
Sanibel Isles Vacations from $254
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $1,045 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Sanibel Isles Vacation
Immerse yourself in the best that Sanibel Isles offers with a Sanibel Isles vacation package. From its views to every other thing that makes it so fascinating, this neighborhood will charm you from start to finish. Hoping to sightsee during your trip to Sanibel Isles? Be sure to stop by nearby attractions such as Sanibel Island Lighthouse, Periwinkle Way and Sanibel Island Northern Beach. Whatever your dream Sanibel Isles vacation may look like, you can make it a reality with Expedia.
The Latest Sanibel Isles Vacation Packages

Courtyard by Marriott Fort Myers Cape Coral
Reviewed on Feb 18, 2026

LaPlaya Beach & Golf Resort - A Noble House Resort
Reviewed on Feb 19, 2026

The Perry Hotel Naples
Reviewed on Feb 20, 2026


Hyatt Vacation Club at Coconut Cove, Bonita Springs
Reviewed on Feb 14, 2026
Where to stay in Sanibel Isles

Mid Island
While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.
Sanibel Isles Hotel Deals

Baymont by Wyndham Fort Myers Central
Floor could have been mopped better
Reviewed on Feb 16, 2026

Margaritaville Beach Resort Fort Myers
United airlines is the worst its know wonder why I have over a million miles with American
Reviewed on Feb 19, 2026

Sanibel Island Beach Resort
Great location, easy access to beach - service was fantastic - rooms are very nice
Reviewed on Feb 19, 2026
Discover the most popular places to visit in Sanibel Isles

Sanibel Island Southern Beach
Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel?

Sanibel Island Lighthouse
Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting.

Bowman's Beach
Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells.
Things to do






















