$182 Cheap Flights from Knoxville (TYS) to Portland (PDX)

Knoxville (TYS) to Portland (PDX) at a glance

Travel between Knoxville (TYS) and Portland (PDX) with a selection of airlines offering routes on this domestic long-haul journey. Explore various options for flights from Knoxville to Portland, whether you prefer full-service carriers or budget-friendly choices. This allows you to find an itinerary that aligns with your budget, schedule, and travel plans as you discover the iconic sights and vibrant neighborhoods of Portland. Here, you’ll find essential information for your flight from McGhee Tyson Airport to Portland International Airport.

• Fastest flight duration: around 6h 30m in-flight, plus roughly 1h 15m layover with one stop
• Route distance: roughly 2,100 miles (3,380 km)
• Flights per week: around 11 departures on average
• Typical fares (one-way): economy tickets often range from $125–$480, depending on seasonality and how far ahead you book

Flights from McGhee Tyson Airport (TYS) to Portland International Airport (PDX)

According to recent traveler bookings, here are the top airlines favored for flights from Knoxville to Portland, particularly for one-stop and multi-stop options. Common layover spots include Dallas-Fort Worth International Airport (DFW) with an approximately 1 hour and 30-minute layover, O'Hare International Airport (ORD) at about 1 hour and 15 minutes, and Hartsfield-Jackson Atlanta International Airport (ATL) also around 1 hour and 30 minutes. This variety allows you to adjust for price, total travel time, and cabin class to create the ideal travel itinerary.

• American Airlines: As a comprehensive service provider, American Airlines offers one-stop flights with one-way fares generally falling between $125 and $490. This airline accounts for about 44% of the departures on this route, featuring an in-flight duration of 6 hours and 30 minutes, and a total travel time of approximately 7 hours and 45 minutes, including layovers.
• United: United Airlines serves as a full-service airline with one-stop options, where one-way ticket prices typically range from $135 to $535. Representing around 30% of departures on this route, it also has an in-flight time of 6 hours and 30 minutes, with a total journey time of about 7 hours and 45 minutes, factoring in the layover.
• Delta: Delta Airlines is another full-service carrier providing one-stop service, with one-way fares usually between $125 and $485. This airline accounts for roughly 19% of departures for this route, featuring an in-flight duration of 6 hours and 30 minutes, alongside a total travel time estimated at 7 hours and 45 minutes, including layover time.
• Frontier Airlines: A budget-friendly option, Frontier Airlines offers one-stop service with one-way fares that typically range from $125 to $310. This low-cost carrier represents about 3% of the departures on this route, with a flight time of 6 hours and 30 minutes and a total travel time of around 7 hours and 45 minutes, including layover.
• Alaska Airlines: Providing full-service one-stop flights, Alaska Airlines has one-way fares generally ranging from $225 to $515. This airline makes up about 3% of the departures on this route, with an in-flight time of 6 hours and 30 minutes and a total journey time of roughly 7 hours and 45 minutes, including layovers.

Travelers flying from Knoxville to Portland can opt for an upgrade. Both American Airlines and United provide first-class service for this route.

Best time to fly from Knoxville (TYS) to Portland (PDX)

The most popular months for travelers flying from Knoxville to Portland are March, April, and June, when peak temperatures in Portland reach up to 62.4°F in June. If you prefer quieter travel, consider September, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 64°F. For better deals, August usually offers the lowest average one-way fare around $214. Flight availability peaks in June, with approximately 17 flights per week, making it easier to find convenient departure times. February and March have the fewest flights, with approximately 9 flights per week.

• Cheapest time to fly: August usually offers good deals with average one-way fare around $214, roughly 22% cheaper than the yearly average.
• Another budget-friendly time to fly: September typically offers an average one-way fare of around $216.
• Most flight options: June has the highest number of flights from Knoxville to Portland, with approximately 17 flights per week, giving you more flexibility in scheduling your trip.

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Knoxville (TYS) to Portland (PDX)

• Chattanooga to Portland (CHA-PDX): Chattanooga Metropolitan Airport (CHA) lies approximately 86 miles from McGhee Tyson Airport (TYS). On this route, one-way economy fares generally vary from $100 to $415, influenced by the season and how in advance you book. Travelers can find both one-stop and multi-stop options, with common layover points being Dallas-Fort Worth International Airport (DFW) and O'Hare International Airport (ORD). The leading airlines for this route include American Airlines and Delta, and first-class service is also offered.

How to find the best prices for flights from Knoxville (TYS) to Portland (PDX)

Getting some of the best deals on flights from Knoxville to Portland is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are usually found when booking 2-8 weeks in advance, which is also the peak time for most travelers. Additionally, afternoon departures between 12 PM and 6 PM not only tend to offer lower prices but are also the most popular flight times. Flying on Thursday can provide both affordability and popularity as a travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Portland International Airport from McGhee Tyson Airport

Portland welcomes travelers from Knoxville with a range of transport options based on price, convenience, and proximity. For departures, McGhee Tyson Airport is roughly a 20-minute drive (covering about 15 miles) from central Knoxville. Here's how to reach Portland efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Portland, with private rides that can be arranged in advance.
• Car rental: Renting a car from Portland International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Portland International Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From Portland International Airport, several key transport links are within easy reach. Both the Portland International Airport Bus Stop (a bus station) and the Portland International Airport Station (a metro station) are located about 0.3 miles from the airport, easily accessible on foot. Meanwhile, Portland Union Station (a train station) is approximately 9 miles away and best reached by car.

Knoxville to Portland Flights

The cheapest times to fly from Knoxville to Portland

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Portland are during the month of November. You can find some of the cheapest flights from Knoxville to Portland with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to Portland

Sunday is one of the best days to book for cheap flights from Knoxville to Portland: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to Portland

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Portland in 2026. You can also book with separate airlines for your outbound and return journeys, from $182 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Portland flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Portland airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.