$239 Cheap Flights from Roanoke (ROA) to Des Moines (DSM)

View $239 flight on Sun, Feb 8, 2026Opens in a new window

Popular airlines from Roanoke Regional Airport (ROA) to Des Moines International Airport (DSM)

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Cheap Flights from Roanoke to Des Moines (ROA-DSM)

Prices were available within the past 7 days and start at $239 for one-way flights and $249 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Mar 3 - Mon, Mar 9
ROA
Roanoke
DSM
Des Moines
$249 Roundtrip, found 1 hour ago
$249
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Mar 3 from Roanoke to Des Moines, returning Mon, Mar 9, priced at $249 found 1 hour ago
United
Tue, Dec 2 - Sat, Dec 6
ROA
Roanoke
DSM
Des Moines
$249 Roundtrip, found 4 hours ago
$249
Roundtrip
found 4 hours ago
Select United flight, departing Tue, Dec 2 from Roanoke to Des Moines, returning Sat, Dec 6, priced at $249 found 4 hours ago
Delta
Wed, Dec 3 - Sat, Dec 13
ROA
Roanoke
DSM
Des Moines
$254 Roundtrip, found 3 hours ago
$254
Roundtrip
found 3 hours ago
Select Delta flight, departing Wed, Dec 3 from Roanoke to Des Moines, returning Sat, Dec 13, priced at $254 found 3 hours ago
Delta
Mon, Nov 17 - Mon, Nov 24
ROA
Roanoke
DSM
Des Moines
$264 Roundtrip, found 6 hours ago
$264
Roundtrip
found 6 hours ago
Select Delta flight, departing Mon, Nov 17 from Roanoke to Des Moines, returning Mon, Nov 24, priced at $264 found 6 hours ago
United
Tue, Dec 2 - Sat, Dec 6
ROA
Roanoke
DSM
Des Moines
$269 Roundtrip, found 4 hours ago
$269
Roundtrip
found 4 hours ago
Select United flight, departing Tue, Dec 2 from Roanoke to Des Moines, returning Sat, Dec 6, priced at $269 found 4 hours ago
United
Wed, Jul 1 - Wed, Jul 8
ROA
Roanoke
DSM
Des Moines
$283 Roundtrip, found 2 days ago
$283
Roundtrip
found 2 days ago
Select United flight, departing Wed, Jul 1 from Roanoke to Des Moines, returning Wed, Jul 8, priced at $283 found 2 days ago
Delta
Mon, Nov 17 - Sat, Nov 22
ROA
Roanoke
DSM
Des Moines
$284 Roundtrip, found 6 hours ago
$284
Roundtrip
found 6 hours ago
Select Delta flight, departing Mon, Nov 17 from Roanoke to Des Moines, returning Sat, Nov 22, priced at $284 found 6 hours ago
United
Sat, Nov 15 - Sat, Nov 22
ROA
Roanoke
DSM
Des Moines
$288 Roundtrip, found 3 days ago
$288
Roundtrip
found 3 days ago
Select United flight, departing Sat, Nov 15 from Roanoke to Des Moines, returning Sat, Nov 22, priced at $288 found 3 days ago
United
Sat, Nov 15 - Sat, Nov 22
ROA
Roanoke
DSM
Des Moines
$293 Roundtrip, found 3 days ago
$293
Roundtrip
found 3 days ago
Select United flight, departing Sat, Nov 15 from Roanoke to Des Moines, returning Sat, Nov 22, priced at $293 found 3 days ago
American Airlines
Fri, Dec 5 - Sun, Dec 7
ROA
Roanoke
DSM
Des Moines
$335 Roundtrip, found 4 hours ago
$335
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Fri, Dec 5 from Roanoke to Des Moines, returning Sun, Dec 7, priced at $335 found 4 hours ago

Find the cheapest month to fly from Roanoke (ROA) to Des Moines (DSM)

February is typically the cheapest month to fly

From $247 - $588 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $264
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $264

Frequently asked questions

How much does a flight from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) cost?
Snag a cheap one-way flight from $239 or cheap return flight from $249 from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
March is the most affordable month to fly from ROA to DSM. Avoiding peak travel times is often the key to finding better fares.
What is the cheapest airline that flies from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from ROA to DSM, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
Nonstop flights from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from ROA to DSM?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* However, this can vary depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
Select a flight from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from ROA to DSM are usually more expensive. To lock in the best rates, start searching for flights ahead of time. That said, if you're flexible with your travel dates, it's possible to score a cheap ticket right before you leave.
Is it cheaper to book a ROA to DSM flight and hotel package?
Securing a ROA to DSM flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Select from our impressive range of accommodations and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
If you booked your ROA to DSM flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

Travel information

Origin airport
Roanoke Regional
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$248
Distance
784 mi

Book with confidence

Roanoke to Des Moines Flights

The cheapest times to fly from Roanoke to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Roanoke to Des Moines are during the month of March. You can find some of the cheapest flights from Roanoke to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Roanoke to Des Moines

Sunday is one of the best days to book for cheap flights from Roanoke to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Roanoke to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Roanoke to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $239 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Roanoke to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Roanoke to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Roanoke to Des Moines Flights

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*Available to One Key members.