap a few photos of the high life that will make your friends green with envy. After all, enjoying the journey is part of the fun.

With so many affordable flights and so many wonderful adventures awaiting you, there’s no reason to put off booking a fantastic flight from PTY to MEX today. So don’t leave it to the last minute to make your dream trip a reality: pack your bags with your go-to travel accessories, put together your list of must-see attractions and can’t-miss activities, and get ready to broaden your horizons – with Expedia, the wonders of Mexico City are only a plane trip away. Book your travel arrangements with us today!

If you would like to book flights to Mexico City more flexibly many prefer to purchase one-way tickets with options to take different airlines. A one way ticket to Mexico City is $216 now!

Frequently asked questions

How much is a one-way flight from PTY to MEX?
Book your next trip with Expedia and you could walk away with one-way Panama City flights to Mexico City from just $214. This was the best fare found for this particular journey departing in the next three months — an Avianca flight, jetting off from Panama Airport on June 5 2024 and arriving at Benito Juárez Intl. Airport. The price was last updated on April 17 2024 and has not changed since. Can’t wait to snap up your own bargain flights? The best offers are only a few clicks away.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Mexico Airport?
With Copa Airlines, a direct flight takes around 2 hours and 47 minutes. Take the 9:13AM flight from PTY and reach MEX at 11:00AM. Pick up a fabulous deal on this and other routes when you purchase your ticket with Expedia.
Is it cheaper to buy a plane ticket from PTY to Mexico Airport last minute?
Being the spontaneous type is a fantastic way to explore the globe, but it isn’t necessarily the smartest way to grab a bargain fare. Consider booking your Panama Airport to Mexico Airport journey ahead of time rather than waiting until the last minute. Based on flight pricing and demand studies in 2022, we have found that the best time to book domestic flights is between 28 – 35 days ahead of the departure date, and international flights three to four months in advance. Save all that spontaneity for when you’re exploring Mexico Airport!
What is the cheapest airline flying from Panama Airport to Mexico City Intl. Airport (MEX) in the next 90 days?
The cheapest airline traveling from Panama City to Mexico City found on Expedia is Avianca, which has fares starting from $214. This price is based on airfares found on Expedia with a departure date within the next 90 days. The flight leaves Tocumen Intl. Airport (PTY) on June 5 2024 and arrives at Mexico Airport. The pricing information was updated on April 17 2024 and has not changed since.
What's the cheapest price for a flight from Tocumen Intl. Airport (PTY) to Benito Juárez Intl. Airport next month?
The cheapest price for a one-way flight from Panama City to Mexico City within the next month is $214. If you’re looking to travel soon, now’s the time to book. This price was found after searching all available flights on Expedia with a departure date within the next 30 days. This airfare is for a one-way Avianca flight journeying from PTY on May 6 2024 and getting into Benito Juárez Intl. Airport. Pricing info was last updated on April 17 2024 and has not changed since.
What airline has the least delays from Panama Airport to MEX?
With an on-time performance score of 96%, Copa Airlines is the airline most likely to get you from PTY to Mexico City Intl. Airport (MEX) without a delay. Flight delays aren’t just frustrating — they can also make you miss an important connection that upends your entire journey. You can stay updated about delays by looking up your flight status through the Expedia App before you even reach the airport. If you’re already at the terminal and you’re worried about how the disruption will affect your trip, head to the customer service desk to discover what your options are.
Can I find cheap nonstop flights from PTY to Mexico City Intl. Airport (MEX) in the next three months?
The cheapest price we could find for a roundtrip nonstop flight from Panama City to Mexico City in the next 90 days is $565. This figure is based on available flights on Expedia with a departure date within the next three months. This fare is for a flight via Copa setting off from Tocumen Intl. Airport (PTY) on May 14 2024 and arriving at Mexico Airport, with a return leg on May 21 2024. This price was last updated on April 17 2024.Make use of our filters to discover nonstop cheap flights from Panama Airport to MEX. Simply click on “Nonstop” under “Filter by” after your search results appear. Travel plans not set in stone? You can also make use of the “Flexible dates” dropdown menu to review prices for nearby dates. Booking a flight that works within your budget and schedule couldn’t be easier.
What airports do you fly into for Mexico City from Tocumen?
With Mexico City Intl. Airport (MEX), Toluca Intl. Airport (TLC) and Hermanos Serdan Intl. Airport (PBC) to choose from, journeying from Tocumen to Mexico City is no sweat. The city’s major hub, Mexico City Intl. Airport (MEX), is around 3 mi east of the center. Apart from ticket costs, consider factors like the ease of getting from the airport and the distance to your hotel before deciding where you’ll get off the plane. Get your Mexico City vacation off to an awesome start by checking out Basilica of Our Lady of Guadalupe and Zócalo.
What are the most popular departure times for flights from PTY to MEX?
The most popular departure times for journeys from Tocumen Intl. Airport (PTY) to Benito Juárez Intl. Airport are between 9:00 PM - 10:00 PM on Copa Airlines. Our tip is to zoom off in the morning. The earlier you travel, the greater your chances of a delay-free flight with less air traffic around.
Can I change the date of my flight from Panama Airport to Mexico Airport?
We know plans can change, so Expedia is here to help make amending your journey easy. First, access your Tocumen Intl. Airport (PTY) to Mexico City Intl. Airport (MEX) itinerary through the Expedia Trips portal and check the ticket rules and conditions about what sorts of changes are allowed. If you purchased your ticket in the last 24 hours, some airlines will let you cancel at no cost and organize new flights. If you booked your fare more than 24 hours ago, connect with us through our Customer Service portal to find out what your options are.
Mexico City nearby Airports

Puebla

Panama City to Hermanos Serdan Intl.
$763.19

Santa Lucía

*Available to One Key members.