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Find 5 Star Hotels in South San Francisco, CA from $142

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Compare South San Francisco 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Fairmont San Francisco
Terrace/patio
Fairmont San Francisco
5.0 star property
8.6 out of 10, Excellent, 1,025 reviews
"Best hotel in San Francisco. A real classic!"
The price is $242
$323 total
includes taxes & fees
Jun 16 - Jun 17
Fairmont San Francisco
Palace Hotel, a Luxury Collection Hotel, San Francisco
Property amenity
Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
9.0 out of 10, Wonderful, 1,002 reviews
"This hotel is excellent. Staff and service top notch. Bed and Bedding are superb. Beautiful grand hotel."
The price is $233
$272 total
includes taxes & fees
Jun 30 - Jul 1
Palace Hotel, a Luxury Collection Hotel, San Francisco
Taj Campton Place
City view
Taj Campton Place
5.0 star property
9.2 out of 10, Wonderful, 1,002 reviews
"The staff were friendly and the service was exceptional. "
The price is $168
$231 total
includes taxes & fees
Jun 22 - Jun 23
Taj Campton Place
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The Ritz-Carlton, San Francisco
Club Suite, 1 Bedroom, Non Smoking | 1 bedroom, Frette Italian sheets, premium bedding, in-room safe
The Ritz-Carlton, San Francisco
5.0 star property
9.2 out of 10, Wonderful, 1,002 reviews
"Property was in excellent condition and the staff very helpful and extremely professional "
The price is $379
$441 total
includes taxes & fees
Jun 21 - Jun 22
The Ritz-Carlton, San Francisco
Claremont Club & Spa - A Fairmont Hotel
Exterior
Claremont Club & Spa - A Fairmont Hotel
5.0 star property
8.8 out of 10, Excellent, 1,005 reviews
"We asked for nightly turn down service for the three nights we were there. We received that service the first and not again. When I originally requested it, I was assured that would take care of it for our stay. Also I was disappointed that your gym was not 24/7. This required me to go to Planet Fitness."
The price is $269
$366 total
includes taxes & fees
Jun 28 - Jun 29
Claremont Club & Spa - A Fairmont Hotel
1 Hotel San Francisco
Gift shop
1 Hotel San Francisco
5.0 star property
9.2 out of 10, Wonderful, 236 reviews
"What we loved: - Stylish and modern design - Overall hotel vibe - Great amenities in the room What we didn't like: - No buffet breakfast option - The minibar in our room had some dust on the items - Bar was out of my fav beer"
The price is $299
$401 total
includes taxes & fees
Jun 15 - Jun 16
1 Hotel San Francisco
Four Seasons Hotel San Francisco
Terrace/patio
Four Seasons Hotel San Francisco
5.0 star property
9.4 out of 10, Exceptional, 911 reviews
"the only thing not good was that I asked for a wake up call at 3:00am and the front desk said they would but no one called."
The price is $415
$484 total
includes taxes & fees
Jun 21 - Jun 22
Four Seasons Hotel San Francisco
Four Seasons Hotel Silicon Valley at East Palo Alto
Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
Four Seasons Hotel Silicon Valley at East Palo Alto
5.0 star property
9.4 out of 10, Exceptional, 551 reviews
"Matthew in the bar was fabulous "
The price is $316
$359 total
includes taxes & fees
Jun 22 - Jun 23
Four Seasons Hotel Silicon Valley at East Palo Alto
The St. Regis San Francisco
Exterior
The St. Regis San Francisco
5.0 star property
9.4 out of 10, Exceptional, 609 reviews
"Beautiful hotel. Great service. Great food and drinks. "
The price is $428
$499 total
includes taxes & fees
Jun 21 - Jun 22
The St. Regis San Francisco
Rosewood Sand Hill
Couples treatment rooms, sauna, spa tub, body treatments, hydrotherapy
Rosewood Sand Hill
5.0 star property
9.4 out of 10, Exceptional, 198 reviews
"Very nice property. Service is excellent "
The price is $901
$1,079 total
includes taxes & fees
Jul 4 - Jul 5
Rosewood Sand Hill
Nobu Hotel Palo Alto
Meeting facility
Nobu Hotel Palo Alto
5.0 star property
9.2 out of 10, Wonderful, 356 reviews
"Comfortable "
The price is $395
$457 total
includes taxes & fees
Jun 21 - Jun 22
Nobu Hotel Palo Alto
The Ritz-Carlton, Half Moon Bay
Egyptian cotton sheets, premium bedding, down comforters, in-room safe
The Ritz-Carlton, Half Moon Bay
5.0 star property
9.0 out of 10, Wonderful, 588 reviews
"Was under construction with early morning noise- not ideal. But beautiful property"
The price is $799
$1,005 total
includes taxes & fees
Jul 11 - Jul 12
The Ritz-Carlton, Half Moon Bay
Hotel Drisco
City view
Hotel Drisco
5.0 star property
9.8 out of 10, Exceptional, 396 reviews
"I love this hotel so much, not only because we got married the weekend we stayed here but I was just honestly blown away by the entire property and service we received. This hotel is the best hotel I’ve ever stayed in!! The suite was just so perfect and clean. The complimentary items from the fresh fruit plate to the Carmel popcorn, I was in awe. I would stay here again and again because of the staff; every person was so welcoming and said hello. The bellman Francis was the absolute sweetest and...
The price is $485
$559 total
includes taxes & fees
Jul 1 - Jul 2
Hotel Drisco
Mansion on Sutter
Front of property
Mansion on Sutter
5.0 star property
9.4 out of 10, Exceptional, 153 reviews
"Amazing staff. Very friendly. They even make espresso and latte. Lobby is beautiful. It’s like a gallery of arts. Very relaxing environment. Location may be the best in the city. "
The price is $261
$332 total
includes taxes & fees
Jun 16 - Jun 17
Mansion on Sutter
Fairmont Heritage Place, Ghirardelli Square
Exterior
Fairmont Heritage Place, Ghirardelli Square
5.0 star property
9.4 out of 10, Exceptional, 348 reviews
"Great place"
The price is $1,055
$1,229 total
includes taxes & fees
Jun 16 - Jun 17
Fairmont Heritage Place, Ghirardelli Square
Dimond Abode Vacation Rental 3428
Terrace/patio
Dimond Abode Vacation Rental 3428
5.0 star property
10.0 out of 10, Exceptional, 3 reviews
"Wonderful place to stay! Host was great and the place was clean. Nice neighborhood, safe, and right near a good gas station. Will definitely stay next time I go back to Oakland."
Dimond Abode Vacation Rental 3428

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in South San Francisco.
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

2500 Mason St, San Francisco, CA
The price is $142 per night from Jun 17 to Jun 18
$142
$199 total
includes taxes & fees
Jun 17 - Jun 18
8.6/10 Excellent! (6,279 reviews)
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Ready for an incredible adventure? Add even more pleasure on your next trip to South San Francisco by treating yourself to the best of the best when it comes to accommodation. It's an ideal fusion. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made South San Francisco so popular in the last year. There's no reason to delay a getaway to South San Francisco any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in South San Francisco and get ready to be pampered like never before. Don't wait any longer!

Get a Great Deal on 5-Star Hotels in South San Francisco

You can expect high quality from your hotel. Spa treatments, delicious meals, and attentive guest service are all at your fingertips. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in South San Francisco offer great customer service, averaging 3.7 in our ranking system, giving you a lot to look forward to. What creature comforts do you want in your lodging? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? High thread-count sheets, piping hot coffees, and even spectacular views...these hotels are one-of-a-kind.

Can't wait to get outside? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in South San Francisco are waiting for you to rest up after a busy day. Ready to learn more? Then explore the 1,590 reviews various guests have left on Expedia and get to know these places.

Make Your Escape

The results are in, and South San Francisco 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Decide on one of Expedia's South San Francisco 5-star hotels today and soothe yourself in complete comfort tomorrow.

Frequently asked questions

What are the best 5-star hotels in South San Francisco?
The St. Regis San Francisco, Four Seasons Hotel San Francisco and Mansion on Sutter are among the best 5-star hotels in South San Francisco, according to our traveler reviews. These upscale hotels rate highly for things like their location, conveniences and guest services. Pick your favorite and experience the best of everything.
How much does it cost to stay in a 5-star hotel in South San Francisco?
The amount you pay for a 5-star hotel in South San Francisco depends on things such as when you plan to go and the length of your break. Our insider tip for bagging the best deal? Use our pricing filters to compare the available hotels for your chosen dates.

  • Search for the lowest price per night from $142

What makes a hotel 5 stars in South San Francisco?
In South San Francisco, a hotel must provide a certain number of upscale amenities to be designated 5 stars. These may include on-site gyms, saunas and spas, gourmet restaurants, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their outstanding standard of service. You can look forward to things like concierge services, in-room massages and nightly turn-down services. Some may also offer thoughtful touches like welcome gifts.
Are there any 5-star all-inclusive resorts in South San Francisco?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in South San Francisco with the help of Expedia’s filter tool. Search for hotels with a 5-star rating and select the “All inclusive” filter. Make sure you check what’s included in the price. This way, you’re ready to take advantage of the many perks on offer from the moment you arrive.
What are the top 5-star spa hotels in South San Francisco?
Four Seasons Hotel San Francisco combines plush accommodations with blissful wellness therapies and experiences. Choose from a menu of facials, massages and more at this well-known 5-star spa retreat in South San Francisco.
Are there any 5-star vacation rentals in South San Francisco?
Our site doesn’t have any 5-star vacation rentals in South San Francisco. However, you will still find a few top-rated options where the only thing on your agenda will be to relax and have fun. See what’s available by searching through our vacation rentals in South San Francisco.