Sanibel Isles Vacations from $360

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Your Sanibel Isles Vacation

Immerse yourself in the best that Sanibel Isles offers with a Sanibel Isles vacation package. From its views to every other thing that makes it so fascinating, this neighborhood will charm you from start to finish. Hoping to sightsee during your trip to Sanibel Isles? Be sure to stop by nearby attractions such as Sanibel Island Lighthouse, Periwinkle Way and Sanibel Island Northern Beach. Whatever your dream Sanibel Isles vacation may look like, you can make it a reality with Expedia.

The Latest Sanibel Isles Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Allure Suites

Allure Suites

3 out of 5
McGregor
Save 100% on your flight
Price was $687, price is now $360 per person
$360
per person
Feb 1 - Feb 8
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
15.2/10 Exceptional! (1,002 reviews)
Everything was great

Reviewed on Oct 30, 2025

Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Price was $1,501, price is now $532 per person
$532
per person
Feb 1 - Feb 8
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
18.4/10 Exceptional! (1,001 reviews)
Nice room and was perfect for a 2 night stay

Reviewed on Nov 20, 2025

Embassy Suites by Hilton Fort Myers Estero

Embassy Suites by Hilton Fort Myers Estero

3.5 out of 5
Price was $1,669, price is now $897 per person
$897
per person
Feb 1 - Feb 8
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
18.4/10 Exceptional! (1,028 reviews)
Everything was perfect , I would definitely stay again . Best hotel breakfast I’ve ever had. I wish I could’ve taken those pillows home with me . Hot tub was perfect for the chilly nights

Reviewed on Nov 16, 2025

LaPlaya Beach & Golf Resort - A Noble House Resort

LaPlaya Beach & Golf Resort - A Noble House Resort

4.5 out of 5
Vanderbilt Beach
Price was $3,185, price is now $1,731 per person
$1,731
per person
Jan 9 - Jan 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
18/10 Exceptional! (1,000 reviews)
Lovely medium size resort. Pools for both morning and afternoon. No pool servers present when we were there, and no water or sunscreen that is typical at higher end resorts. We had an oceanfront room, 2nd floor with balcony in the "beach house", which was appointed beautifully and had 2 doors that opened onto the well furnished balcony. The first floor of this building has fire pit patios which means the other ocean front rooms can get noisy even with 4 people speaking at normal levels, since they are just feet away from the 2nd floor balconies. Most of the staff was friendly; there was one front desk person who was not, but I addressed that with the manager.

Reviewed on Nov 19, 2025

Naples Grande Beach Resort

Naples Grande Beach Resort

4.5 out of 5
Park Shore
Save 100% on your flight
Price was $1,469, price is now $802 per person
$802
per person
Jan 4 - Jan 10
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
18/10 Exceptional! (1,914 reviews)
THE STAFF AND ROOMS WERE GREAT. THE LOCATION IS CLOSE TO EVERYTHING AND ENJOYED THE FOOD AND DRINKS AT THE BAR EXCELLENT CHOICE OF BOURBONS

Reviewed on Nov 21, 2025

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Where to stay in Sanibel Isles

Find the best Sanibel Isles areas and neighborhoods for the activities you enjoy most. Learn more about Sanibel Isles
Fort Myers featuring a sandy beach

West End

3 out of top 10 points of interest in this area

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

Find hotels in West End
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Sanibel Isles

Sanibel Island Southern Beach

Sanibel Island Southern Beach

4.5/5(171 reviews)

Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel?

Sanibel Island Southern Beach
Bowman\'s Beach which includes general coastal views and a sandy beach

Bowman's Beach

4.5/5(481 reviews)

Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells.

Bowman's Beach
Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset

Sanibel Island Lighthouse

4.5/5(1,092 reviews)

Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting.

Sanibel Island Lighthouse

Things to do

Fort Myers Beach Sunset Excursion

Fort Myers Beach Sunset Excursion

$65
per adult
100% of travellers recommend
Fort Myers Beach Sunset Excursion
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

$70
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
Dolphin and Sightseeing Tiki Cruise

Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included

$65
per adult
Fort Myers Beach Dolphin & Sightseeing Tour Refreshments Included
See all activities in Sanibel
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.