San Francisco Vacations from $664

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The Latest San Francisco vacation packages

Price found within the past 48 hours. Click for updated prices.
Residencial Cristina

Residencial Cristina

2.5 out of 5
per person
Sep 5 - Sep 10
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
7.2/10 Good! (5 reviews)
Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Save 100% on your flight
per person
Sep 5 - Sep 10
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
No reviews
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
per person
Sep 28 - Oct 3
found 12 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr 18, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
per person
Aug 16 - Aug 22
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (925 reviews)
Love the location and the restaurant inside the hotel was phenomenal.

Reviewed on Jul 11, 2025

Hotel Paraiso Caribeño

Hotel Paraiso Caribeño

3 out of 5
per person
Sep 5 - Sep 10
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
7.4/10 Good! (3 reviews)
Excellent staff Galvin Edgar Yuri Azizi and owner Andrea the best!!! Close to restaurants and Nice. Galvin fue muy lindo y atento y ademas que consiguio mejor tour para playa Estrella Lo recomiendo . Regresamos pronto gracias Ingrid C journalist

Reviewed on Mar 20, 2025

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San Francisco Hotel Deals

Hotel Gran David
Hotel Gran David
3.5 out of 5
Vía Interamericana, Santiago, Veraguas
Fully refundableReserve now, pay when you stay
8.4/10 Very Good! (310 reviews)
"I did not like the stale smell in the room when I entered it and the smell was persistent."

Reviewed on Jun 12, 2025

Get rates
Hotel Gran David
Hotel Mykonos Panama
Hotel Mykonos Panama
3.5 out of 5
Panamerican Highway, in front of Ruben Cantu Airport, Nuevo Santiago, Veraguas
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $90 total per night from Aug 14 to Aug 15
$90 total
Aug 14 - Aug 15
Total includes taxes and fees
8.8/10 Excellent! (518 reviews)
"Great location and service."

Reviewed on Jun 28, 2025

Hotel Mykonos Panama
HOTEL VISTA LAGO
HOTEL VISTA LAGO
3 out of 5
Rincón Largo, La Pena, Santiago de Veraguas
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $84 total per night from Jul 16 to Jul 17
$84 total
Jul 16 - Jul 17
Total includes taxes and fees
9.2/10 Wonderful! (60 reviews)
"Very clean, food was 10/10"

Reviewed on Jul 10, 2025

HOTEL VISTA LAGO
See all 16 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best San Francisco Vacation Packages

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Frequently asked questions

How to find the best San Francisco package deals?
Start your search for a San Francisco package deal by entering your travel dates and destination under our "Packages" tab. Then add a few filters, like "Property type" and "Popular locations," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with unbeatable savings. If you don't find the perfect San Francisco package deal right away, just change your dates and search again. Remember that deals are only available for a limited time, so book early and get your San Francisco adventure off to a flying start.
When to book a vacation package to San Francisco?
Enjoy amazing discounts by booking your flights in advance with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment San Francisco adventure.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.