Sanibel Isles Vacations from $254

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Your Sanibel Isles Vacation

Immerse yourself in the best that Sanibel Isles offers with a Sanibel Isles vacation package. From its views to every other thing that makes it so fascinating, this neighborhood will charm you from start to finish. Hoping to sightsee during your trip to Sanibel Isles? Be sure to stop by nearby attractions such as Sanibel Island Lighthouse, Periwinkle Way and Sanibel Island Northern Beach. Whatever your dream Sanibel Isles vacation may look like, you can make it a reality with Expedia.

The Latest Sanibel Isles Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Courtyard by Marriott Fort Myers Cape Coral

Courtyard by Marriott Fort Myers Cape Coral

3 out of 5
Save 100% on your flight
Price was $449, price is now $254 per person
$254
per person
Mar 23 - Mar 26
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
8.2/10 Very Good! (997 reviews)
Room was ok a little dated with a couple spots on sofa team there are great

Reviewed on Feb 18, 2026

LaPlaya Beach & Golf Resort - A Noble House Resort

LaPlaya Beach & Golf Resort - A Noble House Resort

4.5 out of 5
Vanderbilt Beach
Save 100% on your flight
Price was $2,544, price is now $1,376 per person
$1,376
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9/10 Wonderful! (1,000 reviews)
Proximity to beach and gulf. Great staff and experience.

Reviewed on Feb 19, 2026

The Perry Hotel Naples

The Perry Hotel Naples

4.5 out of 5
Save 100% on your flight
Price was $1,073, price is now $599 per person
$599
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.6/10 Exceptional! (477 reviews)
We stayed for a night. Wonderful to be charged resort fees. The hotel was nice. Beds were standard. It wasn't the super awesome experience you would think it would be

Reviewed on Feb 20, 2026

Matanzas Inn Bayside Resort and Marina

Matanzas Inn Bayside Resort and Marina

3 out of 5
Save 100% on your flight
Price was $1,163, price is now $668 per person
$668
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.2/10 Wonderful! (1,001 reviews)
Clean room and staff.

Reviewed on Feb 19, 2026

Hyatt Vacation Club at Coconut Cove, Bonita Springs

Hyatt Vacation Club at Coconut Cove, Bonita Springs

4 out of 5
Save 100% on your flight
Price was $813, price is now $507 per person
$507
per person
Apr 26 - May 1
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
9.2/10 Wonderful! (704 reviews)
Wonder people like Teri and Marcelo make this place special. So convenient to everything, Hyatt Regency Tarpon Bay is excellent! Spa manicure service is superb as well ( had a detailed and perfect manicure from Tetiana!) highly recommend!

Reviewed on Feb 14, 2026

Where to stay in Sanibel Isles

Find the best Sanibel Isles areas and neighborhoods for the activities you enjoy most. Learn more about Sanibel Isles
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Mid Island

2 out of top 10 points of interest in this area

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

Find hotels in Mid Island

Sanibel Isles Hotel Deals

Baymont by Wyndham Fort Myers Central

Baymont by Wyndham Fort Myers Central

2.5 out of 5
4850 S Cleveland Ave Fort Myers FL
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $105 total per night from Mar 18 to Mar 19
$105 total
Mar 18 - Mar 19
Total with taxes and fees
6.6/10 (1,015 reviews)
Floor could have been mopped better

Reviewed on Feb 16, 2026

Baymont by Wyndham Fort Myers Central
Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers

4 out of 5
251 Crescent Street Fort Myers Beach FL
$543 nightly
The price is $606 total per night from Feb 22 to Feb 23
$606 total
Feb 22 - Feb 23
Total with taxes and fees
8.8/10 Excellent! (1,897 reviews)
United airlines is the worst its know wonder why I have over a million miles with American

Reviewed on Feb 19, 2026

Margaritaville Beach Resort Fort Myers
Sanibel Island Beach Resort

Sanibel Island Beach Resort

3 out of 5
1231 Middle Gulf Dr Sanibel FL
Fully refundableReserve now, pay when you stay
$434 nightly
The price is $482 total per night from Mar 18 to Mar 19
$482 total
Mar 18 - Mar 19
Total with taxes and fees
9/10 Wonderful! (1,627 reviews)
Great location, easy access to beach - service was fantastic - rooms are very nice

Reviewed on Feb 19, 2026

Sanibel Island Beach Resort
See all 15,481 properties in Sanibel Isles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Sanibel Isles

Seashells on Sanibel Island, Florida

Sanibel Island Southern Beach

Why not spend a lazy afternoon at Sanibel Island Southern Beach during your trip to Sanibel?

Sanibel Island Southern Beach
Sanibel Island Lighthouse which includes a beach, general coastal views and a sunset

Sanibel Island Lighthouse

Although nobody knows how many shipwrecks it’s prevented, this lighthouse has been a welcome beacon for over a century. Visit it on an island that’s noted for shell collecting.

Sanibel Island Lighthouse
Bowman\'s Beach which includes general coastal views and a sandy beach

Bowman's Beach

Relax and revel in a visit to one of the area’s most beautiful beaches, great for swimming, fishing and finding special seashells.

Bowman's Beach

Things to do

Fort Myers Beach Sunset and Dolphin Watching Cruise

Fort Myers Beach Sunset and Dolphin Watching Cruise

$70
per adult
100% of travellers recommend
Fort Myers Beach Sunset and Dolphin Watching Cruise
Copacetic Day Sail

Copacetic Day Sail

$70
per adult
100% of travellers recommend
Copacetic Day Sail
Southwest Florida Sunset Sail

Southwest Florida Sunset Sail

$70
per adult
100% of travellers recommend
Southwest Florida Sunset Sail
See all activities in Sanibel
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.