$239 Cheap Flights from Roanoke (ROA) to Des Moines (DSM)

View $239 flight on Wed, Mar 18, 2026Opens in a new window

Popular airlines from Roanoke Regional Airport (ROA) to Des Moines International Airport (DSM)

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Cheap Flights from Roanoke to Des Moines (ROA-DSM)

Prices were available within the past 7 days and start at $239 for one-way flights and $249 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Oct 30 - Sun, Nov 2
ROA
Roanoke
DSM
Des Moines
$249 Roundtrip, found 14 hours ago
$249
Roundtrip
found 14 hours ago
Select Delta flight, departing Thu, Oct 30 from Roanoke to Des Moines, returning Sun, Nov 2, priced at $249 found 14 hours ago
Delta
Tue, Sep 30 - Mon, Oct 6
ROA
Roanoke
DSM
Des Moines
$254 Roundtrip, found 1 day ago
$254
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Sep 30 from Roanoke to Des Moines, returning Mon, Oct 6, priced at $254 found 1 day ago
Delta
Wed, Nov 12 - Sun, Nov 23
ROA
Roanoke
DSM
Des Moines
$254 Roundtrip, found 5 days ago
$254
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Nov 12 from Roanoke to Des Moines, returning Sun, Nov 23, priced at $254 found 5 days ago
Delta
Tue, Sep 30 - Sat, Oct 4
ROA
Roanoke
DSM
Des Moines
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Sep 30 from Roanoke to Des Moines, returning Sat, Oct 4, priced at $259 found 1 day ago
United
Wed, Oct 29 - Sat, Nov 1
ROA
Roanoke
DSM
Des Moines
$259 Roundtrip, found 6 days ago
$259
Roundtrip
found 6 days ago
Select United flight, departing Wed, Oct 29 from Roanoke to Des Moines, returning Sat, Nov 1, priced at $259 found 6 days ago
American Airlines
Thu, Oct 30 - Sun, Nov 2
ROA
Roanoke
DSM
Des Moines
$274 Roundtrip, found 14 hours ago
$274
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Thu, Oct 30 from Roanoke to Des Moines, returning Sun, Nov 2, priced at $274 found 14 hours ago
United
Wed, Sep 24 - Wed, Oct 1
ROA
Roanoke
DSM
Des Moines
$276 Roundtrip, found 6 days ago
$276
Roundtrip
found 6 days ago
Select United flight, departing Wed, Sep 24 from Roanoke to Des Moines, returning Wed, Oct 1, priced at $276 found 6 days ago
Delta
Sat, Oct 25 - Tue, Oct 28
ROA
Roanoke
DSM
Des Moines
$279 Roundtrip, found 1 day ago
$279
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Oct 25 from Roanoke to Des Moines, returning Tue, Oct 28, priced at $279 found 1 day ago
United
Thu, Oct 23 - Tue, Oct 28
ROA
Roanoke
DSM
Des Moines
$280 Roundtrip, found 6 days ago
$280
Roundtrip
found 6 days ago
Select United flight, departing Thu, Oct 23 from Roanoke to Des Moines, returning Tue, Oct 28, priced at $280 found 6 days ago
United
Wed, Sep 24 - Wed, Oct 1
ROA
Roanoke
DSM
Des Moines
$282 Roundtrip, found 6 days ago
$282
Roundtrip
found 6 days ago
Select United flight, departing Wed, Sep 24 from Roanoke to Des Moines, returning Wed, Oct 1, priced at $282 found 6 days ago

Find the cheapest month to fly from Roanoke (ROA) to Des Moines (DSM)

October is typically the cheapest month to fly

From $238 - $573 per traveler.
Flights from Roanoke (ROA) to Des Moines (DSM)
Origin airport
Roanoke Regional
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$248
Distance
784 mi

Roanoke to Des Moines Flights

The cheapest times to fly from Roanoke to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Roanoke to Des Moines are during the month of October. You can find some of the cheapest flights from Roanoke to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Roanoke to Des Moines

Sunday is one of the best days to book for cheap flights from Roanoke to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Roanoke to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Roanoke to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $239 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Roanoke to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Roanoke to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) cost?
Snag a cheap one-way flight from $239 or cheap return flight from $249 from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
October is the most affordable month to fly from ROA to DSM. Avoiding peak travel times is often the key to finding better fares.
What is the cheapest airline that flies from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from ROA to DSM, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
Nonstop flights from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from ROA to DSM?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* However, this can vary depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
Select a flight from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from ROA to DSM are usually more expensive. To lock in the best rates, start searching for flights ahead of time. That said, if you're flexible with your travel dates, it's possible to score a cheap ticket right before you leave.
Is it cheaper to book a ROA to DSM flight and hotel package?
Securing a ROA to DSM flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Select from our impressive range of accommodations and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Roanoke Regional Airport (ROA) to Des Moines Intl. Airport (DSM)?
If you booked your ROA to DSM flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

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*Available to One Key members.