$335 Cheap Flights from Tampa (TPA) to Florence (FLO)

View $335 flight on Wed, Nov 19, 2025Opens in a new window

Popular airlines from Tampa Intl. Airport (TPA) to Florence, SC (FLO-Florence Regional)

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Cheap Flights from Tampa to Florence (TPA-FLO)

Prices were available within the past 7 days and start at $335 for one-way flights and $411 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Feb 26 - Sat, Apr 25
TPA
Tampa
FLO
Florence
$411 Roundtrip, found 2 hours ago
$411
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Feb 26 from Tampa to Florence, returning Sat, Apr 25, priced at $411 found 2 hours ago
American Airlines
Thu, Feb 26 - Sat, Apr 25
TPA
Tampa
FLO
Florence
$433 Roundtrip, found 2 hours ago
$433
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Feb 26 from Tampa to Florence, returning Sat, Apr 25, priced at $433 found 2 hours ago
American Airlines
Thu, Dec 18 - Mon, Dec 22
TPA
Tampa
FLO
Florence
$435 Roundtrip, found 22 hours ago
$435
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Dec 18 from Tampa to Florence, returning Mon, Dec 22, priced at $435 found 22 hours ago
American Airlines
Sat, Nov 29 - Fri, Dec 5
TPA
Tampa
FLO
Florence
$441 Roundtrip, found 1 day ago
$441
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 29 from Tampa to Florence, returning Fri, Dec 5, priced at $441 found 1 day ago
American Airlines
Thu, Feb 26 - Sat, Apr 25
TPA
Tampa
FLO
Florence
$442 Roundtrip, found 2 hours ago
$442
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Feb 26 from Tampa to Florence, returning Sat, Apr 25, priced at $442 found 2 hours ago
American Airlines
Tue, Feb 24 - Tue, Apr 28
TPA
Tampa
FLO
Florence
$447 Roundtrip, found 2 hours ago
$447
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Tue, Feb 24 from Tampa to Florence, returning Tue, Apr 28, priced at $447 found 2 hours ago
American Airlines
Thu, Dec 18 - Mon, Dec 22
TPA
Tampa
FLO
Florence
$457 Roundtrip, found 22 hours ago
$457
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Thu, Dec 18 from Tampa to Florence, returning Mon, Dec 22, priced at $457 found 22 hours ago
American Airlines
Sat, Nov 29 - Fri, Dec 5
TPA
Tampa
FLO
Florence
$463 Roundtrip, found 1 day ago
$463
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 29 from Tampa to Florence, returning Fri, Dec 5, priced at $463 found 1 day ago
American Airlines
Thu, Feb 26 - Sat, Apr 25
TPA
Tampa
FLO
Florence
$465 Roundtrip, found 2 hours ago
$465
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Thu, Feb 26 from Tampa to Florence, returning Sat, Apr 25, priced at $465 found 2 hours ago
American Airlines
Mon, Feb 23 - Tue, Apr 28
TPA
Tampa
FLO
Florence
$471 Roundtrip, found 2 hours ago
$471
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Mon, Feb 23 from Tampa to Florence, returning Tue, Apr 28, priced at $471 found 2 hours ago

Alternative airports near Florence

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Florence Regional FLO. Cheapest and Closest option available. Average driving time to city center is 5 minutes. Flights from $512
FLO
Florence Regional
CheapestClosest
Average driving time to city center5 min
Flights from $512

Frequently asked questions

How much does a flight from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO) cost?
Snag a cheap one-way flight from $335 or cheap return flight from $411 from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO)?
February is the least expensive month to fly from TPA to FLO. Avoiding peak travel times is often the key to finding a great deal.
What is the cheapest airline that flies from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO)?
To find the cheapest airline that'll fly you from TPA to FLO, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO)?
Nonstop flights from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TPA to FLO?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary depending on various factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO)?
To avoid possible delays on the Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO) route, aim to fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Florence from Tampa Intl. Airport (TPA)?
Browse your flight options from Tampa Intl. Airport (TPA) to Myrtle Beach Intl. Airport (MYR). This is the only Florence airport you can land at if you're taking a direct flight.
Is it cheaper to buy a plane ticket from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO) last-minute?
Booking your flight from TPA to FLO just before your trip is usually more expensive. But if there's some wiggle room with your departure times and dates, you could land a cheap last-minute fare.
Is it cheaper to book a TPA to FLO flight and hotel package?
Booking a TPA to FLO flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our wide range of stays and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Tampa Intl. Airport (TPA) to Florence Regional Airport (FLO)?
If you reserved your TPA to FLO flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you want more information.

Travel information

Origin airport
Tampa Intl.
Destination airport
Florence Regional
Airlines serving
American Airlines
Roundtrip price
$410
Distance
460 mi

Book with confidence

Tampa to Florence Flights

The cheapest times to fly from Tampa to Florence

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tampa to Florence are during the month of February. You can find some of the cheapest flights from Tampa to Florence with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tampa to Florence

Sunday is one of the best days to book for cheap flights from Tampa to Florence: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tampa to Florence

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tampa to Florence in 2025. You can also book with separate airlines for your outbound and return journeys, from $335 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tampa to Florence flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tampa to Florence airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Tampa to Florence Flights

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