A coastal cityscape with a sunset, high-rise buildings, and a marina.

San Antonio Vacations from $723

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    • Your San Antonio Vacation

    From its rich history to its cultural experiences and beyond, there's a whole lot to love about San Antonio. Discover the wonders of this exciting city with a San Antonio vacation package that's tailor-made for you. Metromall Panama is just one of the must-see attractions to add to your sightseeing agenda during a trip to San Antonio. A few clicks is all it takes to craft the ideal San Antonio vacation on Expedia.

    The Latest San Antonio Vacation Packages

    Price found within the past 48 hours. Click for updated prices.

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    Where to stay in San Antonio

    Find the best San Antonio areas and neighborhoods for the activities you enjoy most. Learn more about San Antonio

    View properties in map for Rufina Alfaro

    Rufina Alfaro

    While you're in Rufina Alfaro, take in top sights like Metromall Panama and jump on the metro at San Antonio Station to see more of the city.

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    View properties in map for José Domingo Espinar

    José Domingo Espinar

    When in José Domingo Espinar, you can plan a visit to Estadio Rommel Fernandez and Metromall Panama, some noteworthy sights in the nearby area.

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    View properties in map for Omar Torrijos

    Omar Torrijos

    While you're in Omar Torrijos, take in top sights like Templo Bahá'í and jump on the metro at San Isidro Station to see more of the city.

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    View properties in map for Victoriano Lorenzo

    Victoriano Lorenzo

    When in Victoriano Lorenzo and the surrounding area, you'll want to check out sights like Panama Viejo or Estadio Rommel Fernandez and hop on the metro to see more the city at San Miguelito Station or Paraiso Station.

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    A cable-stayed bridge spanning a river, surrounded by lush greenery and hills.

    View properties in map for Cerro Viento

    Cerro Viento

    Shopping and restaurants are notable features of Cerro Viento. You might consider a stop by Metromall Panama while you're exploring the neighborhood.

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    What to do near San Antonio

    Panama Canal: The Most Complete Monkey Island Experience

    Panama Canal: The Most Complete Wildlife Experience

    $36

    per adult

    100% of travelers recommend

    Picture 3 for Activity Panama City: All-Inclusive Catamaran Cruise to Taboga Island

    Panama City: All-Inclusive Catamaran Cruise to Taboga Island

    $99

    per adult

    94% of travelers recommend

    From Panama City: San Blas Islands Tour with Island Hopping

    From Panama City: San Blas Islands Tour with Island Hopping

    $145

    per adult

    98% of travelers recommend

    See all activities near San Antonio

    San Antonio Hotel Deals

    Courtyard by Marriott Panama Metromall

    A buffet with various food items including fruits, juices, and cheeses.
    • Address: Avenida Domingo Diaz via Tocumen, San Miguelito, Panama, PA
    • Location: San Antonio
    • Star rating: 4/5
    • Guest rating: 9.2/10 (Wonderful, 1001 reviews)
    • Price: $101 nightly, $111 total, Dec 11 - Dec 12, Total with taxes and fees
    • Review: Gracias por todo

    Riande Aeropuerto Hotel & Casino

    A pool area with lounge chairs, umbrellas, and a bridge over the water.
    • Address: Vía Tocumen, Tocumen, Panama, 0819-09190, PA
    • Location: 2.8 mi from San Antonio
    • Star rating: 4/5
    • Guest rating: 8.6/10 (Excellent, 1817 reviews)
    • Price: $108 nightly, $119 total, Nov 24 - Nov 25, Total with taxes and fees
    • Review: I had a mixed but mostly pleasant stay at the Hotel. The bed and pillows were very comfortable, breakfast was good, and the airport shuttle was convenient. However, the jacuzzi wasn’t working as advertised and was cold—the pool was actually warmer. I was also disappointed that the casino wasn’t on site; it was a much longer walk than I expected. Overall, there were some real comforts, but the jacuzzi and casino location didn’t meet my expectations.

    Crowne Plaza Panama Airport by IHG

    A swimming pool with a clear water surface, a poolside area with lounge chairs, and a building with large windows and doors.
    • Address: Ave. Domingo Diaz, Tocumen, Panama, 816016660, PA
    • Location: 3.8 mi from San Antonio
    • Star rating: 4/5
    • Guest rating: 8.6/10 (Excellent, 2789 reviews)
    • Price: $150 nightly, $165 total, Dec 8 - Dec 9, Total with taxes and fees
    • Review: The location is convenient.

    ORHO Hotel Boutique 15 Minutes from PTY Airport

    A building with a red facade, two balconies with wrought iron railings, and a tiled roof.
    • Address: Av. Domingo Díaz, Tocumen, Provincia de Panamá, PA
    • Location: 3.6 mi from San Antonio
    • Star rating: 2/5
    • Guest rating: 9/10 (Wonderful, 265 reviews)
    • Price: $99 nightly, $110 total, Dec 2 - Dec 3, Total with taxes and fees
    • Review: Lovely hotel, great 1 night stay, great host, took us to the airport on time, we recommend it.

    Corporate Stays Arcadia | Executive Furnished Apartments

    A rooftop pool with a city view, lounge chairs, and a clear sky.
    • Address: Calle rio mar, Panama City, Panamá Province, 0801, PA
    • Location: 3.8 mi from San Antonio
    • Star rating: 4/5
    • Guest rating: 9.2/10 (Wonderful, 426 reviews)
    • Price: $127 nightly, $140 total, Nov 22 - Nov 23, Total with taxes and fees
    • Review: These apartment building is not near any restaurant or grocery store, if you are not driving it would be hard. Main door lock was not working and to open and close was not easy. Safe box was not working, they provided steam iron which is not ironing clothes and it was not working either. Second bathroom was very small

    Aloft by Marriott Panama

    A modern hotel with a prominent entrance, multiple floors, and a well-lit facade.
    • Address: Via Israel & Calle 76, Panama City, Panama, 0819-05896, PA
    • Location: 6.4 mi from San Antonio
    • Star rating: 3.5/5
    • Guest rating: 8.8/10 (Excellent, 1005 reviews)
    • Price: $131 nightly, $144 total, Nov 22 - Nov 23, Total with taxes and fees
    • Review: Beautiful, clean and friendly staff. I will stay here again.

    The Westin Panama

    A rooftop pool with a city view, modern architecture, and outdoor seating.
    • Address: La Rotonda Street, Costa del Este, Panama City, Panama, PA
    • Location: 4.2 mi from San Antonio
    • Star rating: 4/5
    • Guest rating: 9/10 (Wonderful, 356 reviews)
    • Price: $292 nightly, $321 total, Nov 27 - Nov 28, Total with taxes and fees

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    * Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.