Ortigia Vacations from $1,423

Book a Hotel + Flight or Car together to unlock savings

Your Ortigia Vacation

Reserving a tailor-made Ortigia vacation package is a superb way to become acquainted with this unique neighborhood. From its renowned sites to its little-known secrets, there's plenty to discover. Eager to do some sightseeing during your trip to Ortigia? Pencil in a visit to nearby attractions like Cathedral of Syracuse, Temple of Apollo and Museo Archeologico Regionale Paolo Orsi. Stop dreaming and start doing. When you're ready to book your next vacation to Ortigia, Expedia will help you get there.

The Latest Ortigia Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Sant Alphio Garden Hotel & Spa

Sant Alphio Garden Hotel & Spa

$1,423
per person
Oct 23 - Oct 27
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Catania (CTA)
8/10 Very Good! (216 reviews)
Palazzo Vecchio Taormina

Palazzo Vecchio Taormina

Taormina City Centre
$1,628
per person
Nov 15 - Nov 19
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.8/10 Exceptional! (61 reviews)
Eurostars Monte Tauro

Eurostars Monte Tauro

$1,905
per person
Oct 26 - Oct 31
found 1 day ago
Roundtrip non-stop flight included
San Francisco (SFO) to Catania (CTA)
8.6/10 Excellent! (486 reviews)
The Ashbee Hotel - The Leading Hotels of the World

The Ashbee Hotel - The Leading Hotels of the World

Save 100% on your flight
$3,468
per person
Oct 8 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.2/10 Wonderful! (145 reviews)
The room was beautiful with a lovely turn down service. The staff were amazing and personable remembering previous orders and offering additions to choices.

Reviewed on Aug 27, 2026

Grand Hotel San Pietro Taormina - Preferred Hotels & Resorts

Grand Hotel San Pietro Taormina - Preferred Hotels & Resorts

$1,688
per person
Nov 15 - Nov 19
found 17 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Catania (CTA)
9.2/10 Wonderful! (261 reviews)

Where to stay in Ortigia

Find the best Ortigia areas and neighborhoods for the activities you enjoy most. Learn more about Ortigia
A modern building with a unique triangular roof and a central spire.

Santa Lucia

1 out of top 10 points of interest in this area

Santa Lucia is noteworthy for its historic sites, and you can make a stop at top attractions like Porto Piccolo and Ionian Sea.

Find hotels in Santa Lucia
Ancient ruins with stone steps and walls, surrounded by trees.

Neapolis

2 out of top 10 points of interest in this area

While visiting Neapolis, you might make a stop by sights like Archaeological Park of Neapolis and Greek Theatre of Syracuse.

Find hotels in Neapolis
An ancient amphitheater with stone ruins and a grassy field.

Tiche

Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.

Find hotels in Tiche
A coastal cityscape with modern buildings, palm trees, and a rocky cliff.

Grottasanta

1 out of top 10 points of interest in this area

Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

Find hotels in Grottasanta
Aerial view of Ortigia, historical centre of the city of Syracuse. Aerial view of Maniace fortress in Ortigia, Sicily, Italy. Sanctuary "Our Lady of Tears" is at the background

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

Find hotels in Acradina

Ortigia Hotel Deals

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
Fully refundableReserve now, pay when you stay
$299 nightly
$340 total
Sep 3 - Sep 4
Total with taxes and fees
9.6/10 Exceptional! (1,004 reviews)
"The hotel was very well located, offered 4 bicycles for use in town, andbfacilitatee seamless valet parking for our rented vehicle. The breakfasts"

Reviewed on Aug 28, 2026

Algila' Ortigia Charme Hotel
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

Via Riva Nazario Sauro Syracuse SR
Fully refundableReserve now, pay when you stay
$506 nightly
$568 total
Sep 1 - Sep 2
Total with taxes and fees
9.2/10 Wonderful! (274 reviews)
"We had a fantastic stay at Ortea Palace. I was travelling with my 2 kids - 11 and 15. The hotel is very conveniently located in Ortigia - right across the bridge from Syracusa so easy access to both. The main train station is about 15 mins walk from the hotel. A lot of good restaurants nearby and ..."

Reviewed on Aug 30, 2026

Ortea Palace Hotel, Sicily, Autograph Collection
Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa

Viale Mazzini, 12 Syracuse SR
$327 nightly
$371 total
Sep 3 - Sep 4
Total with taxes and fees
9/10 Wonderful! (621 reviews)
"Old world Italian charm and great service. Would have preferred something more centrally located with a pool and better breakfast."

Reviewed on Aug 29, 2026

Grand Hotel Ortigia Siracusa
See all 814 properties in Ortigia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations
Golf Vacations
Golf Vacations
Luxury Vacations
Luxury Vacations
Romantic Vacations
Romantic Vacations
Ski Vacations
Ski Vacations
Gay Friendly Vacations
LGBTQ Friendly Vacations
LGBTQ Friendly Vacations
Adventure Vacations
Adventure Vacations
Vacations in Month
Where to go when
Where to go when
Honeymoon Vacations
Honeymoon Vacations
Mountain Vacations
Mountain Vacations
Fishing Vacations
Fishing Vacations
Adults Only Vacations
Adults Only Vacations
Waterpark Vacations
Waterpark Vacations
Scuba Diving Vacations
Scuba Diving Vacations
Yoga Vacations
Yoga Vacations
Cheap Vacations
Cheap Vacations
Solo Vacations
Solo Vacations

Stay near popular Ortigia attractions

A coastal cityscape with buildings along the waterfront, a clear blue sky, and a calm sea.
Photo by Juan Pablo Pantoja

Lungomare di Ortigia

9.4/10 (654 reviews)
You can take time to visit Lungomare di Ortigia during your travels to Syracuse. Wander the seaside in this culturally rich area.
See properties
An ancient stone structure with arches and columns, adjacent to a modern building with a dome and windows.

Temple of Apollo

8.8/10 (692 reviews)
Discover over 2,000 years of history when you visit the oldest Doric temple in Sicily.
See properties

Cathedral of Syracuse

9.4/10 (813 reviews)
Learn about the local history of Syracuse with a stop at Cathedral of Syracuse. Wander the seaside in this culturally rich area.
See properties

Piazza del Duomo

9.6/10 (551 reviews)
You can find out about the history of Syracuse with a trip to Piazza del Duomo. Wander the beautiful beaches and seaside in this romantic area.
See properties

Castello Maniace

Learn about the local history of Syracuse when you take a trip to Castello Maniace. Wander the seaside in this culturally rich area.
See properties

Teatro dei Pupi

7.8/10 (17 reviews)
Enjoy a show at Teatro dei Pupi, a storied theater in Syracuse. Wander the seaside in this culturally rich area.
See properties

Tropical Aquarium of Syracuse

8.0/10 (12 reviews)
You can browse the exhibits at Tropical Aquarium of Syracuse, a museum with a story of its own, during your trip to Syracuse. Wander the seaside in this culturally rich area.
See properties

Fonte Aretusa

9.6/10 (4 reviews)
Fonte Aretusa is just one of the places to see in Syracuse, so why not enjoy the other things to explore during your travels? Wander the seaside in this culturally rich area.
See properties

Things to do

Syracuse: Ortigia Island and Sea Caves Boat Tour

Syracuse: Ortigia Island and Sea Caves Boat Tour

$23
per adult
Syracuse: Ortigia Island and Sea Caves Boat Tour
Siracusa: Ortygia Island Boat Tour with Grotto Visit

Siracusa: Ortygia Island Boat Tour with Grotto Visit

$29
per adult
Siracusa: Ortygia Island Boat Tour with Grotto Visit
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat

$47
per adult
Syracuse: Pillirina, Ortigia, and Sea Caves Tour by Boat
See all activities in Syracuse
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.